{"id":"https://openalex.org/W1496947780","doi":"https://doi.org/10.1111/j.1365-2672.2011.05190.x","title":"Synergistic activity and mode of action of flavonoids isolated from smaller galangal and amoxicillin combinations against amoxicillin-resistant Escherichia coli","display_name":"Synergistic activity and mode of action of flavonoids isolated from smaller galangal and amoxicillin combinations against amoxicillin-resistant Escherichia coli","publication_year":2011,"publication_date":"2011-11-07","ids":{"openalex":"https://openalex.org/W1496947780","doi":"https://doi.org/10.1111/j.1365-2672.2011.05190.x","mag":"1496947780","pmid":"https://pubmed.ncbi.nlm.nih.gov/22111967"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2672.2011.05190.x","doi":"https://doi.org/10.1111/j.1365-2672.2011.05190.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2672.2011.05190.x","pdf_url":null,"source":{"id":"https://openalex.org/S39794811","display_name":"Journal of Applied Microbiology","issn_l":"1364-5072","issn":["1364-5072","1365-2672"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059109370","display_name":"Griangsak Eumkeb","orcid":"https://orcid.org/0000-0003-3884-3022","observed_orcids":["https://orcid.org/0000-0003-3884-3022"]},"institutions":[{"id":"https://openalex.org/I82475049","display_name":"Suranaree University of Technology","ror":"https://ror.org/05sgb8g78","country_code":"TH","type":"education","lineage":["https://openalex.org/I82475049"]}],"countries":["TH"],"is_corresponding":true,"raw_author_name":"G. Eumkeb","raw_affiliation_strings":["School of Pharmacology, Institute of Science, Suranaree University of Technology, 111 University Avenue, Suranaree Subdistrict, Muang District, Nakhonratchasima 30000, Thailand. griang@sut.ac.th","School of Pharmacology, Institute of Science, Suranaree University of Technology, 111 University Avenue, Suranaree Subdistrict, Muang District, Nakhonratchasima 30000, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacology, Institute of Science, Suranaree University of Technology, 111 University Avenue, Suranaree Subdistrict, Muang District, Nakhonratchasima 30000, Thailand. griang@sut.ac.th","institution_ids":["https://openalex.org/I82475049"]},{"raw_affiliation_string":"School of Pharmacology, Institute of Science, Suranaree University of Technology, 111 University Avenue, Suranaree Subdistrict, Muang District, Nakhonratchasima 30000, Thailand","institution_ids":["https://openalex.org/I82475049"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020101174","display_name":"Supatcharee Siriwong","orcid":"https://orcid.org/0000-0003-0941-3189","observed_orcids":["https://orcid.org/0000-0003-0941-3189"]},"institutions":[{"id":"https://openalex.org/I82475049","display_name":"Suranaree University of Technology","ror":"https://ror.org/05sgb8g78","country_code":"TH","type":"education","lineage":["https://openalex.org/I82475049"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"S. Siriwong","raw_affiliation_strings":["School of Pharmacology, Institute of Science, Suranaree University of Technology, 111 University Avenue, Suranaree Subdistrict, Muang District, Nakhonratchasima 30000, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacology, Institute of Science, Suranaree University of Technology, 111 University Avenue, Suranaree Subdistrict, Muang District, Nakhonratchasima 30000, Thailand","institution_ids":["https://openalex.org/I82475049"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082491844","display_name":"Sineewan Phitaktim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I82475049","display_name":"Suranaree University of Technology","ror":"https://ror.org/05sgb8g78","country_code":"TH","type":"education","lineage":["https://openalex.org/I82475049"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"S. Phitaktim","raw_affiliation_strings":["School of Pharmacology, Institute of Science, Suranaree University of Technology, 111 University Avenue, Suranaree Subdistrict, Muang District, Nakhonratchasima 30000, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacology, Institute of Science, Suranaree University of Technology, 111 University Avenue, Suranaree Subdistrict, Muang District, Nakhonratchasima 30000, Thailand","institution_ids":["https://openalex.org/I82475049"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057184171","display_name":"Rojtinnakorn Nitaya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I82475049","display_name":"Suranaree University of Technology","ror":"https://ror.org/05sgb8g78","country_code":"TH","type":"education","lineage":["https://openalex.org/I82475049"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"N. Rojtinnakorn","raw_affiliation_strings":["School of Pharmacology, Institute of Science, Suranaree University of Technology, 111 University Avenue, Suranaree Subdistrict, Muang District, Nakhonratchasima 30000, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacology, Institute of Science, Suranaree University of Technology, 111 University Avenue, Suranaree Subdistrict, Muang District, Nakhonratchasima 30000, Thailand","institution_ids":["https://openalex.org/I82475049"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059492002","display_name":"Santi Sakdarat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I82475049","display_name":"Suranaree University of Technology","ror":"https://ror.org/05sgb8g78","country_code":"TH","type":"education","lineage":["https://openalex.org/I82475049"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"S. Sakdarat","raw_affiliation_strings":["School of Chemistry, Institute of Science, Suranaree University of Technology, 111 University Avenue, Suranaree Subdistrict, Muang District, Nakhonratchasima 30000, Thailands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemistry, Institute of Science, Suranaree University of Technology, 111 University Avenue, Suranaree Subdistrict, Muang District, Nakhonratchasima 30000, Thailands","institution_ids":["https://openalex.org/I82475049"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5059109370"],"corresponding_institution_ids":["https://openalex.org/I82475049"],"apc_list":{"value":2864,"currency":"GBP","value_usd":3777},"apc_paid":null,"fwci":4.3824,"has_fulltext":false,"cited_by_count":98,"citation_normalized_percentile":{"value":0.92862922,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"112","issue":"1","first_page":"55","last_page":"64"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10225","display_name":"Essential Oils and Antimicrobial Activity","score":0.9110999703407288,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10225","display_name":"Essential Oils and Antimicrobial Activity","score":0.9110999703407288,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.03020000085234642,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12257","display_name":"Bioactive natural compounds","score":0.02280000038444996,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ginger","display_name":"ginger","score":0.6129999756813049},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.8820000290870667},{"id":"https://openalex.org/keywords/galangin","display_name":"galangin","score":0.9070000052452087},{"id":"https://openalex.org/keywords/kaempferide","display_name":"kaempferide","score":0.996999979019165},{"id":"https://openalex.org/keywords/amoxicillin","display_name":"amoxicillin","score":0.8259999752044678},{"id":"https://openalex.org/keywords/antibiotic-synergy","display_name":"antibiotic synergy","score":0.671999990940094},{"id":"https://openalex.org/keywords/antibacterial-activity","display_name":"antibacterial activity","score":0.7149999737739563},{"id":"https://openalex.org/keywords/outer-membrane-permeability","display_name":"outer membrane permeability","score":0.8410000205039978},{"id":"https://openalex.org/keywords/penicillinase-inhibition","display_name":"penicillinase inhibition","score":0.9139999747276306},{"id":"https://openalex.org/keywords/herbal-medicine","display_name":"herbal medicine","score":0.8550000190734863}],"concepts":[{"id":"https://openalex.org/C161191863","wikidata":"https://www.wikidata.org/wiki/Q199655","display_name":"Library science","level":1,"score":0.5133775472640991},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.1270231306552887}],"mesh":[{"descriptor_ui":"D000658","descriptor_name":"Amoxicillin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001616","descriptor_name":"beta-Galactosidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002463","descriptor_name":"Cell Membrane Permeability","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D005419","descriptor_name":"Flavonoids","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D005419","descriptor_name":"Flavonoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005419","descriptor_name":"Flavonoids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024881","descriptor_name":"Drug Resistance, Bacterial","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D027343","descriptor_name":"Rhizome","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D032429","descriptor_name":"Alpinia","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D044949","descriptor_name":"Kaempferols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D044949","descriptor_name":"Kaempferols","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1365-2672.2011.05190.x","doi":"https://doi.org/10.1111/j.1365-2672.2011.05190.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2672.2011.05190.x","pdf_url":null,"source":{"id":"https://openalex.org/S39794811","display_name":"Journal of Applied Microbiology","issn_l":"1364-5072","issn":["1364-5072","1365-2672"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Microbiology","raw_type":"journal-article"},{"id":"pmid:22111967","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22111967","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of applied microbiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9074000120162964,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320312585","display_name":"Kentucky Agricultural Experiment Station","ror":"https://ror.org/02k3smh20"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W611976593","https://openalex.org/W1535275007","https://openalex.org/W1535602094","https://openalex.org/W1836967425","https://openalex.org/W1866602906","https://openalex.org/W1943943023","https://openalex.org/W1971333569","https://openalex.org/W1986825499","https://openalex.org/W1992034132","https://openalex.org/W2005854408","https://openalex.org/W2018318100","https://openalex.org/W2021569343","https://openalex.org/W2024117565","https://openalex.org/W2025025266","https://openalex.org/W2027622613","https://openalex.org/W2040972890","https://openalex.org/W2050669773","https://openalex.org/W2052894193","https://openalex.org/W2065706112","https://openalex.org/W2067870143","https://openalex.org/W2072163165","https://openalex.org/W2078926447","https://openalex.org/W2078929341","https://openalex.org/W2084324017","https://openalex.org/W2085122793","https://openalex.org/W2086062236","https://openalex.org/W2092510918","https://openalex.org/W2102368355","https://openalex.org/W2103858149","https://openalex.org/W2107427748","https://openalex.org/W2108647646","https://openalex.org/W2115984022","https://openalex.org/W2119246389","https://openalex.org/W2123967734","https://openalex.org/W2143173806","https://openalex.org/W2318147227","https://openalex.org/W3087471091","https://openalex.org/W6831065988"],"related_works":["https://openalex.org/W1982075935","https://openalex.org/W4322775266","https://openalex.org/W2118970688","https://openalex.org/W2164268747","https://openalex.org/W3010992981","https://openalex.org/W3160719223","https://openalex.org/W2105000298","https://openalex.org/W2506313757","https://openalex.org/W4200557268","https://openalex.org/W3118419221"],"abstract_inverted_index":{"AIM:":[0],"The":[1,12,42,53,60,88,115],"smaller":[2],"galangal":[3],"is":[4,47],"extracted,":[5],"purified":[6],"and":[7,26,37,56,66,74,92,160,169,177],"identified":[8],"the":[9,110,150,190],"bioactive":[10],"compounds.":[11],"purpose":[13],"of":[14,45,64,90,112,167,173,197],"this":[15],"research":[16],"was":[17,80],"to":[18,152,156,192,199],"investigate":[19],"whether":[20],"these":[21,67,86,93,107,119,134,147],"isolated":[22],"compounds":[23],"have":[24,149],"antibacterial":[25],"synergistic":[27,97],"activity":[28,79,139],"against":[29,69,140],"amoxicillin-resistant":[30],"Escherichia":[31],"coli":[32],"(AREC)":[33],"when":[34],"used":[35],"singly":[36],"in":[38,158],"combination":[39],"with":[40,85,179],"amoxicillin.":[41],"primarily":[43],"mode":[44],"action":[46],"also":[48],"studied.":[49],"METHOD":[50],"AND":[51,182],"RESULTS:":[52],"galangin,":[54],"kaempferide":[55],"kaempferide-3-O-\u03b2-d-glucoside":[57],"were":[58,71],"isolated.":[59],"minimum":[61],"inhibitory":[62,138],"concentrations(MIC)":[63],"amoxicillin":[65,84,91,157],"flavonoids":[68,94,135,148],"AREC":[70,100,113,159],"between":[72],"500":[73],">1000":[75],"\u03bcg":[76],"ml(-1).":[77],"Synergistic":[78],"observed":[81],"on":[82],"combining":[83],"flavonoids.":[87],"combinations":[89,108,120],"exhibited":[95],"a":[96,194],"effect,":[98],"reducing":[99],"cell":[101],"numbers.":[102],"Electron":[103],"microscopy":[104],"showed":[105,132],"that":[106,118,133,146],"damaged":[109],"ultrastructure":[111],"cells.":[114],"results":[116,144],"indicated":[117,145],"altered":[121],"outer":[122,174],"membrane":[123,175],"permeability":[124],"but":[125],"not":[126],"affecting":[127],"cytoplasmic":[128],"membrane.":[129],"Enzyme":[130],"assays":[131],"had":[136],"an":[137],"penicillinase.":[141],"CONCLUSION:":[142],"These":[143,187],"potential":[151,191],"reverse":[153],"bacterial":[154],"resistance":[155],"may":[161],"operate":[162],"via":[163],"three":[164],"mechanisms:":[165],"inhibition":[166],"peptidoglycan":[168],"ribosome":[170],"synthesis,":[171],"alteration":[172],"permeability,":[176],"interaction":[178],"\u03b2-lactamases.":[180],"SIGNIFICANCE":[181],"IMPACT":[183],"OF":[184],"THE":[185],"STUDY:":[186],"findings":[188],"offer":[189],"develop":[193],"new":[195],"generation":[196],"phytopharmaceuticals":[198],"treat":[200],"AREC.":[201]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
