{"id":"https://openalex.org/W1492944084","doi":"https://doi.org/10.1523/jneurosci.5609-07.2008","title":"Myelinated Skin Sensory Neurons Project Extensively throughout Adult Mouse Substantia Gelatinosa","display_name":"Myelinated Skin Sensory Neurons Project Extensively throughout Adult Mouse Substantia Gelatinosa","publication_year":2008,"publication_date":"2008-02-27","ids":{"openalex":"https://openalex.org/W1492944084","doi":"https://doi.org/10.1523/jneurosci.5609-07.2008","mag":"1492944084","pmid":"https://pubmed.ncbi.nlm.nih.gov/18305235","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6671842"},"language":"en","primary_location":{"id":"doi:10.1523/jneurosci.5609-07.2008","doi":"https://doi.org/10.1523/jneurosci.5609-07.2008","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.5609-07.2008","pdf_url":"https://www.jneurosci.org/content/jneuro/28/9/2006.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.jneurosci.org/content/jneuro/28/9/2006.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017721249","display_name":"Mario Danilo Boada","orcid":"https://orcid.org/0000-0002-8973-3010","observed_orcids":["https://orcid.org/0000-0002-8973-3010"]},"institutions":[{"id":"https://openalex.org/I12834331","display_name":"University of Wyoming","ror":"https://ror.org/01485tq96","country_code":"US","type":"education","lineage":["https://openalex.org/I12834331"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Danilo Boada","raw_affiliation_strings":["Department of Zoology and Physiology, University of Wyoming, Laramie, Wyoming 82071, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Zoology and Physiology, University of Wyoming, Laramie, Wyoming 82071, USA","institution_ids":["https://openalex.org/I12834331"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111510731","display_name":"C. Jeffery Woodbury","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12834331","display_name":"University of Wyoming","ror":"https://ror.org/01485tq96","country_code":"US","type":"education","lineage":["https://openalex.org/I12834331"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"C. Jeffery Woodbury","raw_affiliation_strings":["Department of Zoology and Physiology, University of Wyoming, Laramie, WY 82071","Department of Zoology and Physiology, University of Wyoming, Laramie, Wyoming 82071"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Zoology and Physiology, University of Wyoming, Laramie, WY 82071","institution_ids":["https://openalex.org/I12834331"]},{"raw_affiliation_string":"Department of Zoology and Physiology, University of Wyoming, Laramie, Wyoming 82071","institution_ids":["https://openalex.org/I12834331"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111510731"],"corresponding_institution_ids":["https://openalex.org/I12834331"],"apc_list":null,"apc_paid":null,"fwci":2.3432,"has_fulltext":true,"cited_by_count":47,"citation_normalized_percentile":{"value":0.86689372,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"28","issue":"9","first_page":"2006","last_page":"2014"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.008500000461935997,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10914","display_name":"Tactile and Sensory Interactions","score":0.007699999958276749,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/substantia-gelatinosa","display_name":"substantia gelatinosa","score":0.9990000128746033},{"id":"https://openalex.org/keywords/myelinated-afferents","display_name":"myelinated afferents","score":0.8069999814033508},{"id":"https://openalex.org/keywords/spinal-cord-dorsal-horn","display_name":"dorsal horn","score":0.6430000066757202},{"id":"https://openalex.org/keywords/nociceptors","display_name":"nociceptors","score":0.8429999947547913},{"id":"https://openalex.org/keywords/a-delta-fibers","display_name":"A-delta fibers","score":0.7950000166893005},{"id":"https://openalex.org/keywords/abeta-fibers","display_name":"A\u03b2 fibers","score":0.9869999885559082},{"id":"https://openalex.org/keywords/tactile-processing","display_name":"tactile processing","score":0.7319999933242798},{"id":"https://openalex.org/keywords/nociception","display_name":"nociception","score":0.9139999747276306},{"id":"https://openalex.org/keywords/temperature-extremes","display_name":"temperature extremes","score":0.4790000021457672},{"id":"https://openalex.org/keywords/adult-mice","display_name":"adult mice","score":0.375},{"id":"https://openalex.org/keywords/spinal-cord","display_name":"spinal cord","score":0.36000001430511475}],"concepts":[{"id":"https://openalex.org/C172659308","wikidata":"https://www.wikidata.org/wiki/Q412542","display_name":"Nociceptor","level":4,"score":0.7872281074523926},{"id":"https://openalex.org/C94487597","wikidata":"https://www.wikidata.org/wiki/Q11101","display_name":"Sensory system","level":2,"score":0.7301346659660339},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7076002955436707},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.6956046223640442},{"id":"https://openalex.org/C15490471","wikidata":"https://www.wikidata.org/wiki/Q2734305","display_name":"Nociception","level":3,"score":0.6905794739723206},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.5227135419845581},{"id":"https://openalex.org/C140530291","wikidata":"https://www.wikidata.org/wiki/Q1225063","display_name":"Dorsum","level":2,"score":0.4825288951396942},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46208876371383667},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.45410382747650146},{"id":"https://openalex.org/C2777216303","wikidata":"https://www.wikidata.org/wiki/Q866324","display_name":"Hair follicle","level":2,"score":0.4479387402534485},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29511842131614685},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.09907829761505127},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000344","descriptor_name":"Afferent Pathways","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D000344","descriptor_name":"Afferent Pathways","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001710","descriptor_name":"Biotin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D001710","descriptor_name":"Biotin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005727","descriptor_name":"Ganglia, Spinal","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009413","descriptor_name":"Nerve Fibers, Myelinated","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009475","descriptor_name":"Neurons, Afferent","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010812","descriptor_name":"Physical Stimulation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000294","qualifier_name":"innervation","is_major_topic":true},{"descriptor_ui":"D013376","descriptor_name":"Substantia Gelatinosa","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1523/jneurosci.5609-07.2008","doi":"https://doi.org/10.1523/jneurosci.5609-07.2008","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.5609-07.2008","pdf_url":"https://www.jneurosci.org/content/jneuro/28/9/2006.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6671842","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6671842","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurosci","raw_type":"Text"},{"id":"pmid:18305235","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18305235","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of neuroscience : the official journal of the Society for Neuroscience","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1523/jneurosci.5609-07.2008","doi":"https://doi.org/10.1523/jneurosci.5609-07.2008","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.5609-07.2008","pdf_url":"https://www.jneurosci.org/content/jneuro/28/9/2006.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.46810001134872437,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1133857822","display_name":null,"funder_award_id":"NS44094","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G5972936518","display_name":"Nociceptor Maturation and Response to Peripheral Injury","funder_award_id":"R01NS044094","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G7303741267","display_name":"Neuroscience Center for Biomedical Research Excellence","funder_award_id":"P20RR015640","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1492944084.pdf","grobid_xml":"https://content.openalex.org/works/W1492944084.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W16801894","https://openalex.org/W594501493","https://openalex.org/W961480823","https://openalex.org/W1490723329","https://openalex.org/W1529421015","https://openalex.org/W1549793748","https://openalex.org/W1803428175","https://openalex.org/W1943095660","https://openalex.org/W1962358525","https://openalex.org/W1964670356","https://openalex.org/W1985247836","https://openalex.org/W1987809797","https://openalex.org/W1990619855","https://openalex.org/W1990832845","https://openalex.org/W1991550485","https://openalex.org/W2001359834","https://openalex.org/W2002522691","https://openalex.org/W2013539122","https://openalex.org/W2013914537","https://openalex.org/W2014747284","https://openalex.org/W2014779151","https://openalex.org/W2019208784","https://openalex.org/W2032432787","https://openalex.org/W2035560252","https://openalex.org/W2036793236","https://openalex.org/W2036866620","https://openalex.org/W2037184775","https://openalex.org/W2050369461","https://openalex.org/W2053026848","https://openalex.org/W2053513632","https://openalex.org/W2060498588","https://openalex.org/W2060791247","https://openalex.org/W2062195812","https://openalex.org/W2100997560","https://openalex.org/W2115568736","https://openalex.org/W2124790162","https://openalex.org/W2126764967","https://openalex.org/W2145473020","https://openalex.org/W2330015572","https://openalex.org/W2339668289","https://openalex.org/W2418073409","https://openalex.org/W4234790514","https://openalex.org/W4299686733"],"related_works":["https://openalex.org/W2062195812","https://openalex.org/W1549793748","https://openalex.org/W2009581026","https://openalex.org/W1992118227","https://openalex.org/W2053513632","https://openalex.org/W146613485","https://openalex.org/W1962358525","https://openalex.org/W7096235431","https://openalex.org/W2058322679","https://openalex.org/W2130034971"],"abstract_inverted_index":{"The":[0,52],"substantia":[1],"gelatinosa":[2],"(SG)":[3],"of":[4,8,24,28,49,117,137,184,194,207],"the":[5,9,25,70,100,122,138,143,154,181,185,198,214],"dorsal":[6],"horn":[7],"spinal":[10,79],"cord":[11,80],"is":[12],"a":[13,47,64,218],"recipient":[14],"zone":[15],"for":[16],"unmyelinated":[17,208],"sensory":[18,32,110],"neurons":[19,33,111],"in":[20,34,75,77,94,121,163,169,221],"adults.":[21],"Recent":[22],"studies":[23],"central":[26],"anatomy":[27],"physiologically":[29],"identified":[30],"skin":[31,109],"neonatal":[35,61],"mice":[36],"have":[37],"shown":[38],"that":[39,67,99,157,213,228],"this":[40,229],"region":[41],"also":[42],"receives":[43],"substantial":[44,105],"inputs":[45,62],"from":[46,69,82,107],"variety":[48],"myelinated":[50,108,118],"afferents.":[51],"present":[53],"experiments":[54],"were":[55,73,87,158],"performed":[56],"to":[57,89,103,147,160,233],"determine":[58],"whether":[59],"these":[60],"represent":[63],"transient":[65],"phenotype":[66],"retracts":[68],"SG.":[71],"Studies":[72],"conducted":[74],"an":[76],"vivo":[78],"preparation":[81],"adult":[83,170],"mice;":[84],"thoracic":[85],"levels":[86],"targeted":[88],"facilitate":[90],"comparisons":[91],"with":[92,205],"previous":[93],"vitro":[95],"findings.":[96],"We":[97],"show":[98],"SG":[101,139,186,200,215],"continues":[102],"receive":[104],"projections":[106,133],"throughout":[112,134,180],"life.":[113],"A":[114,124,128],"large":[115],"population":[116],"nociceptors":[119],"conducting":[120],"upper":[123],"delta":[125],"and":[126,165,190],"low":[127],"beta":[129],"range":[130],"maintained":[131],"extensive":[132],"all":[135],"areas":[136],"well":[140,196],"into":[141,153,197],"adulthood;":[142],"latter":[144],"gave":[145],"rise":[146],"dorsally":[148],"recurving":[149],"\"flame\"-shaped":[150],"arbors":[151],"extending":[152],"marginal":[155],"layer":[156],"identical":[159],"afferents":[161,178],"described":[162],"neonates":[164],"after":[166],"nerve":[167],"injury":[168],"rats.":[171],"Furthermore,":[172],"exquisitely":[173],"sensitive":[174],"down":[175],"hair":[176],"follicle":[177],"projected":[179],"inner":[182],"half":[183],"(i.e.,":[187],"lamina":[188],"IIi)":[189],"sent":[191],"dense":[192],"clusters":[193],"terminals":[195],"outer":[199],"(IIo),":[201],"where":[202],"they":[203],"intermingled":[204],"those":[206],"nociceptors.":[209],"Arguments":[210],"are":[211],"presented":[212],"likely":[216],"plays":[217],"predominant":[219],"role":[220,230],"tactile":[222],"processing":[223],"under":[224],"normal":[225],"conditions,":[226],"but":[227],"switches":[231],"rapidly":[232],"nociceptive-only":[234],"during":[235],"environmental":[236],"exigencies":[237],"imposed":[238],"by":[239],"temperature":[240],"extremes.":[241]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}