{"id":"https://openalex.org/W1494460016","doi":"https://doi.org/10.1089/089771504772695904","title":"Peroxynitrite-Mediated Protein Nitration and Lipid Peroxidation in a Mouse Model of Traumatic Brain Injury","display_name":"Peroxynitrite-Mediated Protein Nitration and Lipid Peroxidation in a Mouse Model of Traumatic Brain Injury","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W1494460016","doi":"https://doi.org/10.1089/089771504772695904","mag":"1494460016","pmid":"https://pubmed.ncbi.nlm.nih.gov/14987461"},"language":"en","primary_location":{"id":"doi:10.1089/089771504772695904","doi":"https://doi.org/10.1089/089771504772695904","is_oa":false,"landing_page_url":"https://doi.org/10.1089/089771504772695904","pdf_url":null,"source":{"id":"https://openalex.org/S85864898","display_name":"Journal of Neurotrauma","issn_l":"0897-7151","issn":["0897-7151","1557-9042"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurotrauma","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W1494460016"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hdl.handle.net/2027.42/63192","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109059843","display_name":"Edward D. Hall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]},{"id":"https://openalex.org/I2801012209","display_name":"Albert B. Chandler Hospital","ror":"https://ror.org/03r8nx235","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285210727","https://openalex.org/I143302722","https://openalex.org/I2801012209"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward D. Hall","raw_affiliation_strings":["Spinal Cord and Brain Injury Research Center, University of Kentucky Chandler Medical Center, Lexington, Kentucky","Spinal Cord and Brain Injury Research Center, University of Kentucky Chandler Medical Center, Lexington, Kentucky 40536-0305, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Spinal Cord and Brain Injury Research Center, University of Kentucky Chandler Medical Center, Lexington, Kentucky","institution_ids":["https://openalex.org/I143302722","https://openalex.org/I2801012209"]},{"raw_affiliation_string":"Spinal Cord and Brain Injury Research Center, University of Kentucky Chandler Medical Center, Lexington, Kentucky 40536-0305, USA","institution_ids":["https://openalex.org/I143302722","https://openalex.org/I2801012209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031803867","display_name":"Megan Ryan Detloff","orcid":"https://orcid.org/0000-0003-2872-1515","observed_orcids":["https://orcid.org/0000-0003-2872-1515"]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Megan R. Detloff","raw_affiliation_strings":["CNS Pharmacology, Pfizer Global Research and Development, Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNS Pharmacology, Pfizer Global Research and Development, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113296464","display_name":"Kjell Johnson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kjell Johnson","raw_affiliation_strings":["CNS Pharmacology, Pfizer Global Research and Development, Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNS Pharmacology, Pfizer Global Research and Development, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084655943","display_name":"Nancy C. Kupina","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nancy C. Kupina","raw_affiliation_strings":["CNS Pharmacology, Pfizer Global Research and Development, Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNS Pharmacology, Pfizer Global Research and Development, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I180857899"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":9.7451,"has_fulltext":true,"cited_by_count":246,"citation_normalized_percentile":{"value":0.98609867,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":100},"biblio":{"volume":"21","issue":"1","first_page":"9","last_page":"20"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10416","display_name":"Traumatic Brain Injury Research","score":0.006500000134110451,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/peroxynitrite","display_name":"peroxynitrite","score":0.9620000123977661},{"id":"https://openalex.org/keywords/traumatic-brain-injury","display_name":"traumatic brain injury","score":0.878000020980835},{"id":"https://openalex.org/keywords/protein-nitration","display_name":"protein nitration","score":0.9120000004768372},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.953000009059906},{"id":"https://openalex.org/keywords/3-nitrotyrosine","display_name":"nitrotyrosine","score":0.9079999923706055},{"id":"https://openalex.org/keywords/4-hydroxynonenal","display_name":"4-hydroxynonenal","score":1.0},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9409999847412109},{"id":"https://openalex.org/keywords/iron-dependent-lipid-peroxidation","display_name":"iron-dependent lipid peroxidation","score":0.7680000066757202},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.6179999709129333},{"id":"https://openalex.org/keywords/silver-staining","display_name":"silver staining","score":0.39399999380111694}],"concepts":[{"id":"https://openalex.org/C2778784160","wikidata":"https://www.wikidata.org/wiki/Q419130","display_name":"Peroxynitrite","level":4,"score":0.839053213596344},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.8180913925170898},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.7271465063095093},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.6697243452072144},{"id":"https://openalex.org/C2781017439","wikidata":"https://www.wikidata.org/wiki/Q1995526","display_name":"Traumatic brain injury","level":2,"score":0.5979669690132141},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5629528164863586},{"id":"https://openalex.org/C4224716","wikidata":"https://www.wikidata.org/wiki/Q10859258","display_name":"Immunostaining","level":3,"score":0.5565732717514038},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5326839089393616},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.5188497304916382},{"id":"https://openalex.org/C2779385521","wikidata":"https://www.wikidata.org/wiki/Q412383","display_name":"Nitrotyrosine","level":4,"score":0.4701770842075348},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4443266987800598},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.36774134635925293},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3244040608406067},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25258582830429077},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.240897536277771},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22129365801811218},{"id":"https://openalex.org/C2780795997","wikidata":"https://www.wikidata.org/wiki/Q413283","display_name":"Superoxide","level":3,"score":0.13803252577781677},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.13775715231895447},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.10361135005950928},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000447","descriptor_name":"Aldehydes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009410","descriptor_name":"Nerve Degeneration","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015227","descriptor_name":"Lipid Peroxidation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D030421","descriptor_name":"Peroxynitrous Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1089/089771504772695904","doi":"https://doi.org/10.1089/089771504772695904","is_oa":false,"landing_page_url":"https://doi.org/10.1089/089771504772695904","pdf_url":null,"source":{"id":"https://openalex.org/S85864898","display_name":"Journal of Neurotrauma","issn_l":"0897-7151","issn":["0897-7151","1557-9042"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurotrauma","raw_type":"journal-article"},{"id":"pmid:14987461","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14987461","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurotrauma","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.866.4055","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.866.4055","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://deepblue.lib.umich.edu/bitstream/handle/2027.42/63192/089771504772695904.pdf%3Bjsessionid%3D51E9C7F9266AF68272209227F24BF23A?sequence%3D1","raw_type":"text"},{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/63192","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/63192","pdf_url":null,"source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/63192","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/63192","pdf_url":null,"source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1494460016.pdf","grobid_xml":"https://content.openalex.org/works/W1494460016.grobid-xml"},"referenced_works_count":81,"referenced_works":["https://openalex.org/W18740259","https://openalex.org/W118575355","https://openalex.org/W1502536868","https://openalex.org/W1502736133","https://openalex.org/W1503545438","https://openalex.org/W1507112934","https://openalex.org/W1598606175","https://openalex.org/W1603434131","https://openalex.org/W1721269439","https://openalex.org/W1958942851","https://openalex.org/W1963689012","https://openalex.org/W1966492855","https://openalex.org/W1968793573","https://openalex.org/W1971216963","https://openalex.org/W1973671786","https://openalex.org/W1977645659","https://openalex.org/W1980933002","https://openalex.org/W1981023844","https://openalex.org/W1981082943","https://openalex.org/W1983574021","https://openalex.org/W1984732054","https://openalex.org/W1987146437","https://openalex.org/W1988414146","https://openalex.org/W1990956265","https://openalex.org/W1992026104","https://openalex.org/W1993128970","https://openalex.org/W1993781471","https://openalex.org/W1998689433","https://openalex.org/W1998700894","https://openalex.org/W1998919607","https://openalex.org/W2001032753","https://openalex.org/W2002984543","https://openalex.org/W2003540939","https://openalex.org/W2003633558","https://openalex.org/W2007922486","https://openalex.org/W2012485229","https://openalex.org/W2014083372","https://openalex.org/W2016198027","https://openalex.org/W2017136647","https://openalex.org/W2019447333","https://openalex.org/W2020914812","https://openalex.org/W2026779396","https://openalex.org/W2028743642","https://openalex.org/W2029545663","https://openalex.org/W2039669642","https://openalex.org/W2045777403","https://openalex.org/W2048279860","https://openalex.org/W2049232502","https://openalex.org/W2055257936","https://openalex.org/W2059982861","https://openalex.org/W2061314122","https://openalex.org/W2062539416","https://openalex.org/W2062931463","https://openalex.org/W2068725250","https://openalex.org/W2071550630","https://openalex.org/W2075729900","https://openalex.org/W2078603857","https://openalex.org/W2080903859","https://openalex.org/W2084523293","https://openalex.org/W2084672945","https://openalex.org/W2086070682","https://openalex.org/W2089885268","https://openalex.org/W2090544950","https://openalex.org/W2090560578","https://openalex.org/W2090643949","https://openalex.org/W2093163969","https://openalex.org/W2104730217","https://openalex.org/W2127002164","https://openalex.org/W2127822816","https://openalex.org/W2131092704","https://openalex.org/W2131347780","https://openalex.org/W2139251967","https://openalex.org/W2148464749","https://openalex.org/W2152384354","https://openalex.org/W2160292181","https://openalex.org/W2173429194","https://openalex.org/W2205987263","https://openalex.org/W2235464535","https://openalex.org/W2341253028","https://openalex.org/W2415492819","https://openalex.org/W4235153446"],"related_works":["https://openalex.org/W7132986225","https://openalex.org/W1992890638","https://openalex.org/W1976722557","https://openalex.org/W2509524200","https://openalex.org/W2602999961","https://openalex.org/W3113733312","https://openalex.org/W2101577668","https://openalex.org/W1578720301","https://openalex.org/W1973570148"],"abstract_inverted_index":{"The":[0,74,202,242],"role":[1,84],"of":[2,26,49,57,82,85,94,105,109,145,151,165,184,232,247,296],"reactive":[3,50,274],"oxygen-induced":[4],"oxidative":[5,58,153,298],"damage":[6,59,154,252,299],"to":[7,36,63,100,119,155,284,304,309,318],"lipids":[8,160],"(i.e.,":[9],"lipid":[10,31],"peroxidation,":[11],"LP)":[12],"and":[13,30,60,96,125,136,148,159,180,193,205,210,236,238,244,250,266,315],"proteins":[14,156],"has":[15],"been":[16,34,71],"strongly":[17],"supported":[18],"in":[19,39,66,90,102,224,258,300],"previous":[20],"work.":[21],"Most":[22],"notably,":[23],"a":[24,120],"number":[25],"free":[27],"radical":[28],"scavengers":[29],"antioxidants":[32],"have":[33,70],"demonstrated":[35],"be":[37],"neuroprotective":[38],"traumatic":[40],"brain":[41,69],"injury":[42,112,124],"(TBI)":[43],"models.":[44],"However,":[45,260],"the":[46,54,67,83,86,91,103,106,198,215,221,230,285,316],"specific":[47],"sources":[48],"oxygen":[51,275],"species":[52],"(ROS),":[53],"time":[55,203],"course":[56,204],"its":[61,97],"relationship":[62,99],"post-traumatic":[64,297],"neurodegeneration":[65,101,140,185],"injured":[68],"incompletely":[72],"defined.":[73],"present":[75],"study":[76],"was":[77,168,186,264],"directed":[78],"at":[79,127],"an":[80],"investigation":[81],"ROS,":[87],"peroxynitrite":[88],"(PON),":[89],"acute":[92],"pathophysiology":[93],"TBI":[95,301],"temporal":[98,243],"context":[104],"mouse":[107],"model":[108],"diffuse":[110,268],"head":[111,123],"model.":[113],"Male":[114],"CF-1":[115],"mice":[116],"were":[117,212],"subjected":[118],"moderately":[121],"severe":[122],"assessed":[126],"1-,":[128],"3-,":[129],"6-,":[130],"12-,":[131],"24-,":[132],"48-,":[133],"72,":[134],"96-":[135],"120-h":[137],"post-injury":[138],"for":[139,191,208],"using":[141],"quantitative":[142],"image":[143],"analysis":[144,150],"silver":[146,166],"staining":[147,167,176,206,217],"semi-quantitative":[149],"PON-mediated":[152],"(3-nitrotyrosine,":[157],"3-NT)":[158],"(4-hydroxynonenal,":[161],"4-HNE).":[162],"Significant":[163],"evidence":[164],"not":[169],"apparent":[170],"until":[171],"24-h":[172],"post-injury,":[173],"with":[174,214],"peak":[175],"seen":[177],"between":[178],"72-":[179],"120-h.":[181],"This":[182,290],"time-course":[183],"preceded":[187],"by":[188,322],"intense":[189],"immunostaining":[190],"3-NT":[192,209],"4-HNE,":[194],"which":[195],"occurred":[196],"within":[197,220],"first":[199,222],"hour":[200],"post-injury.":[201],"pattern":[207],"4-HNE":[211,288],"similar,":[213],"highest":[216],"intensity":[218],"noted":[219],"48-h":[223],"areas":[225],"surrounding":[226],"trauma-induced":[227],"contusions.":[228],"In":[229],"case":[231],"3-NT,":[233,270],"neuronal":[234],"perikarya":[235],"processes":[237],"microvessels":[239],"displayed":[240],"staining.":[241],"spatial":[245],"coincidence":[246],"protein":[248],"nitration":[249],"LP":[251,320],"suggests":[253],"that":[254,272,292],"PON":[255,311],"is":[256],"involved":[257],"both.":[259],"lipid-peroxidative":[261],"(4-HNE)":[262],"immunoreactivity":[263],"broader":[265],"more":[267,286],"than":[269],"suggesting":[271],"other":[273],"mechanisms,":[276],"such":[277],"as":[278],"iron-dependent":[279],"LP,":[280],"may":[281,302],"also":[282],"contribute":[283],"widespread":[287],"immunoreactivity.":[289],"indicates":[291],"optimal":[293],"pharmacological":[294],"inhibition":[295],"need":[303],"combine":[305],"two":[306],"functionalities:":[307],"one":[308],"scavenge":[310],"or":[312],"PON-derived":[313],"radicals,":[314],"second":[317],"inhibit":[319],"caused":[321],"multiple":[323],"ROS":[324],"species.":[325]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":16},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":16}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}
