{"id":"https://openalex.org/W1491680804","doi":"https://doi.org/10.1016/s0021-9258(18)45220-9","title":"Stereochemical requirements for substrate specificity of LTB4 20-hydroxylase.","display_name":"Stereochemical requirements for substrate specificity of LTB4 20-hydroxylase.","publication_year":1987,"publication_date":"1987-09-01","ids":{"openalex":"https://openalex.org/W1491680804","doi":"https://doi.org/10.1016/s0021-9258(18)45220-9","mag":"1491680804","pmid":"https://pubmed.ncbi.nlm.nih.gov/3040745"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-9258(18)45220-9","doi":"https://doi.org/10.1016/s0021-9258(18)45220-9","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(18)45220-9","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0021-9258(18)45220-9","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085550092","display_name":"Roy Jason Soberman","orcid":"https://orcid.org/0000-0002-2817-0517","observed_orcids":["https://orcid.org/0000-0002-2817-0517"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R J Soberman","raw_affiliation_strings":["From the $Department of Medicine, Harvard Medical School, ann' the Department of Rheumatology and Immunology, Brigham and Women's Hospital, Boston, Massachusetts 02115, the VDepartment of Biochemistry,","IIMerck-Frosst Company, Pointe-Claire, Dorual, Canada","Medical College of Wisconsin, Milwaukee, Wisconsin 53226, and the","Mudd Building, Room 610, 250 Longwood Ave., Boston, MA 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the $Department of Medicine, Harvard Medical School, ann' the Department of Rheumatology and Immunology, Brigham and Women's Hospital, Boston, Massachusetts 02115, the VDepartment of Biochemistry,","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"IIMerck-Frosst Company, Pointe-Claire, Dorual, Canada","institution_ids":[]},{"raw_affiliation_string":"Medical College of Wisconsin, Milwaukee, Wisconsin 53226, and the","institution_ids":["https://openalex.org/I204308271"]},{"raw_affiliation_string":"Mudd Building, Room 610, 250 Longwood Ave., Boston, MA 02115","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007500198","display_name":"Richard T. Okita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R T Okita","raw_affiliation_strings":["From the $Department of Medicine, Harvard Medical School, ann' the Department of Rheumatology and Immunology, Brigham and Women's Hospital, Boston, Massachusetts 02115, the VDepartment of Biochemistry,","IIMerck-Frosst Company, Pointe-Claire, Dorual, Canada","Medical College of Wisconsin, Milwaukee, Wisconsin 53226, and the","Mudd Building, Room 610, 250 Longwood Ave., Boston, MA 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the $Department of Medicine, Harvard Medical School, ann' the Department of Rheumatology and Immunology, Brigham and Women's Hospital, Boston, Massachusetts 02115, the VDepartment of Biochemistry,","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"IIMerck-Frosst Company, Pointe-Claire, Dorual, Canada","institution_ids":[]},{"raw_affiliation_string":"Medical College of Wisconsin, Milwaukee, Wisconsin 53226, and the","institution_ids":["https://openalex.org/I204308271"]},{"raw_affiliation_string":"Mudd Building, Room 610, 250 Longwood Ave., Boston, MA 02115","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113548964","display_name":"Brian J. Fitzsimmons","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B Fitzsimmons","raw_affiliation_strings":["From the $Department of Medicine, Harvard Medical School, ann' the Department of Rheumatology and Immunology, Brigham and Women's Hospital, Boston, Massachusetts 02115, the VDepartment of Biochemistry,","IIMerck-Frosst Company, Pointe-Claire, Dorual, Canada","Medical College of Wisconsin, Milwaukee, Wisconsin 53226, and the","Mudd Building, Room 610, 250 Longwood Ave., Boston, MA 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the $Department of Medicine, Harvard Medical School, ann' the Department of Rheumatology and Immunology, Brigham and Women's Hospital, Boston, Massachusetts 02115, the VDepartment of Biochemistry,","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"IIMerck-Frosst Company, Pointe-Claire, Dorual, Canada","institution_ids":[]},{"raw_affiliation_string":"Medical College of Wisconsin, Milwaukee, Wisconsin 53226, and the","institution_ids":["https://openalex.org/I204308271"]},{"raw_affiliation_string":"Mudd Building, Room 610, 250 Longwood Ave., Boston, MA 02115","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028764377","display_name":"Joshua Rokach","orcid":"https://orcid.org/0000-0003-1814-7505","observed_orcids":["https://orcid.org/0000-0003-1814-7505"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Rokach","raw_affiliation_strings":["From the $Department of Medicine, Harvard Medical School, ann' the Department of Rheumatology and Immunology, Brigham and Women's Hospital, Boston, Massachusetts 02115, the VDepartment of Biochemistry,","IIMerck-Frosst Company, Pointe-Claire, Dorual, Canada","Medical College of Wisconsin, Milwaukee, Wisconsin 53226, and the","Mudd Building, Room 610, 250 Longwood Ave., Boston, MA 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the $Department of Medicine, Harvard Medical School, ann' the Department of Rheumatology and Immunology, Brigham and Women's Hospital, Boston, Massachusetts 02115, the VDepartment of Biochemistry,","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"IIMerck-Frosst Company, Pointe-Claire, Dorual, Canada","institution_ids":[]},{"raw_affiliation_string":"Medical College of Wisconsin, Milwaukee, Wisconsin 53226, and the","institution_ids":["https://openalex.org/I204308271"]},{"raw_affiliation_string":"Mudd Building, Room 610, 250 Longwood Ave., Boston, MA 02115","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059546138","display_name":"Bernd Werner Spur","orcid":"https://orcid.org/0000-0002-7581-4741","observed_orcids":["https://orcid.org/0000-0002-7581-4741"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B Spur","raw_affiliation_strings":["From the $Department of Medicine, Harvard Medical School, ann' the Department of Rheumatology and Immunology, Brigham and Women's Hospital, Boston, Massachusetts 02115, the VDepartment of Biochemistry,","IIMerck-Frosst Company, Pointe-Claire, Dorual, Canada","Medical College of Wisconsin, Milwaukee, Wisconsin 53226, and the","Mudd Building, Room 610, 250 Longwood Ave., Boston, MA 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the $Department of Medicine, Harvard Medical School, ann' the Department of Rheumatology and Immunology, Brigham and Women's Hospital, Boston, Massachusetts 02115, the VDepartment of Biochemistry,","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"IIMerck-Frosst Company, Pointe-Claire, Dorual, Canada","institution_ids":[]},{"raw_affiliation_string":"Medical College of Wisconsin, Milwaukee, Wisconsin 53226, and the","institution_ids":["https://openalex.org/I204308271"]},{"raw_affiliation_string":"Mudd Building, Room 610, 250 Longwood Ave., Boston, MA 02115","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009152014","display_name":"K. Frank Austen","orcid":"https://orcid.org/0000-0002-0255-749X","observed_orcids":["https://orcid.org/0000-0002-0255-749X","https://orcid.org/0000-0002-9955-2432"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K F Austen","raw_affiliation_strings":["From the $Department of Medicine, Harvard Medical School, ann' the Department of Rheumatology and Immunology, Brigham and Women's Hospital, Boston, Massachusetts 02115, the VDepartment of Biochemistry,","IIMerck-Frosst Company, Pointe-Claire, Dorual, Canada","Medical College of Wisconsin, Milwaukee, Wisconsin 53226, and the","Mudd Building, Room 610, 250 Longwood Ave., Boston, MA 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the $Department of Medicine, Harvard Medical School, ann' the Department of Rheumatology and Immunology, Brigham and Women's Hospital, Boston, Massachusetts 02115, the VDepartment of Biochemistry,","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"IIMerck-Frosst Company, Pointe-Claire, Dorual, Canada","institution_ids":[]},{"raw_affiliation_string":"Medical College of Wisconsin, Milwaukee, Wisconsin 53226, and the","institution_ids":["https://openalex.org/I204308271"]},{"raw_affiliation_string":"Mudd Building, Room 610, 250 Longwood Ave., Boston, MA 02115","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":3.5553,"has_fulltext":false,"cited_by_count":53,"citation_normalized_percentile":{"value":0.94000779,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"262","issue":"26","first_page":"12421","last_page":"12427"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.007899999618530273,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.006200000178068876,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cytochrome-p450","display_name":"cytochrome P450","score":0.9490000009536743},{"id":"https://openalex.org/keywords/leukotriene-b4","display_name":"leukotriene B4","score":0.9589999914169312},{"id":"https://openalex.org/keywords/omega-oxidation","display_name":"omega-oxidation","score":0.8500000238418579},{"id":"https://openalex.org/keywords/substrate-specificity","display_name":"substrate specificity","score":0.9120000004768372},{"id":"https://openalex.org/keywords/stereochemistry","display_name":"stereochemistry","score":0.8450000286102295},{"id":"https://openalex.org/keywords/hydroxyeicosatetraenoic-acids","display_name":"hydroxyeicosatetraenoic acids","score":0.7940000295639038}],"concepts":[{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.6056432723999023},{"id":"https://openalex.org/C2994592520","wikidata":"https://www.wikidata.org/wiki/Q5090496","display_name":"Substrate specificity","level":3,"score":0.5839776396751404},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5330998301506042},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.41569340229034424},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3816452920436859},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2586665451526642},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.24818384647369385},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000072470","descriptor_name":"Cytochrome P450 Family 4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006899","descriptor_name":"Mixed Function Oxygenases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007975","descriptor_name":"Leukotriene B4","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D007975","descriptor_name":"Leukotriene B4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008861","descriptor_name":"Microsomes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009251","descriptor_name":"NADPH-Ferrihemoprotein Reductase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0021-9258(18)45220-9","doi":"https://doi.org/10.1016/s0021-9258(18)45220-9","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(18)45220-9","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:3040745","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3040745","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0021-9258(18)45220-9","doi":"https://doi.org/10.1016/s0021-9258(18)45220-9","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(18)45220-9","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G12575208","display_name":null,"funder_award_id":"AI-23401","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G1437353112","display_name":null,"funder_award_id":"AI 22531","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G545047735","display_name":null,"funder_award_id":"AI22563","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1544140936","https://openalex.org/W1559174460","https://openalex.org/W1561305541","https://openalex.org/W1577480508","https://openalex.org/W1582769766","https://openalex.org/W1596087630","https://openalex.org/W1602520925","https://openalex.org/W1602588405","https://openalex.org/W1607574695","https://openalex.org/W1616825177","https://openalex.org/W1723660660","https://openalex.org/W1969874059","https://openalex.org/W1985530435","https://openalex.org/W1987782346","https://openalex.org/W1992068598","https://openalex.org/W1992115272","https://openalex.org/W2005495659","https://openalex.org/W2013457634","https://openalex.org/W2013509097","https://openalex.org/W2022518839","https://openalex.org/W2030052595","https://openalex.org/W2032777703","https://openalex.org/W2034730393","https://openalex.org/W2054371863","https://openalex.org/W2059727765","https://openalex.org/W2061411683","https://openalex.org/W2065212708","https://openalex.org/W2066303082","https://openalex.org/W2080822276","https://openalex.org/W2081520863","https://openalex.org/W2085343956","https://openalex.org/W2090254171","https://openalex.org/W2108449184","https://openalex.org/W2128635872","https://openalex.org/W2141817909","https://openalex.org/W2169556932","https://openalex.org/W2468119228"],"related_works":["https://openalex.org/W2224537505","https://openalex.org/W1516940749","https://openalex.org/W2034730393","https://openalex.org/W1978469051","https://openalex.org/W2008917337","https://openalex.org/W2011928246","https://openalex.org/W2151087040","https://openalex.org/W1521197013","https://openalex.org/W1652617759","https://openalex.org/W1500846129"],"abstract_inverted_index":{"LTB4":[0,30,37,56,142,162,191,203,215,237],"20-hydroxylase":[1],"(P-450LTB)":[2],"is":[3,250],"the":[4,8,16,51,59,62,89,152,155,180,185,196,199,218,233,243,264,269,272],"cytochrome":[5,253],"P-450":[6,254],"in":[7],"microsomes":[9],"of":[10,18,27,36,41,47,55,61,88,91,101,139,141,154,161,169,182,190,198,202,209,220,228,236,245,255,271],"human":[11,256],"polymorphonuclear":[12,257],"leukocytes":[13,258],"that":[14,117,140,148,227,240],"catalyzes":[15],"omega-oxidation":[17,219,244],"leukotriene":[19,229],"B4":[20],"(LTB4)":[21],"to":[22,32,82,110,143,167],"20-OH":[23,113,144],"LTB4.":[24],"The":[25,158],"activity":[26],"P-450LTB":[28,48,149,183,241,249],"for":[29,49,58,184,195],"compared":[31,166],"isomers":[33],"and":[34,57,64,75,105,128,175,192,224,238,268],"analogs":[35],"at":[38,115],"a":[39,45,85,92,99,251],"concentration":[40,100],"0.3":[42],"microM":[43],"revealed":[44],"preference":[46,181,194],"both":[50],"triene":[52,187,265],"bond":[53,188,266],"configuration":[54,267],"chirality":[60,153,197,270],"5S":[63],"12R":[65],"hydroxyl":[66,200,273],"groups.":[67,274],"15S-Hydroxyeicosatetraenoic":[68],"acid,":[69,72,74],"8(R/S),":[70],"15S-dihydroxy-5-cis-9,11,13-trans-eicosatetraenoic":[71],"8R,15S-dihydroxy-5,13-cis-9,11-trans-eicosatetraenoic":[73],"5S,15S-dihydroxy-6,13-trans-8,11-cis-eicosatetraenoic":[76],"acid":[77,107],"were":[78,108,118],"each":[79],"not":[80],"subject":[81],"omega-oxidation,":[83],"indicating":[84,147,239],"negative":[86],"effect":[87],"presence":[90],"15-hydroxyl":[93],"group":[94],"on":[95],"substrate":[96,260],"recognition.":[97],"At":[98,211],"1.5":[102],"microM,":[103],"12R-":[104],"12S-hydroxyeicosatetraenoic":[106],"converted":[109],"their":[111],"respective":[112],"derivatives":[114],"rates":[116],"34.2":[119],"+/-":[120,123,130,133],"11.6%":[121],"(mean":[122,132],"S.D.,":[124,134],"n":[125,135],"=":[126,136],"3)":[127],"3.5":[129],"4.3%":[131],"4),":[137],"respectively,":[138],"LTB4,":[145],"further":[146],"can":[150],"distinguish":[151],"12-hydroxyl":[156],"group.":[157],"lower":[159,234],"Km":[160,235],"(2.0":[163],"microM),":[164],"as":[165],"those":[168],"its":[170,193],"6-trans-12-epi":[171],"isomer":[172],"(3.8":[173],"microM)":[174,178],"5-epi-LTB4":[176],"(6.6":[177],"confirmed":[179],"specific":[186],"structure":[189],"groups":[201],"within":[204],"this":[205],"structurally":[206],"related":[207],"class":[208],"molecules.":[210],"equal":[212],"1.5-microM":[213],"concentrations,":[214],"completely":[216],"inhibited":[217],"all":[221,246],"other":[222],"substrates":[223],"partially":[225],"suppressed":[226],"B5,":[230],"consistent":[231],"with":[232,259],"catalyzed":[242],"substrates.":[247],"Thus,":[248],"novel":[252],"recognition":[261],"determined":[262],"by":[263]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
