{"id":"https://openalex.org/W1497590161","doi":"https://doi.org/10.1002/0471728780.ch14","title":"Metal\u2010Enhanced Fluorescence: Application to High\u2010Throughput Screening and Drug Discovery","display_name":"Metal\u2010Enhanced Fluorescence: Application to High\u2010Throughput Screening and Drug Discovery","publication_year":2005,"publication_date":"2005-01-27","ids":{"openalex":"https://openalex.org/W1497590161","doi":"https://doi.org/10.1002/0471728780.ch14","mag":"1497590161"},"language":"en","primary_location":{"id":"doi:10.1002/0471728780.ch14","doi":"https://doi.org/10.1002/0471728780.ch14","is_oa":false,"landing_page_url":"https://doi.org/10.1002/0471728780.ch14","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Discovery Handbook","raw_type":"other"},"volume":{"id":"https://openalex.org/W2481825478","display_name":"Drug Discovery Handbook"},"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038160973","display_name":"Kadir Aslan","orcid":"https://orcid.org/0000-0002-7617-0175","observed_orcids":["https://orcid.org/0000-0002-7617-0175"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I4405261596","display_name":"University of Maryland Biotechnology Institute","ror":"https://ror.org/05j636y43","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405261322","https://openalex.org/I4405261596"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kadir Aslan","raw_affiliation_strings":["Institute of Fluorescence, University of Maryland Biotechnology Institute, Baltimore, Maryland, USA","Institute of Fluorescence, University of Maryland Biotechnology Institute Baltimore Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Fluorescence, University of Maryland Biotechnology Institute, Baltimore, Maryland, USA","institution_ids":["https://openalex.org/I126744593","https://openalex.org/I4405261596"]},{"raw_affiliation_string":"Institute of Fluorescence, University of Maryland Biotechnology Institute Baltimore Maryland","institution_ids":["https://openalex.org/I4405261596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028671955","display_name":"Ignacy Gryczy\u0144ski","orcid":"https://orcid.org/0000-0003-1747-9698","observed_orcids":["https://orcid.org/0000-0003-1747-9698"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ignacy Gryczynski","raw_affiliation_strings":["Center for Fluorescence Spectroscopy, University of Maryland School of Medicine, Baltimore, Maryland, USA","Center for Fluorescence Spectroscopy, University of Maryland School of Medicine, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Fluorescence Spectroscopy, University of Maryland School of Medicine, Baltimore, Maryland, USA","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"Center for Fluorescence Spectroscopy, University of Maryland School of Medicine, Baltimore, Maryland","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051091447","display_name":"Joanna B. Malicka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joanna Malicka","raw_affiliation_strings":["Center for Fluorescence Spectroscopy, University of Maryland School of Medicine, Baltimore, Maryland, USA","Center for Fluorescence Spectroscopy, University of Maryland School of Medicine, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Fluorescence Spectroscopy, University of Maryland School of Medicine, Baltimore, Maryland, USA","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"Center for Fluorescence Spectroscopy, University of Maryland School of Medicine, Baltimore, Maryland","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074798370","display_name":"Joseph R. Lakowicz","orcid":"https://orcid.org/0000-0003-3032-3620","observed_orcids":["https://orcid.org/0000-0003-3032-3620"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph R. Lakowicz","raw_affiliation_strings":["Center for Fluorescence Spectroscopy, University of Maryland School of Medicine, Baltimore, Maryland, USA","Center for Fluorescence Spectroscopy, University of Maryland School of Medicine, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Fluorescence Spectroscopy, University of Maryland School of Medicine, Baltimore, Maryland, USA","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"Center for Fluorescence Spectroscopy, University of Maryland School of Medicine, Baltimore, Maryland","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047713796","display_name":"Chris D. Geddes","orcid":"https://orcid.org/0000-0002-9110-6374","observed_orcids":["https://orcid.org/0000-0002-9110-6374"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I4405261596","display_name":"University of Maryland Biotechnology Institute","ror":"https://ror.org/05j636y43","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405261322","https://openalex.org/I4405261596"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chris D. Geddes","raw_affiliation_strings":["Center for Fluorescence Spectroscopy, University of Maryland School of Medicine, Baltimore, Maryland, USA","Institute of Fluorescence, University of Maryland Biotechnology Institute, Baltimore, Maryland, USA","Center for Fluorescence Spectroscopy, University of Maryland School of Medicine Baltimore Maryland","Institute of Fluorescence, University of Maryland Biotechnology Institute, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Fluorescence Spectroscopy, University of Maryland School of Medicine, Baltimore, Maryland, USA","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"Institute of Fluorescence, University of Maryland Biotechnology Institute, Baltimore, Maryland, USA","institution_ids":["https://openalex.org/I126744593","https://openalex.org/I4405261596"]},{"raw_affiliation_string":"Center for Fluorescence Spectroscopy, University of Maryland School of Medicine Baltimore Maryland","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"Institute of Fluorescence, University of Maryland Biotechnology Institute, Baltimore, Maryland","institution_ids":["https://openalex.org/I4405261596"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"603","last_page":"666"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10131","display_name":"Gold and Silver Nanoparticles Synthesis and Applications","score":0.9351000189781189,"subfield":{"id":"https://openalex.org/subfields/2504","display_name":"Electronic, Optical and Magnetic Materials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10131","display_name":"Gold and Silver Nanoparticles Synthesis and Applications","score":0.9351000189781189,"subfield":{"id":"https://openalex.org/subfields/2504","display_name":"Electronic, Optical and Magnetic Materials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10295","display_name":"Plasmonic and Surface Plasmon Research","score":0.028599999845027924,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11240","display_name":"Luminescence and Fluorescent Materials","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metal-enhanced-fluorescence","display_name":"metal-enhanced fluorescence","score":1.0},{"id":"https://openalex.org/keywords/metal-substrates","display_name":"metal substrates","score":0.9819999933242798},{"id":"https://openalex.org/keywords/fluorescent-sensing","display_name":"fluorescence sensing","score":0.8610000014305115},{"id":"https://openalex.org/keywords/high-throughput-screening","display_name":"high-throughput screening","score":0.9020000100135803},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"drug discovery","score":0.9399999976158142}],"concepts":[{"id":"https://openalex.org/C2778617687","wikidata":"https://www.wikidata.org/wiki/Q2448456","display_name":"Fluorophore","level":3,"score":0.7682888507843018},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.7547229528427124},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.6626636385917664},{"id":"https://openalex.org/C544153396","wikidata":"https://www.wikidata.org/wiki/Q11426","display_name":"Metal","level":2,"score":0.5902402400970459},{"id":"https://openalex.org/C2778775528","wikidata":"https://www.wikidata.org/wiki/Q5135432","display_name":"Closing (real estate)","level":2,"score":0.5200117230415344},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.5116453766822815},{"id":"https://openalex.org/C51323132","wikidata":"https://www.wikidata.org/wiki/Q626251","display_name":"High-throughput screening","level":2,"score":0.4339393079280853},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3721742630004883},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36787107586860657},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.11430943012237549},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.10024812817573547},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.08108603954315186},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06377801299095154},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/0471728780.ch14","doi":"https://doi.org/10.1002/0471728780.ch14","is_oa":false,"landing_page_url":"https://doi.org/10.1002/0471728780.ch14","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Discovery Handbook","raw_type":"other"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W65810327","https://openalex.org/W70975398","https://openalex.org/W1500260520","https://openalex.org/W1508762865","https://openalex.org/W1967053372","https://openalex.org/W1973305697","https://openalex.org/W1980144710","https://openalex.org/W1981672845","https://openalex.org/W1981880287","https://openalex.org/W1990482521","https://openalex.org/W1999358760","https://openalex.org/W2003282883","https://openalex.org/W2005853055","https://openalex.org/W2006835096","https://openalex.org/W2010950228","https://openalex.org/W2013942995","https://openalex.org/W2015549422","https://openalex.org/W2017295885","https://openalex.org/W2023862524","https://openalex.org/W2026153385","https://openalex.org/W2027600997","https://openalex.org/W2028046189","https://openalex.org/W2039669967","https://openalex.org/W2041356602","https://openalex.org/W2042996058","https://openalex.org/W2051043314","https://openalex.org/W2054418165","https://openalex.org/W2059277424","https://openalex.org/W2059539741","https://openalex.org/W2063234039","https://openalex.org/W2066180724","https://openalex.org/W2092492380","https://openalex.org/W2094325935","https://openalex.org/W2101110384","https://openalex.org/W2124741848","https://openalex.org/W2130045861","https://openalex.org/W2135394826","https://openalex.org/W2156374900","https://openalex.org/W2158820070","https://openalex.org/W2172211086","https://openalex.org/W2951768354"],"related_works":["https://openalex.org/W2158820070","https://openalex.org/W1588596717","https://openalex.org/W2596085851","https://openalex.org/W2465867511","https://openalex.org/W2475477008","https://openalex.org/W7098303724","https://openalex.org/W2902857867","https://openalex.org/W2064104834","https://openalex.org/W7097543844","https://openalex.org/W2076733499"],"abstract_inverted_index":{"This":[0],"chapter":[1],"contains":[2],"sections":[3],"titled:":[4],"Metal-Fluorophore":[5],"Interactions":[6],"Metal":[7],"Substrates":[8],"for":[9],"Metal-Enhanced":[10,12],"Fluorescence":[11,13],"Sensing:":[14],"Application":[15],"to":[16],"Sensing":[17],"in":[18,24],"Plate":[19],"Wells":[20],"Role":[21],"of":[22],"MEF":[23],"HTS":[25],"and":[26],"Drug":[27],"Discovery":[28],"Closing":[29],"Remarks":[30],"References":[31]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2016-06-24T00:00:00"}