{"id":"https://openalex.org/W1497981046","doi":"https://doi.org/10.1002/9783527630332.ch1","title":"The Biology ofMYCin Health and Disease: A High Altitude View","display_name":"The Biology ofMYCin Health and Disease: A High Altitude View","publication_year":2010,"publication_date":"2010-04-22","ids":{"openalex":"https://openalex.org/W1497981046","doi":"https://doi.org/10.1002/9783527630332.ch1","mag":"1497981046"},"language":"en","primary_location":{"id":"doi:10.1002/9783527630332.ch1","doi":"https://doi.org/10.1002/9783527630332.ch1","is_oa":false,"landing_page_url":"https://doi.org/10.1002/9783527630332.ch1","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Biostatistics for Complex Diseases","raw_type":"other"},"volume":{"id":"https://openalex.org/W2490447578","display_name":"Medical Biostatistics for Complex Diseases"},"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112928008","display_name":"Brian C. Turner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian C. Turner","raw_affiliation_strings":["University of Colorado Denver, Department of Dermatology, Charles C. Gates Program in Regenerative Medicine and Stem Cell, Biology, 12800 E. 19th Avenue, Aurora, CO 80045, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Colorado Denver, Department of Dermatology, Charles C. Gates Program in Regenerative Medicine and Stem Cell, Biology, 12800 E. 19th Avenue, Aurora, CO 80045, USA","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052564445","display_name":"Gregory A. Bird","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory A. Bird","raw_affiliation_strings":["University of Colorado Denver, Department of Dermatology, Charles C. Gates Program in Regenerative Medicine and Stem Cell, Biology, 12800 E. 19th Avenue, Aurora, CO 80045, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Colorado Denver, Department of Dermatology, Charles C. Gates Program in Regenerative Medicine and Stem Cell, Biology, 12800 E. 19th Avenue, Aurora, CO 80045, USA","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031807330","display_name":"Yosef Refaeli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yosef Refaeli","raw_affiliation_strings":["University of Colorado Denver, Department of Dermatology, Charles C. Gates Program in Regenerative Medicine and Stem Cell, Biology, 12800 E. 19th Avenue, Aurora, CO 80045, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Colorado Denver, Department of Dermatology, Charles C. Gates Program in Regenerative Medicine and Stem Cell, Biology, 12800 E. 19th Avenue, Aurora, CO 80045, USA","institution_ids":["https://openalex.org/I921990950"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I921990950"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"24"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.6650000214576721,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.6650000214576721,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.2281000018119812,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.04129999876022339,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.9449999928474426},{"id":"https://openalex.org/keywords/hematologic-malignancies","display_name":"hematologic malignancies","score":0.8849999904632568},{"id":"https://openalex.org/keywords/lymphoid-malignancies","display_name":"lymphoid malignancies","score":0.8650000095367432},{"id":"https://openalex.org/keywords/b-cell-receptor-signaling","display_name":"B cell receptor signaling","score":0.7310000061988831},{"id":"https://openalex.org/keywords/cell-cycle-regulation","display_name":"cell cycle regulation","score":0.8610000014305115},{"id":"https://openalex.org/keywords/cell-differentiation","display_name":"cell differentiation","score":0.8550000190734863},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6340000033378601},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.7250000238418579},{"id":"https://openalex.org/keywords/myc-mutations","display_name":"MYC mutations","score":0.6209999918937683},{"id":"https://openalex.org/keywords/myc-overexpression","display_name":"MYC overexpression","score":0.7049999833106995},{"id":"https://openalex.org/keywords/tumor-biology","display_name":"tumor biology","score":0.640999972820282},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.5799999833106995},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.7179999947547913},{"id":"https://openalex.org/keywords/protein-synthesis","display_name":"protein synthesis","score":0.7059999704360962},{"id":"https://openalex.org/keywords/metabolism","display_name":"metabolism","score":0.5609999895095825}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6627316474914551},{"id":"https://openalex.org/C2910353367","wikidata":"https://www.wikidata.org/wiki/Q420267","display_name":"Proto-Oncogene Proteins c-myc","level":4,"score":0.645115077495575},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5880283713340759},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.5512955784797668},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5275252461433411},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.5124509930610657},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.5067763924598694},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4748411774635315},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.46095895767211914},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3589589595794678},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2574976980686188},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.155499666929245}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/9783527630332.ch1","doi":"https://doi.org/10.1002/9783527630332.ch1","is_oa":false,"landing_page_url":"https://doi.org/10.1002/9783527630332.ch1","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Biostatistics for Complex Diseases","raw_type":"other"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.46000000834465027,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":106,"referenced_works":["https://openalex.org/W9628304","https://openalex.org/W67883954","https://openalex.org/W71987001","https://openalex.org/W79064856","https://openalex.org/W131544305","https://openalex.org/W133159440","https://openalex.org/W272348287","https://openalex.org/W1498881957","https://openalex.org/W1535776410","https://openalex.org/W1546589729","https://openalex.org/W1547509454","https://openalex.org/W1786563963","https://openalex.org/W1847174723","https://openalex.org/W1847864430","https://openalex.org/W1923330157","https://openalex.org/W1960219558","https://openalex.org/W1965254413","https://openalex.org/W1965854549","https://openalex.org/W1967400657","https://openalex.org/W1968075576","https://openalex.org/W1972778166","https://openalex.org/W1976632546","https://openalex.org/W1977290507","https://openalex.org/W1977372263","https://openalex.org/W1977757897","https://openalex.org/W1982172428","https://openalex.org/W1983751803","https://openalex.org/W1984419027","https://openalex.org/W1992076386","https://openalex.org/W1992137166","https://openalex.org/W1993522288","https://openalex.org/W1995431293","https://openalex.org/W2007296317","https://openalex.org/W2012908073","https://openalex.org/W2014037288","https://openalex.org/W2014624348","https://openalex.org/W2015815772","https://openalex.org/W2026451921","https://openalex.org/W2026496528","https://openalex.org/W2030816211","https://openalex.org/W2032972450","https://openalex.org/W2033384486","https://openalex.org/W2035864711","https://openalex.org/W2039463309","https://openalex.org/W2043395027","https://openalex.org/W2043848225","https://openalex.org/W2044915747","https://openalex.org/W2045899555","https://openalex.org/W2050563044","https://openalex.org/W2055255976","https://openalex.org/W2061035943","https://openalex.org/W2061918976","https://openalex.org/W2062348957","https://openalex.org/W2064772366","https://openalex.org/W2066277278","https://openalex.org/W2066807386","https://openalex.org/W2068606395","https://openalex.org/W2068842251","https://openalex.org/W2068889468","https://openalex.org/W2069795464","https://openalex.org/W2071491707","https://openalex.org/W2078511240","https://openalex.org/W2082044596","https://openalex.org/W2082673082","https://openalex.org/W2083326500","https://openalex.org/W2085877736","https://openalex.org/W2086132387","https://openalex.org/W2090685205","https://openalex.org/W2093296292","https://openalex.org/W2093515639","https://openalex.org/W2096441034","https://openalex.org/W2097034929","https://openalex.org/W2097774235","https://openalex.org/W2101904615","https://openalex.org/W2104014517","https://openalex.org/W2105613536","https://openalex.org/W2105988181","https://openalex.org/W2106119346","https://openalex.org/W2112346826","https://openalex.org/W2119070528","https://openalex.org/W2127150495","https://openalex.org/W2130227763","https://openalex.org/W2136920402","https://openalex.org/W2138366746","https://openalex.org/W2141529421","https://openalex.org/W2147246240","https://openalex.org/W2150608281","https://openalex.org/W2151163426","https://openalex.org/W2154191201","https://openalex.org/W2159287501","https://openalex.org/W2162511924","https://openalex.org/W2164515753","https://openalex.org/W2164559478","https://openalex.org/W2170315615","https://openalex.org/W2320732213","https://openalex.org/W2320782426","https://openalex.org/W2321413240","https://openalex.org/W2322711897","https://openalex.org/W2330609930","https://openalex.org/W2356673736","https://openalex.org/W2410415256","https://openalex.org/W2413228550","https://openalex.org/W2414872847","https://openalex.org/W2419070327","https://openalex.org/W2428242506","https://openalex.org/W4292820908"],"related_works":["https://openalex.org/W3187599602","https://openalex.org/W2031570299","https://openalex.org/W3007473615","https://openalex.org/W4387903714","https://openalex.org/W2144965236","https://openalex.org/W1594695778","https://openalex.org/W1905971800","https://openalex.org/W2903177490","https://openalex.org/W3041415914","https://openalex.org/W2018256173"],"abstract_inverted_index":{"This":[0],"chapter":[1],"contains":[2],"sections":[3],"titled:":[4],"Introduction":[5,44],"MYC":[6,40,50,58,65,82,94],"and":[7,13,19,31,70],"Normal":[8],"Physiology":[9],"Regulation":[10,18,69],"of":[11,29,33,39,45,49,64,76,88],"Transcription":[12],"Gene":[14,59],"Expression":[15],"Metabolism":[16],"Cell-Cycle":[17],"Differentiation":[20,71],"Protein":[21],"Synthesis":[22],"Cell":[23,67],"Adhesion":[24],"Apoptosis":[25],"MicroRNAs":[26],"Physiological":[27],"Effects":[28],"Loss":[30],"Gain":[32],"c-myc":[34],"Function":[35],"in":[36,52,56,60,66,72,79,84,91,95],"Mice":[37],"Contributions":[38],"to":[41,93],"Tumor":[42],"Biology":[43],"Hematopoietic":[46],"Malignancies":[47,54,86],"Mechanisms":[48],"Dysregulation":[51],"Hematological":[53,61,73,96],"Mutation(s)":[55],"the":[57],"Cancers":[62,74,97],"Role":[63,75],"Cycle":[68],"BCR":[77],"Signaling":[78],"Conjunction":[80],"with":[81],"Overexpression":[83],"Lymphoid":[85],"Deregulation":[87],"Auxiliary":[89],"Proteins":[90],"Addition":[92],"Conclusion":[98],"References":[99]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}
