{"id":"https://openalex.org/W1491535447","doi":null,"title":"Estats mixtes, viratges i antidepressius: estudi d'una cohort de pacients bipolars","display_name":"Estats mixtes, viratges i antidepressius: estudi d'una cohort de pacients bipolars","publication_year":2012,"publication_date":"2012-02-21","ids":{"openalex":"https://openalex.org/W1491535447","mag":"1491535447"},"language":"ca","primary_location":{"id":"pmh:oai:dnet:tdr_________::ce2b2adbcc8fc2651b2d26a2d3da52b5","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10803/119602","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/2445/45043","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028170002","display_name":"Marc Valent\u00ed Ribas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Marc Valent\u00ed Ribas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5028170002"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10786","display_name":"Maternal Mental Health During Pregnancy and Postpartum","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bipolar-disorder","display_name":"bipolar disorder","score":0.9179999828338623},{"id":"https://openalex.org/keywords/mixed-states","display_name":"mixed states","score":0.9279999732971191},{"id":"https://openalex.org/keywords/antidepressants","display_name":"antidepressants","score":0.5860000252723694},{"id":"https://openalex.org/keywords/bipolar-depression","display_name":"bipolar depression","score":0.7879999876022339},{"id":"https://openalex.org/keywords/antidepressant-induced-hypomania","display_name":"antidepressant-induced hypomania","score":0.6869999766349792},{"id":"https://openalex.org/keywords/mood-stabilizers","display_name":"mood stabilizers","score":0.7319999933242798},{"id":"https://openalex.org/keywords/lithium","display_name":"lithium","score":0.3930000066757202},{"id":"https://openalex.org/keywords/valproic-acid","display_name":"valproic acid","score":0.6980000138282776},{"id":"https://openalex.org/keywords/antiepileptic-drugs","display_name":"antiepileptic drugs","score":0.6370000243186951},{"id":"https://openalex.org/keywords/bipolar-i-disorder","display_name":"bipolar I disorder","score":0.4830000102519989}],"concepts":[{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.7451541423797607},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.35540470480918884}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:dnet:tdr_________::ce2b2adbcc8fc2651b2d26a2d3da52b5","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10803/119602","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:www.tdx.cat:10803/119602","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10803/119602","pdf_url":null,"source":{"id":"https://openalex.org/S4306401111","display_name":"Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210090028","host_organization_name":"Consorci de Serveis Universitaris de Catalunya","host_organization_lineage":["https://openalex.org/I4210090028"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:diposit.ub.edu:2445/45043","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2445/45043","pdf_url":"http://hdl.handle.net/2445/45043","source":{"id":"https://openalex.org/S4306401653","display_name":"Dip\u00f2sit Digital de la Universitat de Barcelona (Universitat de Barcelona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I71999127","host_organization_name":"Universitat de Barcelona","host_organization_lineage":["https://openalex.org/I71999127"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Tesis Doctorals - Departament - Psiquiatria i Psicobiologia Cl\u00ednica","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:1491535447","doi":null,"is_oa":false,"landing_page_url":"http://diposit.ub.edu/dspace/bitstream/2445/45043/1/MVR_TESI.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306531624","display_name":"TDX (Tesis Doctorals en Xarxa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":null}],"best_oa_location":{"id":"pmh:oai:diposit.ub.edu:2445/45043","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2445/45043","pdf_url":"http://hdl.handle.net/2445/45043","source":{"id":"https://openalex.org/S4306401653","display_name":"Dip\u00f2sit Digital de la Universitat de Barcelona (Universitat de Barcelona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I71999127","host_organization_name":"Universitat de Barcelona","host_organization_lineage":["https://openalex.org/I71999127"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Tesis Doctorals - Departament - Psiquiatria i Psicobiologia Cl\u00ednica","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320322930","display_name":"Ministerio de Ciencia e Innovaci\u00f3n","ror":null},{"id":"https://openalex.org/F4320334923","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1491535447.pdf","grobid_xml":"https://content.openalex.org/works/W1491535447.grobid-xml"},"referenced_works_count":68,"referenced_works":["https://openalex.org/W178516874","https://openalex.org/W192481466","https://openalex.org/W1480066549","https://openalex.org/W1518446047","https://openalex.org/W1531015715","https://openalex.org/W1553680210","https://openalex.org/W1963502314","https://openalex.org/W1966490279","https://openalex.org/W1968266057","https://openalex.org/W1971463734","https://openalex.org/W1974530945","https://openalex.org/W1979999703","https://openalex.org/W1986064100","https://openalex.org/W1999270822","https://openalex.org/W2003490971","https://openalex.org/W2004597728","https://openalex.org/W2008575304","https://openalex.org/W2014214625","https://openalex.org/W2015662968","https://openalex.org/W2023047291","https://openalex.org/W2027429200","https://openalex.org/W2028184617","https://openalex.org/W2031358990","https://openalex.org/W2040674531","https://openalex.org/W2044751121","https://openalex.org/W2061378977","https://openalex.org/W2065174139","https://openalex.org/W2065532317","https://openalex.org/W2065692940","https://openalex.org/W2066725313","https://openalex.org/W2071692582","https://openalex.org/W2075370540","https://openalex.org/W2076444692","https://openalex.org/W2081125298","https://openalex.org/W2082850905","https://openalex.org/W2083482452","https://openalex.org/W2084686735","https://openalex.org/W2085589409","https://openalex.org/W2087539060","https://openalex.org/W2091962144","https://openalex.org/W2093839512","https://openalex.org/W2094848286","https://openalex.org/W2098536584","https://openalex.org/W2108489849","https://openalex.org/W2110449548","https://openalex.org/W2111355579","https://openalex.org/W2114613490","https://openalex.org/W2114971314","https://openalex.org/W2120608834","https://openalex.org/W2121798700","https://openalex.org/W2124509426","https://openalex.org/W2124969157","https://openalex.org/W2129604620","https://openalex.org/W2129715921","https://openalex.org/W2129757014","https://openalex.org/W2136900530","https://openalex.org/W2140160625","https://openalex.org/W2146184755","https://openalex.org/W2152261925","https://openalex.org/W2162401463","https://openalex.org/W2166423384","https://openalex.org/W2167659819","https://openalex.org/W2169868603","https://openalex.org/W2258090296","https://openalex.org/W2394779600","https://openalex.org/W2507515274","https://openalex.org/W2735928575","https://openalex.org/W4238215801"],"related_works":["https://openalex.org/W2514872217","https://openalex.org/W4285601499","https://openalex.org/W2495413739","https://openalex.org/W1999761829","https://openalex.org/W2025588453","https://openalex.org/W2762453997","https://openalex.org/W2141357672","https://openalex.org/W1958008926","https://openalex.org/W2006336517","https://openalex.org/W2091712178"],"abstract_inverted_index":{"El":[0],"trastorn":[1,44,47,73,228,414],"bipolar":[2,45,74,94,116,229,454],"\u00e9s":[3,35,50,95,105,117],"una":[4,138,262,290,313,373,449,493,549],"malaltia":[5,526],"cr\u00f2nica":[6],"i":[7,27,30,62,97,130,183,217,255,316,334,384,397,411,425,447,457,486,513,527,537,559],"recurrent,":[8,49],"caracteritzada":[9],"per":[10,176,208,532],"l\u2019aparici\u00f3":[11],"d\u2019episodis":[12,366,381],"d\u00b4(hipo)mania":[13,148],"i/o":[14,483],"estats":[15],"mixtes,":[16,260],"que":[17,28,40,54,81,122,141,150,160,168,311,341,364,418,492,514],"alternen,":[18],"de":[19,24,32,60,91,113,133,156,165,197,212,237,258,264,277,294,296,309,336,357,392,395,423,440,451,469,480,501,518,524,535,540,562],"manera":[20,303],"irregular,":[21],"amb":[22,72,78,82,153,179,194,227,300,444,448,542],"episodis":[23,147],"depressi\u00f3.\\n\\n\\t\\t\\t\\t":[25],"Tot":[26,182],"l\u2019elevaci\u00f3":[29],"expansi\u00f3":[31],"l\u2019estat":[33,198,481],"d\u2019\u00e0nim":[34,199,482],"la":[36,51,55,57,92,114,134,163,186,209,238,250,297,337,358,393,470,475,525],"principal":[37,58],"caracter\u00edstica":[38],"cl\u00ednica":[39,188],"permet":[41],"distingir":[42],"el":[43,89,98,124,154,256,307,327,332,409,560],"del":[46,223,233,343,355,413,466],"depressiu":[48],"depressi\u00f3,":[52],"m\u00e9s":[53,76],"mania,":[56],"causa":[59],"discapacitat":[61],"mort":[63],"en":[64,103,185,201,249,331,404,408],"els":[65,70,142,270,515],"pacients":[66,71,226,266,284,310,346,453,461,497],"bipolars.":[67],"A":[68],"m\u00e9s,":[69],"passen":[75],"temps":[77],"simptomatologia":[79,83],"depressiva":[80],"(hipo)man\u00edaca":[84],"o":[85,159,505],"mixta.":[86],"D\u2019altra":[87],"banda,":[88],"tractament":[90,112,511],"depressi\u00f3":[93,115,502],"complex":[96],"n\u00famero":[99,380],"d\u2019opcions":[100],"terap\u00e8utiques":[101],"basades":[102],"l\u2019evid\u00e8ncia":[104],"molt":[106],"limitat.\\n\\n\\t\\t\\t\\t":[107],"L\u2019\u00fas":[108],"d\u2019antidepressius":[109,254,558],"com":[110,200,326],"a":[111,279,322,370,372,377,385,426,435,474,503,506],"\u00e0mpliament":[118,190],"debatut.":[119],"Les":[120,203],"dades":[121],"recolzen":[123],"seu":[125],"\u00fas":[126,388],"s\u00f3n":[127,189],"metodol\u00f2gicament":[128],"pobres":[129],"insuficients;":[131],"i,":[132],"mateixa":[135],"manera,":[136],"existeix":[137],"extesa":[139],"creen\u00e7a":[140],"antidepressius":[143,330,407],"poden":[144,161],"induir":[145],"nous":[146],"(viratges),":[149],"estan":[151],"relacionats":[152],"desenvolupament":[155,257,422,561],"fases":[157,204,259],"mixtes":[158,205,367],"accelerar":[162],"taxa":[164],"ciclaci\u00f3,":[166],"afirmacions":[167],"no":[169,547],"han":[170],"estat":[171,286,507],"ni":[172,174],"confirmades":[173],"rebutjades":[175],"estudis":[177,401],"controlats":[178],"placebo.":[180],"\\n\\n\\t\\t\\t\\t":[181],"aix\u00f2,":[184,432],"pr\u00e0ctica":[187],"usats,":[191],"tant":[192],"associats":[193],"f\u00e0rmacs":[195],"estabilitzadors":[196],"monoter\u00e0pia.\\n\\n\\t\\t\\t\\t":[202],"es":[206,419],"caracteritzen":[207],"pres\u00e8ncia":[210],"concomitant":[211],"s\u00edmptomes":[213],"d\u2019ambd\u00f3s":[214],"pols":[215],"afectius":[216],"representen":[218],"un":[219,275,350,378,386,437,499,521,528],"dels":[220,225,329,345,406,496],"principals":[221,516],"reptes":[222],"maneig":[224],"tipus":[230,268,455],"I":[231,456],"(prevalen\u00e7a":[232],"40%":[234,344],"al":[235,288,292,348,353,421,510],"llarg":[236,293,354],"vida,":[239],"dificultat":[240],"diagn\u00f2stica,":[241],"alta":[242],"complexitat":[243],"terap\u00e8utica).":[244],"Per":[245,431],"aportar":[246],"informaci\u00f3":[247],"innovadora":[248],"relaci\u00f3":[251],"entre":[252,553],"l\u2019\u00fas":[253,554],"estudi\u00e0rem":[261],"mostra":[263,450],"144":[265],"bipolars":[267],"I,":[269],"quals":[271],"foren":[272],"seguits":[273,464],"durant":[274,487],"per\u00edode":[276],"fins":[278],"20":[280],"anys.":[281],"Tots":[282],"aquests":[283],"havien":[285],"tractats,":[287],"menys":[289,349],"vegada":[291],"l\u2019evoluci\u00f3":[295,335],"seva":[298],"malaltia,":[299],"antidepressius.":[301,543],"D\u2019aquesta":[302],"vam":[304,362,433],"poder":[305],"determinar":[306,363],"percentatge":[308],"desenvolupava":[312,347,498],"fase":[314],"mixta":[315],"aclarir":[317],"les":[318,427],"caracter\u00edstiques":[319,428],"cl\u00edniques":[320,429],"associades":[321],"aquest":[323],"fet,":[324],"aix\u00ed":[325],"rol":[328],"curs":[333,356,410,529],"malaltia.":[338,359],"L\u2019estudi":[339,490],"identific\u00e0":[340],"prop":[342],"episodi":[351],"mixte":[352,508],"Aix\u00ed":[360,544],"mateix,":[361,545],"l\u2019ocurr\u00e8ncia":[365],"est\u00e0":[368],"associada":[369],"cronicitat,":[371],"pitjor":[374],"evoluci\u00f3":[375],"cl\u00ednica,":[376],"major":[379,387],"depressius":[382],"previs":[383],"d\u2019antidepressius,":[389],"especialment":[390,416],"Inhibidors":[391],"Recaptaci\u00f3":[394],"Serotonina":[396],"Noradrenalina.\\n\\n\\t\\t\\t\\t":[398],"Molt":[399],"pocs":[400],"s\u2019han":[402],"focalitzat":[403],"l\u00b4impacte":[405],"l\u00b4evoluci\u00f3":[412],"bipolar,":[415],"pel":[417],"refereix":[420],"viratges,":[424],"associades.":[430],"portar":[434],"terme":[436],"segon":[438],"estudi":[439],"cohorts,":[441],"prospectiu,":[442],"combinat":[443],"avaluacions":[445],"retrospectives,":[446],"221":[452],"II":[458],"deprimits.":[459],"Els":[460],"van":[462],"ser":[463],"des":[465],"primer":[467],"dia":[468],"introducci\u00f3":[471],"d\u2019un":[472,555],"antidepressiu":[473],"pauta":[476],"psicofarmacol\u00f2gica":[477],"pr\u00e8via":[478],"(estabilitzadors":[479],"antipsic\u00f2tics":[484],"at\u00edpics)":[485],"sis":[488],"mesos.":[489],"determin\u00e0":[491],"quarta":[494],"part":[495],"viratge":[500,541],"(hipo)mania":[504],"associat":[509],"antidepressiu,":[512],"factors":[517],"risc":[519],"eren":[520],"debut":[522],"preco\u00e7":[523],"cl\u00ednic":[530],"caracteritzat":[531],"baixes":[533],"taxes":[534,539],"resposta":[536],"altes":[538],"l\u2019estudi":[546],"trob\u00e0":[548],"associaci\u00f3":[550],"estad\u00edsticament":[551],"significativa":[552],"nombre":[556],"elevat":[557],"viratges.":[563]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}