{"id":"https://openalex.org/W149718698","doi":null,"title":"Exercise intolerance in peripheral arterial disease","display_name":"Exercise intolerance in peripheral arterial disease","publication_year":2002,"publication_date":"2002-01-01","ids":{"openalex":"https://openalex.org/W149718698","mag":"149718698"},"language":"en","primary_location":{"id":"pmh:oai:CiteSeerX.psu:10.1.1.885.6417","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.885.6417","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://www.researchgate.net/profile/Christopher_Askew/publication/27474881_Exercise_intolerance_in_peripheral_arterial_disease/links/0fcfd50e4c6995b1a1000000.pdf","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043193388","display_name":"Christopher David Askew","orcid":"https://orcid.org/0000-0001-8076-8789","observed_orcids":["https://orcid.org/0000-0001-8076-8789"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Christopher D. Askew","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8076-8789","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5043193388"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.5874000191688538,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.5874000191688538,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10926","display_name":"Peripheral Artery Disease Management","score":0.4108999967575073,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10157","display_name":"Sports Performance and Training","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/peripheral-arterial-disease","display_name":"peripheral arterial disease","score":0.9940000176429749},{"id":"https://openalex.org/keywords/exercise-intolerance","display_name":"exercise intolerance","score":0.9919999837875366},{"id":"https://openalex.org/keywords/familiarization","display_name":"familiarization","score":0.578000009059906},{"id":"https://openalex.org/keywords/plantar-flexion-strength","display_name":"plantar flexion strength","score":0.9769999980926514},{"id":"https://openalex.org/keywords/capillary-supply","display_name":"capillary supply","score":0.843999981880188},{"id":"https://openalex.org/keywords/glycogen-stores","display_name":"glycogen stores","score":0.8619999885559082},{"id":"https://openalex.org/keywords/exercise-capacity-assessment","display_name":"exercise capacity assessment","score":0.4169999957084656},{"id":"https://openalex.org/keywords/gas-exchange","display_name":"gas exchange","score":0.35499998927116394}],"concepts":[{"id":"https://openalex.org/C99476002","wikidata":"https://www.wikidata.org/wiki/Q42297","display_name":"Analysis of variance","level":2,"score":0.6574277877807617},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6074628233909607},{"id":"https://openalex.org/C2781464450","wikidata":"https://www.wikidata.org/wiki/Q839144","display_name":"Treadmill","level":2,"score":0.527665913105011},{"id":"https://openalex.org/C2777321227","wikidata":"https://www.wikidata.org/wiki/Q5420062","display_name":"Exercise intolerance","level":3,"score":0.44130733609199524},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4107440710067749},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3929954767227173},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.3923925459384918},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:CiteSeerX.psu:10.1.1.885.6417","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.885.6417","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://www.researchgate.net/profile/Christopher_Askew/publication/27474881_Exercise_intolerance_in_peripheral_arterial_disease/links/0fcfd50e4c6995b1a1000000.pdf","raw_type":"text"},{"id":"mag:149718698","doi":null,"is_oa":false,"landing_page_url":"https://eprints.qut.edu.au/15869/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":190,"referenced_works":["https://openalex.org/W28769912","https://openalex.org/W83435099","https://openalex.org/W102046739","https://openalex.org/W106521292","https://openalex.org/W134317091","https://openalex.org/W160584047","https://openalex.org/W163021786","https://openalex.org/W271495498","https://openalex.org/W271911963","https://openalex.org/W1232758273","https://openalex.org/W1524830325","https://openalex.org/W1573372314","https://openalex.org/W1779654951","https://openalex.org/W1786604681","https://openalex.org/W1787069486","https://openalex.org/W1836225072","https://openalex.org/W1866155897","https://openalex.org/W1912418182","https://openalex.org/W1962028868","https://openalex.org/W1962781538","https://openalex.org/W1965210871","https://openalex.org/W1965376531","https://openalex.org/W1967283720","https://openalex.org/W1967358045","https://openalex.org/W1967771904","https://openalex.org/W1968743288","https://openalex.org/W1969170437","https://openalex.org/W1971815303","https://openalex.org/W1975149240","https://openalex.org/W1976125671","https://openalex.org/W1976264875","https://openalex.org/W1978495288","https://openalex.org/W1980218842","https://openalex.org/W1984768966","https://openalex.org/W1987394187","https://openalex.org/W1987466174","https://openalex.org/W1989769687","https://openalex.org/W1992597176","https://openalex.org/W1994429077","https://openalex.org/W1994561439","https://openalex.org/W1997144747","https://openalex.org/W1997228640","https://openalex.org/W1997488941","https://openalex.org/W1998545414","https://openalex.org/W2003064280","https://openalex.org/W2004370078","https://openalex.org/W2004715449","https://openalex.org/W2005188365","https://openalex.org/W2005256952","https://openalex.org/W2006962176","https://openalex.org/W2006985234","https://openalex.org/W2007712698","https://openalex.org/W2009044819","https://openalex.org/W2010387865","https://openalex.org/W2010764159","https://openalex.org/W2011173296","https://openalex.org/W2011615100","https://openalex.org/W2012140006","https://openalex.org/W2012754581","https://openalex.org/W2012905414","https://openalex.org/W2013284189","https://openalex.org/W2013793215","https://openalex.org/W2014205090","https://openalex.org/W2015128491","https://openalex.org/W2018346927","https://openalex.org/W2018518936","https://openalex.org/W2021867486","https://openalex.org/W2022209658","https://openalex.org/W2029156056","https://openalex.org/W2031619234","https://openalex.org/W2032012686","https://openalex.org/W2033676311","https://openalex.org/W2033823346","https://openalex.org/W2034035190","https://openalex.org/W2034240329","https://openalex.org/W2036813167","https://openalex.org/W2039294750","https://openalex.org/W2039773817","https://openalex.org/W2039955829","https://openalex.org/W2041660097","https://openalex.org/W2042530995","https://openalex.org/W2043693380","https://openalex.org/W2043780783","https://openalex.org/W2044125524","https://openalex.org/W2045833129","https://openalex.org/W2046944178","https://openalex.org/W2047469680","https://openalex.org/W2050474359","https://openalex.org/W2050963766","https://openalex.org/W2051337042","https://openalex.org/W2052723564","https://openalex.org/W2052863747","https://openalex.org/W2056531618","https://openalex.org/W2057927957","https://openalex.org/W2058564351","https://openalex.org/W2058626312","https://openalex.org/W2062509162","https://openalex.org/W2065123079","https://openalex.org/W2065428865","https://openalex.org/W2069727496","https://openalex.org/W2070477759","https://openalex.org/W2070519189","https://openalex.org/W2071429496","https://openalex.org/W2073100814","https://openalex.org/W2074597976","https://openalex.org/W2075144129","https://openalex.org/W2075150137","https://openalex.org/W2076130859","https://openalex.org/W2076353945","https://openalex.org/W2077683047","https://openalex.org/W2079886848","https://openalex.org/W2083431496","https://openalex.org/W2086245087","https://openalex.org/W2086455715","https://openalex.org/W2087408740","https://openalex.org/W2087512347","https://openalex.org/W2088224066","https://openalex.org/W2089219679","https://openalex.org/W2089946259","https://openalex.org/W2090296913","https://openalex.org/W2094108976","https://openalex.org/W2096632664","https://openalex.org/W2096807502","https://openalex.org/W2097542334","https://openalex.org/W2098430424","https://openalex.org/W2099497302","https://openalex.org/W2101037537","https://openalex.org/W2102265814","https://openalex.org/W2102832205","https://openalex.org/W2105853303","https://openalex.org/W2122481145","https://openalex.org/W2122625853","https://openalex.org/W2122791124","https://openalex.org/W2125341506","https://openalex.org/W2125700185","https://openalex.org/W2129233331","https://openalex.org/W2133436341","https://openalex.org/W2134542881","https://openalex.org/W2136985455","https://openalex.org/W2141003681","https://openalex.org/W2143756881","https://openalex.org/W2146952385","https://openalex.org/W2147691241","https://openalex.org/W2148172060","https://openalex.org/W2152721330","https://openalex.org/W2155942116","https://openalex.org/W2158207432","https://openalex.org/W2163076148","https://openalex.org/W2164465803","https://openalex.org/W2164691862","https://openalex.org/W2166317306","https://openalex.org/W2169557264","https://openalex.org/W2170426277","https://openalex.org/W2171459275","https://openalex.org/W2178584222","https://openalex.org/W2181974862","https://openalex.org/W2229048751","https://openalex.org/W2285939474","https://openalex.org/W2301568533","https://openalex.org/W2315630371","https://openalex.org/W2319662074","https://openalex.org/W2328749202","https://openalex.org/W2336831526","https://openalex.org/W2399088688","https://openalex.org/W2401052498","https://openalex.org/W2405603892","https://openalex.org/W2406114915","https://openalex.org/W2406603253","https://openalex.org/W2409794065","https://openalex.org/W2411229054","https://openalex.org/W2411876164","https://openalex.org/W2413129509","https://openalex.org/W2413638815","https://openalex.org/W2418623700","https://openalex.org/W2431402152","https://openalex.org/W2436267904","https://openalex.org/W2461367672","https://openalex.org/W2463036688","https://openalex.org/W2464775571","https://openalex.org/W2467266743","https://openalex.org/W2467660932","https://openalex.org/W2469217615","https://openalex.org/W2473812371","https://openalex.org/W2475141359","https://openalex.org/W2576025771","https://openalex.org/W2748517427","https://openalex.org/W3011678679","https://openalex.org/W3022165476","https://openalex.org/W3041462743","https://openalex.org/W4255692377"],"related_works":["https://openalex.org/W7047632628","https://openalex.org/W1652503187","https://openalex.org/W2011110463","https://openalex.org/W7062008991","https://openalex.org/W1969652949","https://openalex.org/W4409099211","https://openalex.org/W588656640","https://openalex.org/W2161041626","https://openalex.org/W128343176","https://openalex.org/W2170723150"],"abstract_inverted_index":{"Patients":[0],"with":[1,172,268,297,519,537,603,672,685,695,713],"Peripheral":[2],"Arterial":[3],"Disease":[4],"have":[5],"a":[6,29,207,255,270,287,291,542,549,562,577,589,740],"reduced":[7,758],"capacity":[8,384,760,778],"for":[9,116,380,396],"exercise,":[10],"the":[11,36,43,57,69,123,133,159,183,190,198,221,241,248,281,315,327,336,342,362,382,397,404,460,470,483,501,515,520,592,634,642,647,653,657,675,706,714,757,776,795,817],"exact":[12],"causes":[13],"of":[14,35,39,46,60,71,145,164,231,250,338,344,361,364,369,393,399,482,504,565,580,650,665,674,732,761,773,779,800,808],"which":[15,203,745],"are":[16,785],"poorly":[17,663],"understood.":[18],"This":[19,736],"thesis":[20],"investigated":[21],"alternative":[22,379],"testing":[23,357,366,402],"procedures":[24],"that":[25,247,309,573,739],"aim":[26],"to":[27,67,147,153,170,213,226,237,254,277,335,375,409,456,477,493,500,608,627,747,771,775,793],"provide":[28],"more":[30,350],"complete":[31],"and":[32,53,78,98,102,127,150,182,260,280,283,290,329,372,385,415,418,424,440,455,463,490,492,532,548,588,619,629,668,691,726,767,788,797,804,825],"precise":[33],"description":[34],"exercise":[37,58,76,300,383,387,426,467,502,631,759,777,828],"capacities":[38,468,503],"these":[40,496,782],"patients.":[41,636],"Furthermore,":[42,473],"potential":[44],"roles":[45],"gastrocnemius":[47,485],"muscle":[48,486,546,554,596,644,682,751],"fibre":[49,555,597,609,765],"morphometry,":[50],"capillary":[51,593,721,768],"supply":[52,769],"glycogen":[54,651,727,823],"stores":[55,824],"in":[56,81,209,257,266,294,389,403,514,553,591,615,633,641,652,678,702,742,756,811],"tolerance":[59],"PAD":[61,82,400,430,489,516,539,618,635,707,780,812],"patients":[62,83,267,296,431,540,813],"were":[63,111,187,317,498,612,638],"studied.\r\n\r\n\r\n\r\nStudy":[64],"one":[65],"aimed":[66,276,408,476],"determine":[68],"effect":[70],"test":[72,89,95,289,293,414],"repetition":[73],"on":[74,122,138,155,175,302,310,325,509,526],"maximal":[75,103],"performance":[77,173,264,279,427,508,525,697,710],"test-to-test":[79],"variability":[80],"using":[84],"an":[85,92,377],"incremental":[86,93,99],"treadmill":[87,365],"walking":[88,666],"(T)":[90],"(n=5),":[91,97],"cycle":[94,356,394],"(C)":[96],"endurance":[100,218,534,661],"(PF-endurance)":[101],"strength":[104,193,423,530,687,692],"(PF-strength)":[105],"plantar":[106],"flexion":[107],"tests":[108,131,331],"(n=5).":[109],"Tests":[110],"conducted":[112],"once":[113],"per":[114,595],"week":[115,161],"eight":[117,134,160],"weeks.":[118,135],"Performance":[119,324],"was":[120,204,306,332,348,511,524,574,624,662,693,711],"stable":[121,188],"T":[124,139,288,311,328,510,696,709],"(~530":[125],"s)":[126,130,305],"C":[128,156,292,303,330,347,416,527],"(~500":[129],"across":[132],"Test-to-test":[136],"variance":[137,174,185,210,230,265],"decreased":[140],"from":[141,151,211,235],"16%CV":[142],"(CV:":[143],"coefficient":[144],"variation)":[146],"6%CV":[148],"(p=.21,NS),":[149],"~8%CV":[152,212],"2%CV":[154],"(p<.05)":[157,202,239],"over":[158,197,220,240],"period.":[162],"Variance":[163],"peak":[165],"gas":[166],"exchange":[167],"variables":[168,677],"tended":[169],"decrease":[171],"both":[176,326,505,679,703,764],"tests;":[177],"however,":[178],"other":[179],"physiological":[180,282,386],"variables,":[181],"associated":[184],"levels,":[186],"throughout":[189],"study.":[191],"PF":[192,217,529,533,660,686],"(635-712N)":[194],"gradually":[195],"increased":[196,219],"initial":[199],"2-3":[200],"weeks":[201,224],"accompanied":[205],"by":[206,576,816],"reduction":[208,256,551,590,741],"~3%CV":[214],"(p<.05).":[215],"Similarly,":[216],"first":[222],"two":[223,275,316,471,658,783],"(~32,000":[225],"41500":[227],"N.s-1)":[228],"while":[229],"this":[232,474,622],"measure":[233],"fell":[234],"~21%CV":[236],"~10%CV":[238],"study":[242,274,475,737],"duration.":[243],"It":[244],"is":[245,791,814],"concluded":[246],"implementation":[249],"familiarisation":[251],"sessions":[252],"leads":[253],"whole":[258,411,461,826],"body":[259,412,462,827],"local":[261,419,464],"calf":[262,420,465,545,743],"muscular":[263,421,466],"PAD.\r\n\r\n\r\n\r\nUsing":[269],"randomised":[271],"crossover":[272],"design,":[273],"compare":[278,410,478],"symptomatic":[284],"responses":[285,388],"between":[286,428,459,488,617,656,820],"16":[295,429],"PAD.":[298],"Peak":[299],"time":[301],"(690":[304],"greater":[307,578],"than":[308,352],"(495":[312],"s);":[313],"however":[314,341,621],"significantly":[318,625],"correlated":[319,684,694,712],"(n=16,":[320],"r=.69,":[321],"p":[322],"10mmHg.":[323],"closely":[333,786],"related":[334,499,626],"onset":[337],"leg":[339],"symptoms;":[340],"site":[343],"pain":[345],"during":[346,353],"much":[349],"variable":[351],"T.":[354],"Incremental":[355],"would":[358],"overcome":[359],"some":[360,754],"limitations":[363],"(e.g.":[367],"measurement":[368],"mechanical":[370],"work),":[371],"it":[373],"appears":[374,746],"be":[376,748,772],"acceptable":[378],"measuring":[381],"known":[390],"claudicants.":[391,762],"Use":[392],"ergometry":[395],"diagnosis":[398],"requires":[401],"general":[405],"population.\r\n\r\n\r\n\r\nStudy":[406],"three":[407],"(T":[413],"test)":[417],"(PF":[422],"endurance)":[425],"(age:":[432,447],"63":[433],"\u00b1":[434,438,449,453],"2;":[435],"BMI:":[436,451],"25.9":[437,452],"1.1)":[439],"13":[441],"healthy,":[442],"sedentary":[443],"control":[444],"(CON)":[445],"subjects":[446],"62":[448],"1;":[450],"0.4),":[454],"describe":[457],"relationships":[458],"within":[469],"groups.":[472,506,659,680,704],"several":[479],"histochemical":[480],"characteristics":[481],"medial":[484],"fibres":[487,568,583],"CON,":[491,538],"establish":[494,794],"whether":[495],"factors":[497,784],"Maximal":[507],"59%":[512],"lower":[513,543,563],"group":[517],"compared":[518,602],"CON":[521],"group,":[522],"as":[523],"(50%),":[528],"(25%),":[531],"(58%).":[535],"Compared":[536],"had":[541,561],"estimated":[544],"mass":[547,683],"slight":[550],"(10%)":[552],"size":[556],"(p=.14,":[557],"NS).":[558],"They":[559],"also":[560],"proportion":[564,579],"type":[566,581,733,821],"I":[567,734,822],"(PAD:":[569,584,598],"49%;":[570],"CON:":[571,586,600],"62%)":[572],"offset":[575],"IIA":[582],"27%;":[585],"16%),":[587],"contacts":[594,722],"1.63;":[599],"2.12)":[601],"CON.":[604],"When":[605],"expressed":[606],"relative":[607,798],"area":[610,717,766],"there":[611],"no":[613,639],"differences":[614,640],"capillarisation":[616],"CON;":[620],"index":[623],"resting":[628],"post":[630],"ABI":[632],"There":[637],"mixed":[643],"[glycogen],":[645],"nor":[646],"optical":[648],"density":[649,728],"individual":[654],"fibres,":[655],"predictive":[664],"performance,":[667],"did":[669],"not":[670],"correlate":[671],"any":[673],"morphological":[676],"Calf":[681],"(r=.59":[688],"-":[689,700],".62),":[690],"(r=":[698],".61":[699],".63)":[701],"In":[705],"patients,":[708,781],"cross":[715],"sectional":[716],"(n=12,":[718],"r=.72,":[719],"p<.05),":[720],"(n=10,":[723],"r=.81,":[724,730],"p<.05)":[725,731],"(n=9,":[729],"fibres.":[735],"confirms":[738],"strength,":[744],"mediated":[749],"through":[750],"atrophy,":[752],"plays":[753],"role":[755,807],"While":[763],"seem":[770],"relevance":[774],"linked":[787],"further":[789],"research":[790],"required":[792],"determinants,":[796],"importance":[799],"both.":[801],"An":[802],"important,":[803],"possibly":[805],"limiting":[806],"carbohydrate":[809],"oxidisation":[810],"supported":[815],"strong":[818],"relationship":[819],"capacity.":[829]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2016-06-24T00:00:00"}