{"id":"https://openalex.org/W1497747464","doi":"https://doi.org/10.1063/1.3576925","title":"Transport and shear in a microfluidic membrane bilayer device for cell culture","display_name":"Transport and shear in a microfluidic membrane bilayer device for cell culture","publication_year":2011,"publication_date":"2011-06-01","ids":{"openalex":"https://openalex.org/W1497747464","doi":"https://doi.org/10.1063/1.3576925","mag":"1497747464","pmid":"https://pubmed.ncbi.nlm.nih.gov/21799719","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3145238"},"language":"en","primary_location":{"id":"doi:10.1063/1.3576925","doi":"https://doi.org/10.1063/1.3576925","is_oa":true,"landing_page_url":"https://doi.org/10.1063/1.3576925","pdf_url":"https://aip.scitation.org/doi/pdf/10.1063/1.3576925","source":{"id":"https://openalex.org/S173107507","display_name":"Biomicrofluidics","issn_l":"1932-1058","issn":["1932-1058"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320257","host_organization_name":"American Institute of Physics","host_organization_lineage":["https://openalex.org/P4310320257"],"host_organization_lineage_names":["American Institute of Physics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomicrofluidics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://aip.scitation.org/doi/pdf/10.1063/1.3576925","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023760393","display_name":"Niraj K. Inamdar","orcid":"https://orcid.org/0000-0003-0290-3054","observed_orcids":["https://orcid.org/0000-0003-0290-3054"]},"institutions":[{"id":"https://openalex.org/I1343143571","display_name":"Draper Laboratory","ror":"https://ror.org/04378d909","country_code":"US","type":"funder","lineage":["https://openalex.org/I1343143571"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Niraj K. Inamdar","raw_affiliation_strings":["Charles Stark Draper Laboratory 2 Department of Biomedical Engineering, , Cambridge, Massachusetts 02139, USA","Massachusetts Institute of Technology 1 Department of Mechanical Engineering, , Cambridge, Massachusetts 02139, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Charles Stark Draper Laboratory 2 Department of Biomedical Engineering, , Cambridge, Massachusetts 02139, USA","institution_ids":["https://openalex.org/I1343143571"]},{"raw_affiliation_string":"Massachusetts Institute of Technology 1 Department of Mechanical Engineering, , Cambridge, Massachusetts 02139, USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035363566","display_name":"Linda Gay Griffith","orcid":"https://orcid.org/0000-0002-1801-5548","observed_orcids":["https://orcid.org/0000-0002-1801-5548"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linda G. Griffith","raw_affiliation_strings":["Massachusetts Institute of Technology 1 Department of Mechanical Engineering, , Cambridge, Massachusetts 02139, USA","Massachusetts Institute of Technology 3 Department of Biological Engineering, , Cambridge, Massachusetts 02139, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts Institute of Technology 1 Department of Mechanical Engineering, , Cambridge, Massachusetts 02139, USA","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Massachusetts Institute of Technology 3 Department of Biological Engineering, , Cambridge, Massachusetts 02139, USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052258825","display_name":"Jeffrey T. Borenstein","orcid":"https://orcid.org/0000-0002-4482-3274","observed_orcids":["https://orcid.org/0000-0002-4482-3274"]},"institutions":[{"id":"https://openalex.org/I1343143571","display_name":"Draper Laboratory","ror":"https://ror.org/04378d909","country_code":"US","type":"funder","lineage":["https://openalex.org/I1343143571"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey T. Borenstein","raw_affiliation_strings":["Charles Stark Draper Laboratory 2 Department of Biomedical Engineering, , Cambridge, Massachusetts 02139, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Charles Stark Draper Laboratory 2 Department of Biomedical Engineering, , Cambridge, Massachusetts 02139, USA","institution_ids":["https://openalex.org/I1343143571"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.8958,"has_fulltext":true,"cited_by_count":29,"citation_normalized_percentile":{"value":0.83514234,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"5","issue":"2","first_page":"22213","last_page":"22213"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.7217000126838684,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.7217000126838684,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.20319999754428864,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11255","display_name":"Microfluidic and Bio-sensing Technologies","score":0.03959999978542328,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microfluidic-cell-culture","display_name":"microfluidic cell culture","score":0.8259999752044678},{"id":"https://openalex.org/keywords/oxygen-transport","display_name":"oxygen transport","score":0.906000018119812},{"id":"https://openalex.org/keywords/hemodynamic-shear-stress","display_name":"hemodynamic shear stress","score":0.8640000224113464},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.9940000176429749},{"id":"https://openalex.org/keywords/oxygen-gradients","display_name":"oxygen gradients","score":0.5669999718666077},{"id":"https://openalex.org/keywords/analytical-model","display_name":"analytical model","score":0.5730000138282776}],"concepts":[{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.6604154109954834},{"id":"https://openalex.org/C192157962","wikidata":"https://www.wikidata.org/wiki/Q4087243","display_name":"Bilayer","level":3,"score":0.5986573100090027},{"id":"https://openalex.org/C2993864201","wikidata":"https://www.wikidata.org/wiki/Q7873","display_name":"Oxygen transport","level":3,"score":0.5691367387771606},{"id":"https://openalex.org/C96035792","wikidata":"https://www.wikidata.org/wiki/Q43606218","display_name":"Shear (geology)","level":2,"score":0.5264455080032349},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5041085481643677},{"id":"https://openalex.org/C135768490","wikidata":"https://www.wikidata.org/wiki/Q2250602","display_name":"Shear flow","level":2,"score":0.43080902099609375},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4299781322479248},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.41574573516845703},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.41067296266555786},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.40043747425079346},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.3973842263221741},{"id":"https://openalex.org/C57879066","wikidata":"https://www.wikidata.org/wiki/Q41217","display_name":"Mechanics","level":1,"score":0.1973617970943451},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1327243149280548},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09881353378295898},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.07546126842498779},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.07179701328277588},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1063/1.3576925","doi":"https://doi.org/10.1063/1.3576925","is_oa":true,"landing_page_url":"https://doi.org/10.1063/1.3576925","pdf_url":"https://aip.scitation.org/doi/pdf/10.1063/1.3576925","source":{"id":"https://openalex.org/S173107507","display_name":"Biomicrofluidics","issn_l":"1932-1058","issn":["1932-1058"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320257","host_organization_name":"American Institute of Physics","host_organization_lineage":["https://openalex.org/P4310320257"],"host_organization_lineage_names":["American Institute of Physics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomicrofluidics","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2150123","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3145238","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3145238","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3145238","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomicrofluidics","raw_type":"Text"},{"id":"pmid:21799719","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21799719","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomicrofluidics","raw_type":"Journal Article"},{"id":"pmh:oai:dspace.mit.edu:1721.1/75775","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1721.1/75775","pdf_url":null,"source":{"id":"https://openalex.org/S4306400425","display_name":"DSpace@MIT (Massachusetts Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I63966007","host_organization_name":"Massachusetts Institute of Technology","host_organization_lineage":["https://openalex.org/I63966007"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PMC","raw_type":"Article"},{"id":"mag:1497747464","doi":null,"is_oa":false,"landing_page_url":"https://dspace.mit.edu/handle/1721.1/75775","pdf_url":null,"source":{"id":"https://openalex.org/S4306522653","display_name":"PMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PMC","raw_type":null}],"best_oa_location":{"id":"doi:10.1063/1.3576925","doi":"https://doi.org/10.1063/1.3576925","is_oa":true,"landing_page_url":"https://doi.org/10.1063/1.3576925","pdf_url":"https://aip.scitation.org/doi/pdf/10.1063/1.3576925","source":{"id":"https://openalex.org/S173107507","display_name":"Biomicrofluidics","issn_l":"1932-1058","issn":["1932-1058"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320257","host_organization_name":"American Institute of Physics","host_organization_lineage":["https://openalex.org/P4310320257"],"host_organization_lineage_names":["American Institute of Physics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomicrofluidics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.428600013256073,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1449374419","display_name":"Perfused 3D Tissue Surrogates for Complex Cell-Cell Communication Systems","funder_award_id":"R01EB010246","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1497747464.pdf","grobid_xml":"https://content.openalex.org/works/W1497747464.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1497747464","https://openalex.org/W1502442150","https://openalex.org/W1981777800","https://openalex.org/W1986064595","https://openalex.org/W1994219607","https://openalex.org/W2006385054","https://openalex.org/W2008386900","https://openalex.org/W2011628763","https://openalex.org/W2020331803","https://openalex.org/W2024971068","https://openalex.org/W2031375787","https://openalex.org/W2031785809","https://openalex.org/W2040661591","https://openalex.org/W2046873552","https://openalex.org/W2048626875","https://openalex.org/W2051531582","https://openalex.org/W2057896668","https://openalex.org/W2062317385","https://openalex.org/W2069641472","https://openalex.org/W2080376320","https://openalex.org/W2091637934","https://openalex.org/W2096433224","https://openalex.org/W2097258239","https://openalex.org/W2101252590","https://openalex.org/W2101770878","https://openalex.org/W2116167491","https://openalex.org/W2119708685","https://openalex.org/W2122238986","https://openalex.org/W2124918094","https://openalex.org/W2125565875","https://openalex.org/W2131907798","https://openalex.org/W2133515086","https://openalex.org/W2134257943","https://openalex.org/W2134745814","https://openalex.org/W2139301465","https://openalex.org/W2145403292","https://openalex.org/W2161817427","https://openalex.org/W2164527416","https://openalex.org/W2164548118","https://openalex.org/W2171803108","https://openalex.org/W3020969361"],"related_works":["https://openalex.org/W2100417014","https://openalex.org/W4221044979","https://openalex.org/W2291153136","https://openalex.org/W7171964789","https://openalex.org/W1598702483","https://openalex.org/W2038766152","https://openalex.org/W1984162642","https://openalex.org/W2629724424","https://openalex.org/W2006904007","https://openalex.org/W2131907798"],"abstract_inverted_index":{"Microfluidic":[0],"devices":[1,102],"have":[2,37,113],"been":[3,114],"established":[4],"as":[5],"useful":[6],"platforms":[7],"for":[8,11,217],"cell":[9,47,140],"culture":[10,48,78,153],"a":[12,45,51,127,139,147,156,190,200],"broad":[13],"range":[14],"of":[15,23,79,144,167,208],"applications,":[16],"but":[17],"challenges":[18],"associated":[19],"with":[20],"controlling":[21],"gradients":[22],"oxygen":[24,60,109,122,176,193,209],"and":[25,29,62,92,111,124,170,178,203,211,219],"other":[26,220],"soluble":[27,134],"factors":[28,135],"hemodynamic":[30,64,179,227],"shear":[31,65,85,105,125,180,212,228],"forces":[32,66],"in":[33,50,76,100,126,132,199],"small,":[34],"confined":[35],"channels":[36],"emerged.":[38],"For":[39],"instance,":[40],"simple":[41],"microfluidic":[42,101,130],"constructs":[43],"comprising":[44],"single":[46],"compartment":[49],"dynamic":[52],"flow":[53,145],"condition":[54],"must":[55],"handle":[56],"tradeoffs":[57,72],"between":[58,121],"sustaining":[59],"delivery":[61,177],"limiting":[63],"imparted":[67,181],"to":[68,88,97,138,173,182,214,223,226],"the":[69,77,119,152,165,183],"cells.":[70,185],"These":[71],"present":[73,118,159],"significant":[74],"difficulties":[75],"mesenchymal":[80],"stem":[81],"cells":[82,99,221],"(MSCs),":[83],"where":[84],"is":[86,197],"known":[87,222],"regulate":[89],"signaling,":[90],"proliferation,":[91],"expression.":[93],"Several":[94],"approaches":[95],"designed":[96],"shield":[98],"from":[103,151],"excessive":[104],"while":[106],"maintaining":[107],"sufficient":[108],"concentrations":[110],"transport":[112,123,210],"reported.":[115],"Here":[116],"we":[117],"relationship":[120],"\"membrane":[128],"bilayer\"":[129],"device,":[131],"which":[133],"are":[136],"delivered":[137],"population":[141],"by":[142,155],"means":[143],"through":[146],"proximate":[148],"channel":[149,154],"separated":[150],"membrane.":[157],"We":[158],"an":[160],"analytical":[161],"model":[162],"that":[163,196],"describes":[164],"characteristics":[166],"this":[168],"device":[169],"its":[171],"ability":[172],"independently":[174],"modulate":[175],"cultured":[184],"This":[186],"bilayer":[187],"configuration":[188],"provides":[189],"more":[191],"uniform":[192],"concentration":[194],"profile":[195],"possible":[198],"single-channel":[201],"system,":[202],"it":[204],"enables":[205],"independent":[206],"tuning":[207],"parameters":[213],"meet":[215],"requirements":[216],"MSCs":[218],"be":[224],"sensitive":[225],"stresses.":[229]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}