{"id":"https://openalex.org/W1494909324","doi":null,"title":"Development and Validation of Stability-indicating HPLC Method for Simultaneous Estimation of Cefixime and Linezolid.","display_name":"Development and Validation of Stability-indicating HPLC Method for Simultaneous Estimation of Cefixime and Linezolid.","publication_year":2014,"publication_date":"2014-11-01","ids":{"openalex":"https://openalex.org/W1494909324","mag":"1494909324","pmid":"https://pubmed.ncbi.nlm.nih.gov/25593387","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4293685"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4293685","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4293685/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4293685/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian J Pharm Sci","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4293685/pdf/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058089072","display_name":"Nidhi S Patel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I9694494","display_name":"Parul University","ror":"https://ror.org/024v3fg07","country_code":"IN","type":"education","lineage":["https://openalex.org/I9694494"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Nidhi S Patel","raw_affiliation_strings":["Department of Quality Assurance Techniques, Parul Institute of Pharmacy, Limda Ta, Waghodiya, Dist., Vadodara-391 760, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Quality Assurance Techniques, Parul Institute of Pharmacy, Limda Ta, Waghodiya, Dist., Vadodara-391 760, India","institution_ids":["https://openalex.org/I9694494"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024805207","display_name":"Falguni B. Tandel","orcid":"https://orcid.org/0000-0002-6780-2134","observed_orcids":["https://orcid.org/0000-0002-6780-2134"]},"institutions":[{"id":"https://openalex.org/I9694494","display_name":"Parul University","ror":"https://ror.org/024v3fg07","country_code":"IN","type":"education","lineage":["https://openalex.org/I9694494"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Falguni B Tandel","raw_affiliation_strings":["Department of Quality Assurance Techniques, Parul Institute of Pharmacy, Limda Ta, Waghodiya, Dist., Vadodara-391 760, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Quality Assurance Techniques, Parul Institute of Pharmacy, Limda Ta, Waghodiya, Dist., Vadodara-391 760, India","institution_ids":["https://openalex.org/I9694494"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062568439","display_name":"Yogita D Patel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I9694494","display_name":"Parul University","ror":"https://ror.org/024v3fg07","country_code":"IN","type":"education","lineage":["https://openalex.org/I9694494"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Yogita D Patel","raw_affiliation_strings":["Department of Quality Assurance Techniques, Parul Institute of Pharmacy, Limda Ta, Waghodiya, Dist., Vadodara-391 760, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Quality Assurance Techniques, Parul Institute of Pharmacy, Limda Ta, Waghodiya, Dist., Vadodara-391 760, India","institution_ids":["https://openalex.org/I9694494"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010133879","display_name":"Kartavya B Thakkar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I9694494","display_name":"Parul University","ror":"https://ror.org/024v3fg07","country_code":"IN","type":"education","lineage":["https://openalex.org/I9694494"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Kartavya B Thakkar","raw_affiliation_strings":["Department of Quality Assurance Techniques, Parul Institute of Pharmacy, Limda Ta, Waghodiya, Dist., Vadodara-391 760, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Quality Assurance Techniques, Parul Institute of Pharmacy, Limda Ta, Waghodiya, Dist., Vadodara-391 760, India","institution_ids":["https://openalex.org/I9694494"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I9694494"],"apc_list":null,"apc_paid":null,"fwci":0.3958,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.55734906,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"76","issue":"6","first_page":"535","last_page":"40"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12878","display_name":"Pharmaceutical Quality and Counterfeiting","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11423","display_name":"Pesticide Residue Analysis and Safety","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cefixime","display_name":"cefixime","score":1.0},{"id":"https://openalex.org/keywords/linezolid","display_name":"linezolid","score":1.0},{"id":"https://openalex.org/keywords/stability-indicating-method","display_name":"stability-indicating assay","score":0.8330000042915344},{"id":"https://openalex.org/keywords/joint-estimation","display_name":"simultaneous estimation","score":0.8510000109672546},{"id":"https://openalex.org/keywords/forced-degradation","display_name":"forced degradation","score":0.9509999752044678},{"id":"https://openalex.org/keywords/degradation-products","display_name":"degradation products","score":0.6549999713897705},{"id":"https://openalex.org/keywords/tablets","display_name":"tablets","score":0.46700000762939453},{"id":"https://openalex.org/keywords/method-validation","display_name":"method validation","score":0.5619999766349792}],"concepts":[{"id":"https://openalex.org/C2778243283","wikidata":"https://www.wikidata.org/wiki/Q163901","display_name":"Cefixime","level":4,"score":0.8175587058067322},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.7581393718719482},{"id":"https://openalex.org/C2781414143","wikidata":"https://www.wikidata.org/wiki/Q411377","display_name":"Linezolid","level":5,"score":0.6516839861869812},{"id":"https://openalex.org/C2777682752","wikidata":"https://www.wikidata.org/wiki/Q8564473","display_name":"Forced degradation","level":4,"score":0.6138916015625},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5587119460105896},{"id":"https://openalex.org/C77281830","wikidata":"https://www.wikidata.org/wiki/Q718608","display_name":"Dosage form","level":2,"score":0.5456616878509521},{"id":"https://openalex.org/C2779679103","wikidata":"https://www.wikidata.org/wiki/Q5251805","display_name":"Degradation (telecommunications)","level":2,"score":0.5377642512321472},{"id":"https://openalex.org/C119128265","wikidata":"https://www.wikidata.org/wiki/Q900165","display_name":"Detection limit","level":2,"score":0.5349686741828918},{"id":"https://openalex.org/C2779607525","wikidata":"https://www.wikidata.org/wiki/Q14982","display_name":"Methanol","level":2,"score":0.5245799422264099},{"id":"https://openalex.org/C179998833","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"High-performance liquid chromatography","level":2,"score":0.47541266679763794},{"id":"https://openalex.org/C23531484","wikidata":"https://www.wikidata.org/wiki/Q3196863","display_name":"Calibration curve","level":3,"score":0.19641736149787903},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.07088619470596313},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06563189625740051},{"id":"https://openalex.org/C2778980435","wikidata":"https://www.wikidata.org/wiki/Q424027","display_name":"Vancomycin","level":4,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.0},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.0},{"id":"https://openalex.org/C64778159","wikidata":"https://www.wikidata.org/wiki/Q271021","display_name":"Cephalosporin","level":3,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:4293685","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4293685/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4293685/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian J Pharm Sci","raw_type":"Text"},{"id":"pmid:25593387","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25593387","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian journal of pharmaceutical sciences","raw_type":"Journal Article"},{"id":"mag:1494909324","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25593387","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4293685","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4293685/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4293685/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian J Pharm Sci","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4000000059604645,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1494909324.pdf","grobid_xml":"https://content.openalex.org/works/W1494909324.grobid-xml"},"referenced_works_count":3,"referenced_works":["https://openalex.org/W1990869876","https://openalex.org/W1993970416","https://openalex.org/W2411573427"],"related_works":["https://openalex.org/W2188979304","https://openalex.org/W7099733360","https://openalex.org/W2090724102","https://openalex.org/W2797201943","https://openalex.org/W2316120342","https://openalex.org/W7221297852","https://openalex.org/W7218010446","https://openalex.org/W7223011922","https://openalex.org/W2767687407","https://openalex.org/W7217512933"],"abstract_inverted_index":{"A":[0],"stability-indicating":[1],"reverse":[2],"phase":[3,83],"high":[4],"performance":[5],"liquid":[6],"chromatography":[7],"method":[8,26,145],"was":[9,22,43,63,111,128],"developed":[10,163],"and":[11,15,38,54,94,102,116,122,138,168,179],"validated":[12,29],"for":[13,20,30,52,57,135,174],"cefixime":[14,53,93,137,178],"linezolid.":[16,58],"The":[17,25,89,125,144,162],"wavelength":[18],"selected":[19],"quantitation":[21],"276":[23],"nm.":[24],"has":[27],"been":[28],"linearity,":[31],"accuracy,":[32],"precision,":[33],"robustness,":[34],"limit":[35,39],"of":[36,40,49,92,153,177],"detection":[37],"quantitation.":[41],"Linearity":[42],"observed":[44],"in":[45,140,151,181],"the":[46,61,141,149,155],"concentration":[47],"range":[48],"2-12":[50],"\u03bcg/ml":[51,56],"6-36":[55],"For":[59],"RP-HPLC,":[60],"separation":[62],"achieved":[64],"by":[65],"Phenomenex":[66],"Luna":[67],"C18":[68],"(250\u00d74.6":[69],"mm)":[70],"5":[71],"\u03bcm":[72],"column":[73],"using":[74],"phosphate":[75],"buffer":[76],"(pH":[77],"7):methanol":[78],"(60:40":[79],"v/v)":[80],"as":[81],"mobile":[82],"with":[84],"flow":[85],"rate":[86],"1":[87],"ml/min.":[88],"retention":[90],"time":[91],"linezolid":[95,139,180],"were":[96,165],"found":[97,129],"to":[98,113,130,133],"be":[99,131,172],"3.127":[100],"min":[101],"11.986":[103],"min,":[104],"respectively.":[105],"During":[106],"force":[107],"degradation,":[108],"drug":[109],"product":[110],"exposed":[112],"hydrolysis":[114],"(acid":[115],"base":[117],"hydrolysis),":[118],"H2O2,":[119],"thermal":[120],"degradation":[121,127,160],"photo":[123],"degradation.":[124],"%":[126],"10":[132],"20%":[134],"both":[136,148],"given":[142],"condition.":[143],"specifically":[146],"estimates":[147],"drugs":[150],"presence":[152],"all":[154],"degradants":[156],"generated":[157],"during":[158],"forced":[159],"study.":[161],"methods":[164],"simple,":[166],"specific":[167],"economic,":[169],"which":[170],"can":[171],"used":[173],"simultaneous":[175],"estimation":[176],"tablet":[182],"dosage":[183],"form.":[184]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}