{"id":"https://openalex.org/W1494584978","doi":"https://doi.org/10.1016/s0070-2153(07)80002-0","title":"Junction Restructuring and Spermatogenesis: The Biology, Regulation, and Implication in Male Contraceptive Development","display_name":"Junction Restructuring and Spermatogenesis: The Biology, Regulation, and Implication in Male Contraceptive Development","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W1494584978","doi":"https://doi.org/10.1016/s0070-2153(07)80002-0","mag":"1494584978","pmid":"https://pubmed.ncbi.nlm.nih.gov/17950372"},"language":"en","primary_location":{"id":"doi:10.1016/s0070-2153(07)80002-0","doi":"https://doi.org/10.1016/s0070-2153(07)80002-0","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0070-2153(07)80002-0","pdf_url":null,"source":{"id":"https://openalex.org/S36555808","display_name":"Current topics in developmental biology/Current Topics in Developmental Biology","issn_l":"0070-2153","issn":["0070-2153","1557-8933"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Topics in Developmental Biology","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4242988800","display_name":null},"type":"book-chapter","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Helen H.N. Yan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210132262","display_name":"Population Council","ror":"https://ror.org/03zjj0p70","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210132262"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Helen H.N. Yan","raw_affiliation_strings":["Center for Biomedical Research, Population Council, New York, New York 10021, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Biomedical Research, Population Council, New York, New York 10021, USA","institution_ids":["https://openalex.org/I4210132262"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041273456","display_name":"Dolores D. Mruk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210132262","display_name":"Population Council","ror":"https://ror.org/03zjj0p70","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210132262"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dolores D. Mruk","raw_affiliation_strings":["Center for Biomedical Research, Population Council, New York, New York 10021"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Biomedical Research, Population Council, New York, New York 10021","institution_ids":["https://openalex.org/I4210132262"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072413923","display_name":"C. Yan Cheng","orcid":"https://orcid.org/0000-0003-3117-3791","observed_orcids":["https://orcid.org/0000-0003-3117-3791"]},"institutions":[{"id":"https://openalex.org/I4210132262","display_name":"Population Council","ror":"https://ror.org/03zjj0p70","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210132262"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Yan Cheng","raw_affiliation_strings":["Center for Biomedical Research, Population Council, New York, New York 10021"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Biomedical Research, Population Council, New York, New York 10021","institution_ids":["https://openalex.org/I4210132262"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210132262"],"apc_list":null,"apc_paid":null,"fwci":52.6859,"has_fulltext":false,"cited_by_count":61,"citation_normalized_percentile":{"value":0.99922601,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"80","issue":null,"first_page":"57","last_page":"92"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13242","display_name":"Male Reproductive Health Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3600","display_name":"General Health Professions"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spermatogenesis","display_name":"spermatogenesis","score":0.9169999957084656},{"id":"https://openalex.org/keywords/sertoli-cells","display_name":"Sertoli cells","score":0.9470000267028809},{"id":"https://openalex.org/keywords/blood-testis-barrier","display_name":"blood-testis barrier","score":0.8149999976158142},{"id":"https://openalex.org/keywords/ectoplasmic-specialization","display_name":"ectoplasmic specialization","score":0.9470000267028809},{"id":"https://openalex.org/keywords/adherens-junctions","display_name":"adherens junctions","score":0.8840000033378601},{"id":"https://openalex.org/keywords/tight-junctions","display_name":"tight junctions","score":1.0},{"id":"https://openalex.org/keywords/seminiferous-epithelium","display_name":"seminiferous epithelium","score":0.906000018119812},{"id":"https://openalex.org/keywords/spermiation","display_name":"spermiation","score":0.9449999928474426},{"id":"https://openalex.org/keywords/male-contraception","display_name":"male contraception","score":0.6850000023841858}],"concepts":[{"id":"https://openalex.org/C2781068068","wikidata":"https://www.wikidata.org/wiki/Q195614","display_name":"Sertoli cell","level":3,"score":0.903368353843689},{"id":"https://openalex.org/C201508349","wikidata":"https://www.wikidata.org/wiki/Q45173","display_name":"Adherens junction","level":4,"score":0.8273835182189941},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8067876696586609},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7548431754112244},{"id":"https://openalex.org/C123765429","wikidata":"https://www.wikidata.org/wiki/Q36961","display_name":"Spermatogenesis","level":2,"score":0.701571524143219},{"id":"https://openalex.org/C2636012","wikidata":"https://www.wikidata.org/wiki/Q489842","display_name":"Blood\u2013testis barrier","level":4,"score":0.6778433322906494},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.5952370762825012},{"id":"https://openalex.org/C2779122487","wikidata":"https://www.wikidata.org/wiki/Q281579","display_name":"Germ cell","level":3,"score":0.5514300465583801},{"id":"https://openalex.org/C2776053789","wikidata":"https://www.wikidata.org/wiki/Q3486515","display_name":"Spermatocyte","level":4,"score":0.5222302675247192},{"id":"https://openalex.org/C29350253","wikidata":"https://www.wikidata.org/wiki/Q189073","display_name":"Cell junction","level":3,"score":0.4277821183204651},{"id":"https://openalex.org/C177779419","wikidata":"https://www.wikidata.org/wiki/Q1053832","display_name":"Tight junction","level":2,"score":0.41794297099113464},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3017033040523529},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2514069378376007},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20235082507133484},{"id":"https://openalex.org/C148196450","wikidata":"https://www.wikidata.org/wiki/Q21100485","display_name":"Meiosis","level":3,"score":0.1245790421962738},{"id":"https://openalex.org/C149402561","wikidata":"https://www.wikidata.org/wiki/Q24776048","display_name":"Cadherin","level":3,"score":0.06522852182388306},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000728","descriptor_name":"Androgens","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003272","descriptor_name":"Contraceptive Agents, Male","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004705","descriptor_name":"Endocytosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004785","descriptor_name":"Environmental Pollutants","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013091","descriptor_name":"Spermatogenesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013091","descriptor_name":"Spermatogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013737","descriptor_name":"Testis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016326","descriptor_name":"Extracellular Matrix Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019108","descriptor_name":"Tight Junctions","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019108","descriptor_name":"Tight Junctions","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D022005","descriptor_name":"Adherens Junctions","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D022005","descriptor_name":"Adherens Junctions","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/s0070-2153(07)80002-0","doi":"https://doi.org/10.1016/s0070-2153(07)80002-0","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0070-2153(07)80002-0","pdf_url":null,"source":{"id":"https://openalex.org/S36555808","display_name":"Current topics in developmental biology/Current Topics in Developmental Biology","issn_l":"0070-2153","issn":["0070-2153","1557-8933"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Topics in Developmental Biology","raw_type":"book-chapter"},{"id":"pmid:17950372","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17950372","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current topics in developmental biology","raw_type":"Journal Article"},{"id":"pmh:oai:hub.hku.hk:10722/207054","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10722/207054","pdf_url":null,"source":{"id":"https://openalex.org/S4377196271","display_name":"The HKU Scholars Hub (University of Hong Kong)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I889458895","host_organization_name":"University of Hong Kong","host_organization_lineage":["https://openalex.org/I889458895"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8799999952316284,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1792526705","display_name":"Junction Dynamics and Male Fertility Regulation","funder_award_id":"U01HD045908","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G7913906242","display_name":"Cooperative Contraceptive Research Center: New Contraceptives with Dual Benefits","funder_award_id":"U54HD029990","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":180,"referenced_works":["https://openalex.org/W39001782","https://openalex.org/W591684825","https://openalex.org/W1461300049","https://openalex.org/W1493826438","https://openalex.org/W1503392039","https://openalex.org/W1529693453","https://openalex.org/W1579619270","https://openalex.org/W1588115842","https://openalex.org/W1600430222","https://openalex.org/W1604364960","https://openalex.org/W1608755254","https://openalex.org/W1786998712","https://openalex.org/W1869006121","https://openalex.org/W1906485255","https://openalex.org/W1922486470","https://openalex.org/W1958574545","https://openalex.org/W1964157134","https://openalex.org/W1965063267","https://openalex.org/W1966034730","https://openalex.org/W1968787705","https://openalex.org/W1968907717","https://openalex.org/W1970209029","https://openalex.org/W1971029155","https://openalex.org/W1972197584","https://openalex.org/W1973250586","https://openalex.org/W1974598255","https://openalex.org/W1975529428","https://openalex.org/W1977333131","https://openalex.org/W1977591991","https://openalex.org/W1977874001","https://openalex.org/W1978469056","https://openalex.org/W1978837916","https://openalex.org/W1981184799","https://openalex.org/W1982408362","https://openalex.org/W1982527680","https://openalex.org/W1983735042","https://openalex.org/W1984591512","https://openalex.org/W1987082843","https://openalex.org/W1987937341","https://openalex.org/W1989768887","https://openalex.org/W1990200134","https://openalex.org/W1990735189","https://openalex.org/W1993273489","https://openalex.org/W1993350859","https://openalex.org/W1993744150","https://openalex.org/W1995116585","https://openalex.org/W1996645283","https://openalex.org/W1998722329","https://openalex.org/W2005310157","https://openalex.org/W2007991972","https://openalex.org/W2011188133","https://openalex.org/W2011745438","https://openalex.org/W2013394636","https://openalex.org/W2013589663","https://openalex.org/W2015912703","https://openalex.org/W2016759352","https://openalex.org/W2018397538","https://openalex.org/W2022479321","https://openalex.org/W2023720349","https://openalex.org/W2023992908","https://openalex.org/W2025326001","https://openalex.org/W2025381136","https://openalex.org/W2025466075","https://openalex.org/W2027359413","https://openalex.org/W2028525051","https://openalex.org/W2028614483","https://openalex.org/W2029804435","https://openalex.org/W2030227542","https://openalex.org/W2036976320","https://openalex.org/W2039795039","https://openalex.org/W2040671717","https://openalex.org/W2042116389","https://openalex.org/W2042342900","https://openalex.org/W2044788416","https://openalex.org/W2045098597","https://openalex.org/W2047854878","https://openalex.org/W2050022968","https://openalex.org/W2051556121","https://openalex.org/W2052135636","https://openalex.org/W2054297426","https://openalex.org/W2055526203","https://openalex.org/W2056869056","https://openalex.org/W2057566423","https://openalex.org/W2057598257","https://openalex.org/W2058130682","https://openalex.org/W2060186061","https://openalex.org/W2064028548","https://openalex.org/W2064370516","https://openalex.org/W2064488645","https://openalex.org/W2067999123","https://openalex.org/W2068005419","https://openalex.org/W2068857260","https://openalex.org/W2069496044","https://openalex.org/W2069511698","https://openalex.org/W2069962467","https://openalex.org/W2070004947","https://openalex.org/W2073828819","https://openalex.org/W2074741683","https://openalex.org/W2076667246","https://openalex.org/W2079122334","https://openalex.org/W2079145649","https://openalex.org/W2080889785","https://openalex.org/W2080940207","https://openalex.org/W2081659145","https://openalex.org/W2082300142","https://openalex.org/W2082741761","https://openalex.org/W2084460154","https://openalex.org/W2085966326","https://openalex.org/W2089867981","https://openalex.org/W2092822317","https://openalex.org/W2096476993","https://openalex.org/W2097914627","https://openalex.org/W2098036757","https://openalex.org/W2100913647","https://openalex.org/W2101436005","https://openalex.org/W2103536507","https://openalex.org/W2103583173","https://openalex.org/W2104040244","https://openalex.org/W2104689108","https://openalex.org/W2106267004","https://openalex.org/W2106640891","https://openalex.org/W2107207009","https://openalex.org/W2107219745","https://openalex.org/W2107246666","https://openalex.org/W2108935114","https://openalex.org/W2110484500","https://openalex.org/W2110918369","https://openalex.org/W2111369394","https://openalex.org/W2120597716","https://openalex.org/W2122650723","https://openalex.org/W2126065054","https://openalex.org/W2127394834","https://openalex.org/W2127647846","https://openalex.org/W2128016220","https://openalex.org/W2128840922","https://openalex.org/W2132553421","https://openalex.org/W2133133102","https://openalex.org/W2133592011","https://openalex.org/W2138316626","https://openalex.org/W2140997010","https://openalex.org/W2141174737","https://openalex.org/W2143321751","https://openalex.org/W2145155310","https://openalex.org/W2145562458","https://openalex.org/W2147643532","https://openalex.org/W2147965409","https://openalex.org/W2148700019","https://openalex.org/W2148715064","https://openalex.org/W2149136228","https://openalex.org/W2149533732","https://openalex.org/W2150134508","https://openalex.org/W2151111381","https://openalex.org/W2152302131","https://openalex.org/W2153384288","https://openalex.org/W2157189882","https://openalex.org/W2161123101","https://openalex.org/W2162477937","https://openalex.org/W2162553879","https://openalex.org/W2162992279","https://openalex.org/W2163546840","https://openalex.org/W2164490852","https://openalex.org/W2164606029","https://openalex.org/W2166012528","https://openalex.org/W2167696515","https://openalex.org/W2169416991","https://openalex.org/W2169825874","https://openalex.org/W2181998599","https://openalex.org/W2212959237","https://openalex.org/W2324512064","https://openalex.org/W2343182587","https://openalex.org/W2402393700","https://openalex.org/W2411753130","https://openalex.org/W3117476980","https://openalex.org/W4211214945","https://openalex.org/W4231136244","https://openalex.org/W4235334662","https://openalex.org/W4241204613","https://openalex.org/W4285719527","https://openalex.org/W6601548833","https://openalex.org/W6636106239"],"related_works":["https://openalex.org/W1689027623","https://openalex.org/W2016016527","https://openalex.org/W2145562458","https://openalex.org/W1975615008","https://openalex.org/W2140073536","https://openalex.org/W1987082843","https://openalex.org/W1995616568","https://openalex.org/W2162553879","https://openalex.org/W2127370867","https://openalex.org/W2152302131"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}