{"id":"https://openalex.org/W1497277472","doi":"https://doi.org/10.21236/ada381283","title":"The Single Prostate Cell Transcriptome as Biological Assay","display_name":"The Single Prostate Cell Transcriptome as Biological Assay","publication_year":1999,"publication_date":"1999-09-01","ids":{"openalex":"https://openalex.org/W1497277472","doi":"https://doi.org/10.21236/ada381283","mag":"1497277472"},"language":"en","primary_location":{"id":"doi:10.21236/ada381283","doi":"https://doi.org/10.21236/ada381283","is_oa":false,"landing_page_url":"http://doi.org/10.21236/ada381283","pdf_url":null,"source":{"id":"https://openalex.org/S4406923043","display_name":"Defense Technical Information Center (DTIC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"US Dept of the Army","raw_type":"report"},"volume":null,"type":"report","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067800417","display_name":"Peter S. Nelson","orcid":"https://orcid.org/0000-0002-5451-5726","observed_orcids":["https://orcid.org/0000-0002-5451-5726"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Peter S. Nelson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5067800417"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.8169000148773193,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.8169000148773193,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.15760000050067902,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate","display_name":"prostate","score":0.5680000185966492},{"id":"https://openalex.org/keywords/single-cell-transcriptome","display_name":"single-cell transcriptome","score":0.8759999871253967},{"id":"https://openalex.org/keywords/laser-capture-microdissection","display_name":"laser capture microdissection","score":0.859000027179718},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.8840000033378601},{"id":"https://openalex.org/keywords/luminal-epithelium","display_name":"luminal epithelium","score":0.902999997138977},{"id":"https://openalex.org/keywords/prostatic-stroma","display_name":"prostate stroma","score":0.9269999861717224},{"id":"https://openalex.org/keywords/bioassay","display_name":"bioassay","score":0.5799999833106995},{"id":"https://openalex.org/keywords/cdna-microarray","display_name":"cDNA microarray","score":0.5149999856948853}],"concepts":[{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.7770592570304871},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5754792094230652},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.5415393114089966},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4467959403991699},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34609007835388184},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12823516130447388},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.12184575200080872},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10704851150512695},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.05529382824897766}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.21236/ada381283","doi":"https://doi.org/10.21236/ada381283","is_oa":false,"landing_page_url":"http://doi.org/10.21236/ada381283","pdf_url":null,"source":{"id":"https://openalex.org/S4406923043","display_name":"Defense Technical Information Center (DTIC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"US Dept of the Army","raw_type":"report"},{"id":"pmh:ADA381283","doi":null,"is_oa":false,"landing_page_url":"http://oai.dtic.mil/oai/oai?&amp;verb=getRecord&amp;metadataPrefix=html&amp;identifier=ADA381283","pdf_url":null,"source":{"id":"https://openalex.org/S4406923043","display_name":"Defense Technical Information Center (DTIC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"DTIC","raw_type":"Text"},{"id":"pmh:ADA392342","doi":null,"is_oa":false,"landing_page_url":"http://oai.dtic.mil/oai/oai?&amp;verb=getRecord&amp;metadataPrefix=html&amp;identifier=ADA392342","pdf_url":null,"source":{"id":"https://openalex.org/S4406923043","display_name":"Defense Technical Information Center (DTIC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"DTIC AND NTIS","raw_type":"Text"},{"id":"pmh:ADA401685","doi":null,"is_oa":false,"landing_page_url":"http://oai.dtic.mil/oai/oai?&amp;verb=getRecord&amp;metadataPrefix=html&amp;identifier=ADA401685","pdf_url":null,"source":{"id":"https://openalex.org/S4406923043","display_name":"Defense Technical Information Center (DTIC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"DTIC AND NTIS","raw_type":"Text"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4200201246","https://openalex.org/W1513110684","https://openalex.org/W64196889","https://openalex.org/W7098654006","https://openalex.org/W2033588035","https://openalex.org/W2165153892","https://openalex.org/W2032980774","https://openalex.org/W2087183380","https://openalex.org/W2088284538","https://openalex.org/W2794015889"],"abstract_inverted_index":{"Technological":[0],"advances":[1],"in":[2],"robotics":[3],"and":[4,49,76,109,114,123,140],"image":[5],"analysis":[6,21],"software":[7],"have":[8,111,127,155],"expanded":[9,129],"the":[10,38,56,71,82,116,130,167],"capabilities":[11],"of":[12,22,29,55,84,132,147,171],"large-scale":[13],"strategies":[14],"to":[15,34,40,165],"provide":[16],"for":[17,86,102],"a":[18,94,144],"more":[19],"complete":[20],"molecular":[23],"differences":[24],"between":[25],"tissues":[26],"or":[27],"cells":[28,57,104],"interest.":[30],"The":[31,90],"research":[32],"accomplished":[33],"date":[35],"has":[36],"demonstrated":[37],"ability":[39],"reproducibly":[41],"isolate":[42],"defined":[43,172],"prostate":[44,137],"cell":[45,107,138,163,173],"populations":[46],"by":[47,59],"microdissection":[48,80,91],"flow":[50],"cytometry.":[51],"Gene":[52],"expression":[53,64,118,169],"studies":[54],"purified":[58],"flow-cytometry":[60],"reveal":[61],"an":[62,99],"altered":[63],"profile":[65],"that":[66],"we":[67,110,154],"believe":[68],"results":[69],"from":[70,120,135,161],"tissue":[72],"dissociation/dispersion":[73],"procedures.":[74],"Ongoing":[75],"future":[77],"work":[78],"employs":[79],"as":[81],"procedure":[83,101],"choice":[85],"specific":[87,136],"cell-type":[88],"analyses.":[89],"approach":[92],"using":[93],"laser":[95],"capture":[96],"microscope":[97],"is":[98],"efficient":[100],"isolating":[103],"representing":[105],"abundant":[106],"types,":[108,139],"isolated,":[112],"purified,":[113],"analyzed":[115],"gene":[117,168],"profiles":[119,170],"luminal":[121],"epithelium":[122],"stromal":[124],"elements.":[125],"We":[126],"greatly":[128],"database":[131],"sequences":[133],"acquired":[134],"constructed":[141],"arrays":[142],"encompassing":[143],"wide":[145],"range":[146],"diverse":[148],"genes":[149],"(n=6,000).":[150],"In":[151],"preliminary":[152],"experiments":[153],"used":[156],"amplified":[157],"cDNA":[158],"probes":[159],"isolated":[160],"small":[162],"numbers":[164],"assess":[166],"types.":[174]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
