{"id":"https://openalex.org/W1492971972","doi":null,"title":"Breast implant-associated ALK-negative anaplastic large cell lymphoma: a case report and discussion of possible pathogenesis.","display_name":"Breast implant-associated ALK-negative anaplastic large cell lymphoma: a case report and discussion of possible pathogenesis.","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W1492971972","mag":"1492971972","pmid":"https://pubmed.ncbi.nlm.nih.gov/23923082","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3726980"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:2727697","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3726980","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3726980","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051915198","display_name":"Eva Vertes George","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eva V George","raw_affiliation_strings":["Department of Pathology, Immunology, Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL 32607, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Immunology, Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL 32607, USA","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049342737","display_name":"John Pharm","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John Pharm","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Courtney Houston","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Courtney Houston","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027443057","display_name":"Semar Al-Quran","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Semar Al-Quran","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029657894","display_name":"Grey Brian","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Grey Brian","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010208196","display_name":"Hui\u2010Jia Dong","orcid":"https://orcid.org/0000-0003-2494-8392","observed_orcids":["https://orcid.org/0000-0003-2494-8392"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Huijia Dong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Wang Hai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wang Hai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029479045","display_name":"Westley H. Reeves","orcid":"https://orcid.org/0000-0002-2924-4549","observed_orcids":["https://orcid.org/0000-0002-2924-4549"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Westley Reeves","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Li-Jun Yang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Li-Jun Yang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":7.0109,"has_fulltext":false,"cited_by_count":77,"citation_normalized_percentile":{"value":0.97217447,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"6","issue":"8","first_page":"1631","last_page":"42"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11258","display_name":"Breast Implant and Reconstruction","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11258","display_name":"Breast Implant and Reconstruction","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.013399999588727951,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-implant-associated-anaplastic-large-cell-lymphoma","display_name":"breast implant-associated anaplastic large cell lymphoma","score":0.9810000061988831},{"id":"https://openalex.org/keywords/alk-negative-anaplastic-large-cell-lymphoma","display_name":"ALK-negative anaplastic large cell lymphoma","score":0.9359999895095825},{"id":"https://openalex.org/keywords/lymphoid-neogenesis","display_name":"lymphoid neogenesis","score":0.9369999766349792},{"id":"https://openalex.org/keywords/ectopic-lymphoid-tissue","display_name":"ectopic lymphoid tissue","score":0.8100000023841858},{"id":"https://openalex.org/keywords/capsulectomy","display_name":"capsulectomy","score":0.8029999732971191},{"id":"https://openalex.org/keywords/chronic-inflammation","display_name":"chronic inflammation","score":0.8709999918937683},{"id":"https://openalex.org/keywords/genomic-instability","display_name":"genomic instability","score":0.9810000061988831},{"id":"https://openalex.org/keywords/lymphomagenesis","display_name":"lymphomagenesis","score":0.6100000143051147},{"id":"https://openalex.org/keywords/axillary-lymph-node-involvement","display_name":"axillary lymph node involvement","score":0.6830000281333923},{"id":"https://openalex.org/keywords/breast-reconstruction","display_name":"breast reconstruction","score":0.36399999260902405}],"concepts":[{"id":"https://openalex.org/C2777872185","wikidata":"https://www.wikidata.org/wiki/Q486090","display_name":"Anaplastic large-cell lymphoma","level":3,"score":0.8507726192474365},{"id":"https://openalex.org/C2778187792","wikidata":"https://www.wikidata.org/wiki/Q749053","display_name":"Breast implant","level":3,"score":0.6670066118240356},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6657696962356567},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5438223481178284},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.46494001150131226},{"id":"https://openalex.org/C70905583","wikidata":"https://www.wikidata.org/wiki/Q3648608","display_name":"CD30","level":3,"score":0.4457658529281616},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.43878239393234253},{"id":"https://openalex.org/C2781411149","wikidata":"https://www.wikidata.org/wiki/Q486975","display_name":"Implant","level":2,"score":0.34467369318008423},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.3381742537021637},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2827931046485901},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.19255629181861877},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1792510449886322}],"mesh":[{"descriptor_ui":"D000077548","descriptor_name":"Anaplastic Lymphoma Kinase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016609","descriptor_name":"Neoplasms, Second Primary","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D016609","descriptor_name":"Neoplasms, Second Primary","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D017728","descriptor_name":"Lymphoma, Large-Cell, Anaplastic","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D017728","descriptor_name":"Lymphoma, Large-Cell, Anaplastic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018270","descriptor_name":"Carcinoma, Ductal, Breast","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D018427","descriptor_name":"Breast Implants","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D020794","descriptor_name":"Receptor Protein-Tyrosine Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:2727697","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3726980","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3726980","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3726980","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Pathol","raw_type":"Text"},{"id":"pmid:23923082","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23923082","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental pathology","raw_type":"Case Reports"},{"id":"mag:1492971972","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23923082","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2727697","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3726980","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[{"id":"https://openalex.org/G5176667397","display_name":"PATHOGENESIS OF PRISTANE-INDUCED LUPUS","funder_award_id":"R01AR044731","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W123782986","https://openalex.org/W175013290","https://openalex.org/W1524489095","https://openalex.org/W1548967973","https://openalex.org/W1888665141","https://openalex.org/W1969136385","https://openalex.org/W1972063953","https://openalex.org/W1976295398","https://openalex.org/W1983561991","https://openalex.org/W1991133811","https://openalex.org/W1998226303","https://openalex.org/W2008782135","https://openalex.org/W2010724132","https://openalex.org/W2010768033","https://openalex.org/W2013871209","https://openalex.org/W2018486458","https://openalex.org/W2023068350","https://openalex.org/W2031797893","https://openalex.org/W2043168400","https://openalex.org/W2047982267","https://openalex.org/W2048706422","https://openalex.org/W2053556636","https://openalex.org/W2061478340","https://openalex.org/W2067281989","https://openalex.org/W2072669542","https://openalex.org/W2081366076","https://openalex.org/W2084831115","https://openalex.org/W2085953368","https://openalex.org/W2088194700","https://openalex.org/W2090272122","https://openalex.org/W2094333077","https://openalex.org/W2100537129","https://openalex.org/W2100754484","https://openalex.org/W2117289091","https://openalex.org/W2120820674","https://openalex.org/W2125946689","https://openalex.org/W2126639783","https://openalex.org/W2144242078","https://openalex.org/W2148355489","https://openalex.org/W2149566233","https://openalex.org/W2154603191","https://openalex.org/W2517435317","https://openalex.org/W2525347801"],"related_works":["https://openalex.org/W2591350863","https://openalex.org/W3205912216","https://openalex.org/W4405025523","https://openalex.org/W3125703368","https://openalex.org/W3092093067","https://openalex.org/W4413005776","https://openalex.org/W4214812668","https://openalex.org/W2954925637","https://openalex.org/W2972061320","https://openalex.org/W4410828351"],"abstract_inverted_index":{"Breast":[0],"implant":[1,162],"associated":[2],"anaplastic":[3],"large":[4],"cell":[5],"lymphoma":[6],"(BIA-ALCL)":[7],"is":[8,55,204],"a":[9,61,67,71,101],"recently":[10],"recognized":[11],"clinical":[12,29],"entity,":[13],"with":[14,49,70,89,170,194,220],"only":[15],"39":[16],"well-documented":[17],"cases":[18],"reported":[19,207],"worldwide,":[20],"including":[21],"3":[22],"fatalities.":[23],"Because":[24],"of":[25,33,45,63,80,114,131,143,174,189,197,209,214,229,240,249],"its":[26],"rarity,":[27],"the":[28,43,105,112,144,160,181,198,205,218,224,230,237,247],"and":[30,92,127,152,172,223,243],"pathologic":[31],"features":[32,213],"this":[34,203,215],"malignancy":[35],"have":[36,186],"yet":[37],"to":[38,74,159,185],"be":[39],"fully":[40],"defined.":[41],"Moreover,":[42],"pathogenesis":[44,248],"ALCL":[46,116],"in":[47,66,225,246],"association":[48,219],"textured":[50,81],"silicone":[51,82],"gel":[52,83],"breast":[53,75,84,90,107,176],"implants":[54],"poorly":[56],"understood.":[57],"Here":[58],"we":[59],"report":[60],"case":[62,208,216,233],"BIA-ALCL":[64,133,187],"arising":[65],"67-year-old":[68],"woman":[69],"mastectomy":[72],"due":[73],"cancer":[76],"followed":[77],"by":[78],"implantation":[79,173],"prosthesis.":[85],"The":[86,166],"patient":[87,167,182],"presented":[88],"enlargement":[91],"tenderness":[93],"8":[94],"years":[95],"following":[96],"reconstructive":[97],"surgery.":[98],"MRI":[99],"revealed":[100],"fluid":[102],"collection":[103],"surrounding":[104],"affected":[106],"implant.":[108],"Pathologic":[109],"examination":[110],"confirmed":[111],"presence":[113],"malignant":[115],"T":[117],"cells":[118,138],"that":[119],"were":[120,139,164],"CD30+,":[121],"CD8+,":[122],"CD15+,":[123],"HLA-DR+,":[124],"CD25+":[125],"ALK-":[126],"p53.":[128],"A":[129],"diagnosis":[130],"indolent":[132],"was":[134,168,183],"made":[135],"since":[136],"tumor":[137],"not":[140],"found":[141,184],"outside":[142],"capsule.":[145],"Interestingly,":[146],"an":[147,190],"extensive":[148],"mixed":[149],"lymphocytic":[150],"infiltrate":[151],"ectopic":[153],"lymphoid":[154,221],"tissue":[155],"(lymphoid":[156],"neogenesis)":[157],"adjacent":[158],"fibrous":[161],"capsule":[163],"present.":[165],"treated":[169],"capsulectomy":[171],"new":[175],"prostheses.":[177],"Six":[178],"months":[179],"later,":[180],"involvement":[188],"axillary":[191],"lymph":[192],"node":[193],"cytogenetic":[195,227],"evolution":[196],"tumor.":[199,231],"To":[200],"our":[201],"knowledge,":[202],"sixth":[206],"aggressive":[210],"BIA-ALCL.":[211,250],"Unique":[212],"include":[217],"neogenesis":[222],"vivo":[226],"progression":[228],"This":[232],"provides":[234],"insight":[235],"into":[236],"potential":[238],"role":[239],"chronic":[241],"inflammation":[242],"genetic":[244],"instability":[245]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}