{"id":"https://openalex.org/W1497045892","doi":null,"title":"Activation of membrane-type matrix metalloproteinase 3 zymogen by the proprotein convertase furin in the trans-Golgi network.","display_name":"Activation of membrane-type matrix metalloproteinase 3 zymogen by the proprotein convertase furin in the trans-Golgi network.","publication_year":2002,"publication_date":"2002-02-01","ids":{"openalex":"https://openalex.org/W1497045892","mag":"1497045892","pmid":"https://pubmed.ncbi.nlm.nih.gov/11830519"},"language":"en","primary_location":{"id":"pmid:11830519","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11830519","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082321957","display_name":"Tiebang Kang","orcid":"https://orcid.org/0000-0001-8805-4174","observed_orcids":["https://orcid.org/0000-0001-8805-4174"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tiebang Kang","raw_affiliation_strings":["Department of Pharmacology, University of Minnesota, 321 Church Street S.E., 6-120 Jackson Hall, Minneapolis, MN 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Minnesota, 321 Church Street S.E., 6-120 Jackson Hall, Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072867575","display_name":"Hideaki Nagase","orcid":"https://orcid.org/0000-0002-8563-2263","observed_orcids":["https://orcid.org/0000-0002-8563-2263"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hideaki Nagase","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5030110992","display_name":"Duanqing Pei","orcid":"https://orcid.org/0000-0002-5222-014X","observed_orcids":["https://orcid.org/0000-0002-5222-014X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Duanqing Pei","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.6505,"has_fulltext":false,"cited_by_count":90,"citation_normalized_percentile":{"value":0.96066452,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"62","issue":"3","first_page":"675","last_page":"81"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/matrix-metalloproteinase-3","display_name":"matrix metalloproteinase-3","score":0.8619999885559082},{"id":"https://openalex.org/keywords/mt3-mmp","display_name":"MT3-MMP","score":0.8029999732971191},{"id":"https://openalex.org/keywords/furin","display_name":"furin","score":0.8899999856948853},{"id":"https://openalex.org/keywords/proprotein-convertases","display_name":"proprotein convertases","score":0.8859999775886536},{"id":"https://openalex.org/keywords/zymogen-activation","display_name":"zymogen activation","score":0.9940000176429749},{"id":"https://openalex.org/keywords/trans-golgi-network","display_name":"trans-Golgi network","score":0.9660000205039978},{"id":"https://openalex.org/keywords/protein-colocalization","display_name":"protein colocalization","score":0.6039999723434448},{"id":"https://openalex.org/keywords/brefeldin-a","display_name":"brefeldin A","score":0.8679999709129333},{"id":"https://openalex.org/keywords/a23187","display_name":"A23187","score":0.8700000047683716},{"id":"https://openalex.org/keywords/calcium-ionophore","display_name":"calcium ionophore","score":0.7329999804496765},{"id":"https://openalex.org/keywords/golgi-trafficking","display_name":"Golgi trafficking","score":0.6570000052452087},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.7229999899864197}],"concepts":[{"id":"https://openalex.org/C2777265534","wikidata":"https://www.wikidata.org/wiki/Q14916427","display_name":"Furin","level":3,"score":0.9647704362869263},{"id":"https://openalex.org/C2778775115","wikidata":"https://www.wikidata.org/wiki/Q245759","display_name":"Zymogen","level":3,"score":0.8426170349121094},{"id":"https://openalex.org/C40209533","wikidata":"https://www.wikidata.org/wiki/Q5147828","display_name":"Colocalization","level":2,"score":0.7732683420181274},{"id":"https://openalex.org/C119062480","wikidata":"https://www.wikidata.org/wiki/Q83181","display_name":"Golgi apparatus","level":3,"score":0.7445435523986816},{"id":"https://openalex.org/C2781373781","wikidata":"https://www.wikidata.org/wiki/Q168790","display_name":"Brefeldin A","level":4,"score":0.6876232624053955},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.6650123000144958},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5727267265319824},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4873726963996887},{"id":"https://openalex.org/C2910756308","wikidata":"https://www.wikidata.org/wiki/Q7250439","display_name":"Prohormone convertase","level":4,"score":0.4754635691642761},{"id":"https://openalex.org/C2778824825","wikidata":"https://www.wikidata.org/wiki/Q7250439","display_name":"Proprotein convertase","level":5,"score":0.456318199634552},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.38703832030296326},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34348559379577637},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.12938398122787476},{"id":"https://openalex.org/C2780090379","wikidata":"https://www.wikidata.org/wiki/Q419119","display_name":"Prohormone","level":3,"score":0.09203004837036133},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.0},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.0},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.0},{"id":"https://openalex.org/C43554185","wikidata":"https://www.wikidata.org/wiki/Q425649","display_name":"LDL receptor","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004792","descriptor_name":"Enzyme Precursors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006056","descriptor_name":"Golgi Apparatus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008666","descriptor_name":"Metalloendopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013381","descriptor_name":"Subtilisins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013381","descriptor_name":"Subtilisins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019556","descriptor_name":"COS Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045683","descriptor_name":"Furin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053504","descriptor_name":"Matrix Metalloproteinases, Membrane-Associated","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:11830519","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11830519","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:1497045892","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11830519","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4043000042438507,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":68,"referenced_works":["https://openalex.org/W163559175","https://openalex.org/W172276776","https://openalex.org/W200675204","https://openalex.org/W635471586","https://openalex.org/W1487013731","https://openalex.org/W1528301939","https://openalex.org/W1593869902","https://openalex.org/W1845059468","https://openalex.org/W1846470953","https://openalex.org/W1894541755","https://openalex.org/W1914602305","https://openalex.org/W1972146443","https://openalex.org/W1975288990","https://openalex.org/W1976259855","https://openalex.org/W1976831807","https://openalex.org/W1979390430","https://openalex.org/W1980880886","https://openalex.org/W1987452659","https://openalex.org/W1988804288","https://openalex.org/W1990771793","https://openalex.org/W2000458660","https://openalex.org/W2001110380","https://openalex.org/W2001675486","https://openalex.org/W2009545372","https://openalex.org/W2015359970","https://openalex.org/W2020973067","https://openalex.org/W2022527113","https://openalex.org/W2023374250","https://openalex.org/W2026151657","https://openalex.org/W2028727659","https://openalex.org/W2029214965","https://openalex.org/W2029386401","https://openalex.org/W2031474738","https://openalex.org/W2043254359","https://openalex.org/W2049220062","https://openalex.org/W2050536724","https://openalex.org/W2055360422","https://openalex.org/W2056420432","https://openalex.org/W2059919196","https://openalex.org/W2062493098","https://openalex.org/W2062746203","https://openalex.org/W2065053969","https://openalex.org/W2074409617","https://openalex.org/W2074867844","https://openalex.org/W2074881372","https://openalex.org/W2079474526","https://openalex.org/W2079651671","https://openalex.org/W2079887571","https://openalex.org/W2085370249","https://openalex.org/W2091009027","https://openalex.org/W2093241596","https://openalex.org/W2094875212","https://openalex.org/W2095498651","https://openalex.org/W2107026123","https://openalex.org/W2110458761","https://openalex.org/W2120195060","https://openalex.org/W2123091875","https://openalex.org/W2124256395","https://openalex.org/W2132012838","https://openalex.org/W2133019124","https://openalex.org/W2136909982","https://openalex.org/W2141972226","https://openalex.org/W2144763197","https://openalex.org/W2166084156","https://openalex.org/W2167709602","https://openalex.org/W2167869180","https://openalex.org/W2404745717","https://openalex.org/W2410570642"],"related_works":["https://openalex.org/W2078567932","https://openalex.org/W2023374250","https://openalex.org/W2045096405","https://openalex.org/W2005747896","https://openalex.org/W2035834978","https://openalex.org/W2416586448","https://openalex.org/W1840195156","https://openalex.org/W2132012838","https://openalex.org/W1964144934","https://openalex.org/W2033144980"],"abstract_inverted_index":{"Matrix":[0],"metalloproteinases":[1],"(MMPs),":[2],"a":[3,40,75,164],"family":[4],"of":[5,35,58,72,83,141,161,200],"zinc-dependent":[6],"endopeptidases":[7],"implicated":[8],"in":[9,107,122,138,192],"tumor":[10],"invasion":[11],"and":[12,47,97,185],"metastasis,":[13],"must":[14],"undergo":[15],"zymogen":[16,85,191],"activation":[17,71,160,175],"prior":[18],"to":[19,147,151,168],"expressing":[20],"any":[21],"proteolytic":[22],"activity.":[23],"Although":[24],"the":[25,29,36,59,70,81,93,98,108,127,132,139,159,181,193],"cysteine-switch":[26],"model":[27,76],"predicts":[28],"well-established":[30],"autoactivation":[31],"process,":[32,67],"approximately":[33],"40%":[34],"known":[37,146,167],"MMPs":[38],"possess":[39],"conserved":[41],"RXKR":[42],"motif":[43],"between":[44,183],"their":[45,201],"pro-":[46],"catalytic":[48],"domains":[49],"and,":[50],"thus,":[51],"could":[52],"be":[53],"activated":[54],"directly":[55],"by":[56,111],"members":[57],"proprotein":[60],"convertase":[61,95],"family.":[62],"To":[63],"further":[64],"understand":[65],"this":[66],"we":[68],"analyzed":[69],"proMT3-MMP":[73,174],"as":[74],"system.":[77],"We":[78],"demonstrated":[79],"that":[80],"conversion":[82],"MT3-MMP":[84,102,123,184,190],"into":[86],"active":[87],"form":[88],"is":[89,124],"dependent":[90],"on":[91,180],"both":[92],"furin-type":[94],"activity":[96,117],"R(116)RKR":[99],"motif.":[100],"Consistently,":[101],"was":[103],"colocalized":[104],"with":[105],"furin":[106,116,170,188],"trans-Golgi":[109,194],"network":[110],"confocal":[112],"microscopy.":[113],"However,":[114],"neither":[115],"nor":[118],"its":[119],"recognition":[120],"site":[121],"required":[125],"for":[126],"observed":[128],"colocalization.":[129],"In":[130],"fact,":[131],"colocalization":[133,182],"pattern":[134],"remains":[135],"intact,":[136],"even":[137],"presence":[140],"brefeldin":[142,155],"A,":[143],"an":[144],"agent":[145],"block":[148,169],"endoplasmic":[149],"reticulum":[150],"Golgi":[152],"trafficking.":[153],"Yet,":[154],"A":[156],"completely":[157],"blocked":[158,173],"MT3-MMP.":[162],"A23187,":[163],"calcium":[165],"ionophore":[166],"maturation,":[171],"also":[172],"but":[176],"had":[177],"minimal":[178],"effect":[179],"furin.":[186],"Thus,":[187],"processes":[189],"network,":[195],"where":[196],"they":[197],"colocalize":[198],"independently":[199],"apparent":[202],"enzyme-substrate":[203],"relationship.":[204]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
