{"id":"https://openalex.org/W1493230854","doi":"https://doi.org/10.1016/s0021-9258(19)45760-8","title":"Glucocorticoid-binding Macromolecules in Normal Tissues and Tumors","display_name":"Glucocorticoid-binding Macromolecules in Normal Tissues and Tumors","publication_year":1972,"publication_date":"1972-01-01","ids":{"openalex":"https://openalex.org/W1493230854","doi":"https://doi.org/10.1016/s0021-9258(19)45760-8","mag":"1493230854","pmid":"https://pubmed.ncbi.nlm.nih.gov/5067124"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-9258(19)45760-8","doi":"https://doi.org/10.1016/s0021-9258(19)45760-8","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)45760-8","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0021-9258(19)45760-8","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062187360","display_name":"Anthony F. Kirkpatrick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]},{"id":"https://openalex.org/I1298060332","display_name":"New York State Department of Health","ror":"https://ror.org/04hf5kq57","country_code":"US","type":"government","lineage":["https://openalex.org/I1298060332"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony F. Kirkpatrick","raw_affiliation_strings":["From the Department of Experimental Therapeutics, Roswell Park Memorial Institute, New York State Department of Health, Buffalo, New York 14203"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Experimental Therapeutics, Roswell Park Memorial Institute, New York State Department of Health, Buffalo, New York 14203","institution_ids":["https://openalex.org/I1292894508","https://openalex.org/I1298060332"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110124347","display_name":"Nurit Kaiser","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]},{"id":"https://openalex.org/I1298060332","display_name":"New York State Department of Health","ror":"https://ror.org/04hf5kq57","country_code":"US","type":"government","lineage":["https://openalex.org/I1298060332"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nurit Kaiser","raw_affiliation_strings":["From the Department of Experimental Therapeutics, Roswell Park Memorial Institute, New York State Department of Health, Buffalo, New York 14203"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Experimental Therapeutics, Roswell Park Memorial Institute, New York State Department of Health, Buffalo, New York 14203","institution_ids":["https://openalex.org/I1292894508","https://openalex.org/I1298060332"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049801834","display_name":"Richard J. Milholland","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]},{"id":"https://openalex.org/I1298060332","display_name":"New York State Department of Health","ror":"https://ror.org/04hf5kq57","country_code":"US","type":"government","lineage":["https://openalex.org/I1298060332"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard J. Milholland","raw_affiliation_strings":["From the Department of Experimental Therapeutics, Roswell Park Memorial Institute, New York State Department of Health, Buffalo, New York 14203"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Experimental Therapeutics, Roswell Park Memorial Institute, New York State Department of Health, Buffalo, New York 14203","institution_ids":["https://openalex.org/I1292894508","https://openalex.org/I1298060332"]}]},{"author_position":"last","author":{"id":null,"display_name":"Fred Rosen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]},{"id":"https://openalex.org/I1298060332","display_name":"New York State Department of Health","ror":"https://ror.org/04hf5kq57","country_code":"US","type":"government","lineage":["https://openalex.org/I1298060332"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fred Rosen","raw_affiliation_strings":["From the Department of Experimental Therapeutics, Roswell Park Memorial Institute, New York State Department of Health, Buffalo, New York 14203"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Experimental Therapeutics, Roswell Park Memorial Institute, New York State Department of Health, Buffalo, New York 14203","institution_ids":["https://openalex.org/I1292894508","https://openalex.org/I1298060332"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":8.0408,"has_fulltext":false,"cited_by_count":51,"citation_normalized_percentile":{"value":0.97859262,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"247","issue":"1","first_page":"70","last_page":"74"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glucocorticoid-binding-proteins","display_name":"glucocorticoid-binding proteins","score":0.8949999809265137},{"id":"https://openalex.org/keywords/triamcinolone-acetonide","display_name":"triamcinolone acetonide","score":0.9599999785423279},{"id":"https://openalex.org/keywords/cortisol","display_name":"cortisol","score":0.8650000095367432},{"id":"https://openalex.org/keywords/adrenalectomy","display_name":"adrenalectomy","score":0.8550000190734863},{"id":"https://openalex.org/keywords/thymus","display_name":"thymus","score":0.7789999842643738},{"id":"https://openalex.org/keywords/testis","display_name":"testis","score":0.6740000247955322},{"id":"https://openalex.org/keywords/cerebral-cortex","display_name":"cerebral cortex","score":0.9860000014305115},{"id":"https://openalex.org/keywords/steroid-binding-specificity","display_name":"steroid binding specificity","score":0.4560000002384186}],"concepts":[{"id":"https://openalex.org/C2780841215","wikidata":"https://www.wikidata.org/wiki/Q422549","display_name":"Glucocorticoid","level":2,"score":0.6178445816040039},{"id":"https://openalex.org/C204389451","wikidata":"https://www.wikidata.org/wiki/Q178593","display_name":"Macromolecule","level":2,"score":0.6172069311141968},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5172815322875977},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.37684839963912964},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.28602999448776245},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2735106945037842}],"mesh":[{"descriptor_ui":"D000311","descriptor_name":"Adrenal Glands","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000315","descriptor_name":"Adrenalectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002474","descriptor_name":"Cell-Free System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004355","descriptor_name":"Drug Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008228","descriptor_name":"Lymphoma, Non-Hodgkin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013737","descriptor_name":"Testis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013950","descriptor_name":"Thymus Gland","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014222","descriptor_name":"Triamcinolone Acetonide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014316","descriptor_name":"Tritium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046911","descriptor_name":"Macromolecular Substances","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0021-9258(19)45760-8","doi":"https://doi.org/10.1016/s0021-9258(19)45760-8","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)45760-8","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:5067124","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/5067124","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0021-9258(19)45760-8","doi":"https://doi.org/10.1016/s0021-9258(19)45760-8","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)45760-8","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W168803270","https://openalex.org/W257073746","https://openalex.org/W1503878308","https://openalex.org/W1504596048","https://openalex.org/W1529465204","https://openalex.org/W1775749144","https://openalex.org/W1985848644","https://openalex.org/W2025444976","https://openalex.org/W2026912546","https://openalex.org/W2038448150","https://openalex.org/W2058590144","https://openalex.org/W2059814262","https://openalex.org/W2068175877","https://openalex.org/W2082531515","https://openalex.org/W2090261886","https://openalex.org/W2093964893","https://openalex.org/W2108720656","https://openalex.org/W2123164383","https://openalex.org/W2140162351","https://openalex.org/W2280629071","https://openalex.org/W2327546255","https://openalex.org/W2328717398","https://openalex.org/W2416097953","https://openalex.org/W2529490307"],"related_works":["https://openalex.org/W2043413880","https://openalex.org/W1539633722","https://openalex.org/W1523452230","https://openalex.org/W1521361967","https://openalex.org/W2529490307","https://openalex.org/W2167313563","https://openalex.org/W2080072126","https://openalex.org/W2006477794","https://openalex.org/W2076614332","https://openalex.org/W2152638351"],"abstract_inverted_index":{"Abstract":[0],"A":[1,181],"simple":[2],"cell-free":[3],"system":[4],"was":[5,27,52,116],"developed":[6],"for":[7,12],"studying":[8],"specific":[9,158,171],"binding":[10,65,74,80,91,114,126,142,172],"components":[11],"glucocorticoids":[13],"in":[14,93,156,160,170,176],"normal":[15],"as":[16,18,33],"well":[17],"neoplastic":[19],"tissues":[20],"of":[21,57,72,87,89,96,104,106,112,127,149,173],"the":[22,30,55,60,64,73,79,90,94,107,113,119,125,133,141,150,163,177,186,195,200],"mouse.":[23],"The":[24,85,110,146],"steroid-macromolecular":[25],"complex":[26],"extracted":[28],"from":[29,42,82,185,198],"lymphosarcoma":[31,179],"P1798":[32],"a":[34,157],"27,000":[35],"x":[36],"g":[37],"supernatant":[38],"fraction":[39,184,197],"and":[40],"separated":[41],"free":[43],"steroid":[44],"by":[45,70,118,130,143],"gel":[46],"chromatography.":[47],"When":[48],"9\u03b1-fluoro-11\u03b2-16\u03b1,21-tetrahydroxy-pregna-1,4-diene-3,20-dione-16,17-acetonide":[49],"(triamcinolone":[50],"acetonide)":[51],"present":[53],"at":[54],"time":[56],"cell":[58],"breakage,":[59],"results":[61],"indicate":[62],"that":[63,105,121],"process":[66],"is":[67,101],"not":[68],"complicated":[69],"degradation":[71,88],"component.":[75,109],"Triamcinolone":[76],"acetonide":[77,129,155,175,193],"protected":[78],"component":[81,92,115],"spontaneous":[83],"degradation.":[84],"rate":[86],"presence":[95],"this":[97],"potent":[98],"synthetic":[99],"glucocorticoid":[100],"approximately":[102],"one-eightieth":[103],"unprotected":[108],"specificity":[111],"demonstrated":[117],"finding":[120],"11\u03b2,17\u03b1,21-trihydroxypregn-4-ene-3,20-dione":[122],"(cortisol)":[123],"depressed":[124],"[1,2,4-3H3]triamcinolone":[128,174],"90%,":[131],"whereas":[132],"biologically":[134],"inactive":[135],"stereoisomer,":[136],"11\u03b1,":[137],"17\u03b1,21-trihydroxypregn-4-ene-3,20-dione":[138],"(11-epicortisol),":[139],"reduced":[140],"only":[144],"20%.":[145],"resistant":[147],"subline":[148],"tumor":[151],"binds":[152,188],"less":[153],"[1,2,4-3H3]-triamicinolone":[154],"manner":[159],"comparison":[161],"to":[162],"sensitive":[164],"neoplasm.":[165],"Adrenalectomy":[166],"causes":[167],"an":[168],"increase":[169],"glucocorticoidsensitive":[178],"P1798.":[180],"soluble":[182],"macromolecular":[183],"thymus":[187],"3":[189],"times":[190],"more":[191],"[1,2,4-3H3]-triamcinolone":[192],"than":[194],"corresponding":[196],"either":[199],"testis":[201],"or":[202],"cerebral":[203],"cortex.":[204]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}