{"id":"https://openalex.org/W1492556495","doi":"https://doi.org/10.1093/acprof:oso/9780195182187.001.0001","title":"Three-Dimensional Electron Microscopy of Macromolecular Assemblies","display_name":"Three-Dimensional Electron Microscopy of Macromolecular Assemblies","publication_year":2006,"publication_date":"2006-03-02","ids":{"openalex":"https://openalex.org/W1492556495","doi":"https://doi.org/10.1093/acprof:oso/9780195182187.001.0001","mag":"1492556495"},"language":"en","primary_location":{"id":"doi:10.1093/acprof:oso/9780195182187.001.0001","doi":"https://doi.org/10.1093/acprof:oso/9780195182187.001.0001","is_oa":false,"landing_page_url":"https://doi.org/10.1093/acprof:oso/9780195182187.001.0001","pdf_url":null,"source":{"id":"https://openalex.org/S4306463708","display_name":"Oxford University Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"monograph"},"volume":null,"type":"book","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042892654","display_name":"Joachim Frank","orcid":"https://orcid.org/0000-0001-5449-6943","observed_orcids":["https://orcid.org/0000-0001-5449-6943","https://orcid.org/0000-0002-2442-1112"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Joachim Frank","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5042892654"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":18.1148,"has_fulltext":false,"cited_by_count":1115,"citation_normalized_percentile":{"value":1.0,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10857","display_name":"Advanced Electron Microscopy Techniques and Applications","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10857","display_name":"Advanced Electron Microscopy Techniques and Applications","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/single-particle-reconstruction","display_name":"single-particle reconstruction","score":0.8999999761581421},{"id":"https://openalex.org/keywords/3d-structure-determination","display_name":"three-dimensional structure determination","score":0.5950000286102295},{"id":"https://openalex.org/keywords/macromolecular-complexes","display_name":"macromolecular complexes","score":0.9290000200271606},{"id":"https://openalex.org/keywords/molecular-machines","display_name":"molecular machines","score":0.7239999771118164},{"id":"https://openalex.org/keywords/contrast-transfer-function","display_name":"contrast transfer function","score":0.7910000085830688},{"id":"https://openalex.org/keywords/image-registration","display_name":"image registration","score":0.7540000081062317},{"id":"https://openalex.org/keywords/image-segmentation","display_name":"image segmentation","score":0.6639999747276306},{"id":"https://openalex.org/keywords/cryo-electron-microscopy","display_name":"cryo-electron microscopy","score":0.7829999923706055}],"concepts":[{"id":"https://openalex.org/C57493831","wikidata":"https://www.wikidata.org/wiki/Q3134666","display_name":"Projection (relational algebra)","level":2,"score":0.5916126370429993},{"id":"https://openalex.org/C75806775","wikidata":"https://www.wikidata.org/wiki/Q5358194","display_name":"Electron tomography","level":4,"score":0.5521076917648315},{"id":"https://openalex.org/C3018767501","wikidata":"https://www.wikidata.org/wiki/Q130416","display_name":"Electron micrographs","level":3,"score":0.5260714888572693},{"id":"https://openalex.org/C93877712","wikidata":"https://www.wikidata.org/wiki/Q132560","display_name":"Electron microscope","level":2,"score":0.4788341820240021},{"id":"https://openalex.org/C65293305","wikidata":"https://www.wikidata.org/wiki/Q7523967","display_name":"Single particle analysis","level":3,"score":0.4679483473300934},{"id":"https://openalex.org/C164508769","wikidata":"https://www.wikidata.org/wiki/Q5165765","display_name":"Contrast transfer function","level":4,"score":0.4669516980648041},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.45716679096221924},{"id":"https://openalex.org/C36464697","wikidata":"https://www.wikidata.org/wiki/Q451553","display_name":"Visualization","level":2,"score":0.4402090907096863},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.42585471272468567},{"id":"https://openalex.org/C20702342","wikidata":"https://www.wikidata.org/wiki/Q5190506","display_name":"Cryo-electron microscopy","level":2,"score":0.42097240686416626},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3856920897960663},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.35540449619293213},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.3215407133102417},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.28480440378189087},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.2806489169597626},{"id":"https://openalex.org/C193016168","wikidata":"https://www.wikidata.org/wiki/Q874835","display_name":"Scanning transmission electron microscopy","level":3,"score":0.2038116455078125},{"id":"https://openalex.org/C2779345167","wikidata":"https://www.wikidata.org/wiki/Q104541","display_name":"Aerosol","level":2,"score":0.0},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.0},{"id":"https://openalex.org/C153294291","wikidata":"https://www.wikidata.org/wiki/Q25261","display_name":"Meteorology","level":1,"score":0.0},{"id":"https://openalex.org/C70638346","wikidata":"https://www.wikidata.org/wiki/Q2913798","display_name":"Spherical aberration","level":3,"score":0.0},{"id":"https://openalex.org/C15336307","wikidata":"https://www.wikidata.org/wiki/Q1766051","display_name":"Lens (geology)","level":2,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1093/acprof:oso/9780195182187.001.0001","doi":"https://doi.org/10.1093/acprof:oso/9780195182187.001.0001","is_oa":false,"landing_page_url":"https://doi.org/10.1093/acprof:oso/9780195182187.001.0001","pdf_url":null,"source":{"id":"https://openalex.org/S4306463708","display_name":"Oxford University Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"monograph"},{"id":"pmh:oai:203.131.219.242:ebook/7583","doi":null,"is_oa":false,"landing_page_url":"http://203.131.219.242/cdm/ref/collection/ebook/id/7583","pdf_url":null,"source":{"id":"https://openalex.org/S7407064352","display_name":"Thammasat University Digital Collections","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:aleph.bib-bvb.de:BVB01-027742349","doi":null,"is_oa":false,"landing_page_url":"http://www.sciencedirect.com/science/book/9780122650406","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"software, multimedia"},{"id":"pmh:oai:aleph.bib-bvb.de:BVB01-028469373","doi":null,"is_oa":false,"landing_page_url":"http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=230849","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"software, multimedia"},{"id":"pmh:oai:beyond.library.tu.ac.th:ebook/7583","doi":null,"is_oa":false,"landing_page_url":"http://beyond.library.tu.ac.th/cdm/ref/collection/ebook/id/7583","pdf_url":null,"source":{"id":"https://openalex.org/S4406923056","display_name":"TU Digital Collections (Thammasat University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4206574541","https://openalex.org/W4569079","https://openalex.org/W4407833662","https://openalex.org/W2037216529","https://openalex.org/W106874743","https://openalex.org/W4235660333","https://openalex.org/W1969847232","https://openalex.org/W2168243643","https://openalex.org/W2466281853","https://openalex.org/W2020956086"],"abstract_inverted_index":{"In":[0],"this":[1],"book,":[2],"the":[3,59,73,78,81,103],"mathematical":[4,104],"principles":[5,105],"and":[6,88,96,125,152],"working":[7],"methods":[8,145],"of":[9,27,29,37,48,69,80,108,140,154],"single-particle":[10],"reconstruction":[11,107,127],"are":[12,98,123],"described;":[13],"a":[14,34,136],"method":[15],"designed":[16],"to":[17,44],"retrieve":[18],"three-dimensional":[19,46],"structural":[20],"information":[21],"from":[22,111],"electron":[23,74],"micrographs":[24],"showing":[25],"thousands":[26],"\u201ccopies\u201d":[28],"biological":[30],"molecules":[31],"trapped":[32],"in":[33,51,72,130],"thin":[35],"layer":[36],"ice.":[38],"This":[39],"technique":[40],"is":[41,114,128],"uniquely":[42],"suited":[43],"obtain":[45],"images":[47],"molecular":[49],"machines":[50],"different":[52],"functional":[53],"states,":[54],"as":[55,148,150],"it":[56],"dispenses":[57],"with":[58,66,135],"need":[60],"for":[61,90,146],"crystals.":[62],"The":[63,132],"book":[64,133],"starts":[65],"an":[67,109],"introduction":[68,101],"image":[70,91],"formation":[71],"microscope,":[75],"which":[76],"includes":[77],"definition":[79],"contrast":[82],"transfer":[83],"function.":[84],"Next,":[85],"averaging":[86],"techniques":[87],"tools":[89],"alignment,":[92],"multivariate":[93],"data":[94],"analysis,":[95],"classification":[97],"described.":[99],"An":[100],"into":[102],"underlying":[106],"object":[110],"its":[112],"projections":[113],"followed":[115],"by":[116],"detailed":[117],"accounts":[118],"on":[119,138],"how":[120,126],"projection":[121],"angles":[122],"determined,":[124],"done":[129],"practice.":[131],"concludes":[134],"chapter":[137],"interpretation":[139],"density":[141],"maps":[142],"reconstructed,":[143],"including":[144],"segmentation":[147],"well":[149],"fitting":[151],"docking":[153],"atomic":[155],"coordinates.":[156]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":15},{"year":2023,"cited_by_count":27},{"year":2022,"cited_by_count":28},{"year":2021,"cited_by_count":26},{"year":2020,"cited_by_count":38},{"year":2019,"cited_by_count":32},{"year":2018,"cited_by_count":41},{"year":2017,"cited_by_count":27},{"year":2016,"cited_by_count":38},{"year":2015,"cited_by_count":53},{"year":2014,"cited_by_count":46},{"year":2013,"cited_by_count":57},{"year":2012,"cited_by_count":45}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}