{"id":"https://openalex.org/W149477204","doi":null,"title":"[Proteomics analysis of bone marrow cells of acute myeloid leukemia M2a and prognostic significance thereof].","display_name":"[Proteomics analysis of bone marrow cells of acute myeloid leukemia M2a and prognostic significance thereof].","publication_year":2007,"publication_date":"2007-02-27","ids":{"openalex":"https://openalex.org/W149477204","mag":"149477204","pmid":"https://pubmed.ncbi.nlm.nih.gov/17459203"},"language":"zh","primary_location":{"id":"pmid:17459203","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17459203","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhonghua yi xue za zhi","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108901611","display_name":"Shuai Tian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuai Tian","raw_affiliation_strings":["Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100400501","display_name":"Fanyi Meng","orcid":"https://orcid.org/0009-0009-5792-4531","observed_orcids":["https://orcid.org/0009-0009-5792-4531"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fan-yi Meng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5085463953","display_name":"Jiaming Tang","orcid":"https://orcid.org/0009-0000-3930-654X","observed_orcids":["https://orcid.org/0009-0000-3930-654X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jia-ming Tang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"87","issue":"8","first_page":"538","last_page":"41"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.8849999904632568},{"id":"https://openalex.org/keywords/bone-marrow-mononuclear-cells","display_name":"bone marrow mononuclear cells","score":0.878000020980835},{"id":"https://openalex.org/keywords/proteomics","display_name":"proteomics","score":0.640999972820282},{"id":"https://openalex.org/keywords/differentially-expressed-proteins","display_name":"differentially expressed proteins","score":0.8859999775886536},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.5149999856948853},{"id":"https://openalex.org/keywords/relapse","display_name":"relapse","score":0.8420000076293945},{"id":"https://openalex.org/keywords/induction-therapy","display_name":"induction therapy","score":0.3479999899864197},{"id":"https://openalex.org/keywords/myeloperoxidase","display_name":"myeloperoxidase","score":0.9980000257492065},{"id":"https://openalex.org/keywords/transgelin-2","display_name":"TAGLN2","score":0.8889999985694885},{"id":"https://openalex.org/keywords/glutathione-s-transferase","display_name":"glutathione S-transferase","score":0.9610000252723694},{"id":"https://openalex.org/keywords/glyceraldehyde-3-phosphate-dehydrogenase","display_name":"glyceraldehyde-3-phosphate dehydrogenase","score":0.9639999866485596},{"id":"https://openalex.org/keywords/nad-p-h-dehydrogenase","display_name":"NAD(P)H dehydrogenase","score":0.9269999861717224},{"id":"https://openalex.org/keywords/hes1","display_name":"Hes1","score":0.8989999890327454}],"concepts":[{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.6840453743934631},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.6140819191932678},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.5906982421875},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.5342843532562256},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.5195499062538147},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.46622470021247864},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.43735456466674805},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4258861839771271},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38327154517173767},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3806006610393524},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3692302405834198},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.19570320844650269},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.1908751130104065},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16643089056015015},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08469530940055847},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07993975281715393}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010449","descriptor_name":"Peptide Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015180","descriptor_name":"Electrophoresis, Gel, Two-Dimensional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019032","descriptor_name":"Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":1,"locations":[{"id":"pmid:17459203","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17459203","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhonghua yi xue za zhi","raw_type":"English Abstract"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2550301287","https://openalex.org/W1993246083","https://openalex.org/W2057688862","https://openalex.org/W2377533784","https://openalex.org/W2783962825","https://openalex.org/W4405040791","https://openalex.org/W2989225290","https://openalex.org/W2151579579","https://openalex.org/W2352805919","https://openalex.org/W2980019529"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"investigate":[2],"the":[3,6,12,25,30,57,67,79,90,101,110,141,191,196,199],"relationship":[4],"between":[5,130],"distinct":[7,176],"expression":[8,173],"of":[9,15,24,59,93,100,109,144,175,178,181,195,198],"proteins":[10,99,112,127,157,177,194],"in":[11,160],"leukemic":[13,179],"cells":[14,39,180],"leukemia":[16,45,182],"AML-M(2)a":[17,46,183],"patients":[18,26,43,184,200],"before":[19,47,185],"inducible":[20],"treatment":[21,49],"and":[22,29,86,133,152,169],"that":[23],"with":[27,44,66,78,96,190],"relapse":[28,204],"prognosis":[31],"by":[32,105,115,135],"proteomics.":[33],"METHODS:":[34],"The":[35,98,172,193],"bone":[36],"marrow":[37],"mononuclear":[38],"(BMMNC)":[40],"from":[41],"17":[42],"inductive":[48,186],"were":[50,103,113,128,158],"divided":[51],"into":[52],"3":[53,91],"groups":[54],"according":[55],"to":[56],"duration":[58,69,81],"CCR(1):":[60],"Group":[61,73,87,94,161],"A":[62,132],"(n":[63,75],"=":[64,76],"11)":[65],"CCR(1)":[68,80],"exceeding":[70],"12":[71],"months,":[72,85],"B":[74,95,134],"6)":[77],"less":[82],"than":[83],"6":[84,125],"C,":[88],"including":[89],"cases":[92],"relapse.":[97],"BMMNC":[102,197],"separated":[104],"two-dimensional":[106],"electrophoresis,":[107],"part":[108],"differentially-expressed":[111,126,156],"identified":[114,129,159],"matrix":[116],"assisted":[117],"laser":[118],"desorption/ionization":[119],"time-of-flight":[120],"mass":[121],"spectrometry":[122],"(MALDI-TOF-MS).":[123],"RESULTS:":[124],"Groups":[131],"MALDI-TOF-MS:":[136],"tubulin-specific":[137],"chaperone":[138],"B,":[139],"myeloperoxidase,":[140],"CH":[142],"domain":[143],"human":[145],"transgelin-2,":[146],"glutathione":[147],"S-transferase,":[148],"zinc":[149],"finger":[150],"protein,":[151,168],"glyceraldehyde-3-phosphate":[153],"dehydrogenase.":[154],"Three":[155],"C:":[162],"NAD":[163],"(P)":[164],"H":[165],"dehydrogenase,":[166],"hypothetical":[167],"HES1.":[170],"CONCLUSION:":[171],"level":[174],"treatments":[187],"is":[188],"associated":[189],"prognosis.":[192],"would":[201],"change":[202],"when":[203],"occurs.":[205]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}