{"id":"https://openalex.org/W1494085200","doi":"https://doi.org/10.1016/s0065-3233(04)68002-8","title":"The Three-Dimensional Structure of Integrins and their Ligands, and Conformational Regulation of Cell Adhesion","display_name":"The Three-Dimensional Structure of Integrins and their Ligands, and Conformational Regulation of Cell Adhesion","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W1494085200","doi":"https://doi.org/10.1016/s0065-3233(04)68002-8","mag":"1494085200","pmid":"https://pubmed.ncbi.nlm.nih.gov/15500858"},"language":"en","primary_location":{"id":"doi:10.1016/s0065-3233(04)68002-8","doi":"https://doi.org/10.1016/s0065-3233(04)68002-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0065-3233(04)68002-8","pdf_url":null,"source":{"id":"https://openalex.org/S60537068","display_name":"Advances in protein chemistry","issn_l":"0065-3233","issn":["0065-3233","1557-8941"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319955","host_organization_name":"Academic Press","host_organization_lineage":["https://openalex.org/P4310319955","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Academic Press","Elsevier BV"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Protein Chemistry","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4241369341","display_name":"Cell Surface Receptors"},"type":"book-chapter","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003615852","display_name":"Timothy A. Springer","orcid":"https://orcid.org/0000-0001-6627-2904","observed_orcids":["https://orcid.org/0000-0001-6627-2904"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy A. Springer","raw_affiliation_strings":["CBR Institute for Biomedical Research, Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CBR Institute for Biomedical Research, Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006030795","display_name":"Jia\u2010Huai Wang","orcid":"https://orcid.org/0000-0003-3478-829X","observed_orcids":["https://orcid.org/0000-0003-3478-829X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jia-Huai Wang","raw_affiliation_strings":["Dana-Farber Cancer Institute, Departments of Pediatrics, Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Departments of Pediatrics, Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115 USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":40.7947,"has_fulltext":false,"cited_by_count":160,"citation_normalized_percentile":{"value":0.99543379,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"68","issue":null,"first_page":"29","last_page":"63"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13326","display_name":"Biochemical and Structural Characterization","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/integrins","display_name":"integrins","score":0.9900000095367432},{"id":"https://openalex.org/keywords/integrin-ligand-interaction","display_name":"integrin-ligand interaction","score":0.9319999814033508},{"id":"https://openalex.org/keywords/three-dimensional-structure","display_name":"three-dimensional structure","score":0.8659999966621399},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.8289999961853027},{"id":"https://openalex.org/keywords/conformational-control","display_name":"conformational control","score":0.9559999704360962},{"id":"https://openalex.org/keywords/ligand-binding-affinity","display_name":"ligand binding affinity","score":0.6349999904632568},{"id":"https://openalex.org/keywords/cell-matrix-contacts","display_name":"cell-matrix contacts","score":0.6549999713897705},{"id":"https://openalex.org/keywords/cell-cell-adhesion","display_name":"cell-cell adhesion","score":0.7770000100135803},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.5770000219345093}],"concepts":[{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.8526401519775391},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.6660168766975403},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6555109024047852},{"id":"https://openalex.org/C16224149","wikidata":"https://www.wikidata.org/wiki/Q187637","display_name":"Cell adhesion molecule","level":2,"score":0.5726364254951477},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.5534003973007202},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5308730602264404},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.5029682517051697},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.49408772587776184},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4383193254470825},{"id":"https://openalex.org/C197462201","wikidata":"https://www.wikidata.org/wiki/Q2476074","display_name":"Cell surface receptor","level":3,"score":0.4170607030391693},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.41356319189071655},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.38805192708969116},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3209909200668335},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.29546216130256653},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2913617491722107}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016023","descriptor_name":"Integrins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016023","descriptor_name":"Integrins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016023","descriptor_name":"Integrins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0065-3233(04)68002-8","doi":"https://doi.org/10.1016/s0065-3233(04)68002-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0065-3233(04)68002-8","pdf_url":null,"source":{"id":"https://openalex.org/S60537068","display_name":"Advances in protein chemistry","issn_l":"0065-3233","issn":["0065-3233","1557-8941"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319955","host_organization_name":"Academic Press","host_organization_lineage":["https://openalex.org/P4310319955","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Academic Press","Elsevier BV"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Protein Chemistry","raw_type":"book-chapter"},{"id":"pmid:15500858","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15500858","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in protein chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":110,"referenced_works":["https://openalex.org/W1485512525","https://openalex.org/W1503392039","https://openalex.org/W1505634985","https://openalex.org/W1506821897","https://openalex.org/W1509156028","https://openalex.org/W1516591371","https://openalex.org/W1516766157","https://openalex.org/W1550140963","https://openalex.org/W1646222158","https://openalex.org/W1646794664","https://openalex.org/W1899737965","https://openalex.org/W1938388466","https://openalex.org/W1942794198","https://openalex.org/W1965841931","https://openalex.org/W1967460539","https://openalex.org/W1968316337","https://openalex.org/W1972470306","https://openalex.org/W1973800056","https://openalex.org/W1976772770","https://openalex.org/W1977102542","https://openalex.org/W1977706672","https://openalex.org/W1987568997","https://openalex.org/W1992259266","https://openalex.org/W1994990169","https://openalex.org/W1995797967","https://openalex.org/W1996257032","https://openalex.org/W1997345442","https://openalex.org/W1998065958","https://openalex.org/W2002304568","https://openalex.org/W2002590458","https://openalex.org/W2003111769","https://openalex.org/W2007991972","https://openalex.org/W2012691080","https://openalex.org/W2013002982","https://openalex.org/W2013379647","https://openalex.org/W2014643665","https://openalex.org/W2015313829","https://openalex.org/W2015826818","https://openalex.org/W2020021028","https://openalex.org/W2021872713","https://openalex.org/W2022431638","https://openalex.org/W2022962151","https://openalex.org/W2025234475","https://openalex.org/W2025358191","https://openalex.org/W2025361420","https://openalex.org/W2028028180","https://openalex.org/W2029231027","https://openalex.org/W2031261181","https://openalex.org/W2034585843","https://openalex.org/W2037672200","https://openalex.org/W2038642657","https://openalex.org/W2041999765","https://openalex.org/W2044831835","https://openalex.org/W2050681882","https://openalex.org/W2052902681","https://openalex.org/W2053929376","https://openalex.org/W2060400867","https://openalex.org/W2063330553","https://openalex.org/W2063559096","https://openalex.org/W2065921660","https://openalex.org/W2066114684","https://openalex.org/W2066371830","https://openalex.org/W2066946505","https://openalex.org/W2069911462","https://openalex.org/W2080407828","https://openalex.org/W2081432568","https://openalex.org/W2085979652","https://openalex.org/W2088377273","https://openalex.org/W2089625435","https://openalex.org/W2089860497","https://openalex.org/W2092017901","https://openalex.org/W2093661044","https://openalex.org/W2093710498","https://openalex.org/W2094469836","https://openalex.org/W2095272173","https://openalex.org/W2098438673","https://openalex.org/W2099675490","https://openalex.org/W2099801792","https://openalex.org/W2100932704","https://openalex.org/W2102227752","https://openalex.org/W2102376680","https://openalex.org/W2105300288","https://openalex.org/W2109483333","https://openalex.org/W2110782874","https://openalex.org/W2120294554","https://openalex.org/W2125435732","https://openalex.org/W2125956028","https://openalex.org/W2132184505","https://openalex.org/W2133075168","https://openalex.org/W2133169381","https://openalex.org/W2133843914","https://openalex.org/W2136102235","https://openalex.org/W2136384184","https://openalex.org/W2136969158","https://openalex.org/W2147791888","https://openalex.org/W2148377692","https://openalex.org/W2150670309","https://openalex.org/W2164867404","https://openalex.org/W2165751778","https://openalex.org/W2170877356","https://openalex.org/W2171854519","https://openalex.org/W2266492038","https://openalex.org/W2325999030","https://openalex.org/W2377109711","https://openalex.org/W2617516516","https://openalex.org/W2949075749","https://openalex.org/W3139752542","https://openalex.org/W4239023878","https://openalex.org/W4244803411","https://openalex.org/W4250722616"],"related_works":["https://openalex.org/W2016464728","https://openalex.org/W2001457449","https://openalex.org/W2032888143","https://openalex.org/W2063330553","https://openalex.org/W1977602054","https://openalex.org/W2585392279","https://openalex.org/W2037060648","https://openalex.org/W2156293127","https://openalex.org/W2411413723","https://openalex.org/W2096392827"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
