{"id":"https://openalex.org/W1497089935","doi":null,"title":"Segregation analysis of continuous phenotypes by using higher sample moments.","display_name":"Segregation analysis of continuous phenotypes by using higher sample moments.","publication_year":1996,"publication_date":"1996-01-01","ids":{"openalex":"https://openalex.org/W1497089935","mag":"1497089935","pmid":"https://pubmed.ncbi.nlm.nih.gov/8554059","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1914965"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1914965","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1914965","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Hum Genet","raw_type":"Text"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1914965","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108713584","display_name":"H Lee","orcid":"https://orcid.org/0000-0002-3498-236X","observed_orcids":["https://orcid.org/0000-0002-3498-236X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H Lee","raw_affiliation_strings":["Department of Biostatistics, Harvard University, Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Harvard University, Cambridge, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046710077","display_name":"Daniel O. Stram","orcid":"https://orcid.org/0000-0001-7099-9022","observed_orcids":["https://orcid.org/0000-0001-7099-9022"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D O Stram","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7995,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.71241329,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":"58","issue":"1","first_page":"213","last_page":"24"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.8618000149726868,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.8618000149726868,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.07729999721050262,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.027499999850988388,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/segregation-analysis","display_name":"segregation analysis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/continuous-phenotypes","display_name":"continuous phenotypes","score":0.9850000143051147},{"id":"https://openalex.org/keywords/generalized-estimating-equations","display_name":"generalized estimating equations","score":0.8769999742507935},{"id":"https://openalex.org/keywords/major-gene-model","display_name":"major gene model","score":0.8080000281333923},{"id":"https://openalex.org/keywords/dominance-effects","display_name":"dominance effects","score":0.5519999861717224},{"id":"https://openalex.org/keywords/identifiability","display_name":"identifiability","score":0.699999988079071},{"id":"https://openalex.org/keywords/family-data","display_name":"family data","score":0.48100000619888306},{"id":"https://openalex.org/keywords/complex-pedigrees","display_name":"complex pedigrees","score":0.8619999885559082},{"id":"https://openalex.org/keywords/sage","display_name":"sage","score":0.4699999988079071}],"concepts":[{"id":"https://openalex.org/C22593422","wikidata":"https://www.wikidata.org/wiki/Q3242583","display_name":"Pedigree chart","level":3,"score":0.7219744920730591},{"id":"https://openalex.org/C129848803","wikidata":"https://www.wikidata.org/wiki/Q2564360","display_name":"Sample size determination","level":2,"score":0.6243042349815369},{"id":"https://openalex.org/C122770356","wikidata":"https://www.wikidata.org/wiki/Q1656753","display_name":"Identifiability","level":2,"score":0.6042020916938782},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.5600162744522095},{"id":"https://openalex.org/C27403532","wikidata":"https://www.wikidata.org/wiki/Q5532474","display_name":"Generalized estimating equation","level":2,"score":0.5120311379432678},{"id":"https://openalex.org/C49781872","wikidata":"https://www.wikidata.org/wiki/Q1045555","display_name":"Maximum likelihood","level":2,"score":0.5029370188713074},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.4899848997592926},{"id":"https://openalex.org/C198531522","wikidata":"https://www.wikidata.org/wiki/Q485146","display_name":"Sample (material)","level":2,"score":0.46370938420295715},{"id":"https://openalex.org/C162748667","wikidata":"https://www.wikidata.org/wiki/Q683131","display_name":"Generalized method of moments","level":3,"score":0.44379132986068726},{"id":"https://openalex.org/C96250715","wikidata":"https://www.wikidata.org/wiki/Q965330","display_name":"Estimation","level":2,"score":0.440766841173172},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4182320535182953},{"id":"https://openalex.org/C2780033567","wikidata":"https://www.wikidata.org/wiki/Q6823720","display_name":"Method of moments (probability theory)","level":3,"score":0.4177100658416748},{"id":"https://openalex.org/C149782125","wikidata":"https://www.wikidata.org/wiki/Q160039","display_name":"Econometrics","level":1,"score":0.3253803253173828},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19732403755187988},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19704115390777588},{"id":"https://openalex.org/C6422946","wikidata":"https://www.wikidata.org/wiki/Q857354","display_name":"Panel data","level":2,"score":0.09791630506515503},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08974990248680115},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C185429906","wikidata":"https://www.wikidata.org/wiki/Q1130160","display_name":"Estimator","level":2,"score":0.0},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C187736073","wikidata":"https://www.wikidata.org/wiki/Q2920921","display_name":"Management","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005828","descriptor_name":"Genetics, Population","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008433","descriptor_name":"Mathematics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009679","descriptor_name":"Nuclear Family","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010375","descriptor_name":"Pedigree","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1914965","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1914965","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Hum Genet","raw_type":"Text"},{"id":"pmid:8554059","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8554059","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of human genetics","raw_type":"Journal Article"},{"id":"mag:1497089935","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8554059","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1914965","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1914965","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Hum Genet","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2215857313","display_name":"Survival Models for Genetic Epidemiology","funder_award_id":"R01CA052862","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2882500740","display_name":"Human Genetic Analysis Resource","funder_award_id":"P41RR003655","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W1502908645","https://openalex.org/W1971619184","https://openalex.org/W1991311566","https://openalex.org/W2058558131","https://openalex.org/W2127287778","https://openalex.org/W2323119744"],"related_works":["https://openalex.org/W2127287778","https://openalex.org/W2074926678","https://openalex.org/W1919398575","https://openalex.org/W2012901955","https://openalex.org/W6889312143","https://openalex.org/W4388362294","https://openalex.org/W167992241","https://openalex.org/W2323119744","https://openalex.org/W4251923718","https://openalex.org/W5694487"],"abstract_inverted_index":{"The":[0,36],"present":[1],"article":[2],"discusses":[3],"the":[4,53,71,94,108,146,167,178],"use":[5,109],"of":[6,27,46,48,55,93,99,110,148,166],"computational":[7],"methods":[8,130],"based":[9],"on":[10],"generalized":[11],"estimating":[12],"equations":[13],"(GEE),":[14],"as":[15],"a":[16,49,122,183],"potential":[17],"alternative":[18],"to":[19,66,116,134,157],"full":[20],"maximum-likelihood":[21,174],"methods,":[22],"for":[23,87,143,152],"performing":[24],"segregation":[25],"analysis":[26],"continuous":[28],"phenotypes":[29],"by":[30,62,138,177],"using":[31,139],"randomly":[32,102],"selected":[33,103],"family":[34,153],"data.":[35],"method":[37,168],"that":[38,77],"we":[39,106,162],"propose":[40,107],"can":[41],"estimate":[42],"effect":[43],"and":[44,142,172],"degree":[45],"dominance":[47],"major":[50],"gene":[51],"in":[52,80,91,121,145,182],"presence":[54,147],"additional":[56],"nongenetic":[57],"or":[58],"polygenetic":[59],"familial":[60],"associations,":[61],"relating":[63],"sample":[64,97,114],"moments":[65,98,115],"their":[67],"expectations":[68],"calculated":[69],"under":[70],"genetic":[72,136],"model.":[73],"It":[74],"is":[75],"known":[76],"all":[78],"parameters":[79],"basic":[81],"major-gene":[82],"models":[83,137],"cannot":[84],"be":[85,132],"identified,":[86],"estimation":[88,125,144],"purposes,":[89],"solely":[90],"terms":[92],"first":[95],"two":[96],"data":[100,151],"from":[101],"families.":[104],"Thus,":[105],"higher":[111],"(third":[112],"order)":[113],"resolve":[117],"this":[118],"identifiability":[119],"problem,":[120],"pseudo-profile":[123],"likelihood":[124],"scheme.":[126],"In":[127,155],"principle,":[128],"our":[129],"may":[131],"applied":[133],"fitting":[135],"complex":[140],"pedigrees":[141],"missing":[149],"phenotype":[150],"members.":[154],"order":[156],"assess":[158],"its":[159],"statistical":[160],"efficiency":[161],"compare":[163],"several":[164],"variants":[165],"with":[169,173],"each":[170],"other":[171],"estimates":[175],"provided":[176],"SAGE":[179],"computer":[180],"package":[181],"simulation":[184],"study.":[185]},"counts_by_year":[{"year":2014,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}