{"id":"https://openalex.org/W1494893641","doi":null,"title":"Untersuchungen zur Funktion des PI3K/Akt-Signalweges f\u00fcr das Wachstum von disseminierten Tumorzelllinien von Patienten mit Malignomen","display_name":"Untersuchungen zur Funktion des PI3K/Akt-Signalweges f\u00fcr das Wachstum von disseminierten Tumorzelllinien von Patienten mit Malignomen","publication_year":2013,"publication_date":"2013-09-16","ids":{"openalex":"https://openalex.org/W1494893641","mag":"1494893641"},"language":"de","primary_location":{"id":"mag:1494893641","doi":null,"is_oa":false,"landing_page_url":"https://ediss.sub.uni-hamburg.de/volltexte/2013/6379/pdf/Dissertation.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056027854","display_name":"Katharina Grupp","orcid":"https://orcid.org/0000-0003-2849-3743","observed_orcids":["https://orcid.org/0000-0003-2849-3743"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Katharina Grupp","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2849-3743","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5056027854"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.9580000042915344},{"id":"https://openalex.org/keywords/disseminated-tumor-cells","display_name":"disseminated tumor cells","score":0.9639999866485596},{"id":"https://openalex.org/keywords/bone-marrow","display_name":"bone marrow","score":0.5839999914169312},{"id":"https://openalex.org/keywords/tumor-cell-proliferation","display_name":"tumor cell proliferation","score":0.7540000081062317},{"id":"https://openalex.org/keywords/ly294002","display_name":"LY294002","score":0.9539999961853027},{"id":"https://openalex.org/keywords/pi3k-inhibitors","display_name":"PI3K inhibitors","score":0.8389999866485596},{"id":"https://openalex.org/keywords/ship1","display_name":"SHIP1","score":0.9919999837875366},{"id":"https://openalex.org/keywords/inositol-polyphosphate-5-phosphatase","display_name":"inositol polyphosphate 5-phosphatase","score":0.8880000114440918},{"id":"https://openalex.org/keywords/phosphatidylinositol-3-4-5-trisphosphate","display_name":"phosphatidylinositol 3,4,5-trisphosphate","score":0.9300000071525574},{"id":"https://openalex.org/keywords/akt-phosphorylation","display_name":"Akt phosphorylation","score":0.7590000033378601},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.40799999237060547},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.3319999873638153},{"id":"https://openalex.org/keywords/cell-lines","display_name":"cell lines","score":0.30300000309944153},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.3100000023841858}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6425963044166565},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.6095770597457886},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5074643492698669},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.4918675422668457},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.22394955158233643},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.1252714991569519},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08552193641662598},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.040326446294784546}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:1494893641","doi":null,"is_oa":false,"landing_page_url":"https://ediss.sub.uni-hamburg.de/volltexte/2013/6379/pdf/Dissertation.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":155,"referenced_works":["https://openalex.org/W179316992","https://openalex.org/W1488039334","https://openalex.org/W1500729563","https://openalex.org/W1527076593","https://openalex.org/W1595612667","https://openalex.org/W1601571585","https://openalex.org/W1617532721","https://openalex.org/W1668086213","https://openalex.org/W1672882868","https://openalex.org/W1726025741","https://openalex.org/W1753436511","https://openalex.org/W1791888878","https://openalex.org/W1894641937","https://openalex.org/W1908445283","https://openalex.org/W1931438814","https://openalex.org/W1956061739","https://openalex.org/W1966133006","https://openalex.org/W1966823692","https://openalex.org/W1967330952","https://openalex.org/W1970174108","https://openalex.org/W1970476748","https://openalex.org/W1972239225","https://openalex.org/W1973188134","https://openalex.org/W1973890143","https://openalex.org/W1979147887","https://openalex.org/W1979563875","https://openalex.org/W1980791428","https://openalex.org/W1980830316","https://openalex.org/W1986018710","https://openalex.org/W1986137370","https://openalex.org/W1988442083","https://openalex.org/W1988557714","https://openalex.org/W1988901915","https://openalex.org/W1990841830","https://openalex.org/W1995574514","https://openalex.org/W1999447199","https://openalex.org/W1999609185","https://openalex.org/W2002273560","https://openalex.org/W2003832896","https://openalex.org/W2007030561","https://openalex.org/W2008227339","https://openalex.org/W2008940139","https://openalex.org/W2010178768","https://openalex.org/W2011963129","https://openalex.org/W2014169920","https://openalex.org/W2015314629","https://openalex.org/W2020549515","https://openalex.org/W2021012077","https://openalex.org/W2023543654","https://openalex.org/W2024306318","https://openalex.org/W2026989222","https://openalex.org/W2027280636","https://openalex.org/W2028496807","https://openalex.org/W2029849554","https://openalex.org/W2040142253","https://openalex.org/W2043548519","https://openalex.org/W2043732412","https://openalex.org/W2043911313","https://openalex.org/W2044924820","https://openalex.org/W2046933787","https://openalex.org/W2047587366","https://openalex.org/W2051982497","https://openalex.org/W2053143993","https://openalex.org/W2057377598","https://openalex.org/W2057547625","https://openalex.org/W2058138221","https://openalex.org/W2058586542","https://openalex.org/W2058924545","https://openalex.org/W2061385217","https://openalex.org/W2061701210","https://openalex.org/W2062390485","https://openalex.org/W2064047613","https://openalex.org/W2065887259","https://openalex.org/W2066457776","https://openalex.org/W2066655424","https://openalex.org/W2067374132","https://openalex.org/W2068427129","https://openalex.org/W2068912983","https://openalex.org/W2070291618","https://openalex.org/W2070732456","https://openalex.org/W2071531606","https://openalex.org/W2075104267","https://openalex.org/W2077374035","https://openalex.org/W2082431893","https://openalex.org/W2084312697","https://openalex.org/W2086641174","https://openalex.org/W2092229345","https://openalex.org/W2092429540","https://openalex.org/W2092452653","https://openalex.org/W2097767970","https://openalex.org/W2101849511","https://openalex.org/W2104609206","https://openalex.org/W2107304950","https://openalex.org/W2108246579","https://openalex.org/W2108947370","https://openalex.org/W2110835998","https://openalex.org/W2111941775","https://openalex.org/W2115207474","https://openalex.org/W2118135682","https://openalex.org/W2120718661","https://openalex.org/W2121627701","https://openalex.org/W2122572948","https://openalex.org/W2122788299","https://openalex.org/W2123619341","https://openalex.org/W2126314379","https://openalex.org/W2126735047","https://openalex.org/W2126783165","https://openalex.org/W2127101185","https://openalex.org/W2129172946","https://openalex.org/W2129936304","https://openalex.org/W2130049720","https://openalex.org/W2131361386","https://openalex.org/W2134602357","https://openalex.org/W2135098319","https://openalex.org/W2135913015","https://openalex.org/W2137035181","https://openalex.org/W2137622686","https://openalex.org/W2138297714","https://openalex.org/W2139937771","https://openalex.org/W2140375000","https://openalex.org/W2140775102","https://openalex.org/W2141393790","https://openalex.org/W2141905508","https://openalex.org/W2143171062","https://openalex.org/W2143651667","https://openalex.org/W2143877481","https://openalex.org/W2144039299","https://openalex.org/W2145477245","https://openalex.org/W2146404049","https://openalex.org/W2147114673","https://openalex.org/W2149703329","https://openalex.org/W2151313755","https://openalex.org/W2153477391","https://openalex.org/W2155977433","https://openalex.org/W2160703426","https://openalex.org/W2160866033","https://openalex.org/W2160922815","https://openalex.org/W2161810908","https://openalex.org/W2162332365","https://openalex.org/W2162638402","https://openalex.org/W2162724777","https://openalex.org/W2164136158","https://openalex.org/W2164139183","https://openalex.org/W2164682544","https://openalex.org/W2165023381","https://openalex.org/W2166591651","https://openalex.org/W2166649051","https://openalex.org/W2167368130","https://openalex.org/W2171581152","https://openalex.org/W2172225180","https://openalex.org/W2184278156","https://openalex.org/W2321753125","https://openalex.org/W2388163742","https://openalex.org/W2415032506","https://openalex.org/W2530014580"],"related_works":["https://openalex.org/W2747655373","https://openalex.org/W6992864511","https://openalex.org/W6887965573","https://openalex.org/W251725754","https://openalex.org/W2045039913","https://openalex.org/W3031965724","https://openalex.org/W2523948665","https://openalex.org/W2605661706","https://openalex.org/W831228193","https://openalex.org/W3197344018"],"abstract_inverted_index":{"Die":[0,423],"Dissemination":[1],"von":[2,26,65,109,164,178,189,268,354,594,608,627,646,650,686,696,706],"einzelnen":[3],"Tumorzellen":[4,21],"hat":[5],"eine":[6,82,174,206,228,390,419,445,634,678,693],"entscheidende":[7],"Bedeutung":[8,334,483],"im":[9,67],"Prozess":[10],"der":[11,14,41,70,80,88,107,116,139,158,179,231,266,273,289,311,318,320,324,330,364,448,460,484,486,498,522,539,549,564,576,582,599,611,621,630,640,651,663,672],"Tumorgenese.":[12],"In":[13,303],"Tumorbiologie":[15],"des":[16,51,95,98,160,335,342,348,357,366,371,393,413,432,455,491,529,572,592,681,704],"UKE":[17],"wurden":[18,39],"vereinzelte":[19],"dissemi-nierte":[20],"(DTC)":[22],"aus":[23],"dem":[24,214,506,511],"Knochenmark":[25],"Tumorpatienten":[27],"gewonnen":[28],"und":[29,34,46,119,201,241,381,415,501,510,514,567,637,688,690,708],"die":[30,49,54,59,86,93,131,143,156,176,197,253,333,340,369,378,386,396,405,482,489,496,527,545,570,590,606,625,655],"DTC-Zelllinien":[31,89,103,117,316],"PC-E1,":[32],"BC-M1":[33,141],"LC-M1":[35,56,120,204],"etabliert.\r\nDiese":[36],"drei":[37,312],"Zelllinien":[38,437,499],"in":[40,101,225,275,294,298,314,344,351,424,434,462,475,521,532,538,548,575,581,610,629,661,671],"vorliegenden":[42,75,673],"Arbeit":[43,331,426,674],"naher":[44],"untersucht":[45,308],"es":[47],"konnte":[48,224,283,306,459,520,563],"Aktivierung":[50,341,370,431,454,490,528,571],"PI3K/Akt-Signalweges":[52,372,456,492,530,573,682],"fur":[53,85,339,488,683,698],"DTC-Zelllinie":[55,140,203],"nachgewiesen":[57,359],"werden,":[58,309],"ein":[60],"ca.":[61],"23-fach":[62],"hoheres":[63],"Phosphorylierungsniveau":[64],"Akt(Ser473)":[66],"Ver-gleich":[68],"zu":[69,104,373,493,614,666],"Kontrollzelllinie":[71,132],"aufwies.":[72],"\r\nDie":[74,670],"Daten":[76],"zeigen":[77,677],"weiter,":[78],"dass":[79,196,251,286,443],"PI3K/Akt-Signalweg":[81,461],"bedeutende":[83],"Rolle":[84],"Proliferation":[87,622,641],"spielt.":[90],"So":[91],"fuhrte":[92],"Hemmung":[94,159,703],"PI3K/Akt-Signalwegs":[96,161,343,433],"mittels":[97],"PI3K-Inhibitor":[99],"LY294002":[100,124,474],"den":[102,226,315,362,471,557],"deutlichen":[105],"Verringerungen":[106],"Phosphorylierung":[108],"Akt":[110,190],"am":[111],"Serinrest":[112],"473.":[113],"Das":[114],"Wachstum":[115,138,272,288,598,685],"PC-E1":[118],"lies":[121],"sich":[122,136],"durch":[123,142,162,470,556],"mit":[125,198,237,398,438,451,468,505,602],"einer":[126,258,352,399,452,615,657,667],"ahnlichen":[127],"Kinetik":[128],"hemmen":[129,147,536],"wie":[130,296],"MTSV":[133],"1.7,":[134],"wahrend":[135,211],"das":[137,177,183,212,271,287,597,684],"LY294002-Behandlung":[144],"deutlich":[145,533,635],"starker":[146],"lies.":[148],"\r\nNeben":[150],"diesem":[151],"pharmokologischen":[152],"Ansatz":[153,701],"wurde":[154,264,332,375],"auch":[155,297,588],"Asuwirkung":[157],"Expression":[163,230,607,656],"SHIP1,":[165],"einem":[166],"negativen":[167,259],"Regulator":[168],"dieses":[169],"Signalwegs,":[170],"untersucht.":[171,346],"SHIP1":[172,199,256,269,595,609,628,647,697],"ist":[173],"Inositol-5-Phosphatase,":[175],"PI3K":[180,472],"gebildete":[181],"PtdIns(3,4,5)P3,":[182],"als":[184,376,537,580],"second":[185],"messenger":[186],"zur":[187,429,642,702],"Rekrutierung":[188],"fuhrt,":[191],"abbaut.":[192],"Hierbei":[193,282],"zeigte":[194],"sich,":[195],"transduzierte":[200],"selektionierte":[202],"nur":[205,409,417],"sehr":[207,420],"geringe":[208,421],"SHIP1-Expression":[209],"aufwies,":[210],"auf":[213,270,368,596,692],"Co-Expressionsvektor":[215],"gelegene":[216],"EGFP":[217,238],"stark":[218,439],"exprimiert":[219],"wurde.":[220,302],"Im":[221,262],"Gegensatz":[222],"dazu":[223],"LC-M1-Zellen":[227,274,290],"starke":[229,391],"enzymatisch":[232,254,658],"inaktiven":[233,659],"SHIP1-Mutante":[234],"(D672A)":[235],"zusammen":[236],"nach":[239,279],"Transduktion":[240,280],"Selektion":[242,260],"erzielt":[243],"werden.":[244,480],"Diese":[246],"Ergebnisse":[247,676],"deuteten":[248],"darauf":[249],"hin,":[250],"LC-M1-Zellen,":[252],"aktives":[255],"exprimieren,":[257],"unterliegen.":[261],"Weiteren":[263],"daher":[265],"Einfluss":[267,363],"nicht-selektionierten":[276],"Zellen":[277],"direkt":[278],"analysiert.":[281],"gezeigt":[284],"wer-den,":[285],"sowohl":[291],"bei":[292],"Kultivierung":[293],"serumhaltigem":[295],"serumfreien":[299],"Medium":[300],"gehemmt":[301,479,560],"weiterfuhrenden":[304],"Experimenten":[305],"nun":[307],"welche":[310],"Akt-Isoformen":[313],"an":[317],"Weiterleitung":[319],"wachstumsvermittelnden":[321],"Signale":[322],"downstream":[323],"PI3-Kinase":[325],"beteiligt":[326],"ist.\r\nIm":[327],"zweiten":[328],"Teil":[329],"epidermalen":[336],"Wachstumsfaktor-Rezeptors":[337],"(EGFR)":[338],"Mammakarzinom-Zelllinien":[345],"Amplifikationen":[347],"EGFR":[349,367,394,414,503,525,552,585],"sind":[350],"Reihe":[353],"Malignomen":[355],"inklusive":[356],"Mammakarzinoms":[358],"worden.":[360],"Um":[361,481],"Kopien-zahl":[365],"untersuchen,":[374],"Modellsystem":[377],"Mammakarzinomlinie":[379],"MDA-MB-468":[380,382,389,407,500,502,524,551,578,584,613,632],"EGFR-supprimiert":[383,408,633],"verwendet.":[384],"Wahrend":[385,605],"parentale":[387],"Zelllinie":[388,406,523,540,550,577,583,612,631],"Amplifikation":[392],"aufweist,":[395],"starken":[400,453],"EGFR-Uberexpression":[401],"ver-bunden":[402],"ist,":[403],"besitzt":[404],"noch":[410,418],"2":[411],"Kopien":[412],"zeigt":[416],"EGFR-Expression.":[422],"dieser":[425],"durchgefuhrte":[427],"Untersuchung":[428,591],"EGFR-abhangigen":[430],"diesen":[435],"beiden":[436,463,600,664],"unterschiedlicher":[440,603],"EGFR-Kopienzahl":[441],"zeigte,":[442],"uberraschenderweise":[444],"hohe":[446],"Anzahl":[447],"EGFR-Kopien":[449],"nicht":[450,618],"korrelierte.":[457],"Auch":[458],"Mammakarzionom-Linien":[465],"ohne":[466],"bzw.":[467],"EGFR-Amplifikation":[469],"Inhibitor":[473],"gleicher":[476],"Weise":[477],"signifikant":[478],"Rezeptoren":[485],"EGFR-Familie":[487],"analysieren,":[494],"erfolgte":[495,587],"Inkubation":[497],"supprimiert":[504,526],"EGFR-Tyrosinkinase":[507,517,558],"Hemmstoff":[508,518,559],"Gefitinib":[509,519],"dualen":[512],"EGFR-":[513,566],"Her2-Tyrosinkinase-Hemmstoff":[515,568],"Lapatinib.\r\nDer":[516],"schon":[531],"gerin-geren":[534],"Konzentrationen":[535],"MDA-MB-468.":[541],"Unter":[542],"Umstanden":[543],"konnten":[544],"wenigen":[546],"EGFR-Rezeptoren":[547],"suppri-miert":[553],"wesentlich":[554],"effektiver":[555,574],"wer-den.":[561],"Erstaunlicherweise":[562],"duale":[565],"Lapatinib":[569],"hemmen,":[579],"supprimiert.\r\nAbschliessend":[586],"hier":[589],"Einflusses":[593],"Mammakarzinom-Linien":[601,689],"EGFR-Kopienzahl.":[604],"geringen":[616],"aber":[617],"signifikanten":[619],"Abnahme":[620,639],"fuhrte,":[623],"hatte":[624],"expression":[626],"starkere":[636],"signifikante":[638],"Folge.":[643],"Dieser":[644],"Effekt":[645],"war":[648],"abhangig":[649],"enzymatischen":[652],"Aktivitat,":[653],"da":[654],"SHIP-1-Mutante":[660],"keiner":[662],"Linien":[665],"Wachstumshemmung":[668],"fuhrte.":[669],"erworbenen":[675],"funktionelle":[679],"Bedeu-tung":[680],"DTC-":[687],"weisen":[691],"mogliche":[694],"Verwendung":[695],"einen":[699],"gentherapeuti-schen":[700],"Wachstums":[705],"DTCs":[707],"Mammakarzinomen":[709],"hin.":[710]},"counts_by_year":[],"updated_date":"2025-11-06T04:12:42.849631","created_date":"2016-06-24T00:00:00"}
