{"id":"https://openalex.org/W1493481594","doi":null,"title":"Upregulation of extracellular ATP-induced M\u00fcller cell responses in a dispase model of proliferative vitreoretinopathy.","display_name":"Upregulation of extracellular ATP-induced M\u00fcller cell responses in a dispase model of proliferative vitreoretinopathy.","publication_year":2002,"publication_date":"2002-03-01","ids":{"openalex":"https://openalex.org/W1493481594","mag":"1493481594","pmid":"https://pubmed.ncbi.nlm.nih.gov/11867610"},"language":"en","primary_location":{"id":"pmid:11867610","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11867610","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086963728","display_name":"Mike Francke","orcid":"https://orcid.org/0000-0002-0932-8825","observed_orcids":["https://orcid.org/0000-0002-0932-8825"]},"institutions":[{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Mike Francke","raw_affiliation_strings":["Department of Neurophysiology, Paul Flechsig Institute for Brain Research, University of Leipzig, Jahnallee 59, D-04109 Leipzig, Germany. fram@medizin.uni-leipzig.de"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurophysiology, Paul Flechsig Institute for Brain Research, University of Leipzig, Jahnallee 59, D-04109 Leipzig, Germany. fram@medizin.uni-leipzig.de","institution_ids":["https://openalex.org/I926574661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088904956","display_name":"Michael Weick","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Weick","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068456297","display_name":"Thomas Pannicke","orcid":"https://orcid.org/0000-0001-7435-9540","observed_orcids":["https://orcid.org/0000-0001-7435-9540"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas Pannicke","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047835100","display_name":"Ortrud Uckermann","orcid":"https://orcid.org/0000-0001-8196-604X","observed_orcids":["https://orcid.org/0000-0001-8196-604X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ortrud Uckermann","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081196992","display_name":"Jens Grosche","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jens Grosche","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013990406","display_name":"Iwona Goczalik","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Iwona Goczalik","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101495591","display_name":"Ivan Milenkovi\u0107","orcid":"https://orcid.org/0000-0003-1431-9031","observed_orcids":["https://orcid.org/0000-0003-1431-9031"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ivan Milenkovic","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110111394","display_name":"Susann Uhlmann","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Susanne Uhlmann","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111681820","display_name":"Frank Faude","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Frank Faude","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018272749","display_name":"Peter Wiedemann","orcid":"https://orcid.org/0000-0002-5540-6847","observed_orcids":["https://orcid.org/0000-0002-5540-6847"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter Wiedemann","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045138697","display_name":"Andreas Reichenbach","orcid":"https://orcid.org/0000-0001-5398-032X","observed_orcids":["https://orcid.org/0000-0001-5398-032X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andreas Reichenbach","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5006741407","display_name":"Andreas Bringmann","orcid":"https://orcid.org/0000-0001-6193-8041","observed_orcids":["https://orcid.org/0000-0001-6193-8041"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andreas Bringmann","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.3753,"has_fulltext":false,"cited_by_count":59,"citation_normalized_percentile":{"value":0.92465753,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"43","issue":"3","first_page":"870","last_page":"81"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.8422999978065491,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.8422999978065491,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.05000000074505806,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11377","display_name":"Retinal and Macular Surgery","score":0.024700000882148743,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/proliferative-vitreoretinopathy","display_name":"proliferative vitreoretinopathy","score":0.996999979019165},{"id":"https://openalex.org/keywords/muller-cells","display_name":"M\u00fcller cells","score":0.8799999952316284},{"id":"https://openalex.org/keywords/purinergic-receptors","display_name":"purinergic receptors","score":0.8050000071525574},{"id":"https://openalex.org/keywords/p2y-receptors","display_name":"P2Y receptors","score":0.8050000071525574},{"id":"https://openalex.org/keywords/extracellular-atp","display_name":"extracellular ATP","score":0.9129999876022339},{"id":"https://openalex.org/keywords/intravitreal-injection","display_name":"intravitreal injection","score":0.7350000143051147},{"id":"https://openalex.org/keywords/calcium-imaging","display_name":"calcium imaging","score":0.6019999980926514},{"id":"https://openalex.org/keywords/calcium-activated-potassium-current","display_name":"calcium-activated potassium current","score":0.9150000214576721},{"id":"https://openalex.org/keywords/retinal-detachment","display_name":"retinal detachment","score":0.7609999775886536}],"concepts":[{"id":"https://openalex.org/C2779059073","wikidata":"https://www.wikidata.org/wiki/Q7249608","display_name":"Proliferative vitreoretinopathy","level":4,"score":0.6806446313858032},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.6746691465377808},{"id":"https://openalex.org/C57306754","wikidata":"https://www.wikidata.org/wiki/Q1010629","display_name":"Purinergic receptor","level":3,"score":0.4789296090602875},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.47614455223083496},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.45965996384620667},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4425261616706848},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4141137897968292},{"id":"https://openalex.org/C181080969","wikidata":"https://www.wikidata.org/wiki/Q60097","display_name":"Calcium in biology","level":3,"score":0.41279900074005127},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.4077865779399872},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3951902389526367},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3895342946052551},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.381176620721817},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2520520091056824},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.23457473516464233},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.17011207342147827},{"id":"https://openalex.org/C2780428090","wikidata":"https://www.wikidata.org/wiki/Q625164","display_name":"Retinal detachment","level":3,"score":0.1350911557674408},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11820095777511597},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000814","descriptor_name":"Aniline Compounds","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006984","descriptor_name":"Hypertrophy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010450","descriptor_name":"Endopeptidases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014966","descriptor_name":"Xanthenes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018048","descriptor_name":"Receptors, Purinergic P2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018613","descriptor_name":"Microscopy, Confocal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018630","descriptor_name":"Vitreoretinopathy, Proliferative","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D018630","descriptor_name":"Vitreoretinopathy, Proliferative","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018630","descriptor_name":"Vitreoretinopathy, Proliferative","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D024681","descriptor_name":"Potassium Channels, Calcium-Activated","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051036","descriptor_name":"Large-Conductance Calcium-Activated Potassium Channels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:11867610","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11867610","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},{"id":"mag:1493481594","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11867610","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W23729290","https://openalex.org/W1490350600","https://openalex.org/W1530782261","https://openalex.org/W1585018028","https://openalex.org/W1586130507","https://openalex.org/W1978873070","https://openalex.org/W1979361590","https://openalex.org/W1984559839","https://openalex.org/W1993551809","https://openalex.org/W1996551334","https://openalex.org/W2009667219","https://openalex.org/W2017641307","https://openalex.org/W2019067219","https://openalex.org/W2019762265","https://openalex.org/W2021949728","https://openalex.org/W2025634320","https://openalex.org/W2031384113","https://openalex.org/W2033412905","https://openalex.org/W2046229926","https://openalex.org/W2056279586","https://openalex.org/W2082220840","https://openalex.org/W2086238867","https://openalex.org/W2092465351","https://openalex.org/W2141260882","https://openalex.org/W2144239288","https://openalex.org/W2146262948","https://openalex.org/W2146908013","https://openalex.org/W2163161737","https://openalex.org/W2164865107","https://openalex.org/W2184219790","https://openalex.org/W2205048710","https://openalex.org/W2417473798","https://openalex.org/W4254432479"],"related_works":["https://openalex.org/W2055774678","https://openalex.org/W1586130507","https://openalex.org/W12263762","https://openalex.org/W2019751678","https://openalex.org/W2062393450","https://openalex.org/W2327588337","https://openalex.org/W2085569558","https://openalex.org/W2346980908","https://openalex.org/W23729290","https://openalex.org/W1965128300"],"abstract_inverted_index":{"PURPOSE:":[0],"To":[1],"test":[2],"whether":[3],"in":[4,36,101,142,197,204],"an":[5,17],"animal":[6],"model":[7,103],"of":[8,19,31,39,77,92,104,116,123,133,145,157,169,181,191,199,212,218,236,247,252,256,272],"proliferative":[9],"vitreoretinopathy":[10],"(PVR)":[11],"the":[12,32,37,109,124,131,134,143,170,182,200,213,233,253,270],"M\u00fcller":[13,63,111,146,162,257,273],"glial":[14],"cells":[15,64,112,147,163,258,274],"displayed":[16,113],"upregulation":[18,246],"purinergic":[20,240,248],"P2":[21,78],"receptor-mediated":[22,79],"responses.":[23],"METHODS:":[24],"PVR":[25,44],"was":[26,45,82,140,195],"induced":[27],"by":[28,89,229],"intravitreal":[29],"injection":[30],"proteolytic":[33],"enzyme,":[34],"dispase,":[35],"eyes":[38],"adult":[40],"rabbits.":[41],"The":[42,75],"developing":[43],"examined":[46],"ophthalmoscopically.":[47],"After":[48],"3":[49],"weeks,":[50],"small":[51],"retinal":[52,105,219],"pieces":[53],"were":[54,65,73,164,227],"wholemounted":[55],"and":[56,70,107,121,208],"used":[57],"for":[58],"calcium":[59,68],"imaging,":[60,69],"freshly":[61],"dissociated":[62],"subjected":[66],"to":[67,98,149,166],"patch-clamp":[71],"recordings":[72],"made.":[74],"presence":[76],"Ca(2+)":[80,187,266],"responses":[81,226,267],"determined":[83],"both":[84],"directly--that":[85],"is,":[86],"fluorometrically--and":[87],"indirectly,":[88],"electrophysiological":[90],"recording":[91],"Ca(2+)-activated":[93,192],"K(+)":[94,119,193],"currents.":[95],"RESULTS:":[96],"According":[97],"earlier":[99],"observations":[100],"another":[102],"detachment":[106],"PVR,":[108],"reactive":[110,183,214,254],"hypertrophy,":[114],"downregulation":[115],"inwardly":[117],"rectifying":[118],"currents,":[120],"depolarization":[122],"resting":[125],"membrane":[126],"potential,":[127],"all":[128],"dependent":[129],"on":[130],"severity":[132],"PVR.":[135,260,276],"Further,":[136],"significant":[137],"PVR-induced":[138],"increase":[139,190],"observed":[141],"number":[144],"responding":[148],"adenosine":[150],"5'-triphosphate":[151],"(ATP),":[152],"with":[153],"a":[154],"transient":[155],"elevation":[156],"their":[158],"[Ca(2+)](i).":[159],"If":[160],"isolated":[161],"exposed":[165],"ATP,":[167],"13%":[168],"control":[171,201],"cells,":[172,184,202],"but":[173,203],"29%":[174],"(moderate":[175,206],"PVR)":[176,180,207,211],"or":[177],"53%":[178],"(massive":[179,210],"showed":[185],"fluorometric":[186],"increases.":[188],"An":[189,245],"currents":[194],"measured":[196],"11%":[198],"83%":[205],"90%":[209],"cells.":[215],"Confocal":[216],"images":[217],"wholemounts":[220],"revealed":[221],"similar":[222,225],"results.":[223],"Because":[224],"elicited":[228],"uridine":[230],"triphosphate":[231],"(UTP),":[232],"dominant":[234],"involvement":[235],"metabotropic":[237],"(P2Y":[238],"type)":[239],"receptors":[241,249],"is":[242,250,262],"suggested.":[243],"CONCLUSIONS:":[244],"part":[251],"changes":[255],"during":[259,275],"It":[261],"suggested":[263],"that":[264],"ATP-evoked":[265],"may":[268],"support":[269],"proliferation":[271]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}