{"id":"https://openalex.org/W1492706196","doi":null,"title":"Activation of nitrosamines to mutagens by postmitochondrial fraction of hamster pancreas.","display_name":"Activation of nitrosamines to mutagens by postmitochondrial fraction of hamster pancreas.","publication_year":1980,"publication_date":"1980-01-01","ids":{"openalex":"https://openalex.org/W1492706196","mag":"1492706196","pmid":"https://pubmed.ncbi.nlm.nih.gov/7349906"},"language":"en","primary_location":{"id":"pmid:7349906","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7349906","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069454613","display_name":"Dante G. Scarpelli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D G Scarpelli","raw_affiliation_strings":["Northwestern University****"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern University****","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111365293","display_name":"Mahendra S. Rao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M S Rao","raw_affiliation_strings":["Northwestern University****"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern University****","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113766153","display_name":"Vadrevu Subbarao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"V Subbarao","raw_affiliation_strings":["Northwestern University****"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern University****","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031915431","display_name":"Marc Beversluis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Beversluis","raw_affiliation_strings":["Northwestern University****"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern University****","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109256315","display_name":"David P. Gurka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D P Gurka","raw_affiliation_strings":["Northwestern University****"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern University****","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025474639","display_name":"Paul F. Hollenberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P F Hollenberg","raw_affiliation_strings":["Northwestern University****"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern University****","institution_ids":["https://openalex.org/I111979921"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I111979921"],"apc_list":null,"apc_paid":null,"fwci":2.1568,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.84668574,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"40","issue":"1","first_page":"67","last_page":"74"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.019999999552965164,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nitrosamines","display_name":"nitrosamines","score":0.9919999837875366},{"id":"https://openalex.org/keywords/metabolic-activation","display_name":"metabolic activation","score":0.7599999904632568},{"id":"https://openalex.org/keywords/mutagenicity","display_name":"mutagenicity","score":0.6000000238418579},{"id":"https://openalex.org/keywords/n-nitrosobis-2-oxopropyl-amine","display_name":"N-nitrosobis(2-oxopropyl)amine","score":0.9940000176429749},{"id":"https://openalex.org/keywords/mixed-function-oxidase","display_name":"mixed function oxidase","score":0.8930000066757202},{"id":"https://openalex.org/keywords/aryl-hydrocarbon-hydroxylase","display_name":"aryl hydrocarbon hydroxylase","score":0.9300000071525574},{"id":"https://openalex.org/keywords/beta-naphthoflavone","display_name":"beta-naphthoflavone","score":0.9459999799728394},{"id":"https://openalex.org/keywords/2-3-7-8-tetrachlorodibenzo-p-dioxin","display_name":"2,3,7,8-tetrachlorodibenzo-p-dioxin","score":0.9879999756813049},{"id":"https://openalex.org/keywords/3-methylcholanthrene","display_name":"3-methylcholanthrene","score":0.8240000009536743},{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.7450000047683716}],"concepts":[{"id":"https://openalex.org/C2778575167","wikidata":"https://www.wikidata.org/wiki/Q6573","display_name":"Hamster","level":2,"score":0.9551251530647278},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.9177190065383911},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6667048931121826},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.6447879672050476},{"id":"https://openalex.org/C2779525107","wikidata":"https://www.wikidata.org/wiki/Q389919","display_name":"Mesocricetus","level":3,"score":0.5081605911254883},{"id":"https://openalex.org/C2777395278","wikidata":"https://www.wikidata.org/wiki/Q413779","display_name":"Nitrosamine","level":3,"score":0.4959751069545746},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4707050025463104},{"id":"https://openalex.org/C2778362869","wikidata":"https://www.wikidata.org/wiki/Q204175","display_name":"Golden hamster","level":3,"score":0.43371185660362244},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.3296361565589905},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2653997540473938},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.24271517992019653}],"mesh":[{"descriptor_ui":"D000072317","descriptor_name":"Polychlorinated Dibenzodioxins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001189","descriptor_name":"Aryl Hydrocarbon Hydroxylases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001711","descriptor_name":"Biotransformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005419","descriptor_name":"Flavonoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008647","descriptor_name":"Mesocricetus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009153","descriptor_name":"Mutagens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009281","descriptor_name":"Naphthalenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009602","descriptor_name":"Nitrosamines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013347","descriptor_name":"Subcellular Fractions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:7349906","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7349906","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:1492706196","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7349906","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W76764465","https://openalex.org/W1604114682","https://openalex.org/W1914311513","https://openalex.org/W1919415375","https://openalex.org/W1971970555","https://openalex.org/W1982300181","https://openalex.org/W1986283478","https://openalex.org/W2004678494","https://openalex.org/W2013868683","https://openalex.org/W2026481346","https://openalex.org/W2029886618","https://openalex.org/W2032160948","https://openalex.org/W2061128036","https://openalex.org/W2087530289","https://openalex.org/W2129787793","https://openalex.org/W2153152250","https://openalex.org/W2171027024","https://openalex.org/W2286291716","https://openalex.org/W2415962442","https://openalex.org/W2418750717"],"related_works":["https://openalex.org/W2419550688","https://openalex.org/W2116768467","https://openalex.org/W2337048003","https://openalex.org/W2079559893","https://openalex.org/W1623015172","https://openalex.org/W1981937229","https://openalex.org/W2073967812","https://openalex.org/W1593292757","https://openalex.org/W2047273284","https://openalex.org/W2076062711"],"abstract_inverted_index":{"The":[0,66,86,168,320],"nitrosamines":[1],"2,6-dimethylnitrosomorpholine":[2],"(DMNM)":[3],"and":[4,28,114,155,250,256,267,304,309,333,338],"N":[5],"-nitrosobis(2-oxopropyl)amine":[6],"(NBOP)":[7],"are":[8,25,340,347],"carcinogens":[9,27,178],"which":[10],"induce":[11],"adenocarcinoma":[12],"of":[13,41,46,75,89,108,147,153,164,170,186,193,218,245,254,278,296,343],"the":[14,18,38,42,44,47,129,171,187,213,243,251,259,279,297],"pancreatic":[15,173,325],"ducts":[16],"in":[17,50,212,258,274],"Syrian":[19],"golden":[20],"hamster.":[21],"Since":[22],"both":[23,77,177],"compounds":[24,61,78],"indirect":[26],"must":[29],"be":[30,300],"metabolically":[31],"activated":[32],"to":[33,58,62,79,175,179,263,281,287,317],"their":[34,334],"carcinogenic":[35],"form(s)":[36],"by":[37,302,323,336],"enzyme":[39,298],"system(s)":[40],"host,":[43],"capacity":[45,169,277],"mixed-function":[48,348],"oxidases":[49],"hamster":[51,92,172,188],"pancreas":[52,72,93,219],"9000":[53],"\u00d7":[54],"g":[55],"(S-9)":[56,69],"fraction":[57,68],"activate":[59,282],"these":[60,324],"mutagens":[63,180],"was":[64,73,95,134,181,237],"studied.":[65],"postmitochondrial":[67],"prepared":[70],"from":[71,222],"capable":[74],"converting":[76],"forms":[80],"mutagenic":[81,87,288],"for":[82,327],"Salmonella":[83],"typhimurium":[84],"TA-1535.":[85],"activity":[88,217,249],"DMNM":[90,113,255,284,308],"with":[91,98,110,122,138,150,189,225],"S-9":[94,109,148,174,220,280],"dose":[96,192],"dependent,":[97],"22":[99],"\u00b1":[100,116,140,157,196,205],"7":[101],"(S.E.)":[102],"revertants":[103,118,142,159],"formed":[104,119,144,160],"per":[105,120,145],"mg":[106,112,121,124,146,152,163,198,207],"protein":[107,149],"1":[111,151],"109":[115],"9":[117],"10":[123,162],"DMNM.":[125],"Although":[126],"NBOP":[127,154,257,286,310],"is":[128],"more":[130],"potent":[131],"carcinogen,":[132],"it":[133,306],"consistently":[135],"less":[136],"mutagenic,":[137],"12":[139],"4":[141],"being":[143],"39":[156],"8":[158],"when":[161],"carcinogen":[165],"were":[166],"used.":[167],"convert":[176],"increased":[182,276],"significantly":[183],"following":[184],"pretreatment":[185],"a":[190,240,293],"single":[191],"\u03b2-naphthoflavone":[194,226],"(140":[195],"12/10":[197],"DMNM),":[199],"or":[200,230,285],"2,3,7,8-tetrachlorodibenzo-":[201,231,264],"p":[202,232,265],"-dioxin":[203,233,266],"(182":[204],"11/10":[206],"DMNM).":[208],"A":[209],"concomitant":[210],"increase":[211],"aryl":[214,246],"hydrocarbon":[215,247],"hydroxylase":[216,248],"isolated":[221],"hamsters":[223],"treated":[224],"(4":[227],"times":[228,235],"control)":[229,236],"(15":[234],"observed,":[238],"suggesting":[239],"relationship":[241],"between":[242],"levels":[244],"metabolic":[252],"activation":[253],"pancreas.":[260],"In":[261],"contrast":[262],"\u03b2-naphthoflavone,":[268],"3-methyl-cholanthrene":[269],"induction":[270],"did":[271],"not":[272],"result":[273],"an":[275],"either":[283],"metabolites.":[289,319],"This":[290],"suggests":[291],"that":[292,305,345],"different":[294],"form":[295],"may":[299],"induced":[301],"3-methylcholanthrene":[303],"metabolizes":[307],"along":[311],"predominantly":[312],"detoxification":[313],"pathways":[314],"leading":[315],"largely":[316],"noncarcinogenic":[318],"absolute":[321],"requirement":[322],"enzymes":[326],"reduced":[328],"nicotinamide":[329],"adenine":[330],"dinucleotide":[331],"phosphate,":[332],"inhibition":[335],"\u03b1-naphthoflavone":[337],"2,5-diphenyloxazole":[339],"strong":[341],"points":[342],"evidence":[344],"they":[346],"oxidases.":[349]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
