{"id":"https://openalex.org/W1496701554","doi":"https://doi.org/10.1046/j.1432-1327.2002.02822.x","title":"Differential effects of ergosterol and cholesterol on Cdk1 activation and SRE\u2010driven transcription","display_name":"Differential effects of ergosterol and cholesterol on Cdk1 activation and SRE\u2010driven transcription","publication_year":2002,"publication_date":"2002-03-14","ids":{"openalex":"https://openalex.org/W1496701554","doi":"https://doi.org/10.1046/j.1432-1327.2002.02822.x","mag":"1496701554","pmid":"https://pubmed.ncbi.nlm.nih.gov/11895447"},"language":"en","primary_location":{"id":"doi:10.1046/j.1432-1327.2002.02822.x","doi":"https://doi.org/10.1046/j.1432-1327.2002.02822.x","is_oa":true,"landing_page_url":"https://doi.org/10.1046/j.1432-1327.2002.02822.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1432-1327.2002.02822.x","source":{"id":"https://openalex.org/S4210214924","display_name":"European Journal of Biochemistry","issn_l":"0014-2956","issn":["0014-2956","0945-5795","1432-1033"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1432-1327.2002.02822.x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002528642","display_name":"Yajaira Su\u00e1rez","orcid":"https://orcid.org/0000-0003-4549-2953","observed_orcids":["https://orcid.org/0000-0003-4549-2953"]},"institutions":[{"id":"https://openalex.org/I4210161852","display_name":"Hospital Universitario Ram\u00f3n y Cajal","ror":"https://ror.org/050eq1942","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210139293","https://openalex.org/I4210161852"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Yajaira Su\u00e1rez","raw_affiliation_strings":["Servicio de Bioqu\u00edmica-Investigaci\u00f3n, Hospital Ram\u00f3n y Cajal, Spain","Servicio de Bioqu\u00edmica-Investigaci\u00f3n, Hospital Ram\u00f3n y Cajal, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servicio de Bioqu\u00edmica-Investigaci\u00f3n, Hospital Ram\u00f3n y Cajal, Spain","institution_ids":["https://openalex.org/I4210161852"]},{"raw_affiliation_string":"Servicio de Bioqu\u00edmica-Investigaci\u00f3n, Hospital Ram\u00f3n y Cajal, and","institution_ids":["https://openalex.org/I4210161852"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100777754","display_name":"Carlos Fern\u00e1ndez","orcid":"https://orcid.org/0000-0002-6871-454X","observed_orcids":["https://orcid.org/0000-0002-6871-454X"]},"institutions":[{"id":"https://openalex.org/I4210161852","display_name":"Hospital Universitario Ram\u00f3n y Cajal","ror":"https://ror.org/050eq1942","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210139293","https://openalex.org/I4210161852"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Carlos Fern\u00e1ndez","raw_affiliation_strings":["Servicio de Bioqui\u0301mica-Investigacio\u0301n, Hospital Ramo\u0301n y Cajal, and","Servicio de Bioqu\u00edmica-Investigaci\u00f3n, Hospital Ram\u00f3n y Cajal, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servicio de Bioqui\u0301mica-Investigacio\u0301n, Hospital Ramo\u0301n y Cajal, and","institution_ids":["https://openalex.org/I4210161852"]},{"raw_affiliation_string":"Servicio de Bioqu\u00edmica-Investigaci\u00f3n, Hospital Ram\u00f3n y Cajal, and","institution_ids":["https://openalex.org/I4210161852"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086150335","display_name":"Beatriz Ledo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210161852","display_name":"Hospital Universitario Ram\u00f3n y Cajal","ror":"https://ror.org/050eq1942","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210139293","https://openalex.org/I4210161852"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Beatriz Ledo","raw_affiliation_strings":["Servicio de Bioqui\u0301mica-Investigacio\u0301n, Hospital Ramo\u0301n y Cajal, and","Servicio de Bioqu\u00edmica-Investigaci\u00f3n, Hospital Ram\u00f3n y Cajal, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servicio de Bioqui\u0301mica-Investigacio\u0301n, Hospital Ramo\u0301n y Cajal, and","institution_ids":["https://openalex.org/I4210161852"]},{"raw_affiliation_string":"Servicio de Bioqu\u00edmica-Investigaci\u00f3n, Hospital Ram\u00f3n y Cajal, and","institution_ids":["https://openalex.org/I4210161852"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063333424","display_name":"Antonio Ferruelo","orcid":"https://orcid.org/0000-0001-9840-3569","observed_orcids":["https://orcid.org/0000-0001-9840-3569"]},"institutions":[{"id":"https://openalex.org/I4210161852","display_name":"Hospital Universitario Ram\u00f3n y Cajal","ror":"https://ror.org/050eq1942","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210139293","https://openalex.org/I4210161852"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Antonio J. Ferruelo","raw_affiliation_strings":["Servicio de Bioqui\u0301mica-Investigacio\u0301n, Hospital Ramo\u0301n y Cajal, and","Servicio de Bioqu\u00edmica-Investigaci\u00f3n, Hospital Ram\u00f3n y Cajal, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servicio de Bioqui\u0301mica-Investigacio\u0301n, Hospital Ramo\u0301n y Cajal, and","institution_ids":["https://openalex.org/I4210161852"]},{"raw_affiliation_string":"Servicio de Bioqu\u00edmica-Investigaci\u00f3n, Hospital Ram\u00f3n y Cajal, and","institution_ids":["https://openalex.org/I4210161852"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103465429","display_name":"Miguel Mart\u00edn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210161852","display_name":"Hospital Universitario Ram\u00f3n y Cajal","ror":"https://ror.org/050eq1942","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210139293","https://openalex.org/I4210161852"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Miguel Mart\u00edn","raw_affiliation_strings":["Servicio de Bioqui\u0301mica-Investigacio\u0301n, Hospital Ramo\u0301n y Cajal, and","Servicio de Bioqu\u00edmica-Investigaci\u00f3n, Hospital Ram\u00f3n y Cajal, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servicio de Bioqui\u0301mica-Investigacio\u0301n, Hospital Ramo\u0301n y Cajal, and","institution_ids":["https://openalex.org/I4210161852"]},{"raw_affiliation_string":"Servicio de Bioqu\u00edmica-Investigaci\u00f3n, Hospital Ram\u00f3n y Cajal, and","institution_ids":["https://openalex.org/I4210161852"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019972852","display_name":"Miguel A. Vega","orcid":"https://orcid.org/0000-0001-6151-4193","observed_orcids":["https://orcid.org/0000-0001-6151-4193"]},"institutions":[{"id":"https://openalex.org/I4210161852","display_name":"Hospital Universitario Ram\u00f3n y Cajal","ror":"https://ror.org/050eq1942","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210139293","https://openalex.org/I4210161852"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Miguel A. Vega","raw_affiliation_strings":["Servicio de Bioqui\u0301mica-Investigacio\u0301n, Hospital Ramo\u0301n y Cajal, and","Servicio de Bioqu\u00edmica-Investigaci\u00f3n, Hospital Ram\u00f3n y Cajal, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servicio de Bioqui\u0301mica-Investigacio\u0301n, Hospital Ramo\u0301n y Cajal, and","institution_ids":["https://openalex.org/I4210161852"]},{"raw_affiliation_string":"Servicio de Bioqu\u00edmica-Investigaci\u00f3n, Hospital Ram\u00f3n y Cajal, and","institution_ids":["https://openalex.org/I4210161852"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091416189","display_name":"Diego G\u00f3mez\u2010Coronado","orcid":"https://orcid.org/0000-0002-8382-3920","observed_orcids":["https://orcid.org/0000-0002-8382-3920"]},"institutions":[{"id":"https://openalex.org/I4210161852","display_name":"Hospital Universitario Ram\u00f3n y Cajal","ror":"https://ror.org/050eq1942","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210139293","https://openalex.org/I4210161852"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Diego G\u00f3mez\u2010Coronado","raw_affiliation_strings":["Servicio de Bioqui\u0301mica-Investigacio\u0301n, Hospital Ramo\u0301n y Cajal, and","Servicio de Bioqu\u00edmica-Investigaci\u00f3n, Hospital Ram\u00f3n y Cajal, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servicio de Bioqui\u0301mica-Investigacio\u0301n, Hospital Ramo\u0301n y Cajal, and","institution_ids":["https://openalex.org/I4210161852"]},{"raw_affiliation_string":"Servicio de Bioqu\u00edmica-Investigaci\u00f3n, Hospital Ram\u00f3n y Cajal, and","institution_ids":["https://openalex.org/I4210161852"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039534728","display_name":"Miguel Angel Lasunci\u00f3n","orcid":"https://orcid.org/0000-0003-0299-9391","observed_orcids":["https://orcid.org/0000-0003-0299-9391"]},"institutions":[{"id":"https://openalex.org/I189268942","display_name":"Universidad de Alcal\u00e1","ror":"https://ror.org/04pmn0e78","country_code":"ES","type":"education","lineage":["https://openalex.org/I189268942"]},{"id":"https://openalex.org/I4210161852","display_name":"Hospital Universitario Ram\u00f3n y Cajal","ror":"https://ror.org/050eq1942","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210139293","https://openalex.org/I4210161852"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Miguel A. Lasunci\u00f3n","raw_affiliation_strings":["Departamento de Bioqui\u0301mica y Biologi\u0301a Molecular, Universidad de Alcala\u0301, Madrid, Spain","Servicio de Bioqui\u0301mica-Investigacio\u0301n, Hospital Ramo\u0301n y Cajal, and","Departamento de Bioqu\u00edmica y Biolog\u00eda Molecular, Universidad de Alcal\u00e1, Madrid, Spain","Servicio de Bioqu\u00edmica-Investigaci\u00f3n, Hospital Ram\u00f3n y Cajal, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Bioqui\u0301mica y Biologi\u0301a Molecular, Universidad de Alcala\u0301, Madrid, Spain","institution_ids":["https://openalex.org/I189268942"]},{"raw_affiliation_string":"Servicio de Bioqui\u0301mica-Investigacio\u0301n, Hospital Ramo\u0301n y Cajal, and","institution_ids":["https://openalex.org/I4210161852"]},{"raw_affiliation_string":"Departamento de Bioqu\u00edmica y Biolog\u00eda Molecular, Universidad de Alcal\u00e1, Madrid, Spain","institution_ids":["https://openalex.org/I189268942"]},{"raw_affiliation_string":"Servicio de Bioqu\u00edmica-Investigaci\u00f3n, Hospital Ram\u00f3n y Cajal, and","institution_ids":["https://openalex.org/I4210161852"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5039534728"],"corresponding_institution_ids":["https://openalex.org/I189268942","https://openalex.org/I4210161852"],"apc_list":null,"apc_paid":null,"fwci":2.011,"has_fulltext":true,"cited_by_count":45,"citation_normalized_percentile":{"value":0.85562701,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"269","issue":"6","first_page":"1761","last_page":"1771"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.8246999979019165,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.8246999979019165,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.07509999722242355,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.029999999329447746,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cholesterol","display_name":"cholesterol","score":0.968999981880188},{"id":"https://openalex.org/keywords/ergosterol","display_name":"ergosterol","score":1.0},{"id":"https://openalex.org/keywords/cdk1-activation","display_name":"CDK1 activation","score":0.9539999961853027},{"id":"https://openalex.org/keywords/g2-m-cell-cycle-arrest","display_name":"G2/M cell cycle arrest","score":0.8640000224113464},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.628000020980835},{"id":"https://openalex.org/keywords/cyclin-b1","display_name":"cyclin B1","score":0.8309999704360962},{"id":"https://openalex.org/keywords/sterol-homeostasis","display_name":"sterol homeostasis","score":0.6940000057220459},{"id":"https://openalex.org/keywords/cell-membrane-formation","display_name":"cell membrane formation","score":0.7789999842643738},{"id":"https://openalex.org/keywords/g2-m-transition","display_name":"G2/M transition","score":0.4339999854564667},{"id":"https://openalex.org/keywords/cell-cycle-regulation","display_name":"cell cycle regulation","score":0.49399998784065247},{"id":"https://openalex.org/keywords/ucn-01","display_name":"UCN-01","score":0.6549999713897705}],"concepts":[{"id":"https://openalex.org/C2777910421","wikidata":"https://www.wikidata.org/wiki/Q143263","display_name":"Ergosterol","level":2,"score":0.8600918054580688},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.655524492263794},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6488734483718872},{"id":"https://openalex.org/C120504264","wikidata":"https://www.wikidata.org/wiki/Q1147372","display_name":"Cyclin-dependent kinase 1","level":4,"score":0.6424644589424133},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.5925168991088867},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5317721962928772},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5172629952430725},{"id":"https://openalex.org/C93304396","wikidata":"https://www.wikidata.org/wiki/Q14763008","display_name":"Mitosis","level":2,"score":0.42480623722076416},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40308672189712524},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3859058618545532},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.36935174465179443}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004875","descriptor_name":"Ergosterol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007810","descriptor_name":"Lanosterol","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D007810","descriptor_name":"Lanosterol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016203","descriptor_name":"CDC2 Protein Kinase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1046/j.1432-1327.2002.02822.x","doi":"https://doi.org/10.1046/j.1432-1327.2002.02822.x","is_oa":true,"landing_page_url":"https://doi.org/10.1046/j.1432-1327.2002.02822.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1432-1327.2002.02822.x","source":{"id":"https://openalex.org/S4210214924","display_name":"European Journal of Biochemistry","issn_l":"0014-2956","issn":["0014-2956","0945-5795","1432-1033"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Biochemistry","raw_type":"journal-article"},{"id":"pmid:11895447","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11895447","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of biochemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1046/j.1432-1327.2002.02822.x","doi":"https://doi.org/10.1046/j.1432-1327.2002.02822.x","is_oa":true,"landing_page_url":"https://doi.org/10.1046/j.1432-1327.2002.02822.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1432-1327.2002.02822.x","source":{"id":"https://openalex.org/S4210214924","display_name":"European Journal of Biochemistry","issn_l":"0014-2956","issn":["0014-2956","0945-5795","1432-1033"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Biochemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4000000059604645,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334923","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1496701554.pdf","grobid_xml":"https://content.openalex.org/works/W1496701554.grobid-xml"},"referenced_works_count":74,"referenced_works":["https://openalex.org/W57755138","https://openalex.org/W97469372","https://openalex.org/W276882634","https://openalex.org/W561676182","https://openalex.org/W1481748141","https://openalex.org/W1494006401","https://openalex.org/W1498308337","https://openalex.org/W1511240493","https://openalex.org/W1574122095","https://openalex.org/W1580998246","https://openalex.org/W1584439305","https://openalex.org/W1590066614","https://openalex.org/W1592292819","https://openalex.org/W1601992011","https://openalex.org/W1658669968","https://openalex.org/W1676269880","https://openalex.org/W1775749144","https://openalex.org/W1911421926","https://openalex.org/W1958026543","https://openalex.org/W1967802473","https://openalex.org/W1969583685","https://openalex.org/W1972557244","https://openalex.org/W1976641875","https://openalex.org/W1979011664","https://openalex.org/W1981845645","https://openalex.org/W1989383391","https://openalex.org/W1993558309","https://openalex.org/W1995490285","https://openalex.org/W1999349877","https://openalex.org/W2004969276","https://openalex.org/W2008066024","https://openalex.org/W2012956378","https://openalex.org/W2020405150","https://openalex.org/W2023072578","https://openalex.org/W2023286308","https://openalex.org/W2026881257","https://openalex.org/W2037894077","https://openalex.org/W2038837869","https://openalex.org/W2039839254","https://openalex.org/W2039999119","https://openalex.org/W2040063578","https://openalex.org/W2040641918","https://openalex.org/W2047799300","https://openalex.org/W2049601397","https://openalex.org/W2052628907","https://openalex.org/W2054728240","https://openalex.org/W2057991698","https://openalex.org/W2062707142","https://openalex.org/W2065797900","https://openalex.org/W2070979975","https://openalex.org/W2071124826","https://openalex.org/W2075415043","https://openalex.org/W2077544195","https://openalex.org/W2082275436","https://openalex.org/W2089414651","https://openalex.org/W2090070279","https://openalex.org/W2093333003","https://openalex.org/W2094075324","https://openalex.org/W2097173890","https://openalex.org/W2098425631","https://openalex.org/W2115985987","https://openalex.org/W2128635872","https://openalex.org/W2145281774","https://openalex.org/W2163476686","https://openalex.org/W2168526937","https://openalex.org/W2168981012","https://openalex.org/W2188917294","https://openalex.org/W2312832763","https://openalex.org/W2322069423","https://openalex.org/W2340722481","https://openalex.org/W2394778384","https://openalex.org/W2411247746","https://openalex.org/W2464733971","https://openalex.org/W2468321837"],"related_works":["https://openalex.org/W2036022596","https://openalex.org/W1958026543","https://openalex.org/W2023072578","https://openalex.org/W1978908300","https://openalex.org/W2753045797","https://openalex.org/W2077265833","https://openalex.org/W1542679036","https://openalex.org/W2002065472","https://openalex.org/W4377138598","https://openalex.org/W4401304294"],"abstract_inverted_index":{"Cholesterol":[0],"is":[1,11,204,238,258],"essential":[2],"for":[3,226,250],"cell":[4,29,83,87,150,201,219,263],"growth":[5],"and":[6,86,116,147,222,241],"division,":[7],"but":[8,103],"whether":[9,22],"this":[10,43],"just":[12],"a":[13,58,78,244,259],"consequence":[14],"of":[15,42,45,56,66,71,124,127,160,181,191,194,209,213,233,262],"its":[16,52],"use":[17],"in":[18,28,47,74,77,82,152,188,266],"membrane":[19,220],"formation":[20,221],"or":[21],"it":[23],"also":[24],"elicits":[25],"regulatory":[26],"actions":[27],"cycle":[30,88,151,264],"machinery":[31],"remains":[32],"to":[33,63,100,134,139,144,148,165,170,218,247],"be":[34],"established.":[35],"Here,":[36],"we":[37],"report":[38],"on":[39,200,206,235],"the":[40,101,109,122,125,189,207,210,231,254],"specificity":[41],"action":[44,212,232],"cholesterol":[46,67,98,223,234,251,257],"human":[48,114,267],"cells":[49,75,115,153,168],"by":[50,69,97,105,113],"comparing":[51],"effects":[53,94,199],"with":[54,177],"those":[55],"ergosterol,":[57,106],"yeast":[59],"sterol":[60],"structurally":[61],"similar":[62,118],"cholesterol.":[64],"Inhibition":[65],"synthesis":[68],"means":[70],"SKF":[72],"104976":[73],"incubated":[76],"cholesterol-free":[79],"medium":[80,102],"resulted":[81],"proliferation":[84],"inhibition":[85],"arrest":[89],"at":[90,156],"G2/M":[91],"phase.":[92],"These":[93],"were":[95],"abrogated":[96],"added":[99],"not":[104,163],"despite":[107],"that":[108,248,256],"latter":[110],"was":[111,137,162],"used":[112,249],"exerted":[117,197,242],"homeostatic":[119],"actions,":[120],"as":[121,167],"regulation":[123],"transcription":[126],"an":[128,179],"SRE-driven":[129],"gene":[130],"construct.":[131],"In":[132,229],"contrast":[133],"cholesterol,":[135,195],"ergosterol":[136,171,196,216],"unable":[138],"induce":[140],"cyclin":[141],"B1":[142],"expression,":[143],"activate":[145],"Cdk1":[146,227],"resume":[149],"previously":[154],"arrested":[155],"G2.":[157],"This":[158,203],"lack":[159],"effect":[161],"due":[164],"cytotoxicity,":[166],"exposed":[169],"remained":[172],"viable":[173],"and,":[174],"upon":[175],"supplementing":[176],"UCN-01,":[178],"activator":[180],"Cdk1,":[182],"they":[183],"progressed":[184],"through":[185,243],"mitosis.":[186],"However,":[187],"presence":[190],"suboptimal":[192],"concentrations":[193],"synergistic":[198],"proliferation.":[202],"interpreted":[205],"basis":[208],"differential":[211],"these":[214],"sterols,":[215],"contributing":[217],"being":[224],"required":[225],"activation.":[228],"summary,":[230],"G2":[236],"traversal":[237],"highly":[239],"specific":[240,260],"mechanism":[245],"different":[246],"homeostasis,":[252],"reinforcing":[253],"concept":[255],"regulator":[261],"progression":[265],"cells.":[268]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}