{"id":"https://openalex.org/W1495647486","doi":null,"title":"Dynamics of cortisol in depression and anxiety disorders","display_name":"Dynamics of cortisol in depression and anxiety disorders","publication_year":2010,"publication_date":"2010-04-29","ids":{"openalex":"https://openalex.org/W1495647486","mag":"1495647486"},"language":"en","primary_location":{"id":"pmh:oai:alma.31UKB_LEU:9940747223102711","doi":null,"is_oa":true,"landing_page_url":"https://scholarlypublications.universiteitleiden.nl/handle/1887/15340","pdf_url":"https://scholarlypublications.universiteitleiden.nl/download/1887/15340/1?col=81522199220002711","source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"http://purl.org/coar/resource_type/c_db06"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://scholarlypublications.universiteitleiden.nl/download/1887/15340/1?col=81522199220002711","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044784989","display_name":"Gerthe Veen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Gerthe Veen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5044784989"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10853","display_name":"Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cortisol","display_name":"cortisol","score":0.8209999799728394},{"id":"https://openalex.org/keywords/hypothalamic-pituitary-adrenal-axis","display_name":"hypothalamic-pituitary-adrenal axis","score":0.7279999852180481},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.9520000219345093},{"id":"https://openalex.org/keywords/anxiety-disorders","display_name":"anxiety disorders","score":0.9990000128746033},{"id":"https://openalex.org/keywords/endophenotypes","display_name":"endophenotypes","score":0.8650000095367432},{"id":"https://openalex.org/keywords/hypercortisolism","display_name":"hypercortisolism","score":0.9129999876022339},{"id":"https://openalex.org/keywords/adrenal-insufficiency","display_name":"adrenal insufficiency","score":0.9950000047683716},{"id":"https://openalex.org/keywords/stress-response","display_name":"stress response","score":0.5929999947547913},{"id":"https://openalex.org/keywords/metabolic-effects","display_name":"metabolic effects","score":0.7110000252723694},{"id":"https://openalex.org/keywords/immune-system","display_name":"immune system","score":0.7250000238418579}],"concepts":[{"id":"https://openalex.org/C27502469","wikidata":"https://www.wikidata.org/wiki/Q906343","display_name":"Dysfunctional family","level":2,"score":0.705070972442627},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.6826152801513672},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.5541476607322693},{"id":"https://openalex.org/C123273963","wikidata":"https://www.wikidata.org/wiki/Q624758","display_name":"Psychopathology","level":2,"score":0.5072466731071472},{"id":"https://openalex.org/C187869287","wikidata":"https://www.wikidata.org/wiki/Q2032061","display_name":"Endophenotype","level":3,"score":0.436867892742157},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.32468461990356445},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3206195831298828},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.2548282742500305},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.17573317885398865},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.13849160075187683}],"mesh":[],"locations_count":5,"locations":[{"id":"pmh:oai:alma.31UKB_LEU:9940747223102711","doi":null,"is_oa":true,"landing_page_url":"https://scholarlypublications.universiteitleiden.nl/handle/1887/15340","pdf_url":"https://scholarlypublications.universiteitleiden.nl/download/1887/15340/1?col=81522199220002711","source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"http://purl.org/coar/resource_type/c_db06"},{"id":"pmh:oai:scholarlypublications.universiteitleiden.nl:item_2873821","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1887/15340","pdf_url":"https://hdl.handle.net/1887/15340","source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:ul:oai:scholarlypublications.universiteitleiden.nl:item_2873821","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1887/15340","pdf_url":"http://hdl.handle.net/1887/15340","source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"TITLE=None","raw_type":"info:eu-repo/semantics/doctoralthesis"},{"id":"pmh:oai:openaccess.leidenuniv.nl:1887/15340","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1887/15340","pdf_url":null,"source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral Thesis"},{"id":"mag:1495647486","doi":null,"is_oa":false,"landing_page_url":"https://openaccess.leidenuniv.nl/bitstream/1887/15340/1/Stellingen.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:alma.31UKB_LEU:9940747223102711","doi":null,"is_oa":true,"landing_page_url":"https://scholarlypublications.universiteitleiden.nl/handle/1887/15340","pdf_url":"https://scholarlypublications.universiteitleiden.nl/download/1887/15340/1?col=81522199220002711","source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"http://purl.org/coar/resource_type/c_db06"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8999999761581421}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1495647486.pdf","grobid_xml":"https://content.openalex.org/works/W1495647486.grobid-xml"},"referenced_works_count":151,"referenced_works":["https://openalex.org/W144535883","https://openalex.org/W168975520","https://openalex.org/W1486381449","https://openalex.org/W1549685322","https://openalex.org/W1964509380","https://openalex.org/W1964560926","https://openalex.org/W1965036952","https://openalex.org/W1968787277","https://openalex.org/W1973501977","https://openalex.org/W1975330914","https://openalex.org/W1976905142","https://openalex.org/W1978944901","https://openalex.org/W1981824987","https://openalex.org/W1983099697","https://openalex.org/W1983739275","https://openalex.org/W1987330686","https://openalex.org/W1987343094","https://openalex.org/W1990652217","https://openalex.org/W1993516262","https://openalex.org/W1993943676","https://openalex.org/W1997103341","https://openalex.org/W1998128856","https://openalex.org/W2000150063","https://openalex.org/W2005258060","https://openalex.org/W2006523438","https://openalex.org/W2006724319","https://openalex.org/W2014205754","https://openalex.org/W2014228748","https://openalex.org/W2015219993","https://openalex.org/W2018195755","https://openalex.org/W2020121765","https://openalex.org/W2020295852","https://openalex.org/W2020513581","https://openalex.org/W2021536544","https://openalex.org/W2021634787","https://openalex.org/W2021746160","https://openalex.org/W2022029540","https://openalex.org/W2022404177","https://openalex.org/W2023514678","https://openalex.org/W2024831846","https://openalex.org/W2025190775","https://openalex.org/W2029454752","https://openalex.org/W2032136671","https://openalex.org/W2032634579","https://openalex.org/W2032994967","https://openalex.org/W2033154479","https://openalex.org/W2033724481","https://openalex.org/W2033763265","https://openalex.org/W2034860511","https://openalex.org/W2035966509","https://openalex.org/W2037401035","https://openalex.org/W2038555728","https://openalex.org/W2040362798","https://openalex.org/W2041767121","https://openalex.org/W2041989234","https://openalex.org/W2042443117","https://openalex.org/W2043480169","https://openalex.org/W2046792752","https://openalex.org/W2047217999","https://openalex.org/W2051065925","https://openalex.org/W2051598816","https://openalex.org/W2052787253","https://openalex.org/W2056402432","https://openalex.org/W2057119719","https://openalex.org/W2058324403","https://openalex.org/W2059600702","https://openalex.org/W2059995600","https://openalex.org/W2062371885","https://openalex.org/W2063423426","https://openalex.org/W2063572291","https://openalex.org/W2065827234","https://openalex.org/W2066330033","https://openalex.org/W2067648040","https://openalex.org/W2068075763","https://openalex.org/W2068527329","https://openalex.org/W2069375313","https://openalex.org/W2072203790","https://openalex.org/W2073227490","https://openalex.org/W2073546728","https://openalex.org/W2073779547","https://openalex.org/W2074706971","https://openalex.org/W2075797110","https://openalex.org/W2076507733","https://openalex.org/W2077742058","https://openalex.org/W2080182898","https://openalex.org/W2081615427","https://openalex.org/W2081948812","https://openalex.org/W2083907532","https://openalex.org/W2087310911","https://openalex.org/W2089587576","https://openalex.org/W2092224099","https://openalex.org/W2093162411","https://openalex.org/W2095218368","https://openalex.org/W2095812219","https://openalex.org/W2096852712","https://openalex.org/W2099145455","https://openalex.org/W2101232256","https://openalex.org/W2101712015","https://openalex.org/W2101857442","https://openalex.org/W2102011776","https://openalex.org/W2103355275","https://openalex.org/W2105099085","https://openalex.org/W2105194498","https://openalex.org/W2105957748","https://openalex.org/W2107759391","https://openalex.org/W2109539558","https://openalex.org/W2110133619","https://openalex.org/W2111747873","https://openalex.org/W2113929941","https://openalex.org/W2116404316","https://openalex.org/W2116629441","https://openalex.org/W2119008291","https://openalex.org/W2119573232","https://openalex.org/W2120279490","https://openalex.org/W2120300634","https://openalex.org/W2123309495","https://openalex.org/W2124216937","https://openalex.org/W2124489587","https://openalex.org/W2126795224","https://openalex.org/W2129579709","https://openalex.org/W2133256471","https://openalex.org/W2139186181","https://openalex.org/W2139189807","https://openalex.org/W2139205784","https://openalex.org/W2141456647","https://openalex.org/W2142426443","https://openalex.org/W2147732099","https://openalex.org/W2147773046","https://openalex.org/W2148222458","https://openalex.org/W2148916146","https://openalex.org/W2150868134","https://openalex.org/W2150961060","https://openalex.org/W2154278233","https://openalex.org/W2156579478","https://openalex.org/W2159487337","https://openalex.org/W2161393416","https://openalex.org/W2161729260","https://openalex.org/W2162783686","https://openalex.org/W2163092745","https://openalex.org/W2163857054","https://openalex.org/W2164141618","https://openalex.org/W2165340302","https://openalex.org/W2245231029","https://openalex.org/W2320349682","https://openalex.org/W2329267332","https://openalex.org/W2331972648","https://openalex.org/W2334787351","https://openalex.org/W2402182810","https://openalex.org/W2412620681","https://openalex.org/W2907844645","https://openalex.org/W4255304519"],"related_works":["https://openalex.org/W2401463498","https://openalex.org/W956351531","https://openalex.org/W2756603885","https://openalex.org/W142506613","https://openalex.org/W7135828864","https://openalex.org/W2895744448","https://openalex.org/W2001420067","https://openalex.org/W1919000277","https://openalex.org/W2131148130","https://openalex.org/W38289855"],"abstract_inverted_index":{"In":[0],"this":[1,119],"thesis,":[2,120],"we":[3,74,121,159],"provide":[4],"evidence":[5],"in":[6,35,48,81,118,174],"research":[7],"on":[8,107,114,177],"endophenotypes":[9],"of":[10,54,59,103,127,165],"psychopathology":[11],"that":[12,123,161],"it":[13],"is":[14],"fruitful":[15],"not":[16],"to":[17,83,99],"take":[18],"the":[19,24,41,60,68,78,94,101,108,115,124,136,145,166,178],"clinical":[20,79],"picture":[21],"central,":[22],"but":[23],"hypothalamus-pituitary-adrenal":[25],"(HPA)":[26],"axis":[27,70,105,129,143,153],"as":[28,71],"a":[29,140,150],"core":[30],"stress":[31,95,137,146,155],"system":[32,96],"underlying":[33],"psychopathophysiology":[34],"stress-related":[36],"disorders.":[37],"Homeostatic":[38],"systems,":[39],"including":[40],"HPA":[42,69,104,128,142,152,167],"axis,":[43,168],"are":[44],"by":[45],"nature":[46],"nonlinear":[47,125],"their":[49,175],"function,":[50],"with":[51,93],"suboptimal":[52],"states":[53,164],"function":[55,130],"at":[56],"both":[57,84,162],"sides":[58],"curve,":[61],"e.g.":[62],"hyper-":[63,88,170],"versus":[64],"hypofunction.":[65],"By":[66],"taken":[67],"starting":[72,92],"point,":[73],"were":[75],"able":[76],"redefine":[77],"phenotype":[80],"relation":[82],"dysfunctional":[85,163],"states,":[86],"i.e.,":[87,169],"and":[89,110,171,180],"hypocortisolism.":[90],"Furthermore,":[91],"enabled":[97],"us":[98],"investigate":[100],"effects":[102,176],"dysfunction":[106],"metabolic":[109,179],"immune":[111,181],"system.":[112,182],"Based":[113],"studies":[116],"presented":[117],"hypothesize":[122,160],"aspect":[126],"reflects":[131],"different":[132],"time":[133],"points":[134],"during":[135],"process,":[138],"from":[139],"hyperactive":[141],"when":[144,154],"begins":[147],"to,":[148],"eventually,":[149],"hypoactive":[151],"holds":[156],"on.":[157],"Secondly,":[158],"hypocortisolism,":[172],"differ":[173]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
