{"id":"https://openalex.org/W1491607388","doi":"https://doi.org/10.1016/s0021-9258(18)88976-1","title":"The nucleotide sequence of the 17S ribosomal RNA gene of Tetrahymena thermophila and the identification of point mutations resulting in resistance to the antibiotics paromomycin and hygromycin.","display_name":"The nucleotide sequence of the 17S ribosomal RNA gene of Tetrahymena thermophila and the identification of point mutations resulting in resistance to the antibiotics paromomycin and hygromycin.","publication_year":1985,"publication_date":"1985-05-01","ids":{"openalex":"https://openalex.org/W1491607388","doi":"https://doi.org/10.1016/s0021-9258(18)88976-1","mag":"1491607388","pmid":"https://pubmed.ncbi.nlm.nih.gov/3997824"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-9258(18)88976-1","doi":"https://doi.org/10.1016/s0021-9258(18)88976-1","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(18)88976-1","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0021-9258(18)88976-1","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113512370","display_name":"Elizabeth A. Spangler","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E A Spangler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5064437582","display_name":"Elizabeth Helen Blackburn","orcid":"https://orcid.org/0000-0002-4885-0544","observed_orcids":["https://orcid.org/0000-0002-4885-0544"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E H Blackburn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":5.6494,"has_fulltext":false,"cited_by_count":194,"citation_normalized_percentile":{"value":0.97010155,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"260","issue":"10","first_page":"6334","last_page":"6340"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11879","display_name":"Protist diversity and phylogeny","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1105","display_name":"Ecology, Evolution, Behavior and Systematics"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tetrahymena-thermophila","display_name":"Tetrahymena thermophila","score":0.9929999709129333},{"id":"https://openalex.org/keywords/nucleotide-sequence","display_name":"nucleotide sequence","score":0.7509999871253967},{"id":"https://openalex.org/keywords/small-subunit-rrna","display_name":"small subunit rRNA","score":0.7540000081062317},{"id":"https://openalex.org/keywords/paromomycin-resistance","display_name":"paromomycin resistance","score":0.7799999713897705},{"id":"https://openalex.org/keywords/hygromycin-resistance","display_name":"hygromycin resistance","score":1.0},{"id":"https://openalex.org/keywords/aminoglycosides","display_name":"aminoglycosides","score":0.9160000085830688},{"id":"https://openalex.org/keywords/point-mutations","display_name":"point mutations","score":0.8920000195503235},{"id":"https://openalex.org/keywords/rrna-secondary-structure","display_name":"rRNA secondary structure","score":0.8939999938011169},{"id":"https://openalex.org/keywords/ribosome-function","display_name":"ribosome function","score":0.7149999737739563},{"id":"https://openalex.org/keywords/translation-biology","display_name":"translation (biology)","score":0.4880000054836273}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7969272136688232},{"id":"https://openalex.org/C2776114741","wikidata":"https://www.wikidata.org/wiki/Q415625","display_name":"Paromomycin","level":4,"score":0.7936053276062012},{"id":"https://openalex.org/C67905577","wikidata":"https://www.wikidata.org/wiki/Q215980","display_name":"Ribosomal RNA","level":3,"score":0.7668987512588501},{"id":"https://openalex.org/C88478588","wikidata":"https://www.wikidata.org/wiki/Q42244","display_name":"Ribosome","level":4,"score":0.7089388370513916},{"id":"https://openalex.org/C2777166614","wikidata":"https://www.wikidata.org/wiki/Q1198419","display_name":"Tetrahymena","level":2,"score":0.7003437280654907},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6519021391868591},{"id":"https://openalex.org/C40749294","wikidata":"https://www.wikidata.org/wiki/Q4631553","display_name":"23S ribosomal RNA","level":5,"score":0.6493297815322876},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6173062324523926},{"id":"https://openalex.org/C98098607","wikidata":"https://www.wikidata.org/wiki/Q4639691","display_name":"5.8S ribosomal RNA","level":5,"score":0.6139996647834778},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.4940229058265686},{"id":"https://openalex.org/C84148353","wikidata":"https://www.wikidata.org/wiki/Q863908","display_name":"Nucleic acid sequence","level":3,"score":0.49256592988967896},{"id":"https://openalex.org/C47698986","wikidata":"https://www.wikidata.org/wiki/Q10018973","display_name":"18S ribosomal RNA","level":4,"score":0.451901376247406},{"id":"https://openalex.org/C176944494","wikidata":"https://www.wikidata.org/wiki/Q1415380","display_name":"Point mutation","level":4,"score":0.43000009655952454},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4070044457912445},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.3134799003601074},{"id":"https://openalex.org/C2777787772","wikidata":"https://www.wikidata.org/wiki/Q45355603","display_name":"Aminoglycoside","level":3,"score":0.28249844908714294},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.0676833987236023}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002934","descriptor_name":"Cinnamates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004352","descriptor_name":"Drug Resistance, Microbial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005796","descriptor_name":"Genes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006921","descriptor_name":"Hygromycin B","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D006921","descriptor_name":"Hygromycin B","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009690","descriptor_name":"Nucleic Acid Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010303","descriptor_name":"Paromomycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012335","descriptor_name":"RNA, Ribosomal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013768","descriptor_name":"Tetrahymena","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013768","descriptor_name":"Tetrahymena","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0021-9258(18)88976-1","doi":"https://doi.org/10.1016/s0021-9258(18)88976-1","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(18)88976-1","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:3997824","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3997824","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.1016/s0021-9258(18)88976-1","doi":"https://doi.org/10.1016/s0021-9258(18)88976-1","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(18)88976-1","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G7116059693","display_name":"RDNA AMPLIFICATION AND REPLICATION IN TETRAHYMENA","funder_award_id":"R01GM032565","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W3812360","https://openalex.org/W5941849","https://openalex.org/W1489595475","https://openalex.org/W1504260229","https://openalex.org/W1558516755","https://openalex.org/W1617983474","https://openalex.org/W1963597574","https://openalex.org/W1967559077","https://openalex.org/W1971308369","https://openalex.org/W1973017007","https://openalex.org/W1979197786","https://openalex.org/W1981831202","https://openalex.org/W1990431217","https://openalex.org/W1991040185","https://openalex.org/W1991346121","https://openalex.org/W2000764465","https://openalex.org/W2012795877","https://openalex.org/W2019400001","https://openalex.org/W2022125701","https://openalex.org/W2024370620","https://openalex.org/W2025962789","https://openalex.org/W2033047771","https://openalex.org/W2040276985","https://openalex.org/W2044133901","https://openalex.org/W2050077441","https://openalex.org/W2058425184","https://openalex.org/W2061689785","https://openalex.org/W2062674704","https://openalex.org/W2065612681","https://openalex.org/W2073795033","https://openalex.org/W2077077850","https://openalex.org/W2082699691","https://openalex.org/W2087211462","https://openalex.org/W2090262721","https://openalex.org/W2091524642","https://openalex.org/W2110230145","https://openalex.org/W2121234754","https://openalex.org/W2157010941","https://openalex.org/W2166064969","https://openalex.org/W2167340225","https://openalex.org/W2169588346"],"related_works":["https://openalex.org/W1931176780","https://openalex.org/W2084988722","https://openalex.org/W4254318552","https://openalex.org/W2097580085","https://openalex.org/W2415676437","https://openalex.org/W2047475857","https://openalex.org/W2049622192","https://openalex.org/W75730325","https://openalex.org/W2088934284","https://openalex.org/W1989807871"],"abstract_inverted_index":{"We":[0,68],"have":[1,69,99],"determined":[2,71],"the":[3,7,11,18,38,51,56,72,79,89,106,110,128,138,149,152],"complete":[4],"sequence":[5,36,122],"of":[6,17,37,47,63,74,109,127,130,137,140,151],"nuclear":[8],"gene":[9,24,83],"encoding":[10],"small":[12,40,65,153],"subunit":[13,41,66,154],"(17":[14],"S)":[15],"rRNA":[16,42,134],"ciliated":[19],"protozoan":[20],"Tetrahymena":[21,39,80],"thermophila.":[22],"The":[23,35],"encodes":[25],"an":[26],"RNA":[27,156],"molecule":[28,57],"which":[29,60,84],"is":[30,43,116],"1753":[31],"nucleotides":[32],"in":[33,78,86,120,157],"length.":[34],"homologous":[44],"to":[45,88,147],"those":[46],"other":[48],"eukaryotes,":[49],"and":[50,93,123,136],"predicted":[52],"secondary":[53,124],"structure":[54],"for":[55],"includes":[58],"features":[59],"are":[61],"characteristic":[62],"eukaryotic":[64],"rRNAs.":[67],"also":[70],"nature":[73],"two":[75],"different":[76],"mutations":[77,132],"17":[81],"S":[82],"result":[85],"resistance":[87],"aminoglycoside":[90],"antibiotics":[91],"paromomycin":[92],"hygromycin.":[94],"In":[95],"each":[96],"case":[97],"we":[98],"identified":[100],"a":[101,113],"single":[102],"base":[103],"change":[104],"near":[105],"3'":[107],"end":[108],"rRNA,":[111],"within":[112],"region":[114],"that":[115],"highly":[117],"evolutionarily":[118],"conserved":[119],"both":[121],"structure.":[125],"Analysis":[126],"effects":[129],"these":[131,141],"on":[133,143],"structure,":[135],"impact":[139],"drugs":[142],"translation,":[144],"should":[145],"help":[146],"elucidate":[148],"role":[150],"ribosomal":[155],"ribosome":[158],"function.":[159]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
