{"id":"https://openalex.org/W1492848335","doi":"https://doi.org/10.1016/s0021-9258(19)45640-8","title":"Subcellular Distribution of Proteins Synthesized in Slices of Rat Cerebral Cortex","display_name":"Subcellular Distribution of Proteins Synthesized in Slices of Rat Cerebral Cortex","publication_year":1972,"publication_date":"1972-02-01","ids":{"openalex":"https://openalex.org/W1492848335","doi":"https://doi.org/10.1016/s0021-9258(19)45640-8","mag":"1492848335","pmid":"https://pubmed.ncbi.nlm.nih.gov/4258679"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-9258(19)45640-8","doi":"https://doi.org/10.1016/s0021-9258(19)45640-8","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)45640-8","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0021-9258(19)45640-8","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111614815","display_name":"Fredric P. White","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fredric P. White","raw_affiliation_strings":["From the Brain Research Group, Department of Chemistry, Indiana University, Bloomington, Indiana 47401"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Brain Research Group, Department of Chemistry, Indiana University, Bloomington, Indiana 47401","institution_ids":["https://openalex.org/I4210119109","https://openalex.org/I592451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036789705","display_name":"William J. McBride","orcid":"https://orcid.org/0000-0001-8894-533X","observed_orcids":["https://orcid.org/0000-0001-8894-533X"]},"institutions":[{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William J. McBride","raw_affiliation_strings":["From the Brain Research Group, Department of Chemistry, Indiana University, Bloomington, Indiana 47401"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Brain Research Group, Department of Chemistry, Indiana University, Bloomington, Indiana 47401","institution_ids":["https://openalex.org/I4210119109","https://openalex.org/I592451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112099249","display_name":"Henry R. Mahler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Henry R. Mahler","raw_affiliation_strings":["From the Brain Research Group, Department of Chemistry, Indiana University, Bloomington, Indiana 47401"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Brain Research Group, Department of Chemistry, Indiana University, Bloomington, Indiana 47401","institution_ids":["https://openalex.org/I4210119109","https://openalex.org/I592451"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109037278","display_name":"Walter John Moore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Walter J. Moore","raw_affiliation_strings":["From the Brain Research Group, Department of Chemistry, Indiana University, Bloomington, Indiana 47401"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Brain Research Group, Department of Chemistry, Indiana University, Bloomington, Indiana 47401","institution_ids":["https://openalex.org/I4210119109","https://openalex.org/I592451"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":2.3475,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.87360215,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"247","issue":"4","first_page":"1247","last_page":"1256"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9140999913215637,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9140999913215637,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.04270000010728836,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.017999999225139618,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/subcellular-protein-distribution","display_name":"subcellular protein distribution","score":0.8410000205039978},{"id":"https://openalex.org/keywords/cerebral-cortex-slices","display_name":"cerebral cortex slices","score":0.7979999780654907},{"id":"https://openalex.org/keywords/leucine-incorporation","display_name":"leucine incorporation","score":0.8299999833106995},{"id":"https://openalex.org/keywords/membrane-protein-synthesis","display_name":"membrane protein synthesis","score":0.6330000162124634},{"id":"https://openalex.org/keywords/cycloheximide-inhibition","display_name":"cycloheximide inhibition","score":0.8479999899864197},{"id":"https://openalex.org/keywords/synaptic-membrane-proteins","display_name":"synaptic membrane proteins","score":0.48100000619888306},{"id":"https://openalex.org/keywords/potassium-ions","display_name":"potassium ions","score":0.33000001311302185},{"id":"https://openalex.org/keywords/ouabain","display_name":"ouabain","score":0.9850000143051147},{"id":"https://openalex.org/keywords/na-k-atpase","display_name":"Na+/K+-ATPase","score":0.8709999918937683},{"id":"https://openalex.org/keywords/plasma-membrane","display_name":"plasma membrane","score":0.7850000262260437},{"id":"https://openalex.org/keywords/mitochondrial-proteins","display_name":"mitochondrial proteins","score":0.5849999785423279}],"concepts":[{"id":"https://openalex.org/C2781041448","wikidata":"https://www.wikidata.org/wiki/Q75839","display_name":"Cerebral cortex","level":2,"score":0.765587568283081},{"id":"https://openalex.org/C110121322","wikidata":"https://www.wikidata.org/wiki/Q865811","display_name":"Distribution (mathematics)","level":2,"score":0.6027039289474487},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5698035359382629},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.45691001415252686},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4359418749809265},{"id":"https://openalex.org/C2911126425","wikidata":"https://www.wikidata.org/wiki/Q786278","display_name":"Brain chemistry","level":2,"score":0.42255699634552},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.39524930715560913},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3803873360157013},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27733057737350464},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.12508359551429749},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000110","descriptor_name":"Acetylcholinesterase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000251","descriptor_name":"Adenosine Triphosphatases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002499","descriptor_name":"Centrifugation, Density Gradient","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003513","descriptor_name":"Cycloheximide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007930","descriptor_name":"Leucine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008566","descriptor_name":"Membranes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008861","descriptor_name":"Microsomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010042","descriptor_name":"Ouabain","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012270","descriptor_name":"Ribosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012964","descriptor_name":"Sodium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013347","descriptor_name":"Subcellular Fractions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013574","descriptor_name":"Synaptosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014316","descriptor_name":"Tritium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0021-9258(19)45640-8","doi":"https://doi.org/10.1016/s0021-9258(19)45640-8","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)45640-8","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:4258679","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4258679","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0021-9258(19)45640-8","doi":"https://doi.org/10.1016/s0021-9258(19)45640-8","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)45640-8","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":65,"referenced_works":["https://openalex.org/W12711178","https://openalex.org/W74306928","https://openalex.org/W205755798","https://openalex.org/W1138546939","https://openalex.org/W1491462592","https://openalex.org/W1502724146","https://openalex.org/W1507243792","https://openalex.org/W1507522791","https://openalex.org/W1537295851","https://openalex.org/W1570319355","https://openalex.org/W1589853271","https://openalex.org/W1600804495","https://openalex.org/W1818078027","https://openalex.org/W1876759880","https://openalex.org/W1969665154","https://openalex.org/W1974845204","https://openalex.org/W1977230978","https://openalex.org/W1980916224","https://openalex.org/W1982374080","https://openalex.org/W1983765259","https://openalex.org/W1984627512","https://openalex.org/W1988820830","https://openalex.org/W1990676652","https://openalex.org/W1998159930","https://openalex.org/W1999021687","https://openalex.org/W1999865966","https://openalex.org/W2003091985","https://openalex.org/W2020198792","https://openalex.org/W2021504472","https://openalex.org/W2038153280","https://openalex.org/W2038498153","https://openalex.org/W2039881275","https://openalex.org/W2043158235","https://openalex.org/W2043583500","https://openalex.org/W2043742761","https://openalex.org/W2045441408","https://openalex.org/W2047096085","https://openalex.org/W2078710325","https://openalex.org/W2085634386","https://openalex.org/W2089791283","https://openalex.org/W2091571513","https://openalex.org/W2104382385","https://openalex.org/W2106858079","https://openalex.org/W2112086625","https://openalex.org/W2125562918","https://openalex.org/W2130810272","https://openalex.org/W2131182702","https://openalex.org/W2135890222","https://openalex.org/W2136506108","https://openalex.org/W2139940051","https://openalex.org/W2146855480","https://openalex.org/W2205753780","https://openalex.org/W2211975456","https://openalex.org/W2214771906","https://openalex.org/W2229607560","https://openalex.org/W2284455566","https://openalex.org/W2329186418","https://openalex.org/W2341125004","https://openalex.org/W2343170542","https://openalex.org/W2410148073","https://openalex.org/W2414524760","https://openalex.org/W4236527247","https://openalex.org/W4238881703","https://openalex.org/W4239864477","https://openalex.org/W4248860732"],"related_works":["https://openalex.org/W1483383153","https://openalex.org/W2336416793","https://openalex.org/W2017346322","https://openalex.org/W1963741570","https://openalex.org/W12711178","https://openalex.org/W2112086625","https://openalex.org/W2046183337","https://openalex.org/W2168421123","https://openalex.org/W2022526352","https://openalex.org/W2100444823"],"abstract_inverted_index":{"Abstract":[0],"The":[1],"incorporation":[2],"of":[3,7,20,23,49,59,65,82,101,116,133],"l-[4,5-3H]leucine":[4],"into":[5],"slices":[6],"rat":[8],"cerebral":[9],"cortex":[10],"has":[11],"been":[12],"measured,":[13],"with":[14,138],"emphasis":[15],"on":[16],"the":[17,21,44,50,60,63,80,109,134,139,147],"time":[18],"course":[19],"distribution":[22],"label":[24,83],"in":[25,33,42,108,125,146],"subcellular":[26],"fractions":[27,91],"prepared":[28],"by":[29,72,78,97],"zonal":[30],"isopycnic":[31],"centrifugation":[32],"continuous":[34],"sucrose":[35],"gradients.":[36],"Rapidly":[37],"labeled":[38],"proteins":[39,68,104],"are":[40],"found":[41],"both":[43],"soluble":[45],"and":[46,120],"membranous":[47],"components":[48],"nerve":[51],"end":[52],"particles.":[53],"Except":[54],"for":[55,85],"a":[56,98,131],"minor":[57],"part":[58],"mitochondrial":[61],"protein,":[62],"synthesis":[64,75,124],"all":[66],"membrane-bound":[67],"is":[69,76],"inhibited":[70],"drastically":[71],"cycloheximide.":[73],"When":[74],"blocked":[77],"cycloheximide,":[79],"supply":[81],"continues":[84],"some":[86,126],"minutes":[87],"to":[88],"certain":[89],"membrane":[90],"derived":[92],"from":[93,105],"synaptic":[94],"structures,":[95],"apparently":[96],"rapid":[99],"transport":[100],"newly":[102],"synthesized":[103],"cytoplasmic":[106],"ribosomes":[107],"neuronal":[110],"perikaryon.":[111],"An":[112],"increased":[113],"extracellular":[114],"concentration":[115],"potassium":[117],"ion":[118],"inhibits":[119],"ouabain":[121],"accelerates":[122],"protein":[123,135],"fractions.":[127],"These":[128],"effects":[129],"suggest":[130],"coupling":[132],"synthesizing":[136],"system":[137],"(Na+":[140],"+":[141],"K+)-activated":[142],"ouabain-sensitive":[143],"adenosine":[144],"triphosphatase":[145],"plasma":[148],"membranes.":[149]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
