{"id":"https://openalex.org/W1493328409","doi":null,"title":"Antivasculature effects of doxorubicin-containing liposomes in an intracranial rat brain tumor model.","display_name":"Antivasculature effects of doxorubicin-containing liposomes in an intracranial rat brain tumor model.","publication_year":2002,"publication_date":"2002-05-01","ids":{"openalex":"https://openalex.org/W1493328409","mag":"1493328409","pmid":"https://pubmed.ncbi.nlm.nih.gov/11980650"},"language":"en","primary_location":{"id":"pmid:11980650","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11980650","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069305433","display_name":"Rong Zhou","orcid":"https://orcid.org/0000-0003-4018-381X","observed_orcids":["https://orcid.org/0000-0003-4018-381X"]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rong Zhou","raw_affiliation_strings":["Department of Pharmaceutical Sciences, University at Buffalo, State University of New York, Amherst, New York 14260-1200, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, University at Buffalo, State University of New York, Amherst, New York 14260-1200, USA","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082718881","display_name":"Richard Mazurchuk","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard Mazurchuk","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5057883761","display_name":"Robert M. Straubinger","orcid":"https://orcid.org/0000-0003-0870-9236","observed_orcids":["https://orcid.org/0000-0003-0870-9236"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert M Straubinger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.2244,"has_fulltext":false,"cited_by_count":71,"citation_normalized_percentile":{"value":0.91477927,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"62","issue":"9","first_page":"2561","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.8910999894142151,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.8910999894142151,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.049300000071525574,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.014100000262260437,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.9200000166893005},{"id":"https://openalex.org/keywords/liposomes","display_name":"liposomes","score":0.6579999923706055},{"id":"https://openalex.org/keywords/gliosarcoma","display_name":"gliosarcoma","score":0.8080000281333923},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.7149999737739563},{"id":"https://openalex.org/keywords/vascular-permeability","display_name":"vascular permeability","score":0.8629999756813049},{"id":"https://openalex.org/keywords/intratumoral-hemorrhage","display_name":"intratumoral hemorrhage","score":0.8769999742507935},{"id":"https://openalex.org/keywords/fmri","display_name":"functional MRI","score":0.5889999866485596},{"id":"https://openalex.org/keywords/bold-contrast","display_name":"BOLD contrast","score":0.5759999752044678},{"id":"https://openalex.org/keywords/tumor-necrosis","display_name":"tumor necrosis","score":0.5490000247955322},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.5429999828338623},{"id":"https://openalex.org/keywords/drug-delivery","display_name":"drug delivery","score":0.375}],"concepts":[{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.8115253448486328},{"id":"https://openalex.org/C2777295375","wikidata":"https://www.wikidata.org/wiki/Q609503","display_name":"Gliosarcoma","level":3,"score":0.6045209169387817},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5571969151496887},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5498051643371582},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.47891223430633545},{"id":"https://openalex.org/C2778271429","wikidata":"https://www.wikidata.org/wiki/Q1281049","display_name":"Neovascularization","level":3,"score":0.46102720499038696},{"id":"https://openalex.org/C2779130545","wikidata":"https://www.wikidata.org/wiki/Q233309","display_name":"Brain tumor","level":2,"score":0.44955241680145264},{"id":"https://openalex.org/C185154212","wikidata":"https://www.wikidata.org/wiki/Q410454","display_name":"Liposome","level":2,"score":0.43305543065071106},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.34224408864974976},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.31607192754745483},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.31522852182388306},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2997049391269684},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.25388485193252563},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.20911332964897156},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19757837057113647},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.08400934934616089},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000903","descriptor_name":"Antibiotics, Antineoplastic","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011916","descriptor_name":"Rats, Inbred F344","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:11980650","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11980650","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:1493328409","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11980650","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W16822270","https://openalex.org/W103074952","https://openalex.org/W173329501","https://openalex.org/W1513897103","https://openalex.org/W1519808760","https://openalex.org/W1902883158","https://openalex.org/W1966553263","https://openalex.org/W1978728063","https://openalex.org/W2001107461","https://openalex.org/W2002165841","https://openalex.org/W2002267109","https://openalex.org/W2009058800","https://openalex.org/W2028065774","https://openalex.org/W2029587579","https://openalex.org/W2037563014","https://openalex.org/W2042098439","https://openalex.org/W2046102796","https://openalex.org/W2056574134","https://openalex.org/W2061350341","https://openalex.org/W2078796888","https://openalex.org/W2086459955","https://openalex.org/W2094013932","https://openalex.org/W2097282168","https://openalex.org/W2101961850","https://openalex.org/W2103681669","https://openalex.org/W2115036341","https://openalex.org/W2118878458","https://openalex.org/W2141394481","https://openalex.org/W2158449037","https://openalex.org/W2167455663","https://openalex.org/W2168454302","https://openalex.org/W2169794253","https://openalex.org/W2263515907","https://openalex.org/W2426107805"],"related_works":["https://openalex.org/W16822270","https://openalex.org/W2400387842","https://openalex.org/W2909775501","https://openalex.org/W2009058800","https://openalex.org/W2048395537","https://openalex.org/W2132257982","https://openalex.org/W2754152900","https://openalex.org/W1991980008","https://openalex.org/W2185469212","https://openalex.org/W2165824272"],"abstract_inverted_index":{"Increased":[0],"neovascularization":[1],"and":[2,10,31,66,79,176,179,200,204,221,229,255],"vascular":[3,231,260],"hyperpermeability":[4],"are":[5],"integral":[6],"processes":[7],"in":[8,23,33,46,103,122,142,146,156,253],"tumors,":[9],"various":[11],"therapeutic":[12,67],"strategies":[13],"seek":[14],"to":[15,95],"reverse":[16],"the":[17,27,61,73,117,172,184,187,237,248],"angiogenic":[18],"phenotype.":[19],"Long-circulating":[20],"liposomes":[21,107,252],"extravasate":[22],"tumors":[24],"such":[25,37],"as":[26],"rat":[28],"9L":[29,92],"gliosarcoma":[30],"accumulate":[32],"perivascular":[34,249],"areas.":[35],"Under":[36],"conditions,":[38],"liposome-encapsulated":[39],"doxorubicin":[40],"(DOX)":[41],"provides":[42],"approximately":[43],"30%":[44],"increase":[45],"life":[47],"span,":[48],"but":[49],"free":[50,99,150],"DOX":[51,100,102,151],"is":[52,69],"no":[53],"more":[54],"beneficial":[55],"than":[56],"a":[57,137],"saline":[58,157],"control.":[59],"However,":[60],"relationship":[62],"between":[63],"drug":[64],"deposition":[65],"effect":[68],"understood":[70],"poorly.":[71],"In":[72],"present":[74],"work,":[75],"magnetic":[76],"resonance":[77],"(MR)":[78],"functional":[80],"MR":[81,114,134,169],"(fMR)":[82],"imaging":[83,115,135,170],"were":[84,191],"used":[85],"for":[86],"noninvasive,":[87],"serial":[88],"evaluation":[89],"of":[90,98,112,119,124,140,186,224,239,251],"intracranial":[91],"tumor":[93,181,240,254,259],"responses":[94],"repetitive":[96],"doses":[97,111,223],"or":[101,155],"sterically":[104],"stabilized":[105],"long-circulating":[106],"(SSL-DOX).":[108],"After":[109],"multiple":[110,222],"SSL-DOX,":[113,141,225],"revealed":[116,177],"induction":[118],"intratumor":[120],"hemorrhage":[121,130],"63-75%":[123],"rats":[125,165],"(n":[126,152,159],"=":[127,153,160],"8).":[128],"No":[129],"was":[131],"observed":[132],"by":[133,193,243],"after":[136,168,218],"single":[138,220],"dose":[139],"normal":[143],"brain":[144],"regions":[145,175],"animals":[147],"treated":[148],"with":[149],"3)":[154],"controls":[158],"9).":[161],"Histological":[162],"sections":[163],"from":[164,247],"sacrificed":[166],"immediately":[167],"verified":[171],"putative":[173],"hemorrhagic":[174],"necrotic":[178],"apoptotic":[180],"cells":[182],"surrounding":[183],"area":[185],"hemorrhage.":[188],"fMR":[189,212],"maps":[190,213],"obtained":[192],"comparing":[194],"paired":[195],"images":[196],"acquired":[197],"during":[198],"air":[199],"Carbogen":[201],"(7%":[202],"CO2":[203],"93%":[205],"oxygen)":[206],"breathing.":[207],"These":[208],"blood":[209],"oxygenation":[210],"level-dependent":[211],"showed":[214],"enhanced":[215],"image":[216],"intensity":[217],"both":[219],"which":[226],"suggested":[227],"increased":[228],"progressive":[230],"permeabilization.":[232],"The":[233],"results":[234],"suggest":[235],"that":[236],"breakdown":[238],"vasculature":[241],"induced":[242],"SSL-DOX":[244],"may":[245],"arise":[246],"accumulation":[250],"cytotoxic":[256],"effects":[257],"on":[258],"endothelium.":[261]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
