{"id":"https://openalex.org/W14958219","doi":null,"title":"Aetiological, clinical and metabolic profile of hypokalaemic periodic paralysis in adults: a single-centre experience.","display_name":"Aetiological, clinical and metabolic profile of hypokalaemic periodic paralysis in adults: a single-centre experience.","publication_year":2006,"publication_date":"2006-09-01","ids":{"openalex":"https://openalex.org/W14958219","mag":"14958219","pmid":"https://pubmed.ncbi.nlm.nih.gov/17203677"},"language":"en","primary_location":{"id":"pmid:17203677","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17203677","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The National medical journal of India","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059724993","display_name":"N. Karthik Rao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I172917736","display_name":"Christian Medical College, Vellore","ror":"https://ror.org/00c7kvd80","country_code":"IN","type":"education","lineage":["https://openalex.org/I172917736"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Narsing Rao","raw_affiliation_strings":["Department of Endocrinology, Diabetes and Metabolism, Christian Medical College, Ida Scudder Road, Vellore 632004, Tamil Nadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, Diabetes and Metabolism, Christian Medical College, Ida Scudder Road, Vellore 632004, Tamil Nadu, India","institution_ids":["https://openalex.org/I172917736"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031586597","display_name":"Mathew John","orcid":"https://orcid.org/0000-0002-6435-7995","observed_orcids":["https://orcid.org/0000-0002-6435-7995"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mathew John","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001401729","display_name":"Nihal Thomas","orcid":"https://orcid.org/0000-0002-4614-9519","observed_orcids":["https://orcid.org/0000-0002-4614-9519"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nihal Thomas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057511400","display_name":"Simon Rajaratnam","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Simon Rajaratnam","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5005799299","display_name":"Mandalam Subramaniam Seshadri","orcid":"https://orcid.org/0000-0002-6180-8957","observed_orcids":["https://orcid.org/0000-0002-6180-8957"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mandalam Subramaniam Seshadri","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2304,"has_fulltext":false,"cited_by_count":46,"citation_normalized_percentile":{"value":0.61534396,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"19","issue":"5","first_page":"246","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12876","display_name":"Potassium and Related Disorders","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12876","display_name":"Potassium and Related Disorders","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12840","display_name":"Renal function and acid-base balance","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypokalemic-periodic-paralysis","display_name":"hypokalemic periodic paralysis","score":0.996999979019165},{"id":"https://openalex.org/keywords/renal-tubular-acidosis","display_name":"renal tubular acidosis","score":0.7960000038146973},{"id":"https://openalex.org/keywords/primary-aldosteronism","display_name":"primary aldosteronism","score":0.9950000047683716},{"id":"https://openalex.org/keywords/gitelman-syndrome","display_name":"Gitelman syndrome","score":0.7509999871253967},{"id":"https://openalex.org/keywords/thyrotoxic-periodic-paralysis","display_name":"thyrotoxic periodic paralysis","score":0.9829999804496765},{"id":"https://openalex.org/keywords/sjogren-s-syndrome","display_name":"Sj\u00f6gren's syndrome","score":0.8119999766349792},{"id":"https://openalex.org/keywords/serum-bicarbonate","display_name":"serum bicarbonate","score":0.8460000157356262},{"id":"https://openalex.org/keywords/chloride","display_name":"chloride","score":0.6230000257492065},{"id":"https://openalex.org/keywords/adrenal-adenoma","display_name":"adrenal adenoma","score":0.8140000104904175},{"id":"https://openalex.org/keywords/indian-patients","display_name":"Indian patients","score":0.5090000033378601}],"concepts":[{"id":"https://openalex.org/C2776598079","wikidata":"https://www.wikidata.org/wiki/Q2896802","display_name":"Distal renal tubular acidosis","level":3,"score":0.8857988119125366},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8109903335571289},{"id":"https://openalex.org/C2776292634","wikidata":"https://www.wikidata.org/wiki/Q1640860","display_name":"Hyperaldosteronism","level":3,"score":0.8056131601333618},{"id":"https://openalex.org/C2781079508","wikidata":"https://www.wikidata.org/wiki/Q1516211","display_name":"Renal tubular acidosis","level":3,"score":0.72817063331604},{"id":"https://openalex.org/C2778242168","wikidata":"https://www.wikidata.org/wiki/Q794086","display_name":"Hypokalemia","level":2,"score":0.6947447061538696},{"id":"https://openalex.org/C2781079590","wikidata":"https://www.wikidata.org/wiki/Q622828","display_name":"Hypokalemic periodic paralysis","level":3,"score":0.6917995810508728},{"id":"https://openalex.org/C2776532573","wikidata":"https://www.wikidata.org/wiki/Q1788314","display_name":"Periodic paralysis","level":3,"score":0.6883667707443237},{"id":"https://openalex.org/C137627325","wikidata":"https://www.wikidata.org/wiki/Q156318","display_name":"Etiology","level":2,"score":0.5911235809326172},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5686904788017273},{"id":"https://openalex.org/C2779246250","wikidata":"https://www.wikidata.org/wiki/Q1598200","display_name":"Metabolic acidosis","level":2,"score":0.49449679255485535},{"id":"https://openalex.org/C2779618896","wikidata":"https://www.wikidata.org/wiki/Q107231","display_name":"Paralysis","level":2,"score":0.4700671136379242},{"id":"https://openalex.org/C2778553927","wikidata":"https://www.wikidata.org/wiki/Q185089","display_name":"Acidosis","level":2,"score":0.44399991631507874},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.44163960218429565},{"id":"https://openalex.org/C2777261373","wikidata":"https://www.wikidata.org/wiki/Q5898267","display_name":"Hyperchloremia","level":3,"score":0.43849918246269226},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4093093276023865},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3814283609390259},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.22380569577217102},{"id":"https://openalex.org/C2778525890","wikidata":"https://www.wikidata.org/wiki/Q184564","display_name":"Aldosterone","level":2,"score":0.1386113166809082},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000141","descriptor_name":"Acidosis, Renal Tubular","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006929","descriptor_name":"Hyperaldosteronism","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D007194","descriptor_name":"India","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010245","descriptor_name":"Paralyses, Familial Periodic","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D010245","descriptor_name":"Paralyses, Familial Periodic","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020514","descriptor_name":"Hypokalemic Periodic Paralysis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D020514","descriptor_name":"Hypokalemic Periodic Paralysis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:17203677","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17203677","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The National medical journal of India","raw_type":"Journal Article"},{"id":"mag:14958219","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17203677","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1910265189","https://openalex.org/W1996200974","https://openalex.org/W2016313902","https://openalex.org/W2063266089","https://openalex.org/W2064103541","https://openalex.org/W2083116747","https://openalex.org/W2086553307","https://openalex.org/W2102064576","https://openalex.org/W2154951696","https://openalex.org/W2159477041","https://openalex.org/W2183948700","https://openalex.org/W2313800539","https://openalex.org/W2403812948","https://openalex.org/W2409943826","https://openalex.org/W2419454122","https://openalex.org/W2419769163"],"related_works":["https://openalex.org/W2043267964","https://openalex.org/W2402940503","https://openalex.org/W2369976734","https://openalex.org/W2939923391","https://openalex.org/W3184585437","https://openalex.org/W2908552763","https://openalex.org/W2278530063","https://openalex.org/W2790863461","https://openalex.org/W2103912442","https://openalex.org/W2884175424"],"abstract_inverted_index":{"BACKGROUND:":[0],"Hypokalaemic":[1],"periodic":[2,43,97,101,227,253],"paralysis":[3,44,98],"constitutes":[4],"a":[5],"heterogeneous":[6],"group":[7],"of":[8,64,76,126,161,214,225],"disorders":[9],"that":[10,24],"present":[11],"with":[12,42,84,89,95,105,112,129,173,196,251],"acute":[13],"muscular":[14],"weakness.":[15],"In":[16],"this":[17,217],"analysis,":[18],"we":[19],"discuss":[20],"the":[21,31,53,109,180],"aetiological":[22],"factors":[23],"appear":[25],"to":[26,37,139,206],"be":[27,246],"more":[28],"common":[29,230],"in":[30,216,248],"Indian":[32,249],"population.":[33],"METHODS:":[34],"From":[35],"1995":[36],"2001,":[38],"31":[39,54],"patients":[40,66,82,111,128,137,195,215,250],"presented":[41],"(mean":[45],"age":[46],"34.5":[47],"years,":[48],"range":[49],"11-68":[50],"years).":[51],"Of":[52,108],"patients,":[55],"19":[56],"were":[57,67,70,80,183,204,232],"men.":[58],"The":[59,136,229],"clinical":[60],"and":[61,99,103,119,158,203,221,236],"laboratory":[62],"data":[63],"these":[65,127],"analysed.":[68],"Patients":[69],"investigated":[71],"for":[72,242],"possible":[73],"secondary":[74,220,243],"causes":[75,224,231,244],"hypokalaemla.":[77],"RESULTS:":[78],"There":[79],"13":[81,88,110],"(42%)":[83],"renal":[85,113,122,130,141,233],"tubular":[86,114,123,131,142,234],"acidosis,":[87,115],"primary":[90,177,197,237],"hyperaldosteronism":[91,198],"(42%),":[92],"2":[93],"each":[94],"thyrotoxic":[96],"sporadic":[100],"paralysis,":[102],"I":[104],"Gitelman":[106],"syndrome.":[107,135],"10":[116],"had":[117,133,144,176,199,219],"proximal":[118],"3":[120],"distal":[121],"acidosis.":[124],"Three":[125],"acidosis":[132,143,235],"Sjogren":[134],"diagnosed":[138],"have":[140,207],"significantly":[145],"lower":[146],"serum":[147],"bicarbonate":[148],"(18.7":[149],"[14.6]":[150],"v.":[151,165,187],"29.6":[152],"[5.0]":[153],"mEq/L;":[154,168,190],"p":[155,169,191],"<":[156,170],"0.05)":[157,171],"higher":[159],"levels":[160],"chloride":[162],"(107.5":[163],"[6.0]":[164],"99.5":[166],"[3.4]":[167],"compared":[172],"those":[174],"who":[175],"hyperaldosteronism,":[178],"although":[179],"potassium":[181],"values":[182],"similar":[184],"(2.4":[185],"[0.65]":[186],"2.26":[188],"[0.48]":[189],"=":[192],"0.43).":[193],"All":[194],"hypertension":[200],"at":[201],"presentation":[202],"proven":[205],"adrenal":[208],"adenomas.":[209],"CONCLUSION:":[210],"A":[211,239],"significant":[212],"number":[213],"study":[218],"potentially":[222],"reversible":[223],"hypokalaemic":[226,252],"paralysis.":[228,254],"hyperaldosteronism.":[238],"detailed":[240],"work-up":[241],"should":[245],"undertaken":[247]},"counts_by_year":[{"year":2023,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}