{"id":"https://openalex.org/W1497632048","doi":"https://doi.org/10.1111/j.0954-6820.1981.tb09818.x","title":"Progression of Bone Marrow Abnormalities in Malignant Hemopoietic Dysplasia","display_name":"Progression of Bone Marrow Abnormalities in Malignant Hemopoietic Dysplasia","publication_year":1981,"publication_date":"1981-01-12","ids":{"openalex":"https://openalex.org/W1497632048","doi":"https://doi.org/10.1111/j.0954-6820.1981.tb09818.x","mag":"1497632048","pmid":"https://pubmed.ncbi.nlm.nih.gov/6947685"},"language":"en","primary_location":{"id":"doi:10.1111/j.0954-6820.1981.tb09818.x","doi":"https://doi.org/10.1111/j.0954-6820.1981.tb09818.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.0954-6820.1981.tb09818.x","pdf_url":null,"source":{"id":"https://openalex.org/S91099313","display_name":"Acta Medica Scandinavica","issn_l":"0001-6101","issn":["0001-6101"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Medica Scandinavica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050711191","display_name":"Jan Lidbeck","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151885","display_name":"Link\u00f6ping University Hospital","ror":"https://ror.org/05h1aye87","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210151885"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Jan Lidbeck","raw_affiliation_strings":["Department of Internal Medicine and Laboratory of Clinical Cytology, University Hospital, Linko\u0308ping, Sweden","Department of Internal Medicine and Laboratory of Clinical Cytology, University Hospital, Link\u00f6ping, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine and Laboratory of Clinical Cytology, University Hospital, Linko\u0308ping, Sweden","institution_ids":["https://openalex.org/I4210151885"]},{"raw_affiliation_string":"Department of Internal Medicine and Laboratory of Clinical Cytology, University Hospital, Link\u00f6ping, Sweden","institution_ids":["https://openalex.org/I4210151885"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021636429","display_name":"Jan Christer M\u00e5nson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151885","display_name":"Link\u00f6ping University Hospital","ror":"https://ror.org/05h1aye87","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210151885"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Jan Christer M\u00e5nson","raw_affiliation_strings":["Department of Internal Medicine and Laboratory of Clinical Cytology, University Hospital, Linko\u0308ping, Sweden","Department of Internal Medicine and Laboratory of Clinical Cytology, University Hospital, Link\u00f6ping, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine and Laboratory of Clinical Cytology, University Hospital, Linko\u0308ping, Sweden","institution_ids":["https://openalex.org/I4210151885"]},{"raw_affiliation_string":"Department of Internal Medicine and Laboratory of Clinical Cytology, University Hospital, Link\u00f6ping, Sweden","institution_ids":["https://openalex.org/I4210151885"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210151885"],"apc_list":null,"apc_paid":null,"fwci":1.035,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.7420238,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"210","issue":"1-6","first_page":"293","last_page":"298"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13374","display_name":"Hematological disorders and diagnostics","score":0.01360000018030405,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12919","display_name":"Blood disorders and treatments","score":0.008100000210106373,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bone-marrow-abnormalities","display_name":"bone marrow abnormalities","score":0.9359999895095825},{"id":"https://openalex.org/keywords/progression","display_name":"progression","score":0.42899999022483826},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9039999842643738},{"id":"https://openalex.org/keywords/leukemic-transformation","display_name":"leukemic transformation","score":0.9229999780654907},{"id":"https://openalex.org/keywords/abnormal-cytology","display_name":"atypical cytology","score":0.7099999785423279}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8829470276832581},{"id":"https://openalex.org/C2775894508","wikidata":"https://www.wikidata.org/wiki/Q1128996","display_name":"Dysplasia","level":2,"score":0.755112886428833},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.742956817150116},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.6506150960922241},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.6266916990280151},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.6119799613952637},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6083836555480957},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.4549115002155304},{"id":"https://openalex.org/C31033888","wikidata":"https://www.wikidata.org/wiki/Q752076","display_name":"Malignant transformation","level":2,"score":0.42065468430519104},{"id":"https://openalex.org/C2780817109","wikidata":"https://www.wikidata.org/wiki/Q954625","display_name":"Myelodysplastic syndromes","level":3,"score":0.4205487072467804},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28895634412765503},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.08628714084625244},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.04954338073730469},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001853","descriptor_name":"Bone Marrow","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004915","descriptor_name":"Leukemia, Erythroblastic, Acute","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011289","descriptor_name":"Preleukemia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012306","descriptor_name":"Risk","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.0954-6820.1981.tb09818.x","doi":"https://doi.org/10.1111/j.0954-6820.1981.tb09818.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.0954-6820.1981.tb09818.x","pdf_url":null,"source":{"id":"https://openalex.org/S91099313","display_name":"Acta Medica Scandinavica","issn_l":"0001-6101","issn":["0001-6101"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Medica Scandinavica","raw_type":"journal-article"},{"id":"pmid:6947685","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6947685","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta medica Scandinavica","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9789000153541565,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W12294476","https://openalex.org/W147799191","https://openalex.org/W282087568","https://openalex.org/W1480768564","https://openalex.org/W1570204373","https://openalex.org/W1596570898","https://openalex.org/W1972503225","https://openalex.org/W1994046450","https://openalex.org/W2013135996","https://openalex.org/W2028924492","https://openalex.org/W2030924173","https://openalex.org/W2058304156","https://openalex.org/W2076426515","https://openalex.org/W2109687016","https://openalex.org/W2137422732","https://openalex.org/W2172029953","https://openalex.org/W2315215569","https://openalex.org/W2414417418","https://openalex.org/W2414505891","https://openalex.org/W2419560640","https://openalex.org/W2432981163","https://openalex.org/W2468986509","https://openalex.org/W3023705485"],"related_works":["https://openalex.org/W1596570898","https://openalex.org/W2138319630","https://openalex.org/W4320914444","https://openalex.org/W2000573556","https://openalex.org/W1976961774","https://openalex.org/W1966394053","https://openalex.org/W2045476156","https://openalex.org/W3029847571","https://openalex.org/W2059118942","https://openalex.org/W1967124049"],"abstract_inverted_index":{"Progression":[0],"of":[1,87,93,113],"bone":[2,19,98],"marrow":[3,20],"abnormalities":[4,36],"in":[5,17,34,37,59,96,117],"12":[6],"patients":[7,119],"with":[8,120],"malignant":[9],"(fatal)":[10],"hemopoietic":[11],"dysplasia":[12],"(HD)":[13],"was":[14,30],"evaluated":[15],"retrospectively":[16],"sequential":[18],"samples,":[21],"using":[22],"a":[23,55,114],"simple":[24],"morphological":[25,101],"scoring":[26,82,102],"technique.":[27],"Special":[28],"attention":[29],"paid":[31],"to":[32,109],"alterations":[33],"cytological":[35,88,94],"the":[38,51,97,111],"myeloid":[39,45,61,70],"series.":[40],"Patients":[41,64],"who":[42,65],"developed":[43],"acute":[44],"leukemia":[46,71],"showed":[47,84],"increasing":[48],"scores":[49],"during":[50],"clinical":[52],"course":[53],"and":[54,80,83,100],"rapid":[56],"final":[57],"increase":[58],"particularly":[60],"nucleolar":[62],"abnormalities.":[63,89],"did":[66],"not":[67],"develop":[68],"overt":[69],"but":[72],"died":[73],"from":[74],"bleeding":[75],"and/or":[76],"infection":[77],"had":[78],"low":[79],"stable":[81],"no":[85],"progression":[86],"Repeated":[90],"evaluation,":[91],"especially":[92],"changes":[95],"marrow,":[99],"might":[103],"be":[104],"useful":[105],"as":[106],"predictive":[107],"tools":[108],"estimate":[110],"risk":[112],"leukemic":[115],"transformation":[116],"some":[118],"HD.":[121]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}