{"id":"https://openalex.org/W1492276333","doi":"https://doi.org/10.1096/fasebj.28.1_supplement.1130.20","title":"Reduced GABAergic synaptic transmission in the nucleus tractus solitarius in Mecp2 \u2010null mice (1130.20)","display_name":"Reduced GABAergic synaptic transmission in the nucleus tractus solitarius in Mecp2 \u2010null mice (1130.20)","publication_year":2014,"publication_date":"2014-04-01","ids":{"openalex":"https://openalex.org/W1492276333","doi":"https://doi.org/10.1096/fasebj.28.1_supplement.1130.20","mag":"1492276333"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.28.1_supplement.1130.20","doi":"https://doi.org/10.1096/fasebj.28.1_supplement.1130.20","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.28.1_supplement.1130.20","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5106033732","display_name":"Chao-Yin Chen","orcid":"https://orcid.org/0000-0003-3001-7543","observed_orcids":["https://orcid.org/0000-0003-3001-7543"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chao\u2010Yin Chen","raw_affiliation_strings":["Pharmacology UC\u2010Davis Davis CA United States","4Pharmacology UC-Davis Davis CA United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology UC\u2010Davis Davis CA United States","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"4Pharmacology UC-Davis Davis CA United States","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yen\u2010Chu Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yen\u2010Chu Lin","raw_affiliation_strings":["Pathology and Laboratory Medicine UC\u2010Davis Davis CA United States","3Pathology and Laboratory Medicine UC-Davis Davis CA United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology and Laboratory Medicine UC\u2010Davis Davis CA United States","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"3Pathology and Laboratory Medicine UC-Davis Davis CA United States","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004551722","display_name":"Michael A. Rogawski","orcid":"https://orcid.org/0000-0002-3296-8193","observed_orcids":["https://orcid.org/0000-0002-3296-8193"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Rogawski","raw_affiliation_strings":["Neurology UC\u2010Davis Davis CA United States","2Neurology UC-Davis Davis CA United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology UC\u2010Davis Davis CA United States","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"2Neurology UC-Davis Davis CA United States","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014611690","display_name":"Cheng\u2010Chang Lien","orcid":"https://orcid.org/0000-0002-6692-9942","observed_orcids":["https://orcid.org/0000-0002-6692-9942"]},"institutions":[{"id":"https://openalex.org/I4387156312","display_name":"National Yang Ming University","ror":"https://ror.org/009h5ks85","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613","https://openalex.org/I4387156312"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Cheng\u2010Chang Lien","raw_affiliation_strings":["National Yang\u2010Ming University Taipei Taiwan","#N# 1National Yang Ming University, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Yang\u2010Ming University Taipei Taiwan","institution_ids":["https://openalex.org/I4387156312"]},{"raw_affiliation_string":"#N# 1National Yang Ming University, Taipei, Taiwan","institution_ids":["https://openalex.org/I4387156312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070072260","display_name":"Izumi Maezawa","orcid":"https://orcid.org/0000-0002-8666-3520","observed_orcids":["https://orcid.org/0000-0002-8666-3520"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Izumi Maezawa","raw_affiliation_strings":["Pathology and Laboratory Medicine UC\u2010Davis Davis CA United States","3Pathology and Laboratory Medicine UC-Davis Davis CA United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology and Laboratory Medicine UC\u2010Davis Davis CA United States","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"3Pathology and Laboratory Medicine UC-Davis Davis CA United States","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022477562","display_name":"Lee\u2010Way Jin","orcid":"https://orcid.org/0000-0001-9729-1032","observed_orcids":["https://orcid.org/0000-0001-9729-1032"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lee\u2010Way Jin","raw_affiliation_strings":["Pathology and Laboratory Medicine UC\u2010Davis Davis CA United States","3Pathology and Laboratory Medicine UC-Davis Davis CA United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology and Laboratory Medicine UC\u2010Davis Davis CA United States","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"3Pathology and Laboratory Medicine UC-Davis Davis CA United States","institution_ids":["https://openalex.org/I84218800"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.04911407,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"28","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rett-syndrome","display_name":"Rett syndrome","score":0.9959999918937683},{"id":"https://openalex.org/keywords/mecp2","display_name":"MeCP2","score":0.8759999871253967},{"id":"https://openalex.org/keywords/nucleus-tractus-solitarius","display_name":"nucleus tractus solitarius","score":0.8980000019073486},{"id":"https://openalex.org/keywords/gabaergic-transmission","display_name":"GABAergic neurotransmission","score":0.9620000123977661},{"id":"https://openalex.org/keywords/respiratory-dysfunction","display_name":"respiratory dysfunction","score":0.7960000038146973},{"id":"https://openalex.org/keywords/inhibitory-postsynaptic-currents","display_name":"inhibitory postsynaptic currents","score":0.9150000214576721},{"id":"https://openalex.org/keywords/miniature-ipscs","display_name":"miniature IPSCs","score":0.9559999704360962},{"id":"https://openalex.org/keywords/spontaneous-ipscs","display_name":"spontaneous IPSCs","score":0.8090000152587891},{"id":"https://openalex.org/keywords/mecp2-null-mice","display_name":"Mecp2-null mice","score":0.8510000109672546},{"id":"https://openalex.org/keywords/brainstem-neurons","display_name":"brainstem neurons","score":0.5889999866485596}],"concepts":[{"id":"https://openalex.org/C2778863441","wikidata":"https://www.wikidata.org/wiki/Q18028997","display_name":"MECP2","level":4,"score":0.8620147705078125},{"id":"https://openalex.org/C2779177108","wikidata":"https://www.wikidata.org/wiki/Q18356742","display_name":"GABAergic","level":3,"score":0.7801334857940674},{"id":"https://openalex.org/C200170125","wikidata":"https://www.wikidata.org/wiki/Q969316","display_name":"Neurotransmission","level":3,"score":0.6340442299842834},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5598698854446411},{"id":"https://openalex.org/C2777543196","wikidata":"https://www.wikidata.org/wiki/Q917357","display_name":"Rett syndrome","level":3,"score":0.5334876775741577},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.5152802467346191},{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.5109617114067078},{"id":"https://openalex.org/C551621295","wikidata":"https://www.wikidata.org/wiki/Q182228","display_name":"Brainstem","level":2,"score":0.4973144829273224},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45968008041381836},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3922918140888214},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3583943247795105},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27422213554382324},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.21940234303474426},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14829260110855103},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1310039758682251},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.11018601059913635}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.28.1_supplement.1130.20","doi":"https://doi.org/10.1096/fasebj.28.1_supplement.1130.20","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.28.1_supplement.1130.20","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.5799999833106995,"display_name":"Partnerships for the goals","id":"https://metadata.un.org/sdg/17"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3831633592","display_name":null,"funder_award_id":"1R01 HD064817","funder_id":"https://openalex.org/F4320306812","funder_display_name":"International Rett Syndrome Foundation"}],"funders":[{"id":"https://openalex.org/F4320306812","display_name":"International Rett Syndrome Foundation","ror":"https://ror.org/00e7vz537"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2754205176","https://openalex.org/W4225417703","https://openalex.org/W1585883279","https://openalex.org/W1840672965","https://openalex.org/W2152850555","https://openalex.org/W2611915160","https://openalex.org/W2129032286","https://openalex.org/W2082405299","https://openalex.org/W3038710321","https://openalex.org/W3101432858"],"abstract_inverted_index":{"Rett":[0,202],"syndrome":[1],"(RTT),":[2],"a":[3,124,148],"devastating":[4],"neurodevelopmental":[5],"disorder,":[6],"is":[7,25,71],"caused":[8],"by":[9],"loss\u2010of\u2010function":[10],"mutations":[11],"in":[12,49,58,65,90,127,139,152,184,191],"the":[13,28,43,54,66,173,185],"X\u2010linked":[14],"methyl\u2010CpG":[15],"binding":[16],"protein":[17],"2":[18],"(":[19],"Mecp2":[20,59,97,116],")":[21],"gene.":[22],"Respiratory":[23],"dysfunction":[24,190],"one":[26],"of":[27,130,156],"major":[29],"clinical":[30],"features,":[31],"presumably":[32],"due":[33],"to":[34,104,188],"defective":[35],"GABAergic":[36,40,62,179],"function":[37],"because":[38],"enhancing":[39],"transmission":[41,64],"improved":[42],"respiratory":[44,69,189],"phenotype":[45],"and":[46,74,81,100,175],"prolonged":[47],"survival":[48],"RTT":[50],"mice.":[51],"We":[52],"test":[53],"hypothesis":[55,174],"that":[56,177],"deficiency":[57],"gene":[60],"reduces":[61],"signal":[63],"NTS":[67,88,113,186],"where":[68],"information":[70],"first":[72],"received":[73],"integrated.":[75],"Spontaneous":[76],"inhibitory":[77],"postsynaptic":[78],"currents":[79],"(sIPSCs)":[80],"miniature":[82],"IPSCs":[83],"(mIPSCs)":[84],"were":[85],"recorded":[86],"from":[87,94,106,115],"neurons":[89,114],"brainstem":[91],"slices":[92],"obtained":[93],"age\u2010matched":[95],"male":[96],"\u2010null":[98,117],"mice":[99,108,118],"wild\u2010type":[101,107],"littermates.":[102],"Compared":[103],"those":[105],"(n":[109,119],"=":[110,120],"11":[111],"neurons),":[112],"12":[121],"neurons)":[122],"had":[123],"left\u2010ward":[125,150],"shift":[126,151],"cumulative":[128,154],"probability":[129,155],"sIPSC":[131],"amplitudes":[132,157],"(p":[133,142,158,165],"<":[134,159],"0.05)":[135,160],"without":[136],"significant":[137,149],"changes":[138],"inter\u2010event":[140,163],"intervals":[141,164],">":[143,166],"0.05).":[144,167],"Similarly,":[145],"there":[146],"was":[147],"mIPSC":[153],"but":[161],"not":[162],"The":[168],"data":[169],"are":[170],"consistent":[171],"with":[172],"suggest":[176],"reduced":[178],"signaling":[180],"via":[181],"post\u2010synaptic":[182],"mechanism(s)":[183],"contributes":[187],"RTT.":[192],"Grant":[193],"Funding":[194],"Source":[195],":":[196],"supported":[197],"by:":[198],"1R01":[199],"HD064817,":[200],"International":[201],"Syndrome":[203],"Foundation":[204]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}
