{"id":"https://openalex.org/W1493345827","doi":"https://doi.org/10.1161/circ.118.suppl_18.s_1150-c","title":"Abstract 5144: Extended-Release Niacin Reduces LDL-C Particle Number Even In The Absence Of Changes In Total LDL-C Levels","display_name":"Abstract 5144: Extended-Release Niacin Reduces LDL-C Particle Number Even In The Absence Of Changes In Total LDL-C Levels","publication_year":2008,"publication_date":"2008-10-28","ids":{"openalex":"https://openalex.org/W1493345827","doi":"https://doi.org/10.1161/circ.118.suppl_18.s_1150-c","mag":"1493345827"},"language":"en","primary_location":{"id":"doi:10.1161/circ.118.suppl_18.s_1150-c","doi":"https://doi.org/10.1161/circ.118.suppl_18.s_1150-c","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.118.suppl_18.s_1150-c","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038643717","display_name":"Haseeb Jafri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haseeb Jafri","raw_affiliation_strings":["Tufts Med Cntr, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tufts Med Cntr, Boston, MA","institution_ids":["https://openalex.org/I1290900354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109224887","display_name":"Jeffrey T. Kuvin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey T Kuvin","raw_affiliation_strings":["Tufts Med Cntr, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tufts Med Cntr, Boston, MA","institution_ids":["https://openalex.org/I1290900354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053927567","display_name":"Alawi A.A. Alsheikh-Ali","orcid":"https://orcid.org/0000-0002-1213-4546","observed_orcids":["https://orcid.org/0000-0002-1213-4546"]},"institutions":[{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alawi A Alsheikh-Ali","raw_affiliation_strings":["Tufts Med Cntr, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tufts Med Cntr, Boston, MA","institution_ids":["https://openalex.org/I1290900354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003306835","display_name":"Paula Mooney","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paula Mooney","raw_affiliation_strings":["Tufts Med Cntr, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tufts Med Cntr, Boston, MA","institution_ids":["https://openalex.org/I1290900354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058442171","display_name":"Carey D. Kimmelstiel","orcid":"https://orcid.org/0000-0002-1902-1739","observed_orcids":["https://orcid.org/0000-0002-1902-1739"]},"institutions":[{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carey D Kimmelstiel","raw_affiliation_strings":["Tufts Med Cntr, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tufts Med Cntr, Boston, MA","institution_ids":["https://openalex.org/I1290900354"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102904713","display_name":"Richard H. Karas","orcid":"https://orcid.org/0000-0001-7799-091X","observed_orcids":["https://orcid.org/0000-0001-7799-091X"]},"institutions":[{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard H Karas","raw_affiliation_strings":["Tufts Med Cntr, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tufts Med Cntr, Boston, MA","institution_ids":["https://openalex.org/I1290900354"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1290900354"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"118","issue":"suppl_18","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/extended-release-niacin","display_name":"extended-release niacin","score":0.9940000176429749},{"id":"https://openalex.org/keywords/stable-coronary-artery-disease","display_name":"stable coronary artery disease","score":0.9300000071525574},{"id":"https://openalex.org/keywords/proton-nuclear-magnetic-resonance-spectroscopy","display_name":"proton nuclear magnetic resonance spectroscopy","score":0.7720000147819519},{"id":"https://openalex.org/keywords/atherogenic-lipoproteins","display_name":"atherogenic lipoproteins","score":0.7839999794960022},{"id":"https://openalex.org/keywords/lipid-lowering-therapy","display_name":"lipid-lowering therapy","score":0.5950000286102295},{"id":"https://openalex.org/keywords/anti-atherosclerotic-effects","display_name":"anti-atherosclerotic effects","score":0.8999999761581421}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7645772695541382},{"id":"https://openalex.org/C2911022245","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein particle","level":5,"score":0.7249451875686646},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6566580533981323},{"id":"https://openalex.org/C2780092750","wikidata":"https://www.wikidata.org/wiki/Q134658","display_name":"Niacin","level":2,"score":0.6169671416282654},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.6164969205856323},{"id":"https://openalex.org/C62746215","wikidata":"https://www.wikidata.org/wiki/Q14890615","display_name":"Apolipoprotein B","level":3,"score":0.565372109413147},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.547373354434967},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.52284175157547},{"id":"https://openalex.org/C2778213512","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary artery disease","level":2,"score":0.5085946321487427},{"id":"https://openalex.org/C74412414","wikidata":"https://www.wikidata.org/wiki/Q181155","display_name":"Particle number","level":3,"score":0.49938082695007324},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.3837854266166687},{"id":"https://openalex.org/C8243546","wikidata":"https://www.wikidata.org/wiki/Q419074","display_name":"Very low-density lipoprotein","level":4,"score":0.21243491768836975},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0710567831993103},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C82706917","wikidata":"https://www.wikidata.org/wiki/Q10251","display_name":"Plasma","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.118.suppl_18.s_1150-c","doi":"https://doi.org/10.1161/circ.118.suppl_18.s_1150-c","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.118.suppl_18.s_1150-c","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2121763108","https://openalex.org/W2019863077","https://openalex.org/W2049858854","https://openalex.org/W2051258281","https://openalex.org/W2006296978","https://openalex.org/W7097157230","https://openalex.org/W2947974592","https://openalex.org/W2142227674","https://openalex.org/W2115096598","https://openalex.org/W2123059441"],"abstract_inverted_index":{"Introduction:":[0],"The":[1,24,39,174],"importance":[2],"of":[3,6,19,26,42,83,107,165,179,247,250,255,271],"the":[4,16,81,162,187,226,245,251,297],"number":[5,34,62,119,164,246,281],"circulating":[7,248],"low-density":[8],"lipoprotein":[9,58],"cholesterol":[10,59],"(LDL-C)":[11],"particles,":[12],"in":[13,112,143,177,186,219,225,279],"addition":[14,82,113],"to":[15,46,104,114,147,191,209,284],"total":[17,156,262],"level":[18],"LDL-C":[20,32,51,78,88,99,157,171,240,263],"is":[21],"increasingly":[22],"recognized.":[23],"effects":[25,49,291],"Extended":[27],"Release":[28],"Niacin":[29],"(ERN)":[30],"on":[31,50,56,155,261],"particle":[33,52,61,89,181,223,269,280],"have":[35],"not":[36,293],"been":[37],"studied.":[38],"primary":[40],"objective":[41],"this":[43],"study":[44],"was":[45,63,120,183],"evaluate":[47],"ERN\u2019s":[48,54],"number.":[53,90],"effect":[55,154,260],"high-density":[57],"(HDL-C)":[60],"a":[64],"secondary":[65],"objective.":[66],"Hypothesis":[67],":":[68],"In":[69,233],"patients":[70,93,228,234],"with":[71,94,235],"stable":[72,95,236],"coronary":[73],"artery":[74],"disease":[75],"(CAD)":[76],"and":[77,97,130,136,167,203,238,288],"at":[79,128],"goal,":[80],"ERN":[84,108,150,188,198,242,265],"will":[85],"favorably":[86,267],"alter":[87],"Methods:":[91],"60":[92],"CAD":[96,237],"well-controlled":[98,239],"levels":[100,202],"were":[101,215],"randomly":[102],"assigned":[103],"3":[105,132],"months":[106],"(1g/d)":[109],"or":[110,222],"placebo":[111,192],"their":[115],"baseline":[116,129],"medications.":[117],"Particle":[118],"analyzed":[121],"by":[122],"proton":[123],"nuclear":[124],"magnetic":[125],"resonance":[126],"spectroscopy":[127],"after":[131],"months.":[133],"Results:":[134],"Baseline":[135],"follow":[137],"up":[138],"lipid":[139,220,299],"values":[140,221],"are":[141],"shown":[142],"Table":[144,230],".":[145],"Compared":[146],"baseline,":[148],"while":[149],"had":[151],"no":[152,216,259],"significant":[153,217],"levels,":[158,241],"it":[159],"significantly":[160,184,205,243],"decreased":[161],"mean":[163],"medium":[166],"small":[168,170,208],"very":[169],"particles":[172,212,249],"(p=0.005).":[173],"percent":[175],"change":[176],"each":[178],"these":[180,290],"numbers":[182,224,270],"greater":[185],"group":[189],"compared":[190],"as":[193],"well":[194],"(p<0.05":[195],"for":[196],"each)":[197],"therapy":[199],"raised":[200],"HDL-C":[201,211],"also":[204,266],"shifted":[206],"from":[207,296],"large":[210],"(p<0.001).":[213],"There":[214],"changes":[218],"placebo-treated":[227],"(":[229],").":[231],"Conclusion:":[232],"reduced":[244],"more":[252],"atherogenic":[253],"subtypes":[254],"LDL-C,":[256],"despite":[257],"having":[258],"levels.":[264],"altered":[268],"HDL-C.":[272],"These":[273],"findings":[274],"suggest":[275],"that":[276,289],"ERN-induced":[277],"alterations":[278],"may":[282,292],"contribute":[283],"its":[285],"anti-atherosclerotic":[286],"effects,":[287],"be":[294],"evident":[295],"standard":[298],"profile.":[300]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}
