{"id":"https://openalex.org/W1496800501","doi":null,"title":"HEPATOPROTECTIVE ACTIVITY OF LEAF OF METHANOL EXTRACT OF LAURUS NOBILIS.L AGAINST PARACETAMOL INDUCED HEPATOTOXICITY IN RATS","display_name":"HEPATOPROTECTIVE ACTIVITY OF LEAF OF METHANOL EXTRACT OF LAURUS NOBILIS.L AGAINST PARACETAMOL INDUCED HEPATOTOXICITY IN RATS","publication_year":2013,"publication_date":"2013-09-01","ids":{"openalex":"https://openalex.org/W1496800501","mag":"1496800501"},"language":"en","primary_location":{"id":"pmh:oai:CiteSeerX.psu:10.1.1.897.8153","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.897.8153","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://innovareacademics.in/journals/index.php/ajpcr/article/download/375/261/","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://innovareacademics.in/journals/index.php/ajpcr/article/download/375/261","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047379209","display_name":"Chandrasekaran Arcot Ravindran","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chandrasekaran Arcot Ravindran","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044968633","display_name":"A Vikneswaran","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Vikneswaran","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089016927","display_name":"Vikneswaran Murugaiyah","orcid":"https://orcid.org/0000-0003-1768-7577","observed_orcids":["https://orcid.org/0000-0003-1768-7577"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vikneswaran Murugaiyah","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1768-7577","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080108206","display_name":"Peh Kok Khiang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peh Kok Khiang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5051270589","display_name":"R. Xavior","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. Xavior","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2172,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.49554805,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"6","issue":"8","first_page":"153","last_page":"157"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13919","display_name":"Medicinal plant effects and applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12756","display_name":"Plant Toxicity and Pharmacological Properties","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/laurus-nobilis","display_name":"Laurus nobilis","score":0.9869999885559082},{"id":"https://openalex.org/keywords/bay-leaf","display_name":"bay leaf","score":0.7580000162124634},{"id":"https://openalex.org/keywords/hepatoprotective-effect","display_name":"hepatoprotection","score":0.984000027179718},{"id":"https://openalex.org/keywords/acetaminophen-induced-hepatotoxicity","display_name":"acetaminophen hepatotoxicity","score":0.9129999876022339},{"id":"https://openalex.org/keywords/methanol-extract","display_name":"methanol extract","score":0.8169999718666077},{"id":"https://openalex.org/keywords/liver-injury","display_name":"liver injury","score":0.6190000176429749},{"id":"https://openalex.org/keywords/liver-enzymes","display_name":"liver enzymes","score":0.7450000047683716},{"id":"https://openalex.org/keywords/bilirubin","display_name":"bilirubin","score":0.8029999732971191},{"id":"https://openalex.org/keywords/free-radical-scavenging-activity","display_name":"free radical scavenging","score":0.8690000176429749},{"id":"https://openalex.org/keywords/silymarin","display_name":"silymarin","score":0.9380000233650208}],"concepts":[{"id":"https://openalex.org/C2909356100","wikidata":"https://www.wikidata.org/wiki/Q26006","display_name":"Laurus nobilis","level":3,"score":0.9528807997703552},{"id":"https://openalex.org/C2777513400","wikidata":"https://www.wikidata.org/wiki/Q104219","display_name":"Bilirubin","level":2,"score":0.6585766077041626},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5765461325645447},{"id":"https://openalex.org/C2992872382","wikidata":"https://www.wikidata.org/wiki/Q305481","display_name":"Alanine aminotransferase","level":2,"score":0.5330421328544617},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5163165926933289},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.4947633147239685},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.4738110601902008},{"id":"https://openalex.org/C2778722691","wikidata":"https://www.wikidata.org/wiki/Q57055","display_name":"Acetaminophen","level":2,"score":0.43560537695884705},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27388796210289},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24950921535491943},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.18852758407592773},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.18023046851158142},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10419967770576477},{"id":"https://openalex.org/C2777278459","wikidata":"https://www.wikidata.org/wiki/Q170885","display_name":"Essential oil","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:CiteSeerX.psu:10.1.1.897.8153","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.897.8153","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://innovareacademics.in/journals/index.php/ajpcr/article/download/375/261/","raw_type":"text"},{"id":"mag:1496800501","doi":null,"is_oa":true,"landing_page_url":"http://innovareacademics.in/journals/index.php/ajpcr/article/download/375/261","pdf_url":null,"source":{"id":"https://openalex.org/S2764968390","display_name":"Asian Journal of Pharmaceutical and Clinical Research","issn_l":"0974-2441","issn":["0974-2441","2455-3891"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-40"],"host_organization":"https://openalex.org/P4322697801","host_organization_name":"Innovare Academic Sciences","host_organization_lineage":["https://openalex.org/P4322697801"],"host_organization_lineage_names":["Innovare Academic Sciences"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Asian Journal of Pharmaceutical and Clinical Research","raw_type":null}],"best_oa_location":{"id":"mag:1496800501","doi":null,"is_oa":true,"landing_page_url":"http://innovareacademics.in/journals/index.php/ajpcr/article/download/375/261","pdf_url":null,"source":{"id":"https://openalex.org/S2764968390","display_name":"Asian Journal of Pharmaceutical and Clinical Research","issn_l":"0974-2441","issn":["0974-2441","2455-3891"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-40"],"host_organization":"https://openalex.org/P4322697801","host_organization_name":"Innovare Academic Sciences","host_organization_lineage":["https://openalex.org/P4322697801"],"host_organization_lineage_names":["Innovare Academic Sciences"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Asian Journal of Pharmaceutical and Clinical Research","raw_type":null},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W73757016","https://openalex.org/W1482266597","https://openalex.org/W1551586253","https://openalex.org/W1554188337","https://openalex.org/W1879184430","https://openalex.org/W1944984946","https://openalex.org/W1971072237","https://openalex.org/W1985744856","https://openalex.org/W1999287710","https://openalex.org/W1999360862","https://openalex.org/W2041997034","https://openalex.org/W2051096835","https://openalex.org/W2056127477","https://openalex.org/W2061790323","https://openalex.org/W2071968836","https://openalex.org/W2078641508","https://openalex.org/W2079333784","https://openalex.org/W2081568627","https://openalex.org/W2085306532","https://openalex.org/W2090886218","https://openalex.org/W2108791332","https://openalex.org/W2138808174","https://openalex.org/W2141348928","https://openalex.org/W2263023695","https://openalex.org/W2419661021","https://openalex.org/W2499087708"],"related_works":["https://openalex.org/W7096562189","https://openalex.org/W4409271436","https://openalex.org/W3020050560","https://openalex.org/W2135647610","https://openalex.org/W2186431270","https://openalex.org/W1997699910","https://openalex.org/W4245108253","https://openalex.org/W2291463549","https://openalex.org/W4312466511","https://openalex.org/W7138234502"],"abstract_inverted_index":{"Objective:":[0],"The":[1,27],"present":[2],"study":[3],"was":[4,38,53,101,126,148],"conducted":[5],"to":[6,41,171],"evaluate":[7],"the":[8,42,59,78,87,105,108,151,154,162,173],"hepatoprotective":[9],"activity":[10],"of":[11,14,30,80,98,117,157,168,176],"methanol":[12,28,96,155],"extract":[13,29,97,156],"Laurus":[15,31,99,158],"nobilis":[16,32,100,159],"against":[17,107],"paracetamol":[18,48,112,177],"induced":[19,46,110,178],"liver":[20,106,163],"damage":[21],"in":[22,67,103,113,132,180],"rats.":[23,181],"Materials":[24],"and":[25,84,144],"Methods:":[26],"(200":[33],"mg/kg":[34,93],"&":[35],"400":[36],"mg/kg)":[37],"administered":[39,63],"orally":[40,64],"animals":[43],"with":[44],"hepatotoxicity":[45,179],"by":[47,65,111],"(400":[49,92],"mg/kg).":[50],"Silymarin":[51],"(25mg/kg)":[52],"given":[54],"as":[55,164],"reference":[56],"standard.":[57],"All":[58],"test":[60],"drugs":[61],"were":[62],"suspending":[66],"0.5":[68],"%":[69],"Carboxy":[70],"methyl":[71],"cellulose":[72],"solution.":[73],"Results:":[74],"Paracetamol":[75],"has":[76],"enhanced":[77],"levels":[79],"ALT,":[81],"AST,":[82],"ALP":[83],"bilirubin,":[85],"whereas":[86],"group":[88],"receiving":[89],"high":[90],"dose":[91,119],"body":[94,121],"weight)":[95,122],"effective":[102],"protecting":[104],"injury":[109],"rats":[114],"than":[115],"that":[116,153],"low":[118],"(200mg/kg":[120],"treated":[123],"group.":[124],"This":[125],"evident":[127],"from":[128,150],"a":[129,165],"significant":[130],"reduction":[131],"serum":[133],"enzymes":[134],"alanine":[135],"aminotransferase":[136,139],"(ALT),":[137],"aspartate":[138],"(AST),":[140],"alkaline":[141],"phosphatase":[142],"(ALP)":[143],"bilirubin.":[145],"Conclusion:":[146],"It":[147],"concluded":[149],"result":[152],"acts":[160],"on":[161],"potent":[166],"scavenger":[167],"free":[169],"radicals":[170],"prevent":[172],"toxic":[174],"effects":[175]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}