{"id":"https://openalex.org/W1492488087","doi":null,"title":"Estradiol attenuates directed migration of vascular smooth muscle cells in vitro.","display_name":"Estradiol attenuates directed migration of vascular smooth muscle cells in vitro.","publication_year":1996,"publication_date":"1996-03-01","ids":{"openalex":"https://openalex.org/W1492488087","mag":"1492488087","pmid":"https://pubmed.ncbi.nlm.nih.gov/8774151","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1861726"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:1533236","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1861726","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1861726","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068524141","display_name":"Frank D. Kolodgie","orcid":"https://orcid.org/0000-0002-6007-2044","observed_orcids":["https://orcid.org/0000-0002-6007-2044"]},"institutions":[{"id":"https://openalex.org/I4210151970","display_name":"Armed Forces Institute of Pathology","ror":"https://ror.org/04se3fj97","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210151970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F D Kolodgie","raw_affiliation_strings":["Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306-6000, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306-6000, USA","institution_ids":["https://openalex.org/I4210151970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113480187","display_name":"Asha Jacob","orcid":"https://orcid.org/0000-0002-8280-8999","observed_orcids":["https://orcid.org/0000-0002-8280-8999"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Jacob","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"P S Wilson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P S Wilson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109889289","display_name":"Greg C. Carlson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G C Carlson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023854199","display_name":"Andrew A. Farb","orcid":"https://orcid.org/0000-0002-1468-7224","observed_orcids":["https://orcid.org/0000-0002-1468-7224"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Farb","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"A Verma","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Verma","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5071287538","display_name":"Renu Virmani","orcid":"https://orcid.org/0000-0003-1879-0015","observed_orcids":["https://orcid.org/0000-0003-1879-0015"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Virmani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.8144,"has_fulltext":false,"cited_by_count":100,"citation_normalized_percentile":{"value":0.87856669,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"148","issue":"3","first_page":"969","last_page":"76"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11318","display_name":"Phytoestrogen effects and research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.9139999747276306},{"id":"https://openalex.org/keywords/beta-estradiol","display_name":"beta-estradiol","score":0.9020000100135803},{"id":"https://openalex.org/keywords/vascular-smooth-muscle-cells","display_name":"vascular smooth muscle cells","score":0.9769999980926514},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.9229999780654907},{"id":"https://openalex.org/keywords/estrogen-receptor","display_name":"estrogen receptor","score":0.8679999709129333},{"id":"https://openalex.org/keywords/platelet-derived-growth-factor","display_name":"platelet-derived growth factor","score":0.8519999980926514},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.9909999966621399},{"id":"https://openalex.org/keywords/fibronectin","display_name":"fibronectin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/chemoattractants","display_name":"chemoattractants","score":0.8339999914169312},{"id":"https://openalex.org/keywords/diethylstilbestrol","display_name":"diethylstilbestrol","score":0.8880000114440918},{"id":"https://openalex.org/keywords/ici-164-384","display_name":"ICI 164,384","score":0.9490000009536743},{"id":"https://openalex.org/keywords/antiestrogens","display_name":"antiestrogens","score":0.7210000157356262},{"id":"https://openalex.org/keywords/dactinomycin","display_name":"actinomycin D","score":0.9229999780654907},{"id":"https://openalex.org/keywords/aortic-smooth-muscle","display_name":"aortic smooth muscle","score":0.6209999918937683}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7627788782119751},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.7554527521133423},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7521660327911377},{"id":"https://openalex.org/C2779395532","wikidata":"https://www.wikidata.org/wiki/Q7916469","display_name":"Vascular smooth muscle","level":3,"score":0.6859233379364014},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.512400209903717},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.47428375482559204},{"id":"https://openalex.org/C2781397067","wikidata":"https://www.wikidata.org/wiki/Q423989","display_name":"Diethylstilbestrol","level":3,"score":0.4645499885082245},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.454046368598938},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.4310155510902405},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.42932701110839844},{"id":"https://openalex.org/C86492073","wikidata":"https://www.wikidata.org/wiki/Q413766","display_name":"Fibronectin","level":3,"score":0.41503891348838806},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.4112921357154846},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4077078104019165},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3275721073150635},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32092687487602234},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1746240258216858},{"id":"https://openalex.org/C2992686903","wikidata":"https://www.wikidata.org/wiki/Q208453","display_name":"Smooth muscle","level":2,"score":0.10289314389228821},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08947020769119263},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003609","descriptor_name":"Dactinomycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004054","descriptor_name":"Diethylstilbestrol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004965","descriptor_name":"Estrogen Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013739","descriptor_name":"Testosterone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053284","descriptor_name":"Polyunsaturated Alkamides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:1533236","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1861726","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:1861726","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1861726","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},{"id":"pmid:8774151","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8774151","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of pathology","raw_type":"Journal Article"},{"id":"mag:1492488087","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8774151","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1533236","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1861726","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W138085915","https://openalex.org/W1487009260","https://openalex.org/W1880674199","https://openalex.org/W1966323574","https://openalex.org/W1971867327","https://openalex.org/W1974175370","https://openalex.org/W1980040083","https://openalex.org/W1986842366","https://openalex.org/W1988359235","https://openalex.org/W1999162852","https://openalex.org/W2003991752","https://openalex.org/W2004687187","https://openalex.org/W2006545669","https://openalex.org/W2007841512","https://openalex.org/W2008323911","https://openalex.org/W2014001936","https://openalex.org/W2015219342","https://openalex.org/W2015652844","https://openalex.org/W2018312028","https://openalex.org/W2021123282","https://openalex.org/W2029566146","https://openalex.org/W2040074029","https://openalex.org/W2040530673","https://openalex.org/W2046017097","https://openalex.org/W2051109788","https://openalex.org/W2058977087","https://openalex.org/W2059153388","https://openalex.org/W2063277519","https://openalex.org/W2065619491","https://openalex.org/W2067154451","https://openalex.org/W2079802650","https://openalex.org/W2083578330","https://openalex.org/W2103126172","https://openalex.org/W2103423185","https://openalex.org/W2118678876","https://openalex.org/W2125966163","https://openalex.org/W2130902918","https://openalex.org/W2137570167","https://openalex.org/W2141991871","https://openalex.org/W2143015087","https://openalex.org/W2145754645","https://openalex.org/W2147673480","https://openalex.org/W2148307287","https://openalex.org/W2156886795","https://openalex.org/W2158873133","https://openalex.org/W2261198346","https://openalex.org/W2323251034","https://openalex.org/W2397294110","https://openalex.org/W3125706683"],"related_works":["https://openalex.org/W1964909729","https://openalex.org/W1897927953","https://openalex.org/W7036242318","https://openalex.org/W7038530482","https://openalex.org/W2052684907","https://openalex.org/W1978178007","https://openalex.org/W2085192542","https://openalex.org/W2123329935","https://openalex.org/W2284433681","https://openalex.org/W3012592445"],"abstract_inverted_index":{"Although":[0],"the":[1,5,25,48,75,131,142,159,164,172],"cardiovascular":[2],"benefits":[3],"of":[4,27,50,53,70,154,188],"hormone":[6,144],"estrogen":[7,133,196],"are":[8,171],"at":[9,87],"least,":[10],"in":[11,44,61,101,178],"part,":[12],"mediated":[13],"by":[14,95,158,184],"its":[15,22],"antiproliferative":[16],"effect":[17,49],"on":[18,24,55],"vascular":[19],"smooth":[20,39,71,137,180],"muscle,":[21],"action":[23],"migration":[26,58,140,155,183],"these":[28],"cells":[29,41,73,108],"is":[30],"unknown.":[31],"To":[32],"explore":[33],"this":[34,189],"relationship,":[35],"female":[36],"rat":[37],"aortic":[38],"muscle":[40,72,138,181],"were":[42],"grown":[43],"hormone-free":[45],"medium,":[46],"and":[47,84,122,163],"various":[51],"concentrations":[52],"beta-estradiol":[54,96],"directed":[56,136,179],"cellular":[57],"was":[59,93,116,123,146,156],"measured":[60],"vitro":[62],"using":[63],"a":[64,102,176],"microwell":[65],"Boyden":[66],"chamber":[67],"apparatus.":[68],"Migration":[69],"to":[74,98,106,118,193],"known":[76],"chemoattractants":[77],"platelet-derived":[78],"growth":[79,82],"factor,":[80],"insulin-like":[81],"factor-1,":[83],"fibronectin":[85],"(all":[86],"peak":[88],"doses":[89],"for":[90],"migratory":[91],"activity)":[92],"attenuated":[94,135],"(0.5":[97],"10":[99],"ng/ml)":[100],"concentration-dependent":[103],"manner":[104],"relative":[105],"control":[107],"treated":[109],"with":[110,120],"vehicle":[111],"(0.01%":[112],"ethanol).":[113],"This":[114],"response":[115,191],"insensitive":[117],"pretreatment":[119],"indomethacin":[121],"stereospecific":[124],"(17":[125],"alpha-estradiol":[126],"lacked":[127],"response).":[128],"Like":[129],"beta-estradiol,":[130],"synthetic":[132],"diethylstilbestrol":[134],"cell":[139,182],"whereas":[141],"male":[143],"testosterone":[145],"ineffective.":[147],"Additional":[148],"studies":[149],"showed":[150],"that":[151],"beta-estradiol-mediated":[152],"suppression":[153],"inhibited":[157],"anti-estrogen":[160],"ICI":[161],"164,384":[162],"gene":[165],"transcription":[166],"inhibitor":[167],"actinomycin":[168],"D.":[169],"These":[170],"first":[173],"results":[174],"demonstrating":[175],"reduction":[177],"beta-estradiol.":[185],"The":[186],"mechanism":[187],"estrogen-mediated":[190],"appears":[192],"involve":[194],"conventional":[195],"receptors.":[197]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
