{"id":"https://openalex.org/W1491667086","doi":null,"title":"Collaboration of Toll-like and RIG-I-like receptors in human dendritic cells: tRIGgering antiviral innate immune responses.","display_name":"Collaboration of Toll-like and RIG-I-like receptors in human dendritic cells: tRIGgering antiviral innate immune responses.","publication_year":2013,"publication_date":"2013-10-16","ids":{"openalex":"https://openalex.org/W1491667086","mag":"1491667086","pmid":"https://pubmed.ncbi.nlm.nih.gov/24179728","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3808934"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:2803995","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3808934","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/articles/PMC3808934","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061229287","display_name":"Attila Szab\u00f3","orcid":"https://orcid.org/0000-0001-7833-8894","observed_orcids":["https://orcid.org/0000-0001-7833-8894"]},"institutions":[{"id":"https://openalex.org/I132735039","display_name":"University of Debrecen","ror":"https://ror.org/02xf66n48","country_code":"HU","type":"education","lineage":["https://openalex.org/I132735039"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Attila Szabo","raw_affiliation_strings":["Department of Immunology, University of Debrecen Medical and Health Science Center Debrecen, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, University of Debrecen Medical and Health Science Center Debrecen, Hungary","institution_ids":["https://openalex.org/I132735039"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027516577","display_name":"\u00c9va Rajnav\u00f6lgyi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eva Rajnavolgyi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.167,"has_fulltext":true,"cited_by_count":63,"citation_normalized_percentile":{"value":0.94579028,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"2","issue":"3","first_page":"195","last_page":"207"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9223999977111816,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9223999977111816,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.05730000138282776,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.016300000250339508,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.9819999933242798},{"id":"https://openalex.org/keywords/toll-like-receptors","display_name":"Toll-like receptors","score":0.9570000171661377},{"id":"https://openalex.org/keywords/rig-i-like-receptors","display_name":"RIG-I-like receptors","score":0.996999979019165},{"id":"https://openalex.org/keywords/plasmacytoid-dendritic-cells","display_name":"plasmacytoid dendritic cells","score":0.8970000147819519},{"id":"https://openalex.org/keywords/myeloid-dendritic-cells","display_name":"myeloid dendritic cells","score":0.9860000014305115},{"id":"https://openalex.org/keywords/antiviral-innate-immunity","display_name":"antiviral innate immunity","score":0.8220000267028809},{"id":"https://openalex.org/keywords/type-i-interferon","display_name":"type I interferon","score":0.765999972820282},{"id":"https://openalex.org/keywords/viral-rna-sensing","display_name":"viral RNA sensing","score":0.6349999904632568},{"id":"https://openalex.org/keywords/pattern-recognition-receptors","display_name":"pattern recognition receptors","score":0.7770000100135803},{"id":"https://openalex.org/keywords/microbe-associated-molecular-patterns","display_name":"microbe-associated molecular patterns","score":0.6579999923706055}],"concepts":[{"id":"https://openalex.org/C2779836521","wikidata":"https://www.wikidata.org/wiki/Q14914081","display_name":"TLR7","level":5,"score":0.8484181761741638},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.8429321050643921},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7854293584823608},{"id":"https://openalex.org/C2778420691","wikidata":"https://www.wikidata.org/wiki/Q14866230","display_name":"TLR3","level":5,"score":0.7579808831214905},{"id":"https://openalex.org/C134474686","wikidata":"https://www.wikidata.org/wiki/Q21111069","display_name":"MDA5","level":5,"score":0.6636340618133545},{"id":"https://openalex.org/C111289621","wikidata":"https://www.wikidata.org/wiki/Q418772","display_name":"Pattern recognition receptor","level":4,"score":0.6303911805152893},{"id":"https://openalex.org/C2779138994","wikidata":"https://www.wikidata.org/wiki/Q15332550","display_name":"TLR9","level":5,"score":0.5843533873558044},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5461590886116028},{"id":"https://openalex.org/C102747710","wikidata":"https://www.wikidata.org/wiki/Q824237","display_name":"Endosome","level":3,"score":0.5378476977348328},{"id":"https://openalex.org/C24107716","wikidata":"https://www.wikidata.org/wiki/Q123619","display_name":"Nucleic acid","level":2,"score":0.5324011445045471},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5036641955375671},{"id":"https://openalex.org/C2776954689","wikidata":"https://www.wikidata.org/wiki/Q21100537","display_name":"RIG-I","level":4,"score":0.5007815361022949},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.47853025794029236},{"id":"https://openalex.org/C2776709828","wikidata":"https://www.wikidata.org/wiki/Q408004","display_name":"Toll-like receptor","level":4,"score":0.47440123558044434},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.45329564809799194},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.352402001619339},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.2936081886291504},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2739010751247406},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20626768469810486},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.19605770707130432},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19048714637756348},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.12644514441490173},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"pmh:oai:europepmc.org:2803995","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3808934","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3808934","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3808934","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Clin Exp Immunol","raw_type":"Text"},{"id":"pmid:24179728","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24179728","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of clinical and experimental immunology","raw_type":"Journal Article"},{"id":"pmh:oai:ganymedesd.lib.unideb.hu:2437/179748","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2437/179748","pdf_url":"http://hdl.handle.net/2437/179748","source":{"id":"https://openalex.org/S4306402089","display_name":"University of Debrecen Electronic Archive (University of Debrecen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I132735039","host_organization_name":"University of Debrecen","host_organization_lineage":["https://openalex.org/I132735039"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"foly\u00f3iratcikk"},{"id":"pmh:oai:dea.lib.unideb.hu:2437/179748","doi":null,"is_oa":true,"landing_page_url":"http://www.ncbi.nlm.nih.gov/pubmed/24179728","pdf_url":null,"source":{"id":"https://openalex.org/S4306402089","display_name":"University of Debrecen Electronic Archive (University of Debrecen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I132735039","host_organization_name":"University of Debrecen","host_organization_lineage":["https://openalex.org/I132735039"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"foly\u00f3iratcikk"},{"id":"mag:1491667086","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24179728","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2803995","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3808934","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4163893859","display_name":null,"funder_award_id":"4.2.2.A-11","funder_id":"https://openalex.org/F4320325658","funder_display_name":"Debreceni Egyetem"},{"id":"https://openalex.org/G4412332886","display_name":null,"funder_award_id":"OTKA NK 101538","funder_id":"https://openalex.org/F4320321994","funder_display_name":"Hungarian Scientific Research Fund"}],"funders":[{"id":"https://openalex.org/F4320321994","display_name":"Hungarian Scientific Research Fund","ror":"https://ror.org/00v349e63"},{"id":"https://openalex.org/F4320325658","display_name":"Debreceni Egyetem","ror":"https://ror.org/02xf66n48"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1491667086.pdf","grobid_xml":"https://content.openalex.org/works/W1491667086.grobid-xml"},"referenced_works_count":99,"referenced_works":["https://openalex.org/W45302836","https://openalex.org/W1661544713","https://openalex.org/W1839501951","https://openalex.org/W1857843111","https://openalex.org/W1858171089","https://openalex.org/W1951338100","https://openalex.org/W1967588904","https://openalex.org/W1973179284","https://openalex.org/W1973646620","https://openalex.org/W1974546926","https://openalex.org/W1976239804","https://openalex.org/W1980085931","https://openalex.org/W1982467145","https://openalex.org/W1983921697","https://openalex.org/W1994942139","https://openalex.org/W1995586746","https://openalex.org/W1996804517","https://openalex.org/W1997724110","https://openalex.org/W2004312418","https://openalex.org/W2007296839","https://openalex.org/W2007608885","https://openalex.org/W2009708031","https://openalex.org/W2010057180","https://openalex.org/W2010091770","https://openalex.org/W2010507429","https://openalex.org/W2017161741","https://openalex.org/W2017515700","https://openalex.org/W2018167033","https://openalex.org/W2020516948","https://openalex.org/W2023746601","https://openalex.org/W2023923107","https://openalex.org/W2027552314","https://openalex.org/W2031747611","https://openalex.org/W2033448006","https://openalex.org/W2036054262","https://openalex.org/W2037380046","https://openalex.org/W2038538882","https://openalex.org/W2042991127","https://openalex.org/W2047219566","https://openalex.org/W2049309853","https://openalex.org/W2050216284","https://openalex.org/W2051731494","https://openalex.org/W2054626826","https://openalex.org/W2056628849","https://openalex.org/W2056970059","https://openalex.org/W2057837626","https://openalex.org/W2060004514","https://openalex.org/W2061623879","https://openalex.org/W2062368346","https://openalex.org/W2064355457","https://openalex.org/W2067706259","https://openalex.org/W2068518836","https://openalex.org/W2071340590","https://openalex.org/W2074225638","https://openalex.org/W2080287136","https://openalex.org/W2080658428","https://openalex.org/W2081654862","https://openalex.org/W2083465591","https://openalex.org/W2087994618","https://openalex.org/W2088456748","https://openalex.org/W2088895400","https://openalex.org/W2089187782","https://openalex.org/W2089941298","https://openalex.org/W2090640877","https://openalex.org/W2091978007","https://openalex.org/W2092024651","https://openalex.org/W2099039895","https://openalex.org/W2100665873","https://openalex.org/W2101528736","https://openalex.org/W2102683798","https://openalex.org/W2109468835","https://openalex.org/W2111975769","https://openalex.org/W2114038958","https://openalex.org/W2116773729","https://openalex.org/W2116803339","https://openalex.org/W2117053011","https://openalex.org/W2121921857","https://openalex.org/W2124651203","https://openalex.org/W2125566625","https://openalex.org/W2125845521","https://openalex.org/W2126737730","https://openalex.org/W2127144270","https://openalex.org/W2128500473","https://openalex.org/W2131811503","https://openalex.org/W2136329789","https://openalex.org/W2137303998","https://openalex.org/W2138560966","https://openalex.org/W2141137217","https://openalex.org/W2144611757","https://openalex.org/W2146201900","https://openalex.org/W2150058561","https://openalex.org/W2150324671","https://openalex.org/W2155547995","https://openalex.org/W2158347684","https://openalex.org/W2158692368","https://openalex.org/W2161340928","https://openalex.org/W2163853272","https://openalex.org/W2168028214","https://openalex.org/W2177327503"],"related_works":["https://openalex.org/W1999288311","https://openalex.org/W2080287136","https://openalex.org/W2004312418","https://openalex.org/W2168116459","https://openalex.org/W4234707226","https://openalex.org/W2119685963","https://openalex.org/W1967686012","https://openalex.org/W1987047581","https://openalex.org/W2403267133","https://openalex.org/W2066728093"],"abstract_inverted_index":{"Dendritic":[0],"cells":[1,12,115],"(DCs)":[2],"represent":[3],"a":[4],"functionally":[5,60],"diverse":[6],"and":[7,20,24,59,68,76,103,112,117,134,143,151,163,171,203,206,231],"flexible":[8],"population":[9],"of":[10,17,30,43,128,157,189,194,200,229],"rare":[11],"with":[13,56],"the":[14,28,41,129,135,148,155,187,191,226],"unique":[15],"capability":[16],"binding,":[18],"internalizing":[19],"detecting":[21,190],"various":[22,178],"microorganisms":[23],"their":[25],"components.":[26],"However,":[27],"response":[29],"DCs":[31],"to":[32,85,92,215,225],"innocuous":[33],"or":[34],"pathogenic":[35],"microbes":[36],"is":[37,223],"highly":[38],"dependent":[39],"on":[40],"type":[42,100],"microbe-associated":[44],"molecular":[45],"patterns":[46],"(MAMPs)":[47],"recognized":[48],"by":[49,99,196],"pattern":[50],"recognition":[51,156],"receptors":[52,88],"(PRRs)":[53],"that":[54,64,89,176,211],"interact":[55],"phylogenetically":[57],"conserved":[58],"indispensable":[61],"microbial":[62],"targets":[63],"involve":[65],"both":[66],"self":[67],"foreign":[69],"structures":[70],"such":[71,125],"as":[72,126],"lipids,":[73],"carbohydrates,":[74],"proteins,":[75],"nucleic":[77,86,121],"acids.":[78],"Recently,":[79],"special":[80],"attention":[81,222],"has":[82],"been":[83],"drawn":[84],"acid":[87,122],"are":[90,145,152,173],"able":[91],"evoke":[93],"robust":[94],"innate":[95,202],"immune":[96],"responses":[97],"mediated":[98],"I":[101],"interferons":[102],"inflammatory":[104],"cytokine":[105],"production":[106],"against":[107],"intracellular":[108],"pathogens.":[109],"Both":[110],"conventional":[111],"plasmacytoid":[113],"dendritic":[114],"(cDCs":[116],"pDCs)":[118],"express":[119],"specific":[120],"recognizing":[123],"receptors,":[124],"members":[127],"membrane":[130,150],"Toll-like":[131],"receptor":[132,138],"(TLR)":[133],"cytosolic":[136,174],"RIG-I-like":[137],"(RLR)":[139],"families.":[140],"TLR3,":[141],"TLR7/TLR8":[142],"TLR9":[144],"localized":[146],"in":[147,234],"endosomal":[149],"specialized":[153],"for":[154],"viral":[158,179,208],"double-stranded":[159],"RNA,":[160,162],"single-stranded":[161],"nonmethylated":[164],"DNA,":[165],"respectively":[166],"whereas":[167],"RLRs":[168],"(RIG-I,":[169],"MDA5,":[170],"LGP2)":[172],"proteins":[175],"sense":[177],"RNA":[180],"species.":[181],"In":[182],"this":[183],"review":[184],"we":[185],"discuss":[186],"significance":[188],"genomic":[192],"content":[193],"viruses":[195],"DC":[197],"subsets":[198],"capable":[199],"linking":[201],"adaptive":[204],"immunity,":[205],"several":[207],"evasion":[209],"mechanisms":[210],"may":[212],"allow":[213],"us":[214],"better":[216],"understand":[217],"these":[218],"responses.":[219],"A":[220],"particular":[221],"paid":[224],"possible":[227],"collaboration":[228],"TLR":[230],"RLR":[232],"sensors":[233],"anti-viral":[235],"protection.":[236]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":15},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
