{"id":"https://openalex.org/W1495136254","doi":null,"title":"Calcium Kinetics During Space Flight","display_name":"Calcium Kinetics During Space Flight","publication_year":1999,"publication_date":"1999-01-01","ids":{"openalex":"https://openalex.org/W1495136254","mag":"1495136254"},"language":"en","primary_location":{"id":"mag:1495136254","doi":null,"is_oa":false,"landing_page_url":"https://ntrs.nasa.gov/search.jsp?R=20060010507","pdf_url":null,"source":{"id":"https://openalex.org/S4306402118","display_name":"NASA Technical Reports Server (NASA)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210124779","host_organization_name":"National Aeronautics and Space Administration","host_organization_lineage":["https://openalex.org/I4210124779"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075879804","display_name":"Scott M. Smith","orcid":"https://orcid.org/0000-0001-9313-7900","observed_orcids":["https://orcid.org/0000-0001-9313-7900"]},"institutions":[{"id":"https://openalex.org/I4210149382","display_name":"Johnson Space Center","ror":"https://ror.org/04xx4z452","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210124779","https://openalex.org/I4210149382"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott M. Smith","raw_affiliation_strings":["NASA Johnson Space Center Houston, TX, United States"],"raw_orcid":"https://orcid.org/0000-0001-9313-7900","affiliations":[{"raw_affiliation_string":"NASA Johnson Space Center Houston, TX, United States","institution_ids":["https://openalex.org/I4210149382"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091197879","display_name":"Kimberly O O'Brien","orcid":"https://orcid.org/0000-0002-0954-1706","observed_orcids":["https://orcid.org/0000-0002-0954-1706"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kimberly O\u2019Brien","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0954-1706","affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Steven A. Abrams","orcid":"https://orcid.org/0000-0003-4972-9233","observed_orcids":["https://orcid.org/0000-0003-4972-9233"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steven A. Abrams","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4972-9233","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5113773167","display_name":"Meryl E. Wastney","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Meryl E. Wastney","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.11273863,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/calcium-kinetics","display_name":"calcium kinetics","score":0.8600000143051147},{"id":"https://openalex.org/keywords/bone-resorption","display_name":"bone resorption","score":0.9800000190734863},{"id":"https://openalex.org/keywords/bone-formation","display_name":"bone formation","score":0.7879999876022339},{"id":"https://openalex.org/keywords/intestinal-calcium-absorption","display_name":"intestinal calcium absorption","score":0.9810000061988831},{"id":"https://openalex.org/keywords/calcium-balance","display_name":"calcium balance","score":0.9380000233650208},{"id":"https://openalex.org/keywords/microgravity","display_name":"microgravity","score":0.7940000295639038},{"id":"https://openalex.org/keywords/sts-107","display_name":"STS-107","score":0.8370000123977661},{"id":"https://openalex.org/keywords/collagen-cross-links","display_name":"collagen cross-links","score":0.6520000100135803}],"concepts":[{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.7377126812934875},{"id":"https://openalex.org/C673006","wikidata":"https://www.wikidata.org/wiki/Q4941581","display_name":"Bone resorption","level":2,"score":0.7137352824211121},{"id":"https://openalex.org/C146562846","wikidata":"https://www.wikidata.org/wiki/Q96649518","display_name":"Resorption","level":2,"score":0.6084961295127869},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5854507088661194},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.488104909658432},{"id":"https://openalex.org/C170033053","wikidata":"https://www.wikidata.org/wiki/Q952019","display_name":"Bone remodeling","level":2,"score":0.4743719696998596},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4689326584339142},{"id":"https://openalex.org/C37752432","wikidata":"https://www.wikidata.org/wiki/Q4299309","display_name":"Weightlessness","level":2,"score":0.4543927311897278},{"id":"https://openalex.org/C148898269","wikidata":"https://www.wikidata.org/wiki/Q1108792","display_name":"Kinetics","level":2,"score":0.41740065813064575},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1960262954235077},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.14847531914710999},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C1276947","wikidata":"https://www.wikidata.org/wiki/Q333","display_name":"Astronomy","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"mag:1495136254","doi":null,"is_oa":false,"landing_page_url":"https://ntrs.nasa.gov/search.jsp?R=20060010507","pdf_url":null,"source":{"id":"https://openalex.org/S4306402118","display_name":"NASA Technical Reports Server (NASA)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210124779","host_organization_name":"National Aeronautics and Space Administration","host_organization_lineage":["https://openalex.org/I4210124779"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"mag:3176019233","doi":null,"is_oa":false,"landing_page_url":"https://ntrs.nasa.gov/search.jsp?R=20000020628","pdf_url":null,"source":{"id":"https://openalex.org/S4306402118","display_name":"NASA Technical Reports Server (NASA)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210124779","host_organization_name":"National Aeronautics and Space Administration","host_organization_lineage":["https://openalex.org/I4210124779"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7246000170707703}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W996961784","https://openalex.org/W1936547246","https://openalex.org/W2026178464","https://openalex.org/W1506287604","https://openalex.org/W1994206981","https://openalex.org/W824742354","https://openalex.org/W7030263603","https://openalex.org/W829980392","https://openalex.org/W1939967883","https://openalex.org/W163988318"],"abstract_inverted_index":{"Bone":[0,52],"loss":[1,36,228,370],"during":[2,37,127,158,196,231,317],"space":[3,16,38,67,102,232,261,297],"flight":[4,103,128,131,159,162,197,208,233,298],"is":[5,54,234,275,371],"one":[6,372],"of":[7,25,57,74,86,101,237,260,281,289,313,323,335,373],"the":[8,20,58,77,87,91,99,185,190,226,247,255,279,300,308,320,332,355,374],"most":[9],"critical":[10,276],"challenges":[11],"to":[12,33,277,284,296,349,354,360,365],"astronaut":[13],"health":[14,53],"on":[15,106,184,269,299,319,340],"exploration":[17],"missions.":[18],"Defining":[19],"time":[21],"course":[22],"and":[23,40,63,148,204,241,251,258,310,357,388],"mechanism":[24],"these":[26,75,290],"changes":[27,248],"will":[28,41],"aid":[29],"in":[30,81,90,187,249,254,327],"developing":[31],"means":[32],"counteract":[34],"bone":[35,61,64,82,107,110,123,188,227,239,250,282,294,369],"flight,":[39,262],"have":[42],"relevance":[43],"for":[44,351,384],"other":[45],"clinical":[46],"situations":[47],"that":[48,98,122,151,225,229],"impair":[49],"weight-bearing":[50],"activity.":[51],"a":[55,95,181,235,328,381],"product":[56],"balance":[59,186,195,206],"between":[60,192],"formation":[62,111],"resorption.":[65],"Early":[66],"research":[68],"could":[69],"not":[70],"clearly":[71,149],"identify":[72],"which":[73],"was":[76,104,125,156],"main":[78],"process":[79],"altered":[80],"loss,":[83,387],"but":[84],"identification":[85],"collagen":[88],"crosslinks":[89],"1990s":[92],"made":[93],"possible":[94],"clear":[96],"understanding":[97,278],"impact":[100],"greater":[105,126],"resorption,":[108],"with":[109],"being":[112],"unchanged":[113],"or":[114,134,140,165,171,200,211],"only":[115],"slightly":[116],"decreased.":[117],"Calcium":[118,377],"kinetics":[119,378],"data":[120,223],"showed":[121],"resorption":[124,240],"than":[129,146,160,177,220,272],"before":[130,161,207],"(668":[132],"plus":[133,139,164,170,199,210],"minus":[135,141,166,172,201,212],"130":[136],"vs.":[137,168],"427":[138],"153":[142],"mg/d,":[143,174],"p":[144,175],"less":[145,176,219],"0.001),":[147],"documented":[150],"true":[152],"intestinal":[153,243],"calcium":[154,194,205,244,252],"absorption":[155],"lower":[157],"(233":[163],"87":[167],"460":[169],"47":[173],"0.01).":[178,221],"Weightlessness":[179],"had":[180],"detrimental":[182],"effect":[183],"turnover:":[189],"difference":[191],"daily":[193],"(-234":[198],"102":[202],"mg/d)":[203,214],"(63":[209],"75":[213],"approached":[215],"300":[216],"mg/d":[217],"(p":[218],"These":[222],"demonstrate":[224],"occurs":[230],"consequence":[236],"increased":[238],"decreased":[242],"absorption.":[245],"Examining":[246],"homeostasis":[253],"initial":[256],"days":[257],"weeks":[259],"as":[263,265,344],"well":[264],"at":[266],"later":[267],"times":[268],"missions":[270,352],"longer":[271],"6":[273],"months,":[274],"nature":[280],"adaptation":[283,295],"weightlessness.":[285],"To":[286],"increase":[287],"knowledge":[288],"changes,":[291],"we":[292,347],"studied":[293],"16-day":[301],"Space":[302],"Shuttle":[303],"Columbia":[304,314],"(STS-107)":[305],"mission.":[306],"When":[307],"brave":[309],"talented":[311],"crew":[312],"were":[315,342],"lost":[316,343],"reentry":[318],"tragic":[321],"morning":[322],"February":[324],"1,":[325],"2003,":[326],"much":[329],"smaller":[330],"matter,":[331],"scientific":[333],"products":[334],"this":[336,386],"experiment,":[337],"successfully":[338],"obtained":[339],"orbit,":[341],"well.":[345],"As":[346],"begin":[348],"plan":[350],"back":[353],"Moon,":[356],"even":[358],"off":[359],"Mars,":[361],"many":[362],"questions":[363],"remain":[364],"be":[366],"answered.":[367],"Counteracting":[368],"greatest":[375],"challenges.":[376],"studies":[379],"provide":[380],"valuable":[382],"tool":[383],"assessing":[385],"evaluating":[389],"countermeasures.":[390]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}