{"id":"https://openalex.org/W1495836119","doi":null,"title":"THE EFFECT OF POLYCHLORINATED BIPHENYLS ON LIVER TUMOR PROMOTION: A ROLE FOR KUPFFER CELLS?","display_name":"THE EFFECT OF POLYCHLORINATED BIPHENYLS ON LIVER TUMOR PROMOTION: A ROLE FOR KUPFFER CELLS?","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W1495836119","mag":"1495836119"},"language":"en","primary_location":{"id":"pmh:oai:uknowledge.uky.edu:gradschool_diss-1405","doi":null,"is_oa":true,"landing_page_url":"https://uknowledge.uky.edu/gradschool_diss/402","pdf_url":"https://uknowledge.uky.edu/gradschool_diss/402","source":{"id":"https://openalex.org/S4306402623","display_name":"UKnowledge (University of Kentucky)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143302722","host_organization_name":"University of Kentucky","host_organization_lineage":["https://openalex.org/I143302722"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"University of Kentucky Doctoral Dissertations","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://uknowledge.uky.edu/gradschool_diss/402","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027126263","display_name":"Rodica Petruta Bunaciu","orcid":"https://orcid.org/0000-0002-3101-0928","observed_orcids":["https://orcid.org/0000-0002-3101-0928"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Rodica P. Bunaciu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3101-0928","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5027126263"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.8184000253677368,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.8184000253677368,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.07620000094175339,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.04100000113248825,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polychlorinated-biphenyls","display_name":"polychlorinated biphenyls","score":1.0},{"id":"https://openalex.org/keywords/liver-tumor-promotion","display_name":"liver tumor promotion","score":0.8650000095367432},{"id":"https://openalex.org/keywords/kupffer-cells","display_name":"Kupffer cells","score":0.9819999933242798},{"id":"https://openalex.org/keywords/pcb-153","display_name":"PCB 153","score":0.847000002861023},{"id":"https://openalex.org/keywords/pcb-77","display_name":"PCB 77","score":0.9359999895095825},{"id":"https://openalex.org/keywords/glycine","display_name":"glycine","score":0.6330000162124634},{"id":"https://openalex.org/keywords/hepatocyte-proliferation","display_name":"hepatocyte proliferation","score":0.878000020980835},{"id":"https://openalex.org/keywords/nf-kappab-activation","display_name":"NF-\u03baB activation","score":0.9160000085830688},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8920000195503235},{"id":"https://openalex.org/keywords/preneoplastic-foci","display_name":"preneoplastic foci","score":0.9390000104904175},{"id":"https://openalex.org/keywords/kupffer-cell-depletion","display_name":"Kupffer cell depletion","score":0.7559999823570251},{"id":"https://openalex.org/keywords/hepatocarcinogenesis","display_name":"hepatocarcinogenesis","score":0.8029999732971191}],"concepts":[{"id":"https://openalex.org/C2778904781","wikidata":"https://www.wikidata.org/wiki/Q513486","display_name":"Kupffer cell","level":2,"score":0.5936665534973145},{"id":"https://openalex.org/C98147612","wikidata":"https://www.wikidata.org/wiki/Q215599","display_name":"Promotion (chess)","level":3,"score":0.5359450578689575},{"id":"https://openalex.org/C2780122803","wikidata":"https://www.wikidata.org/wiki/Q7852681","display_name":"Tumor promotion","level":4,"score":0.4371323585510254},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42967522144317627},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.37972986698150635},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.3427169919013977},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3389293849468231},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2756892442703247},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.24858957529067993},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.22808679938316345},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18523713946342468},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.1171116828918457},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09162312746047974},{"id":"https://openalex.org/C94625758","wikidata":"https://www.wikidata.org/wiki/Q7163","display_name":"Politics","level":2,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:uknowledge.uky.edu:gradschool_diss-1405","doi":null,"is_oa":true,"landing_page_url":"https://uknowledge.uky.edu/gradschool_diss/402","pdf_url":"https://uknowledge.uky.edu/gradschool_diss/402","source":{"id":"https://openalex.org/S4306402623","display_name":"UKnowledge (University of Kentucky)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143302722","host_organization_name":"University of Kentucky","host_organization_lineage":["https://openalex.org/I143302722"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"University of Kentucky Doctoral Dissertations","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.896.2778","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.896.2778","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://uknowledge.uky.edu/cgi/viewcontent.cgi?article%3D1405%26context%3Dgradschool_diss","raw_type":"text"},{"id":"mag:1495836119","doi":null,"is_oa":false,"landing_page_url":"https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1405&context=gradschool_diss","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:uknowledge.uky.edu:gradschool_diss-1405","doi":null,"is_oa":true,"landing_page_url":"https://uknowledge.uky.edu/gradschool_diss/402","pdf_url":"https://uknowledge.uky.edu/gradschool_diss/402","source":{"id":"https://openalex.org/S4306402623","display_name":"UKnowledge (University of Kentucky)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143302722","host_organization_name":"University of Kentucky","host_organization_lineage":["https://openalex.org/I143302722"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"University of Kentucky Doctoral Dissertations","raw_type":"text"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1495836119.pdf","grobid_xml":"https://content.openalex.org/works/W1495836119.grobid-xml"},"referenced_works_count":253,"referenced_works":["https://openalex.org/W29671035","https://openalex.org/W65036109","https://openalex.org/W105279024","https://openalex.org/W175497547","https://openalex.org/W181214577","https://openalex.org/W185941675","https://openalex.org/W1491499843","https://openalex.org/W1494123774","https://openalex.org/W1503918891","https://openalex.org/W1523227020","https://openalex.org/W1525067025","https://openalex.org/W1538577248","https://openalex.org/W1542438031","https://openalex.org/W1548860972","https://openalex.org/W1550838340","https://openalex.org/W1568529372","https://openalex.org/W1568783875","https://openalex.org/W1577403013","https://openalex.org/W1583645666","https://openalex.org/W1590514634","https://openalex.org/W1608832835","https://openalex.org/W1641228030","https://openalex.org/W1670312687","https://openalex.org/W1838640007","https://openalex.org/W1846597099","https://openalex.org/W1852941485","https://openalex.org/W1875294959","https://openalex.org/W1894739254","https://openalex.org/W1908884573","https://openalex.org/W1919150642","https://openalex.org/W1931618361","https://openalex.org/W1940201944","https://openalex.org/W1966635260","https://openalex.org/W1966654614","https://openalex.org/W1966910483","https://openalex.org/W1967179667","https://openalex.org/W1968269528","https://openalex.org/W1968485858","https://openalex.org/W1968657325","https://openalex.org/W1969723123","https://openalex.org/W1970793060","https://openalex.org/W1971936300","https://openalex.org/W1973238763","https://openalex.org/W1974253904","https://openalex.org/W1974934266","https://openalex.org/W1975172478","https://openalex.org/W1976346979","https://openalex.org/W1976875130","https://openalex.org/W1977139178","https://openalex.org/W1977261775","https://openalex.org/W1977444929","https://openalex.org/W1977592927","https://openalex.org/W1977872674","https://openalex.org/W1979520552","https://openalex.org/W1979995523","https://openalex.org/W1980768491","https://openalex.org/W1981279226","https://openalex.org/W1981884734","https://openalex.org/W1982076021","https://openalex.org/W1982438763","https://openalex.org/W1983623331","https://openalex.org/W1984306914","https://openalex.org/W1984690547","https://openalex.org/W1985599707","https://openalex.org/W1986637935","https://openalex.org/W1987620723","https://openalex.org/W1987677373","https://openalex.org/W1988339232","https://openalex.org/W1989721362","https://openalex.org/W1989783048","https://openalex.org/W1992748701","https://openalex.org/W1993224368","https://openalex.org/W1995686777","https://openalex.org/W1996228469","https://openalex.org/W1996253097","https://openalex.org/W1996637994","https://openalex.org/W1996717793","https://openalex.org/W1997042740","https://openalex.org/W1997313701","https://openalex.org/W1998371186","https://openalex.org/W1998412465","https://openalex.org/W2002066494","https://openalex.org/W2002518019","https://openalex.org/W2003951360","https://openalex.org/W2004376987","https://openalex.org/W2006984441","https://openalex.org/W2007456673","https://openalex.org/W2007887289","https://openalex.org/W2008532209","https://openalex.org/W2010276709","https://openalex.org/W2010554063","https://openalex.org/W2011549104","https://openalex.org/W2012121526","https://openalex.org/W2013066674","https://openalex.org/W2013282373","https://openalex.org/W2014166217","https://openalex.org/W2016060547","https://openalex.org/W2016360836","https://openalex.org/W2016440344","https://openalex.org/W2016759194","https://openalex.org/W2017729229","https://openalex.org/W2018251493","https://openalex.org/W2018867477","https://openalex.org/W2019167682","https://openalex.org/W2019969638","https://openalex.org/W2022433330","https://openalex.org/W2023508043","https://openalex.org/W2024728100","https://openalex.org/W2024828342","https://openalex.org/W2025297233","https://openalex.org/W2025297909","https://openalex.org/W2025332686","https://openalex.org/W2028964145","https://openalex.org/W2030818705","https://openalex.org/W2030918525","https://openalex.org/W2031062973","https://openalex.org/W2031468048","https://openalex.org/W2032943659","https://openalex.org/W2033091557","https://openalex.org/W2033187549","https://openalex.org/W2039127922","https://openalex.org/W2041487496","https://openalex.org/W2041953822","https://openalex.org/W2042628846","https://openalex.org/W2043493252","https://openalex.org/W2044375515","https://openalex.org/W2044608904","https://openalex.org/W2045773619","https://openalex.org/W2047526932","https://openalex.org/W2047571073","https://openalex.org/W2048548035","https://openalex.org/W2049192149","https://openalex.org/W2052405890","https://openalex.org/W2054511859","https://openalex.org/W2054587239","https://openalex.org/W2054876803","https://openalex.org/W2056320080","https://openalex.org/W2056480540","https://openalex.org/W2060380984","https://openalex.org/W2063043675","https://openalex.org/W2063407488","https://openalex.org/W2064619488","https://openalex.org/W2066861312","https://openalex.org/W2067125599","https://openalex.org/W2067355567","https://openalex.org/W2067815496","https://openalex.org/W2069121050","https://openalex.org/W2069328385","https://openalex.org/W2071750798","https://openalex.org/W2075543221","https://openalex.org/W2077597042","https://openalex.org/W2077599125","https://openalex.org/W2078036072","https://openalex.org/W2078144575","https://openalex.org/W2081367726","https://openalex.org/W2081794014","https://openalex.org/W2081983296","https://openalex.org/W2083203074","https://openalex.org/W2083622552","https://openalex.org/W2083990249","https://openalex.org/W2084101944","https://openalex.org/W2090602617","https://openalex.org/W2092128892","https://openalex.org/W2092946849","https://openalex.org/W2092963288","https://openalex.org/W2092964260","https://openalex.org/W2094703619","https://openalex.org/W2095191454","https://openalex.org/W2096428903","https://openalex.org/W2097682695","https://openalex.org/W2098189120","https://openalex.org/W2099158786","https://openalex.org/W2100837628","https://openalex.org/W2103069793","https://openalex.org/W2103675433","https://openalex.org/W2104137320","https://openalex.org/W2105598342","https://openalex.org/W2106012039","https://openalex.org/W2106397455","https://openalex.org/W2106639107","https://openalex.org/W2106877484","https://openalex.org/W2109973304","https://openalex.org/W2113333095","https://openalex.org/W2118986158","https://openalex.org/W2119615783","https://openalex.org/W2121487239","https://openalex.org/W2121858846","https://openalex.org/W2122559781","https://openalex.org/W2123045403","https://openalex.org/W2123800186","https://openalex.org/W2124132939","https://openalex.org/W2127460630","https://openalex.org/W2128456415","https://openalex.org/W2128935878","https://openalex.org/W2130821715","https://openalex.org/W2131960045","https://openalex.org/W2133982451","https://openalex.org/W2134384378","https://openalex.org/W2134422963","https://openalex.org/W2135248587","https://openalex.org/W2137337123","https://openalex.org/W2140044218","https://openalex.org/W2140117920","https://openalex.org/W2142943268","https://openalex.org/W2143868171","https://openalex.org/W2145773977","https://openalex.org/W2145829829","https://openalex.org/W2147469694","https://openalex.org/W2149013296","https://openalex.org/W2149089362","https://openalex.org/W2150210946","https://openalex.org/W2152225084","https://openalex.org/W2154487009","https://openalex.org/W2155098516","https://openalex.org/W2159079024","https://openalex.org/W2159121293","https://openalex.org/W2160553550","https://openalex.org/W2163279811","https://openalex.org/W2163411441","https://openalex.org/W2166279203","https://openalex.org/W2166468702","https://openalex.org/W2166781237","https://openalex.org/W2166873130","https://openalex.org/W2169053713","https://openalex.org/W2170747221","https://openalex.org/W2171908596","https://openalex.org/W2171982487","https://openalex.org/W2178044610","https://openalex.org/W2187489219","https://openalex.org/W2204123985","https://openalex.org/W2254933028","https://openalex.org/W2265137151","https://openalex.org/W2266129269","https://openalex.org/W2274906522","https://openalex.org/W2289480026","https://openalex.org/W2302005959","https://openalex.org/W2336266906","https://openalex.org/W2342400171","https://openalex.org/W2395359300","https://openalex.org/W2399101485","https://openalex.org/W2411854521","https://openalex.org/W2413104078","https://openalex.org/W2414277113","https://openalex.org/W2414311833","https://openalex.org/W2420706738","https://openalex.org/W2421037982","https://openalex.org/W3110791223","https://openalex.org/W3142897392","https://openalex.org/W3146153095","https://openalex.org/W4230542296","https://openalex.org/W4237928571","https://openalex.org/W4319308505","https://openalex.org/W7164863902"],"related_works":["https://openalex.org/W7097046368","https://openalex.org/W1497504026","https://openalex.org/W2007874406","https://openalex.org/W2052500522","https://openalex.org/W2084101944","https://openalex.org/W7126230772","https://openalex.org/W1966635260","https://openalex.org/W7097175034","https://openalex.org/W2097682695","https://openalex.org/W246632755"],"abstract_inverted_index":{"Polychlorinated":[0],"biphenyls":[1],"(PCBs)":[2],"are":[3,17,23,67],"ubiquitious":[4],"lipophilic":[5],"environmental":[6],"pollutants.":[7],"At":[8],"least":[9],"some":[10],"of":[11,57,73,77,83,126,136,151,160,182,188,196,221,243],"the":[12,33,38,70,120,133,142,149,158,183,194,212,231,235,241,249],"PCB":[13,208],"congeners":[14],"and":[15,27,108,114,157,260],"mixtures":[16],"hepatic":[18,64],"tumor":[19,94,121],"promoters.":[20],"The":[21,55,75,96,170],"mechanisms":[22],"not":[24,130,200,228,264],"fully":[25],"understood":[26],"might":[28],"be":[29],"multifactorial":[30],"Besides":[31],"being":[32],"most":[34],"abundant":[35],"congener":[36],"in":[37,53,69,102,116,223,234,248,270],"environment,":[39],"2,2,4,4,5,5-hexachlorobiphenyl":[40],"(PCB-153),":[41],"has":[42],"been":[43],"previously":[44],"shown":[45],"to":[46,61,91,211,266],"increase":[47,230],"hepatocyte":[48,168,271],"proliferation":[49,203],"48h":[50],"after":[51,207],"exposure":[52,112,145],"rats.":[54],"goal":[56],"this":[58,78],"study":[59,79],"was":[60,80],"determine":[62],"whether":[63],"Kupffer":[65,84,127,152,161,189,197,224,261],"cells":[66,128,190,198,225,262],"important":[68],"promoting":[71,134],"activity":[72,86,135,220],"PCBs.":[74],"hypothesis":[76],"that":[81],"modulation":[82],"cell":[85,153,162,202,258],"by":[87,155],"PCBs":[88],"may":[89],"contribute":[90],"PCB-induced":[92],"liver":[93,247],"promotion.":[95],"experimental":[97],"approach":[98],"consisted":[99],"on":[100,164,167,180,257],"three":[101],"vivo":[103],"models":[104],"(tumor":[105],"promotion":[106,122],"model":[107],"two":[109],"short":[110,143],"term":[111,144],"models)":[113],"one":[115],"vitro":[117],"model.":[118],"In":[119,214,237],"model,":[123,146],"glycine":[124,156,192],"inactivation":[125,154],"did":[129,199,227],"significantly":[131,229],"influence":[132],"PCB-77":[137],"(3,3,4,4-tetrachlorobiphenyl)":[138],"or":[139,193,204],"PCB-153.":[140],"For":[141],"we":[147],"investigated":[148],"effect":[150,159,179,256],"depletion":[163],"PCB-153s":[165],"impact":[166],"proliferation.":[169,272],"oil":[171],"used":[172],"as":[173],"a":[174,268],"vehicle":[175],"had":[176,253],"no":[177,254],"significant":[178,255],"any":[181],"end":[184],"points":[185],"considered.":[186],"Inhibition":[187],"with":[191],"absence":[195],"affect":[201],"NF-B":[205,222],"activation":[206],"treatment":[209],"compared":[210],"control.":[213],"vitro,":[215],"PCB-153":[216,239],"increased":[217,240],"DNA":[218],"binding":[219],"but":[226,252],"TNF-":[232],"concentration":[233],"medium.":[236],"conclusion,":[238],"number":[242],"preneoplastic":[244],"foci":[245],"per":[246],"casein":[250],"group":[251],"proliferation,":[259],"do":[263],"seem":[265],"play":[267],"role":[269]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}