{"id":"https://openalex.org/W1493774181","doi":"https://doi.org/10.1111/j.1439-0272.2011.01168.x","title":"Standardised water-soluble extract of Eurycoma longifolia, Tongkat ali, as testosterone booster for managing men with late-onset hypogonadism?","display_name":"Standardised water-soluble extract of Eurycoma longifolia, Tongkat ali, as testosterone booster for managing men with late-onset hypogonadism?","publication_year":2011,"publication_date":"2011-06-15","ids":{"openalex":"https://openalex.org/W1493774181","doi":"https://doi.org/10.1111/j.1439-0272.2011.01168.x","mag":"1493774181","pmid":"https://pubmed.ncbi.nlm.nih.gov/21671978"},"language":"en","primary_location":{"id":"doi:10.1111/j.1439-0272.2011.01168.x","doi":"https://doi.org/10.1111/j.1439-0272.2011.01168.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1439-0272.2011.01168.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1439-0272.2011.01168.x","source":{"id":"https://openalex.org/S87865284","display_name":"Andrologia","issn_l":"0303-4569","issn":["0303-4569","1439-0272"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Andrologia","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1439-0272.2011.01168.x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069547134","display_name":"Mohd Ismail Bin Mohd Tambi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139322472","display_name":"Universiti Sains Malaysia","ror":"https://ror.org/02rgb2k63","country_code":"MY","type":"education","lineage":["https://openalex.org/I139322472"]},{"id":"https://openalex.org/I2799421553","display_name":"Hospital Kuala Lumpur","ror":"https://ror.org/03n0nnh89","country_code":"MY","type":"healthcare","lineage":["https://openalex.org/I2799421553"]}],"countries":["MY"],"is_corresponding":true,"raw_author_name":"M. I. B. M. Tambi","raw_affiliation_strings":["Wellmen Clinic, Damai Service Hospital, Kuala Lumpur, Malaysia. dr_tambi@yahoo.com","Department of Community Medicine, School of Medical Sciences, Universiti Sains Malaysia, Kbg Kerian, Kelantan, Malaysia","Wellmen Clinic, Damai Service Hospital, Kuala Lumpur, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellmen Clinic, Damai Service Hospital, Kuala Lumpur, Malaysia. dr_tambi@yahoo.com","institution_ids":["https://openalex.org/I2799421553"]},{"raw_affiliation_string":"Department of Community Medicine, School of Medical Sciences, Universiti Sains Malaysia, Kbg Kerian, Kelantan, Malaysia","institution_ids":["https://openalex.org/I139322472"]},{"raw_affiliation_string":"Wellmen Clinic, Damai Service Hospital, Kuala Lumpur, Malaysia","institution_ids":["https://openalex.org/I2799421553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050827129","display_name":"Kamarul Imran Musa","orcid":"https://orcid.org/0000-0002-3708-0628","observed_orcids":["https://orcid.org/0000-0002-3708-0628"]},"institutions":[{"id":"https://openalex.org/I139322472","display_name":"Universiti Sains Malaysia","ror":"https://ror.org/02rgb2k63","country_code":"MY","type":"education","lineage":["https://openalex.org/I139322472"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"M. K. Imran","raw_affiliation_strings":["Department of Community Medicine, School of Medical Sciences, Universiti Sains Malaysia, Kbg Kerian, Kelantan, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Community Medicine, School of Medical Sciences, Universiti Sains Malaysia, Kbg Kerian, Kelantan, Malaysia","institution_ids":["https://openalex.org/I139322472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057033632","display_name":"Ralf Henkel","orcid":"https://orcid.org/0000-0003-1128-2982","observed_orcids":["https://orcid.org/0000-0003-1128-2982"]},"institutions":[{"id":"https://openalex.org/I869660684","display_name":"University of the Western Cape","ror":"https://ror.org/00h2vm590","country_code":"ZA","type":"education","lineage":["https://openalex.org/I869660684"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"R. R. Henkel","raw_affiliation_strings":["Department of Medical Bioscience, University of the Western Cape, Bellville, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Bioscience, University of the Western Cape, Bellville, South Africa","institution_ids":["https://openalex.org/I869660684"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5069547134"],"corresponding_institution_ids":["https://openalex.org/I139322472","https://openalex.org/I2799421553"],"apc_list":{"value":2700,"currency":"USD","value_usd":2700},"apc_paid":null,"fwci":5.3406,"has_fulltext":true,"cited_by_count":124,"citation_normalized_percentile":{"value":0.95985939,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"44","issue":null,"first_page":"226","last_page":"230"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12298","display_name":"Phytochemicals and Medicinal Plants","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/eurycoma-longifolia","display_name":"Eurycoma longifolia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/andropause","display_name":"andropause","score":0.9869999885559082},{"id":"https://openalex.org/keywords/testosterone","display_name":"testosterone","score":0.5400000214576721},{"id":"https://openalex.org/keywords/herbal-medicine","display_name":"herbal medicine","score":0.6949999928474426},{"id":"https://openalex.org/keywords/water-soluble-extract","display_name":"water-soluble extract","score":0.8190000057220459},{"id":"https://openalex.org/keywords/serum-testosterone","display_name":"serum testosterone","score":0.5770000219345093},{"id":"https://openalex.org/keywords/men-s-sexual-health","display_name":"male sexual health","score":0.4560000002384186},{"id":"https://openalex.org/keywords/aphrodisiac-effect","display_name":"aphrodisiac effect","score":0.7080000042915344}],"concepts":[{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.6519402265548706},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6507566571235657},{"id":"https://openalex.org/C2778951191","wikidata":"https://www.wikidata.org/wiki/Q211420","display_name":"Aphrodisiac","level":3,"score":0.6420522928237915},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.6014676094055176},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38985615968704224},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.18616324663162231},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.07879003882408142}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007006","descriptor_name":"Hypogonadism","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D013739","descriptor_name":"Testosterone","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D013739","descriptor_name":"Testosterone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035701","descriptor_name":"Eurycoma","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1439-0272.2011.01168.x","doi":"https://doi.org/10.1111/j.1439-0272.2011.01168.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1439-0272.2011.01168.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1439-0272.2011.01168.x","source":{"id":"https://openalex.org/S87865284","display_name":"Andrologia","issn_l":"0303-4569","issn":["0303-4569","1439-0272"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Andrologia","raw_type":"journal-article"},{"id":"pmid:21671978","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21671978","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Andrologia","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/j.1439-0272.2011.01168.x","doi":"https://doi.org/10.1111/j.1439-0272.2011.01168.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1439-0272.2011.01168.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1439-0272.2011.01168.x","source":{"id":"https://openalex.org/S87865284","display_name":"Andrologia","issn_l":"0303-4569","issn":["0303-4569","1439-0272"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Andrologia","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.979200005531311,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1493774181.pdf","grobid_xml":"https://content.openalex.org/works/W1493774181.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1562767874","https://openalex.org/W1571788509","https://openalex.org/W1600973336","https://openalex.org/W1968077233","https://openalex.org/W1970196313","https://openalex.org/W1980577433","https://openalex.org/W1990988407","https://openalex.org/W2000843976","https://openalex.org/W2003561270","https://openalex.org/W2008785291","https://openalex.org/W2024345219","https://openalex.org/W2028690134","https://openalex.org/W2029121529","https://openalex.org/W2036850077","https://openalex.org/W2044906861","https://openalex.org/W2052718395","https://openalex.org/W2057073439","https://openalex.org/W2064603088","https://openalex.org/W2085095343","https://openalex.org/W2088364786","https://openalex.org/W2097830439","https://openalex.org/W2117786508","https://openalex.org/W2119775385","https://openalex.org/W2123806896","https://openalex.org/W2125025234","https://openalex.org/W2133541977","https://openalex.org/W2150490050","https://openalex.org/W2184283194","https://openalex.org/W2265386051","https://openalex.org/W2565562075","https://openalex.org/W3135779939"],"related_works":["https://openalex.org/W3128612269","https://openalex.org/W4406896607","https://openalex.org/W7047556732","https://openalex.org/W2029121529","https://openalex.org/W2118090432","https://openalex.org/W7093696069","https://openalex.org/W2065326994","https://openalex.org/W2565521617","https://openalex.org/W4289731116","https://openalex.org/W7028386964"],"abstract_inverted_index":{"In":[0,16],"most":[1],"countries,":[2],"millions":[3],"of":[4,45,48,71,83,88,116,144,170,192,198],"people":[5],"are":[6,51,67],"relying":[7],"on":[8],"herbal":[9],"medicines":[10],"as":[11,24,132,134,185],"remedy":[12],"for":[13,91,195],"numerous":[14],"ailments.":[15],"South-East":[17],"Asia,":[18],"Eurycoma":[19],"longifolia":[20],"Jack,":[21],"also":[22],"known":[23],"'Malaysian":[25],"ginseng'":[26],"or":[27],"Tongkat":[28,89,121,178],"ali,":[29],"is":[30],"used":[31],"to":[32,38,53,100,153,182],"combat":[33],"stress":[34],"and":[35,37,56,105,157,168,194],"disease":[36],"improve":[39],"physical":[40],"strength.":[41],"Moreover,":[42],"the":[43,46,61,101,106,129,135,145,154,164,171,190,196],"compounds":[44],"roots":[47],"this":[49,120],"plant":[50],"reported":[52],"have":[54],"aphrodisiac":[55],"testosterone":[57,108,137,161],"enhancing":[58],"effects":[59],"in":[60,188],"rat.":[62],"Considering":[63],"that":[64,114],"human":[65],"studies":[66],"not":[68,148],"available,":[69],"76":[70],"320":[72],"patients":[73,118,146,172],"suffering":[74],"from":[75],"late-onset":[76],"hypogonadism":[77],"(LOH)":[78],"were":[79,110],"given":[80],"200":[81],"mg":[82],"a":[84,186],"standardised":[85,102],"water-soluble":[86],"extract":[87,123,180],"ali":[90,122,179],"1":[92],"month.":[93],"The":[94],"Ageing":[95],"Males'":[96],"Symptoms":[97],"(AMS)":[98],"according":[99,152],"rating":[103],"scale":[104,156],"serum":[107,136],"concentration":[109],"taken.":[111],"Results":[112],"show":[113,149],"treatment":[115,141,166],"LOH":[117,193],"with":[119],"significantly":[124],"(P":[125],"<":[126],"0.0001)":[127],"improved":[128],"AMS":[130,155],"score":[131],"well":[133],"concentration.":[138],"While":[139],"before":[140],"only":[142],"10.5%":[143],"did":[147],"any":[150],"complaint":[151],"35.5%":[158],"had":[159],"normal":[160,174],"levels,":[162],"after":[163],"completed":[165],"71.7%":[167],"90.8%":[169],"showed":[173],"values,":[175],"respectively.":[176],"Thus,":[177],"appears":[181],"be":[183],"useful":[184],"supplement":[187],"overcoming":[189],"symptoms":[191],"management":[197],"hypogonadism.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}