{"id":"https://openalex.org/W1496786509","doi":null,"title":"Molecular mechanisms of pre- and postsynaptic EphB/ephrin-B signaling in synapse formation and function","display_name":"Molecular mechanisms of pre- and postsynaptic EphB/ephrin-B signaling in synapse formation and function","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W1496786509","mag":"1496786509"},"language":"en","primary_location":{"id":"pmh:oai:repository.upenn.edu:edissertations-1641","doi":null,"is_oa":true,"landing_page_url":"https://repository.upenn.edu/edissertations/483","pdf_url":"https://repository.upenn.edu/cgi/viewcontent.cgi?article=1641&context=edissertations","source":{"id":"https://openalex.org/S4306402083","display_name":"ScholarlyCommons (University of Pennsylvania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79576946","host_organization_name":"University of Pennsylvania","host_organization_lineage":["https://openalex.org/I79576946"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Publicly Accessible Penn Dissertations","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://repository.upenn.edu/cgi/viewcontent.cgi?article=1641&context=edissertations","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045705020","display_name":"Sean I. Sheffler-Collins","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Sean I. Sheffler-Collins","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5045705020"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.4916999936103821,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.4916999936103821,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12061","display_name":"Axon Guidance and Neuronal Signaling","score":0.49000000953674316,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/presynaptic-specialization","display_name":"presynaptic specialization","score":0.800000011920929},{"id":"https://openalex.org/keywords/postsynaptic-specialization","display_name":"postsynaptic specialization","score":0.9419999718666077},{"id":"https://openalex.org/keywords/synaptogenesis","display_name":"synaptogenesis","score":0.8489999771118164},{"id":"https://openalex.org/keywords/nmda-receptor","display_name":"NMDA receptor","score":0.8240000009536743},{"id":"https://openalex.org/keywords/syntenin-1","display_name":"syntenin-1","score":0.8830000162124634},{"id":"https://openalex.org/keywords/pdz-domain","display_name":"PDZ domain","score":0.6710000038146973},{"id":"https://openalex.org/keywords/ephrin-b1","display_name":"ephrin-B1","score":0.9049999713897705},{"id":"https://openalex.org/keywords/ephrin-b2","display_name":"ephrin-B2","score":1.0},{"id":"https://openalex.org/keywords/receptor-tyrosine-kinases","display_name":"receptor tyrosine kinase","score":0.8040000200271606},{"id":"https://openalex.org/keywords/neurotransmitter-release","display_name":"neurotransmitter release","score":0.7099999785423279},{"id":"https://openalex.org/keywords/nr2b-subunit","display_name":"NR2B subunit","score":0.8840000033378601},{"id":"https://openalex.org/keywords/synaptic-plasticity","display_name":"synaptic plasticity","score":0.7369999885559082},{"id":"https://openalex.org/keywords/axon-guidance","display_name":"axon guidance","score":0.6539999842643738},{"id":"https://openalex.org/keywords/neurological-disorders","display_name":"neurological disorders","score":0.5740000009536743}],"concepts":[{"id":"https://openalex.org/C127445978","wikidata":"https://www.wikidata.org/wiki/Q187181","display_name":"Synapse","level":2,"score":0.6755800247192383},{"id":"https://openalex.org/C197341189","wikidata":"https://www.wikidata.org/wiki/Q863533","display_name":"Postsynaptic potential","level":3,"score":0.6513676643371582},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.544159471988678},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5076073408126831},{"id":"https://openalex.org/C2909795284","wikidata":"https://www.wikidata.org/wiki/Q1813773","display_name":"Synapse formation","level":3,"score":0.4950820505619049},{"id":"https://openalex.org/C170286479","wikidata":"https://www.wikidata.org/wiki/Q24787399","display_name":"Ephrin","level":3,"score":0.4499800503253937},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.34377944469451904},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3365252614021301},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3258567154407501},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2645401656627655},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2470359206199646},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09071210026741028}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:repository.upenn.edu:edissertations-1641","doi":null,"is_oa":true,"landing_page_url":"https://repository.upenn.edu/edissertations/483","pdf_url":"https://repository.upenn.edu/cgi/viewcontent.cgi?article=1641&context=edissertations","source":{"id":"https://openalex.org/S4306402083","display_name":"ScholarlyCommons (University of Pennsylvania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79576946","host_organization_name":"University of Pennsylvania","host_organization_lineage":["https://openalex.org/I79576946"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Publicly Accessible Penn Dissertations","raw_type":"text"},{"id":"pmh:oai:repository.upenn.edu:20.500.14332/31760","doi":null,"is_oa":false,"landing_page_url":"https://repository.upenn.edu/handle/20.500.14332/31760","pdf_url":null,"source":{"id":"https://openalex.org/S4306402083","display_name":"ScholarlyCommons (University of Pennsylvania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79576946","host_organization_name":"University of Pennsylvania","host_organization_lineage":["https://openalex.org/I79576946"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"published","raw_type":"Dissertation/Thesis"},{"id":"pmh:oai:repository.upenn.edu:dissertations-10980","doi":null,"is_oa":false,"landing_page_url":"https://repository.upenn.edu/dissertations/AAI3509482","pdf_url":null,"source":{"id":"https://openalex.org/S4377196331","display_name":"Scholarly Commons (University of Pennsylvania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79576946","host_organization_name":"University of Pennsylvania","host_organization_lineage":["https://openalex.org/I79576946"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations available from ProQuest","raw_type":"text"},{"id":"mag:1496786509","doi":null,"is_oa":false,"landing_page_url":"https://repository.upenn.edu/cgi/viewcontent.cgi?article=10980&context=dissertations","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:repository.upenn.edu:edissertations-1641","doi":null,"is_oa":true,"landing_page_url":"https://repository.upenn.edu/edissertations/483","pdf_url":"https://repository.upenn.edu/cgi/viewcontent.cgi?article=1641&context=edissertations","source":{"id":"https://openalex.org/S4306402083","display_name":"ScholarlyCommons (University of Pennsylvania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79576946","host_organization_name":"University of Pennsylvania","host_organization_lineage":["https://openalex.org/I79576946"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Publicly Accessible Penn Dissertations","raw_type":"text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1692762303","display_name":"Intellectual and Development Disabilities Research Center","funder_award_id":"P30HD026979","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G4832134646","display_name":"REST-Activated Program of Gene Expression in Ischemia","funder_award_id":"R01NS046742","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G623562291","display_name":null,"funder_award_id":"P30 HD26979","funder_id":"https://openalex.org/F4320332591","funder_display_name":"Intellectual and Developmental Disabilities Research Center"},{"id":"https://openalex.org/G8476345702","display_name":"Connexins in Ischemia-Induced Neuronal Death","funder_award_id":"R01NS045287","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G9000882082","display_name":"Cell-Contact Mediated Mechanisms Assembling Synapses (R01DA022727)","funder_award_id":"R01DA022727","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"}],"funders":[{"id":"https://openalex.org/F4320306402","display_name":"F. M. Kirby Foundation","ror":"https://ror.org/03kz2rg33"},{"id":"https://openalex.org/F4320306812","display_name":"International Rett Syndrome Foundation","ror":"https://ror.org/00e7vz537"},{"id":"https://openalex.org/F4320309099","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48"},{"id":"https://openalex.org/F4320309370","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10"},{"id":"https://openalex.org/F4320310145","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95"},{"id":"https://openalex.org/F4320314616","display_name":"James N. Kirby Foundation","ror":"https://ror.org/0367ekx87"},{"id":"https://openalex.org/F4320324161","display_name":"Korea Advanced Institute of Science and Technology","ror":"https://ror.org/05apxxy63"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332591","display_name":"Intellectual and Developmental Disabilities Research Center","ror":"https://ror.org/02pttbw34"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1496786509.pdf","grobid_xml":"https://content.openalex.org/works/W1496786509.grobid-xml"},"referenced_works_count":116,"referenced_works":["https://openalex.org/W123990481","https://openalex.org/W338661492","https://openalex.org/W1534400204","https://openalex.org/W1552913606","https://openalex.org/W1581958701","https://openalex.org/W1688463639","https://openalex.org/W1839705883","https://openalex.org/W1876061808","https://openalex.org/W1905134447","https://openalex.org/W1931460634","https://openalex.org/W1964571728","https://openalex.org/W1966017317","https://openalex.org/W1969375092","https://openalex.org/W1970851711","https://openalex.org/W1972334605","https://openalex.org/W1973485468","https://openalex.org/W1973629131","https://openalex.org/W1974436068","https://openalex.org/W1977679299","https://openalex.org/W1978597334","https://openalex.org/W1979684334","https://openalex.org/W1980185403","https://openalex.org/W1981108945","https://openalex.org/W1982315043","https://openalex.org/W1985241009","https://openalex.org/W1986760345","https://openalex.org/W1987207529","https://openalex.org/W1987375729","https://openalex.org/W1988011192","https://openalex.org/W1989240245","https://openalex.org/W1992187858","https://openalex.org/W1992488586","https://openalex.org/W1997670728","https://openalex.org/W1998255137","https://openalex.org/W1999966549","https://openalex.org/W2001528712","https://openalex.org/W2003309701","https://openalex.org/W2004464973","https://openalex.org/W2004518871","https://openalex.org/W2007352788","https://openalex.org/W2015699238","https://openalex.org/W2016752859","https://openalex.org/W2017201573","https://openalex.org/W2017894590","https://openalex.org/W2018851715","https://openalex.org/W2020939800","https://openalex.org/W2023179463","https://openalex.org/W2025395171","https://openalex.org/W2025432867","https://openalex.org/W2029534471","https://openalex.org/W2030667115","https://openalex.org/W2038783205","https://openalex.org/W2039517834","https://openalex.org/W2040268226","https://openalex.org/W2044208012","https://openalex.org/W2044284660","https://openalex.org/W2050078032","https://openalex.org/W2054978737","https://openalex.org/W2055720472","https://openalex.org/W2058230858","https://openalex.org/W2060623922","https://openalex.org/W2061159466","https://openalex.org/W2062408585","https://openalex.org/W2063034817","https://openalex.org/W2063512037","https://openalex.org/W2063559465","https://openalex.org/W2063997169","https://openalex.org/W2065169750","https://openalex.org/W2069164790","https://openalex.org/W2069918422","https://openalex.org/W2071312927","https://openalex.org/W2072180889","https://openalex.org/W2073355679","https://openalex.org/W2073439662","https://openalex.org/W2075204586","https://openalex.org/W2075308337","https://openalex.org/W2076090607","https://openalex.org/W2076770982","https://openalex.org/W2081551641","https://openalex.org/W2082494746","https://openalex.org/W2083022553","https://openalex.org/W2085865633","https://openalex.org/W2086494545","https://openalex.org/W2088239473","https://openalex.org/W2089031748","https://openalex.org/W2089717004","https://openalex.org/W2090658464","https://openalex.org/W2090714277","https://openalex.org/W2093552981","https://openalex.org/W2098214132","https://openalex.org/W2103960901","https://openalex.org/W2104726963","https://openalex.org/W2105342083","https://openalex.org/W2108613636","https://openalex.org/W2119813254","https://openalex.org/W2120558693","https://openalex.org/W2121220699","https://openalex.org/W2123491442","https://openalex.org/W2130139983","https://openalex.org/W2130283578","https://openalex.org/W2134236497","https://openalex.org/W2140273147","https://openalex.org/W2142255838","https://openalex.org/W2143485434","https://openalex.org/W2143495412","https://openalex.org/W2148670413","https://openalex.org/W2150445069","https://openalex.org/W2153987796","https://openalex.org/W2154315446","https://openalex.org/W2157726561","https://openalex.org/W2158474463","https://openalex.org/W2161352090","https://openalex.org/W2169261803","https://openalex.org/W2171263596","https://openalex.org/W2808176952","https://openalex.org/W2894613750"],"related_works":["https://openalex.org/W7100703489","https://openalex.org/W2167768159","https://openalex.org/W2058544036","https://openalex.org/W118950700","https://openalex.org/W2105342083","https://openalex.org/W2800983890","https://openalex.org/W2082718062","https://openalex.org/W2011848026","https://openalex.org/W58353741","https://openalex.org/W2101643682"],"abstract_inverted_index":{"Proper":[0],"function":[1],"of":[2,29,35,55,61,94,117,137,174,191,214,243,285],"the":[3,47,78,92,112,121,135,153,159,199,211,215,230,253,261,264,292],"central":[4,48],"nervous":[5,49],"system":[6,50],"relies":[7],"on":[8,186,210],"precise":[9],"and":[10,14,39,57,66,97,100,120,126,146,168,189,226,275,288,290],"coordinated":[11],"cell-cell":[12],"interactions":[13,142],"communication":[15],"via":[16],"synaptic":[17,24,64,183],"transmission":[18,25],"to":[19,73,110,179,182,197,205,228,251,299],"assemble":[20],"neuronal":[21,30],"networks.":[22],"Aberrant":[23],"is":[26,224,249],"a":[27,219,234,296],"hallmark":[28],"disease.":[31,67,302],"The":[32],"EphB":[33],"family":[34],"receptor":[36,272],"tyrosine":[37],"kinases":[38],"their":[40],"ephrin-B":[41,247],"ligands":[42],"play":[43],"critical":[44],"roles":[45],"in":[46,51,260],"axon":[52],"guidance,":[53],"formation":[54,93,116,136,173,287],"pre-":[56,96],"post-synaptic":[58],"specializations,":[59,99,176],"localization":[60],"glutamate":[62,105],"receptors,":[63],"plasticity,":[65],"EphB/ephrin-B":[68],"signaling":[69],"has":[70,86],"been":[71],"reported":[72],"modulate":[74],"these":[75,280],"processes,":[76],"but":[77,177],"molecular":[79,113,200,236],"mechanisms":[80,114],"remain":[81],"poorly":[82],"understood.":[83],"Our":[84],"laboratory":[85],"previously":[87],"shown":[88],"that":[89,131,190,223,240,259],"EphBs":[90,125,132,204],"organize":[91],"both":[95,144],"postsynaptic":[98,203,212],"interact":[101],"directly":[102],"with":[103,143],"NMDA-type":[104],"receptors.":[106,128],"Therefore,":[107],"I":[108,129,194,217,238,257],"sought":[109],"investigate":[111],"for":[115,155,172],"presynaptic":[118,138,175,206],"specializations":[119,139],"interaction":[122,266,294],"domain":[123],"between":[124],"NMDA":[127,271],"found":[130],"can":[133,150],"induce":[134,252],"by":[140],"trans-synaptic":[141],"ephrin-B1":[145,167],"ephrin-B2.":[147],"These":[148],"ephrin-Bs":[149],"then":[151],"recruit":[152,180],"machinery":[154],"neurotransmitter":[156],"release":[157],"through":[158],"multiple":[160],"PDZ-domain":[161],"containing":[162,270],"adaptor":[163],"protein":[164],"syntenin-1.":[165],"Furthermore,":[166,209,256],"ephrin-B2":[169],"act":[170],"independently":[171],"together":[178],"syntenin-1":[181],"sites.":[184],"Based":[185],"this":[187,244],"work":[188],"other":[192],"laboratories,":[193],"was":[195],"able":[196],"define":[198,218],"pathway":[201],"from":[202],"glutamatergic":[207],"vesicles.":[208],"side":[213],"synapse,":[216],"single":[220],"amino":[221],"acid":[222],"necessary":[225],"sufficient":[227,250],"mediate":[229],"EphB-NMDAR":[231,254,265,293],"interaction.":[232,255],"In":[233],"novel":[235],"mechanism,":[237],"show":[239,258],"extracellular":[241],"phosphorylation":[242],"residue":[245],"after":[246],"binding":[248],"mature":[262],"brain,":[263],"preferentially":[267],"regulates":[268],"NR2B-subunit":[269],"localization,":[273],"function,":[274,289],"downstream":[276],"gene":[277],"transcription.":[278],"Together,":[279],"findings":[281],"impact":[282],"our":[283],"understanding":[284],"synapse":[286],"highlight":[291],"as":[295],"potential":[297],"target":[298],"treat":[300],"neurological":[301]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2016-06-24T00:00:00"}