{"id":"https://openalex.org/W1496915735","doi":null,"title":"Coagulation and Inflammation in Very Low Birth Weight Infants","display_name":"Coagulation and Inflammation in Very Low Birth Weight Infants","publication_year":2014,"publication_date":"2014-01-17","ids":{"openalex":"https://openalex.org/W1496915735","mag":"1496915735"},"language":"en","primary_location":{"id":"pmh:oai:helda.helsinki.fi:10138/42293","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/42293","pdf_url":"http://hdl.handle.net/10138/42293","source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10138/42293","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055183542","display_name":"Anniina Paloj\u00e4rvi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Anniina Paloj\u00e4rvi","raw_affiliation_strings":["Children\u2032s Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2032s Hospital","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5055183542"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.4916999936103821,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.4916999936103821,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.2168000042438507,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11961","display_name":"Neonatal and Maternal Infections","score":0.07119999825954437,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/very-low-birth-weight-infants","display_name":"very low birth weight infants","score":0.9380000233650208},{"id":"https://openalex.org/keywords/blood-coagulation","display_name":"coagulation","score":0.7630000114440918},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.9929999709129333},{"id":"https://openalex.org/keywords/tissue-factor","display_name":"tissue factor","score":0.7730000019073486},{"id":"https://openalex.org/keywords/tissue-factor-pathway-inhibitor","display_name":"tissue factor pathway inhibitor","score":0.9829999804496765},{"id":"https://openalex.org/keywords/respiratory-distress-syndrome","display_name":"respiratory distress syndrome","score":0.8989999890327454},{"id":"https://openalex.org/keywords/immunodepression","display_name":"immunodepression","score":0.8510000109672546},{"id":"https://openalex.org/keywords/hla-dr-expression","display_name":"HLA-DR expression","score":0.7289999723434448},{"id":"https://openalex.org/keywords/monocytes","display_name":"monocytes","score":0.9240000247955322},{"id":"https://openalex.org/keywords/antenatal-betamethasone","display_name":"antenatal betamethasone","score":0.953000009059906},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.777999997138977},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":1.0},{"id":"https://openalex.org/keywords/protease-activated-receptors","display_name":"protease-activated receptors","score":0.8180000185966492},{"id":"https://openalex.org/keywords/thrombin","display_name":"thrombin","score":0.46399998664855957},{"id":"https://openalex.org/keywords/neonatal-infection","display_name":"neonatal infection","score":0.5270000100135803},{"id":"https://openalex.org/keywords/preterm-birth","display_name":"preterm birth","score":0.6159999966621399},{"id":"https://openalex.org/keywords/gestational-age","display_name":"gestational age","score":0.5640000104904175},{"id":"https://openalex.org/keywords/neonatal-intensive-care","display_name":"neonatal intensive care","score":0.6480000019073486}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5769559144973755},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5744980573654175},{"id":"https://openalex.org/C2778382381","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation","level":2,"score":0.47709399461746216},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3302631974220276},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3134499788284302},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16588467359542847}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:helda.helsinki.fi:10138/42293","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/42293","pdf_url":"http://hdl.handle.net/10138/42293","source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoralThesis"},{"id":"mag:1496915735","doi":null,"is_oa":false,"landing_page_url":"https://helda.helsinki.fi/handle/10138/42293","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:helda.helsinki.fi:10138/42293","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/42293","pdf_url":"http://hdl.handle.net/10138/42293","source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoralThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320310086","display_name":"Helsingin Yliopisto","ror":"https://ror.org/040af2s02"},{"id":"https://openalex.org/F4320310467","display_name":"Helsingin ja Uudenmaan Sairaanhoitopiiri","ror":"https://ror.org/020cpqb94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1496915735.pdf","grobid_xml":"https://content.openalex.org/works/W1496915735.grobid-xml"},"referenced_works_count":133,"referenced_works":["https://openalex.org/W9494736","https://openalex.org/W130520532","https://openalex.org/W145204325","https://openalex.org/W204546040","https://openalex.org/W1483035379","https://openalex.org/W1507312029","https://openalex.org/W1523598805","https://openalex.org/W1535294272","https://openalex.org/W1559683688","https://openalex.org/W1569758706","https://openalex.org/W1578821085","https://openalex.org/W1589757596","https://openalex.org/W1662919691","https://openalex.org/W1776324538","https://openalex.org/W1811402656","https://openalex.org/W1902039366","https://openalex.org/W1965636034","https://openalex.org/W1965778925","https://openalex.org/W1968182968","https://openalex.org/W1972458687","https://openalex.org/W1975212304","https://openalex.org/W1980119094","https://openalex.org/W1980220254","https://openalex.org/W1984505810","https://openalex.org/W1986514022","https://openalex.org/W1988275451","https://openalex.org/W1988830183","https://openalex.org/W1988921184","https://openalex.org/W1992893247","https://openalex.org/W1995584620","https://openalex.org/W2000793438","https://openalex.org/W2004119748","https://openalex.org/W2005948700","https://openalex.org/W2006183945","https://openalex.org/W2007531589","https://openalex.org/W2009075292","https://openalex.org/W2011290533","https://openalex.org/W2011531678","https://openalex.org/W2013293305","https://openalex.org/W2014176337","https://openalex.org/W2015626542","https://openalex.org/W2017046795","https://openalex.org/W2018235565","https://openalex.org/W2019949742","https://openalex.org/W2020345920","https://openalex.org/W2020363094","https://openalex.org/W2021012065","https://openalex.org/W2021725822","https://openalex.org/W2021773314","https://openalex.org/W2023079617","https://openalex.org/W2023760764","https://openalex.org/W2034090955","https://openalex.org/W2035667751","https://openalex.org/W2038439560","https://openalex.org/W2040189863","https://openalex.org/W2040625725","https://openalex.org/W2042503076","https://openalex.org/W2043290332","https://openalex.org/W2044400860","https://openalex.org/W2045461909","https://openalex.org/W2046151267","https://openalex.org/W2046224781","https://openalex.org/W2046913887","https://openalex.org/W2048425176","https://openalex.org/W2050137315","https://openalex.org/W2053397495","https://openalex.org/W2055698835","https://openalex.org/W2057221557","https://openalex.org/W2058053382","https://openalex.org/W2058662052","https://openalex.org/W2063096978","https://openalex.org/W2063866881","https://openalex.org/W2063908549","https://openalex.org/W2064723143","https://openalex.org/W2065731781","https://openalex.org/W2066805822","https://openalex.org/W2067889106","https://openalex.org/W2068290447","https://openalex.org/W2069690283","https://openalex.org/W2070061207","https://openalex.org/W2071228946","https://openalex.org/W2072076087","https://openalex.org/W2072229464","https://openalex.org/W2072889142","https://openalex.org/W2086194193","https://openalex.org/W2088579185","https://openalex.org/W2089180140","https://openalex.org/W2090667112","https://openalex.org/W2101345467","https://openalex.org/W2104335628","https://openalex.org/W2106530602","https://openalex.org/W2107026281","https://openalex.org/W2107611361","https://openalex.org/W2108446523","https://openalex.org/W2110463517","https://openalex.org/W2111454506","https://openalex.org/W2112927272","https://openalex.org/W2113057501","https://openalex.org/W2115390875","https://openalex.org/W2118902632","https://openalex.org/W2119315831","https://openalex.org/W2119883401","https://openalex.org/W2122833219","https://openalex.org/W2124551895","https://openalex.org/W2129677851","https://openalex.org/W2131630407","https://openalex.org/W2137035430","https://openalex.org/W2139657682","https://openalex.org/W2140069482","https://openalex.org/W2142333500","https://openalex.org/W2142423474","https://openalex.org/W2142649232","https://openalex.org/W2143682143","https://openalex.org/W2146270870","https://openalex.org/W2148321601","https://openalex.org/W2148596132","https://openalex.org/W2149883421","https://openalex.org/W2151069215","https://openalex.org/W2151746312","https://openalex.org/W2160675125","https://openalex.org/W2163101729","https://openalex.org/W2168852120","https://openalex.org/W2169101968","https://openalex.org/W2171225273","https://openalex.org/W2220166796","https://openalex.org/W2254552946","https://openalex.org/W2286978725","https://openalex.org/W2322121630","https://openalex.org/W2326987869","https://openalex.org/W2417623843","https://openalex.org/W2420590647","https://openalex.org/W2527337776","https://openalex.org/W2768146862"],"related_works":["https://openalex.org/W2001170951","https://openalex.org/W2087568614","https://openalex.org/W2009537811","https://openalex.org/W2163263247","https://openalex.org/W2175417405","https://openalex.org/W3044932397","https://openalex.org/W1989893850","https://openalex.org/W1969343643","https://openalex.org/W6964901425","https://openalex.org/W2060006097"],"abstract_inverted_index":{"A":[0,83,182],"complex":[1],"interaction":[2,143],"prevails":[3],"between":[4,47,144,304],"coagulation":[5,9,26,50,147],"and":[6,17,32,49,61,68,120,136,146,148,173,273,278,296,307,321],"inflammation.":[7],"The":[8],"system":[10,27,75],"is":[11,44,115,312],"adapted":[12],"to":[13,21,77,86,108,226,340,361,393],"thrombotic":[14],"challenges":[15],"during":[16],"after":[18],"birth,":[19],"leading":[20],"specific":[22],"features":[23],"in":[24,113,152,219,240,285,314,389,409],"the":[25,29,53,69,73,78,92,104,141,150,237,241,248,252,256,315,329,406],"of":[28,72,80,168,177,192,208,262,288,317,382],"newborn.":[30],"Inflammation":[31],"intra-alveolar":[33],"fibrin":[34],"formation":[35],"characterize":[36],"respiratory":[37,366],"distress":[38,367],"syndrome":[39],"(RDS).":[40],"Tissue":[41],"factor":[42,232],"(TF)":[43],"a":[45,87,164,174,190,260,286,302,318,373,390],"link":[46,303],"inflammation":[48,145],"pathways.":[51],"In":[52,228,265],"very":[54],"low":[55,200,294,305],"birth":[56,60,175,404],"weight":[57,176],"(VLBW)":[58],"infant,":[59],"intensive":[62,81],"care":[63],"present":[64],"major":[65],"immunological":[66],"challenges,":[67],"developmental":[70],"immaturity":[71],"immune":[74],"adds":[76],"risks":[79],"care.":[82],"protective":[84],"response":[85,105],"strong":[88],"inflammatory":[89,348,358],"stimulus":[90],"downregulates":[91],"antigen-presenting":[93],"molecules":[94],"(Human":[95],"leukocyte":[96],"antigen":[97],"(HLA)-DR)":[98],"on":[99,244,332],"monocytes.":[100],"If":[101],"severe,":[102],"however,":[103,247],"may":[106,300],"lead":[107,225,339],"immunodepression":[109,272],"or":[110,364],"immunoparalysis,":[111],"which":[112,222,290],"adults":[114],"associated":[116,270,291,388],"with":[117,155,163,189,211,259,271,292,369,397],"increased":[118],"morbidity":[119,135],"death.":[121],"Antenatal":[122,384],"betamethasone":[123,269,385],"treatment":[124],"for":[125,129,309,347],"mothers":[126],"at":[127],"risk":[128,308],"premature":[130],"delivery":[131],"effectively":[132],"reduces":[133],"neonatal":[134],"mortality.":[137],"This":[138],"thesis":[139],"evaluates":[140],"bidirectional":[142],"combines":[149],"findings":[151],"VLBW":[153,161,197,213,229,257,266,281,319,354],"infants":[154,188,198,209,214,282,355,396],"clinical":[156],"morbidity.":[157],"Patients":[158],"were":[159],"56":[160],"infants,":[162,230,267],"gestational":[165],"age":[166],"(GA)":[167],"less":[169,178,399],"than":[170,179,194,400],"32":[171],"weeks":[172],"1500":[180],"g.":[181],"control":[183,328],"population":[184],"comprised":[185],"25":[186],"healthy":[187],"GA":[191,306],"more":[193],"34":[195],"weeks.":[196],"showed":[199,215,356],"monocyte":[201],"HLA-DR":[202,410],"expression.":[203,411],"On":[204],"day":[205,245,333],"3,":[206,246],"45%":[207],"presented":[210],"immunodepression.":[212],"high":[216],"plasma":[217,263],"TF":[218,249,311,330,336],"circulation,":[220],"but":[221],"did":[223],"not":[224,327,338],"coagulation.":[227,383],"tissue":[231],"pathway":[233],"inhibitor":[234],"(TFPI)":[235],"was":[236,387],"main":[238],"anticoagulant":[239],"first":[242],"days;":[243],"surge":[250,331],"exceeded":[251],"TFPI":[253,325],"capacity,":[254],"leaving":[255],"infant":[258,320],"pool":[261],"TF.":[264],"antenatal":[268],"suppressed":[274],"both":[275],"proinflammatory":[276],"IL-6":[277],"anti-inflammatory":[279,376],"IL-10.":[280],"are":[283],"postnatally":[284],"state":[287],"immunodepression,":[289,394],"RDS,":[293],"GA,":[295],"subsequent":[297],"infections.":[298,310],"Immunodepression":[299],"represent":[301],"expressed":[313],"lungs":[316],"leaks":[322],"into":[323],"circulation.":[324],"could":[326],"3.":[334],"Plasma":[335],"does":[337],"thrombin":[341],"formation,":[342],"thereby":[343],"making":[344],"it":[345],"available":[346],"pathways":[349],"(e.g.":[350],"protease-activated":[351],"receptors":[352],"(PARs)).":[353],"an":[357],"profile":[359],"similar":[360],"adult":[362],"sepsis":[363],"acute":[365],"syndrome,":[368],"additional":[370],"VLBW-specific":[371],"features:":[372],"lower":[374],"net":[375],"cytokine":[377],"effect":[378],"without":[379],"TF-induced":[380],"activation":[381],"(BM)":[386],"time-dependent":[391],"manner":[392],"those":[395],"BM":[398],"24":[401],"hours":[402],"before":[403],"showing":[405],"deepest":[407],"nadir":[408]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}