{"id":"https://openalex.org/W1494767597","doi":null,"title":"Comparison of normal saline and heparin solutions for maintenance of arterial catheter patency.","display_name":"Comparison of normal saline and heparin solutions for maintenance of arterial catheter patency.","publication_year":1991,"publication_date":"1991-03-01","ids":{"openalex":"https://openalex.org/W1494767597","mag":"1494767597","pmid":"https://pubmed.ncbi.nlm.nih.gov/2004920"},"language":"en","primary_location":{"id":"pmid:2004920","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2004920","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heart & lung : the journal of critical care","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111697767","display_name":"G. Dennis Clifton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]},{"id":"https://openalex.org/I2801012209","display_name":"Albert B. Chandler Hospital","ror":"https://ror.org/03r8nx235","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285210727","https://openalex.org/I143302722","https://openalex.org/I2801012209"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G D Clifton","raw_affiliation_strings":["College of Pharmacy, Department of Nursing, A.B. Chandler Medical Center, University of Kentucky, Lexington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Department of Nursing, A.B. Chandler Medical Center, University of Kentucky, Lexington","institution_ids":["https://openalex.org/I143302722","https://openalex.org/I2801012209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023828278","display_name":"Pamela Branson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Branson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"H J Kelly","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H J Kelly","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075370736","display_name":"L R Dotson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L R Dotson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069019107","display_name":"Kenneth E. Record","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K E Record","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103627505","display_name":"Barbara A. Phillips","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B A Phillips","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"J R Thompson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J R Thompson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9706,"has_fulltext":false,"cited_by_count":51,"citation_normalized_percentile":{"value":0.77364865,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"20","issue":"2","first_page":"115","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10641","display_name":"Central Venous Catheters and Hemodialysis","score":0.5669000148773193,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10641","display_name":"Central Venous Catheters and Hemodialysis","score":0.5669000148773193,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11554","display_name":"Vascular Procedures and Complications","score":0.32499998807907104,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11700","display_name":"Hemodynamic Monitoring and Therapy","score":0.08389999717473984,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heparin","display_name":"heparin","score":0.7990000247955322},{"id":"https://openalex.org/keywords/normal-saline","display_name":"normal saline","score":0.7490000128746033},{"id":"https://openalex.org/keywords/radial-artery-catheter","display_name":"radial artery catheter","score":0.8230000138282776},{"id":"https://openalex.org/keywords/catheter-occlusion","display_name":"catheter occlusion","score":0.9950000047683716},{"id":"https://openalex.org/keywords/intensive-care-unit-patients","display_name":"intensive care unit patients","score":0.7599999904632568},{"id":"https://openalex.org/keywords/anticoagulation","display_name":"anticoagulation","score":0.7009999752044678}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8977963924407959},{"id":"https://openalex.org/C2777557582","wikidata":"https://www.wikidata.org/wiki/Q190016","display_name":"Heparin","level":2,"score":0.8530870079994202},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.67268306016922},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.6556906700134277},{"id":"https://openalex.org/C2781267111","wikidata":"https://www.wikidata.org/wiki/Q652297","display_name":"Catheter","level":2,"score":0.6497166752815247},{"id":"https://openalex.org/C2778218979","wikidata":"https://www.wikidata.org/wiki/Q662857","display_name":"Radial artery","level":3,"score":0.5474338531494141},{"id":"https://openalex.org/C2777274338","wikidata":"https://www.wikidata.org/wiki/Q707794","display_name":"Arterial line","level":2,"score":0.5473374128341675},{"id":"https://openalex.org/C2910590557","wikidata":"https://www.wikidata.org/wiki/Q707794","display_name":"Arterial catheter","level":3,"score":0.5384222865104675},{"id":"https://openalex.org/C2776820930","wikidata":"https://www.wikidata.org/wiki/Q9655","display_name":"Artery","level":2,"score":0.45351120829582214},{"id":"https://openalex.org/C2776268601","wikidata":"https://www.wikidata.org/wiki/Q968808","display_name":"Occlusion","level":2,"score":0.427106648683548},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.42383503913879395}],"mesh":[{"descriptor_ui":"D002406","descriptor_name":"Catheterization, Peripheral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002408","descriptor_name":"Catheters, Indwelling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006493","descriptor_name":"Heparin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007362","descriptor_name":"Intensive Care Units","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012965","descriptor_name":"Sodium Chloride","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:2004920","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2004920","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heart & lung : the journal of critical care","raw_type":"Clinical Trial"},{"id":"mag:1494767597","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2004920","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3102371059","https://openalex.org/W2188117168","https://openalex.org/W2012070416","https://openalex.org/W2157578950","https://openalex.org/W3140381205","https://openalex.org/W7097418800","https://openalex.org/W7097052429","https://openalex.org/W2112366983","https://openalex.org/W2080740521","https://openalex.org/W2475441194"],"abstract_inverted_index":{"A":[0],"double-blind,":[1],"randomized":[2],"study":[3,48],"was":[4,78],"conducted":[5],"in":[6,21,67,89,169],"30":[7],"adult":[8],"medical":[9],"intensive":[10],"care":[11],"unit":[12],"patients":[13,170],"to":[14,52,124],"determine":[15],"if":[16],"the":[17,25,47,84,117],"presence":[18],"of":[19,29,74,83,94,103,138,154],"heparin":[20,64],"continuous-flush":[22],"solutions":[23,38,57],"prolongs":[24],"functional":[26],"life":[27],"span":[28],"radial":[30,145],"arterial":[31,54,129],"catheters":[32,35,119,147],"compared":[33,99,159],"with":[34,37,100,109,150,160,171],"flushed":[36],"not":[39,167],"containing":[40,58,162],"heparin.":[41],"Patients":[42],"were":[43],"consecutively":[44],"entered":[45],"into":[46],"and":[49,128,157,164,175],"randomly":[50],"assigned":[51],"receive":[53],"line":[55],"flush":[56,76,86,143],"0.9%":[59,68],"sodium":[60,69],"chloride":[61],"(NSS)":[62],"or":[63],"4":[65],"U/ml":[66],"chloride.":[70],"The":[71,136],"flow":[72],"rate":[73,93,102],"each":[75],"solution":[77,87,161],"approximately":[79],"3":[80],"ml/hr.":[81],"Use":[82],"heparin-containing":[85],"resulted":[88],"a":[90,101,141],"catheter":[91,126,155],"survival":[92],"86%":[95],"at":[96],"96":[97],"hours":[98,108],"only":[104],"52%":[105],"after":[106],"40":[107],"NSS":[110,139],"(p":[111,132],"less":[112,122,133],"than":[113,134],"0.05).":[114],"In":[115],"addition,":[116],"heparin-flushed":[118],"required":[120],"significantly":[121],"manipulation":[123],"prevent":[125],"occlusion":[127,156],"pressure-wave":[130],"dampening":[131],"0.01).":[135],"use":[137],"as":[140],"continuous":[142],"for":[144],"artery":[146],"is":[148,166],"associated":[149],"an":[151],"increased":[152],"frequency":[153],"malfunctions":[158],"heparin,":[163],"thus":[165],"recommended":[168],"normal":[172],"coagulation":[173],"status":[174],"platelet":[176],"count.":[177]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}