{"id":"https://openalex.org/W149395500","doi":null,"title":"Designed Biodegradable and Osteoconductive Porous Scaffolds for Human Trabecular Bone","display_name":"Designed Biodegradable and Osteoconductive Porous Scaffolds for Human Trabecular Bone","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W149395500","mag":"149395500"},"language":"en","primary_location":{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/89789","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/89789","pdf_url":"https://hdl.handle.net/2027.42/89789","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hdl.handle.net/2027.42/89789","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002862662","display_name":"Eiji Saito","orcid":"https://orcid.org/0000-0002-0752-1170","observed_orcids":["https://orcid.org/0000-0002-0752-1170"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Eiji Saito","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0752-1170","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5002862662"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biodegradable-polymer-scaffolds","display_name":"biodegradable polymer scaffolds","score":0.8199999928474426},{"id":"https://openalex.org/keywords/trabecular-bone","display_name":"trabecular bone","score":0.8289999961853027},{"id":"https://openalex.org/keywords/osteoconductivity","display_name":"osteoconductivity","score":0.7879999876022339},{"id":"https://openalex.org/keywords/bone-ingrowth","display_name":"bone ingrowth","score":0.8169999718666077},{"id":"https://openalex.org/keywords/plga","display_name":"PLGA","score":0.6570000052452087},{"id":"https://openalex.org/keywords/poly-l-lactic-acid","display_name":"poly(L-lactic acid)","score":0.9330000281333923},{"id":"https://openalex.org/keywords/polycaprolactone","display_name":"polycaprolactone","score":0.9549999833106995},{"id":"https://openalex.org/keywords/calcium-phosphate-coatings","display_name":"calcium phosphate coatings","score":0.6320000290870667},{"id":"https://openalex.org/keywords/biomineralization","display_name":"biomineralization","score":0.890999972820282},{"id":"https://openalex.org/keywords/scaffold-porosity","display_name":"scaffold porosity","score":0.6740000247955322},{"id":"https://openalex.org/keywords/scaffold-degradation","display_name":"scaffold degradation","score":0.5289999842643738},{"id":"https://openalex.org/keywords/craniofacial-bone-regeneration","display_name":"craniofacial bone regeneration","score":0.6359999775886536},{"id":"https://openalex.org/keywords/bone-graft-substitutes","display_name":"bone graft substitutes","score":0.718999981880188}],"concepts":[{"id":"https://openalex.org/C3018268312","wikidata":"https://www.wikidata.org/wiki/Q2671642","display_name":"Trabecular bone","level":3,"score":0.531732976436615},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.44142138957977295},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.43999993801116943},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.34089195728302},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.23995113372802734},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2282278835773468},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.07821890711784363},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/89789","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/89789","pdf_url":"https://hdl.handle.net/2027.42/89789","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:149395500","doi":null,"is_oa":false,"landing_page_url":"https://deepblue.lib.umich.edu/bitstream/2027.42/89789/1/esaito_1.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/89789","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/89789","pdf_url":"https://hdl.handle.net/2027.42/89789","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4000000059604645,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W149395500.pdf","grobid_xml":"https://content.openalex.org/works/W149395500.grobid-xml"},"referenced_works_count":247,"referenced_works":["https://openalex.org/W1977212","https://openalex.org/W105202280","https://openalex.org/W107244998","https://openalex.org/W126565513","https://openalex.org/W155930765","https://openalex.org/W1482730594","https://openalex.org/W1493766271","https://openalex.org/W1521603321","https://openalex.org/W1604277770","https://openalex.org/W1827480158","https://openalex.org/W1964727874","https://openalex.org/W1964782931","https://openalex.org/W1965750162","https://openalex.org/W1966316996","https://openalex.org/W1968093224","https://openalex.org/W1968194419","https://openalex.org/W1968202950","https://openalex.org/W1968444628","https://openalex.org/W1969094978","https://openalex.org/W1970023570","https://openalex.org/W1970036613","https://openalex.org/W1971339046","https://openalex.org/W1971732908","https://openalex.org/W1972211130","https://openalex.org/W1972451730","https://openalex.org/W1973125811","https://openalex.org/W1975258497","https://openalex.org/W1975478078","https://openalex.org/W1976751657","https://openalex.org/W1977278215","https://openalex.org/W1977947034","https://openalex.org/W1979169277","https://openalex.org/W1980302953","https://openalex.org/W1980353103","https://openalex.org/W1981607266","https://openalex.org/W1981731794","https://openalex.org/W1982816605","https://openalex.org/W1983283949","https://openalex.org/W1983635030","https://openalex.org/W1983943835","https://openalex.org/W1984671834","https://openalex.org/W1984765004","https://openalex.org/W1984821835","https://openalex.org/W1985354494","https://openalex.org/W1985395264","https://openalex.org/W1985862595","https://openalex.org/W1989572711","https://openalex.org/W1990918168","https://openalex.org/W1991766367","https://openalex.org/W1992005807","https://openalex.org/W1993694424","https://openalex.org/W1994232298","https://openalex.org/W1996058081","https://openalex.org/W1996115570","https://openalex.org/W1996130375","https://openalex.org/W1996507095","https://openalex.org/W1997651375","https://openalex.org/W1998111806","https://openalex.org/W2000132081","https://openalex.org/W2000725343","https://openalex.org/W2001291592","https://openalex.org/W2001579238","https://openalex.org/W2002399504","https://openalex.org/W2002896651","https://openalex.org/W2003835394","https://openalex.org/W2004632190","https://openalex.org/W2008029193","https://openalex.org/W2009324167","https://openalex.org/W2009758095","https://openalex.org/W2010361875","https://openalex.org/W2010815972","https://openalex.org/W2012011266","https://openalex.org/W2012150557","https://openalex.org/W2013553103","https://openalex.org/W2013613206","https://openalex.org/W2014949387","https://openalex.org/W2015228859","https://openalex.org/W2015404892","https://openalex.org/W2015513845","https://openalex.org/W2015733583","https://openalex.org/W2016814255","https://openalex.org/W2017066441","https://openalex.org/W2019254961","https://openalex.org/W2019404921","https://openalex.org/W2020434425","https://openalex.org/W2020594734","https://openalex.org/W2021441304","https://openalex.org/W2022867533","https://openalex.org/W2023894506","https://openalex.org/W2024333596","https://openalex.org/W2026975571","https://openalex.org/W2027116665","https://openalex.org/W2028067707","https://openalex.org/W2029209385","https://openalex.org/W2029375632","https://openalex.org/W2029705383","https://openalex.org/W2029737011","https://openalex.org/W2030379955","https://openalex.org/W2032260996","https://openalex.org/W2033708966","https://openalex.org/W2034650092","https://openalex.org/W2035674015","https://openalex.org/W2037349387","https://openalex.org/W2038659352","https://openalex.org/W2038860414","https://openalex.org/W2039277642","https://openalex.org/W2039873196","https://openalex.org/W2039983887","https://openalex.org/W2041786566","https://openalex.org/W2042932723","https://openalex.org/W2044203477","https://openalex.org/W2044417136","https://openalex.org/W2045482198","https://openalex.org/W2048176002","https://openalex.org/W2048816489","https://openalex.org/W2049435279","https://openalex.org/W2049550331","https://openalex.org/W2049592557","https://openalex.org/W2049805949","https://openalex.org/W2050905519","https://openalex.org/W2050930565","https://openalex.org/W2052726451","https://openalex.org/W2052887931","https://openalex.org/W2053602894","https://openalex.org/W2055630021","https://openalex.org/W2055688454","https://openalex.org/W2055833036","https://openalex.org/W2056318812","https://openalex.org/W2056833999","https://openalex.org/W2057484062","https://openalex.org/W2058153577","https://openalex.org/W2062740063","https://openalex.org/W2064137774","https://openalex.org/W2064522198","https://openalex.org/W2066460508","https://openalex.org/W2066533176","https://openalex.org/W2066646366","https://openalex.org/W2067667764","https://openalex.org/W2067779779","https://openalex.org/W2068512435","https://openalex.org/W2070814817","https://openalex.org/W2071107789","https://openalex.org/W2071862112","https://openalex.org/W2073335558","https://openalex.org/W2073583505","https://openalex.org/W2074380747","https://openalex.org/W2074484561","https://openalex.org/W2074725999","https://openalex.org/W2078079939","https://openalex.org/W2078126231","https://openalex.org/W2080132400","https://openalex.org/W2081115178","https://openalex.org/W2081860645","https://openalex.org/W2082112547","https://openalex.org/W2082135472","https://openalex.org/W2082972185","https://openalex.org/W2083674376","https://openalex.org/W2084304606","https://openalex.org/W2084344211","https://openalex.org/W2085733003","https://openalex.org/W2086724256","https://openalex.org/W2087635529","https://openalex.org/W2087987629","https://openalex.org/W2088113615","https://openalex.org/W2090763065","https://openalex.org/W2091124315","https://openalex.org/W2091975029","https://openalex.org/W2093316102","https://openalex.org/W2093998120","https://openalex.org/W2094009987","https://openalex.org/W2094810226","https://openalex.org/W2095489950","https://openalex.org/W2096265932","https://openalex.org/W2097196921","https://openalex.org/W2097892579","https://openalex.org/W2100221459","https://openalex.org/W2101682146","https://openalex.org/W2103116614","https://openalex.org/W2103378167","https://openalex.org/W2103745164","https://openalex.org/W2103814793","https://openalex.org/W2104427836","https://openalex.org/W2104558470","https://openalex.org/W2106035984","https://openalex.org/W2106121106","https://openalex.org/W2108865536","https://openalex.org/W2109846255","https://openalex.org/W2110803235","https://openalex.org/W2111312751","https://openalex.org/W2113042424","https://openalex.org/W2113335122","https://openalex.org/W2113733895","https://openalex.org/W2115870439","https://openalex.org/W2119838587","https://openalex.org/W2120761640","https://openalex.org/W2121341738","https://openalex.org/W2121496050","https://openalex.org/W2122180971","https://openalex.org/W2122574954","https://openalex.org/W2122951429","https://openalex.org/W2123651842","https://openalex.org/W2126109007","https://openalex.org/W2127524214","https://openalex.org/W2129297913","https://openalex.org/W2130966935","https://openalex.org/W2132131875","https://openalex.org/W2132877445","https://openalex.org/W2133716550","https://openalex.org/W2135372180","https://openalex.org/W2135859840","https://openalex.org/W2136691001","https://openalex.org/W2137228458","https://openalex.org/W2137492380","https://openalex.org/W2138248037","https://openalex.org/W2139076385","https://openalex.org/W2140083800","https://openalex.org/W2141845204","https://openalex.org/W2141850961","https://openalex.org/W2143334477","https://openalex.org/W2145374357","https://openalex.org/W2146656953","https://openalex.org/W2147340276","https://openalex.org/W2147721391","https://openalex.org/W2149064558","https://openalex.org/W2151585742","https://openalex.org/W2152621785","https://openalex.org/W2154066806","https://openalex.org/W2159210886","https://openalex.org/W2159480327","https://openalex.org/W2159774995","https://openalex.org/W2161508576","https://openalex.org/W2161515689","https://openalex.org/W2162073465","https://openalex.org/W2165275770","https://openalex.org/W2166454694","https://openalex.org/W2166543184","https://openalex.org/W2169884717","https://openalex.org/W2170515999","https://openalex.org/W2171171939","https://openalex.org/W2172388158","https://openalex.org/W2199338994","https://openalex.org/W2223724969","https://openalex.org/W2347098498","https://openalex.org/W2400533743","https://openalex.org/W2406187077","https://openalex.org/W2408716805","https://openalex.org/W2478504379"],"related_works":["https://openalex.org/W2171179423","https://openalex.org/W2116152676","https://openalex.org/W2783383140","https://openalex.org/W1980302953","https://openalex.org/W4292295558","https://openalex.org/W1997480694","https://openalex.org/W2032260996","https://openalex.org/W6945940510","https://openalex.org/W7064250482","https://openalex.org/W7223183642"],"abstract_inverted_index":{"Current":[0],"bone":[1,19,109,113,173,190,204,221,233,268,303,312,330,334],"graft":[2],"substitutes,":[3],"such":[4,63],"as":[5,64,336,338],"calcium":[6,281],"phosphate":[7,282],"and":[8,32,52,67,86,102,111,170,183,187,189,219,271,275,345],"metals,":[9],"do":[10],"not":[11,202],"have":[12,56,75],"proper":[13],"mechanical":[14,80,125,156,315],"properties":[15,110,126,157,316],"to":[16,29,107,152,209,265,328],"match":[17,108],"native":[18],"tissues":[20],"and/or":[21],"permanently":[22],"stay":[23],"in":[24,192,197,247],"the":[25,139,144,165,193,238,253,297,307,318],"body,":[26],"which":[27],"leads":[28],"stress":[30],"shielding":[31],"chronic":[33],"inflammation.":[34],"As":[35],"an":[36],"alternative":[37],"approach,":[38],"synthetic":[39],"biodegradable":[40,94],"polymer":[41],"scaffolds,":[42,273],"including":[43,78],"Poly":[44],"(lactic-co-glycolic":[45],"acid)":[46,50],"(PLGA),":[47],"poly":[48,53],"(L-lactic":[49],"(PLLA)":[51],"(\u03b5-caprolactone)":[54],"(PCL),":[55],"been":[57],"developed":[58,91],"using":[59,96,158,185,285],"conventional":[60],"fabrication":[61,100],"techniques,":[62],"porogen":[65],"leaching":[66],"phase":[68],"separation":[69],"techniques.":[70],"However,":[71,223],"these":[72],"scaffolds":[73,95,120,180,194,200,207,215,242,277,300,331],"still":[74],"some":[76],"limitations,":[77],"poor":[79],"properties,":[81],"poorly":[82],"interconnected":[83],"porous":[84,93],"architectures,":[85],"lack":[87],"of":[88,118,129,167,179,228,240,317],"osteoconductivity.":[89],"We":[90,250],"osteoconductive":[92],"indirect":[97],"solid":[98],"freeform":[99],"(SFF)":[101],"a":[103,159,286],"biomineral":[104,283,298],"coating":[105],"techniques":[106],"enhance":[112],"formation.":[114,234],"First,":[115],"two":[116],"designs":[117],"50:50PLGA":[119,186,199],"were":[121,181,195,257,278],"fabricated":[122,140,184],"that":[123,138,252,296],"achieved":[124],"within":[127],"those":[128],"human":[130],"trabecular":[131],"bone.":[132],"Micro-computed":[133],"tomography":[134],"(\u00b5-CT)":[135],"data":[136,148,294],"confirmed":[137],"scaffold":[141,155,168,229,340],"architectures":[142,169,218,243],"matched":[143],"designs.":[145],"The":[146],"\u00b5-CT":[147],"was":[149,175,225],"further":[150],"utilized":[151],"computationally":[153],"simulate":[154],"voxel-based":[160],"finite":[161],"element":[162],"method.":[163],"Secondly,":[164],"effect":[166,227,239],"materials":[171],"on":[172,232,244,270],"formation":[174,191,269,335],"examined.":[176],"Three":[177],"types":[178],"designed":[182,262],"PLLA,":[188],"tested":[196],"vivo.":[198],"did":[201],"support":[203],"formation/ingrowth":[205],"into":[206,272],"due":[208],"their":[210,217,260],"rapid":[211],"degradation,":[212],"while":[213],"PLLA":[214,241,274,320],"maintained":[216],"supported":[220,314],"ingrowth.":[222],"there":[224],"no":[226],"pore":[230],"architecture":[231],"Thirdly,":[235],"we":[236],"examined":[237],"long":[245],"term":[246],"vivo":[248,293],"degradation.":[249],"found":[251],"scaffolds\u2019":[254],"degradation":[255,341],"rates":[256],"determined":[258],"by":[259],"initially":[261],"architectures.":[263],"Lastly,":[264],"achieve":[266],"better":[267],"PCL":[276],"coated":[279,299,319],"with":[280,306,332],"layers":[284],"modified":[287],"simulated":[288],"body":[289],"fluid":[290],"technique.":[291],"In":[292],"showed":[295],"had":[301],"improved":[302],"ingrowth":[304,313],"compared":[305],"uncoated":[308],"scaffolds.":[309,321],"Furthermore,":[310],"advanced":[311],"Overall,":[322],"this":[323],"study":[324],"provides":[325],"beneficial":[326],"information":[327],"develop":[329],"enhanced":[333],"well":[337],"controlled":[339],"for":[342],"craniofacial,":[343],"orthopaedic":[344],"spinal":[346],"applications.":[347]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
