{"id":"https://openalex.org/W1494237671","doi":"https://doi.org/10.18632/oncotarget.2070","title":"Targeting FANCD2 for therapy sensitization","display_name":"Targeting FANCD2 for therapy sensitization","publication_year":2014,"publication_date":"2014-06-07","ids":{"openalex":"https://openalex.org/W1494237671","doi":"https://doi.org/10.18632/oncotarget.2070","mag":"1494237671","pmid":"https://pubmed.ncbi.nlm.nih.gov/24913333","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4116492"},"language":"en","primary_location":{"id":"doi:10.18632/oncotarget.2070","doi":"https://doi.org/10.18632/oncotarget.2070","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.2070","pdf_url":"https://doi.org/10.18632/oncotarget.2070","source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},"volume":null,"type":"editorial","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.18632/oncotarget.2070","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036285129","display_name":"Changxian Shen","orcid":"https://orcid.org/0000-0002-7668-7166","observed_orcids":["https://orcid.org/0000-0002-7668-7166"]},"institutions":[{"id":"https://openalex.org/I1314135232","display_name":"Nationwide Children's Hospital","ror":"https://ror.org/003rfsp33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1314135232"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Changxian Shen","raw_affiliation_strings":["Center for Childhood Cancer and Blood Diseases, Nationwide Children's Hospital, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Childhood Cancer and Blood Diseases, Nationwide Children's Hospital, Columbus, OH","institution_ids":["https://openalex.org/I1314135232"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109173471","display_name":"Peter J. Houghton","orcid":"https://orcid.org/0000-0002-2400-8184","observed_orcids":["https://orcid.org/0000-0002-2400-8184"]},"institutions":[{"id":"https://openalex.org/I1314135232","display_name":"Nationwide Children's Hospital","ror":"https://ror.org/003rfsp33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1314135232"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter J. Houghton","raw_affiliation_strings":["Center for Childhood Cancer and Blood Diseases, Nationwide Children's Hospital, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Childhood Cancer and Blood Diseases, Nationwide Children's Hospital, Columbus, OH","institution_ids":["https://openalex.org/I1314135232"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1314135232"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"5","issue":"11","first_page":"3426","last_page":"3427"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fancd2","display_name":"FANCD2","score":1.0},{"id":"https://openalex.org/keywords/fanconi-anemia-pathway","display_name":"Fanconi anemia pathway","score":0.9409999847412109},{"id":"https://openalex.org/keywords/interstrand-crosslinks","display_name":"interstrand cross-links","score":0.7300000190734863},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.8930000066757202},{"id":"https://openalex.org/keywords/translesion-synthesis","display_name":"translesion synthesis","score":0.800000011920929},{"id":"https://openalex.org/keywords/nucleotide-excision-repair","display_name":"nucleotide excision repair","score":0.9879999756813049},{"id":"https://openalex.org/keywords/homologous-recombination","display_name":"homologous recombination","score":0.9990000128746033},{"id":"https://openalex.org/keywords/atr-checkpoint","display_name":"ATR checkpoint","score":0.9449999928474426},{"id":"https://openalex.org/keywords/replication-stress","display_name":"replication stress","score":0.8980000019073486},{"id":"https://openalex.org/keywords/genomic-stability","display_name":"genome stability","score":0.44200000166893005}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7171118855476379},{"id":"https://openalex.org/C2776653068","wikidata":"https://www.wikidata.org/wiki/Q17927069","display_name":"FANCD2","level":5,"score":0.6840031147003174},{"id":"https://openalex.org/C2776217527","wikidata":"https://www.wikidata.org/wiki/Q944828","display_name":"Sensitization","level":2,"score":0.6140131950378418},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3784220814704895},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.34446391463279724},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3267078399658203},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.2016168236732483},{"id":"https://openalex.org/C2778124228","wikidata":"https://www.wikidata.org/wiki/Q845779","display_name":"Fanconi anemia","level":4,"score":0.17192256450653076},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14814451336860657},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09712979197502136},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005199","descriptor_name":"Fanconi Anemia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005199","descriptor_name":"Fanconi Anemia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D052236","descriptor_name":"Fanconi Anemia Complementation Group D2 Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D052236","descriptor_name":"Fanconi Anemia Complementation Group D2 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.18632/oncotarget.2070","doi":"https://doi.org/10.18632/oncotarget.2070","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.2070","pdf_url":"https://doi.org/10.18632/oncotarget.2070","source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3090105","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4116492","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4116492","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4116492","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"Text"},{"id":"pmid:24913333","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24913333","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"Editorial"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.779.5799","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.779.5799","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/45/d6/oncotarget-05-3426.PMC4116492.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.18632/oncotarget.2070","doi":"https://doi.org/10.18632/oncotarget.2070","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.2070","pdf_url":"https://doi.org/10.18632/oncotarget.2070","source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1494237671.pdf","grobid_xml":"https://content.openalex.org/works/W1494237671.grobid-xml"},"referenced_works_count":8,"referenced_works":["https://openalex.org/W1981711832","https://openalex.org/W2005711961","https://openalex.org/W2034745548","https://openalex.org/W2044292152","https://openalex.org/W2110817748","https://openalex.org/W2110938265","https://openalex.org/W2139330894","https://openalex.org/W2167844213"],"related_works":["https://openalex.org/W2098585738","https://openalex.org/W2756203475","https://openalex.org/W2761481949","https://openalex.org/W2094977104","https://openalex.org/W2168964269","https://openalex.org/W1983750443","https://openalex.org/W2134071049","https://openalex.org/W2028285902","https://openalex.org/W2159152986","https://openalex.org/W2610250376"],"abstract_inverted_index":{"essential":[0],"for":[1],"the":[2,35,52,55,105,115],"maintenance":[3],"of":[4,44,54,89,108],"genome":[5],"integrity":[6],"and":[7,29,46,59,87],"cells":[8,77],"to":[9,96,113],"survive":[10],"DNA":[11,17,22,57,80,90,97],"interstrand":[12],"crosslink":[13],"(ICL)":[14],"by":[15,41],"coordinating":[16],"damage":[18,58,91,98],"repair":[19,27],"through":[20],"translesion":[21],"synthesis":[23],"(TLS),":[24],"nucleotide":[25],"excision":[26],"(NER)":[28],"homologous":[30],"recombination":[31],"(HR).":[32],"Besides":[33],"ICL,":[34,114],"FA":[36,71,109,116],"signaling":[37],"pathway":[38,117],"is":[39,104],"activated":[40],"different":[42],"kinds":[43],"genotoxins":[45],"plays":[47],"an":[48],"important":[49],"role":[50],"in":[51,70,94],"activation":[53,93],"ATM":[56],"ATR":[60],"intra-S":[61],"phase":[62],"checkpoints.":[63],"There":[64],"are":[65],"fifteen":[66],"FANC":[67],"genes":[68],"identified":[69],"or":[72,99],"FA-like":[73],"patients.":[74],"FA-pathway":[75],"deficient":[76],"display":[78],"spontaneous":[79],"strand":[81],"breaks":[82],"under":[83],"normal":[84],"growth":[85],"conditions":[86],"defect":[88],"checkpoint":[92],"response":[95,112],"replication":[100],"stress":[101],"[1].":[102],"FANCD2":[103],"critical":[106],"component":[107],"signaling.":[110],"In":[111],"activates":[118]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
