{"id":"https://openalex.org/W1491510143","doi":null,"title":"Mutations in the L3 loop of zinc-binding domain of p53 are poor prognostic indicators of Caucasians with colorectal adenocarcinomas","display_name":"Mutations in the L3 loop of zinc-binding domain of p53 are poor prognostic indicators of Caucasians with colorectal adenocarcinomas","publication_year":2005,"publication_date":"2005-05-01","ids":{"openalex":"https://openalex.org/W1491510143","mag":"1491510143"},"language":"en","primary_location":{"id":"mag:1491510143","doi":null,"is_oa":false,"landing_page_url":"https://cancerres.aacrjournals.org/content/65/9_Supplement/598.2","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Cancer Research","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073586472","display_name":"Venkat Rao Katkoori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Venkat R. Katkoori","raw_affiliation_strings":["University of Alabama at Birmingham; Birmingham AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Alabama at Birmingham; Birmingham AL","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079147357","display_name":"Chakrapani Chatla","orcid":"https://orcid.org/0000-0002-3259-0602","observed_orcids":["https://orcid.org/0000-0002-3259-0602"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chakrapani Chatla","raw_affiliation_strings":["University of Alabama at Birmingham; Birmingham AL"],"raw_orcid":"https://orcid.org/0000-0002-3259-0602","affiliations":[{"raw_affiliation_string":"University of Alabama at Birmingham; Birmingham AL","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jia Xu","orcid":"https://orcid.org/0000-0002-0019-9502","observed_orcids":["https://orcid.org/0000-0002-0019-9502"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jia Xu","raw_affiliation_strings":["University of Alabama at Birmingham; Birmingham AL"],"raw_orcid":"https://orcid.org/0000-0002-0019-9502","affiliations":[{"raw_affiliation_string":"University of Alabama at Birmingham; Birmingham AL","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076077003","display_name":"William E. Grizzle","orcid":"https://orcid.org/0000-0001-9245-0401","observed_orcids":["https://orcid.org/0000-0001-9245-0401"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William E. Grizzle","raw_affiliation_strings":["University of Alabama at Birmingham; Birmingham AL"],"raw_orcid":"https://orcid.org/0000-0001-9245-0401","affiliations":[{"raw_affiliation_string":"University of Alabama at Birmingham; Birmingham AL","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038817160","display_name":"Upender Manne","orcid":"https://orcid.org/0000-0002-1545-3032","observed_orcids":["https://orcid.org/0000-0002-1545-3032"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Upender Manne","raw_affiliation_strings":["University of Alabama at Birmingham; Birmingham AL"],"raw_orcid":"https://orcid.org/0000-0002-1545-3032","affiliations":[{"raw_affiliation_string":"University of Alabama at Birmingham; Birmingham AL","institution_ids":["https://openalex.org/I32389192"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I32389192"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.12088095,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"65","issue":null,"first_page":"598","last_page":"598"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9179999828338623,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9179999828338623,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.07909999787807465,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tp53-mutation","display_name":"TP53 mutation","score":0.925000011920929},{"id":"https://openalex.org/keywords/colorectal-adenocarcinoma","display_name":"colorectal adenocarcinoma","score":0.9860000014305115},{"id":"https://openalex.org/keywords/zinc-binding-domain","display_name":"zinc-binding domain","score":0.9940000176429749},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7310000061988831},{"id":"https://openalex.org/keywords/racial-differences","display_name":"racial differences","score":0.7179999947547913},{"id":"https://openalex.org/keywords/african-americans","display_name":"African Americans","score":0.7839999794960022},{"id":"https://openalex.org/keywords/caucasians","display_name":"Caucasians","score":0.9679999947547913},{"id":"https://openalex.org/keywords/codon-72-polymorphism","display_name":"codon 72 polymorphism","score":0.8019999861717224},{"id":"https://openalex.org/keywords/mutation-hotspots","display_name":"mutational hotspots","score":0.777999997138977},{"id":"https://openalex.org/keywords/patient-survival","display_name":"patient survival","score":0.9070000052452087},{"id":"https://openalex.org/keywords/mutational-patterns","display_name":"mutation patterns","score":0.6629999876022339},{"id":"https://openalex.org/keywords/tumor-aggressiveness","display_name":"tumor aggressiveness","score":0.6290000081062317},{"id":"https://openalex.org/keywords/kaplan-meier-survival-analysis","display_name":"Kaplan-Meier survival analysis","score":0.6650000214576721}],"concepts":[{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.6901448369026184},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.5585358142852783},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5048189759254456},{"id":"https://openalex.org/C91779695","wikidata":"https://www.wikidata.org/wiki/Q3780824","display_name":"Coding region","level":3,"score":0.48564282059669495},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47813236713409424},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4327335059642792},{"id":"https://openalex.org/C176944494","wikidata":"https://www.wikidata.org/wiki/Q1415380","display_name":"Point mutation","level":4,"score":0.42980656027793884},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42716777324676514},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4209756851196289},{"id":"https://openalex.org/C144301174","wikidata":"https://www.wikidata.org/wiki/Q7893852","display_name":"Univariate analysis","level":3,"score":0.4151299297809601},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.401218056678772},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.38084080815315247},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.28405654430389404},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2834101915359497},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.13861984014511108}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:1491510143","doi":null,"is_oa":false,"landing_page_url":"https://cancerres.aacrjournals.org/content/65/9_Supplement/598.2","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Cancer Research","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2511241212","https://openalex.org/W2130128213","https://openalex.org/W2967256669","https://openalex.org/W2132992573","https://openalex.org/W2527617732","https://openalex.org/W2885038346","https://openalex.org/W2109825478","https://openalex.org/W2094031633","https://openalex.org/W2104212561","https://openalex.org/W2101109428"],"abstract_inverted_index":{"Proc":[0],"Amer":[1],"Assoc":[2],"Cancer":[3],"Res,":[4],"Volume":[5],"46,":[6],"2005\n\n2548":[7],"\n\nBackground:":[8],"We":[9,56],"previously":[10],"reported":[11],"that":[12,242],"abnormalities":[13],"in":[14,20,31,43,145,149,156,181,195,198,213,217,223,250,279],"p53":[15,41,79,106,134,146,234,247,267,284],"have":[16],"different":[17],"biologic":[18],"consequences":[19],"colorectal":[21,293],"adenocarcinoma":[22],"(CRC)":[23],"when":[24],"analyzed":[25],"based":[26,136],"on":[27,137],"patient":[28,53],"race.":[29,138],"Therefore,":[30],"the":[32,37,69,130,182,243,260,280],"current":[33],"study,":[34],"we":[35],"assessed":[36,82],"mutational":[38,244],"patterns":[39],"of":[40,71,78,86,105,133,142,152,159,165,185,246,252,263,266,274,283,288,292],"gene":[42,80,248],"CRCs":[44,251],"collected":[45,57],"from":[46,60,68],"Caucasians":[47,196,218,220],"and":[48,50,63,114,118,254,304],"African-Americans,":[49],"correlated":[51],"with":[52,221,231,270],"survival.":[54],"Methods:":[55],"frozen":[58],"tissues":[59],"121":[61],"Caucasian":[62,150,253,275],"63":[64],"African-American":[65,157,255],"CRC":[66],"patients":[67],"University":[70],"Alabama":[72],"at":[73,167,204],"Birmingham":[74],"Hospital.":[75],"The":[76,97,140,163],"status":[77],"was":[81,147,192],"by":[83,300],"direct":[84],"sequencing":[85],"all":[87,108],"coding":[88],"regions":[89],"(exons":[90,101],"2":[91],"-":[92,103],"11),":[93],"using":[94],"exon-specific":[95],"primers.":[96],"DNA":[98],"binding":[99],"domain":[100,187,225,265],"5":[102],"8)":[104],"includes":[107],"important":[109],"structural":[110],"motifs":[111],"like":[112],"L2":[113],"L3":[115,183,224,261,281],"zinc-binding":[116,186,264],"domains":[117],"LSH":[119],"(loop-sheet-helix)":[120],"motif.":[121],"Univariate":[122],"Kaplan-Meier":[123],"survival":[124],"analyses":[125],"were":[126,210],"used":[127],"to":[128,208],"assess":[129],"prognostic":[131],"significance":[132],"mutations":[135,144,166,203,222,258,278],"Results:":[139],"incidence":[141],"point":[143],"higher":[148,227],"(60":[151],"121,":[153],"50%)":[154],"than":[155,197,216,229],"(23":[158],"63,":[160],"37%)":[161],"patients.":[162,276],"prevalence":[164],"hotspot":[168],"codons":[169],"175,":[170],"245,":[171],"248,":[172],"273,":[173],"or":[174],"282":[175],"(52%":[176],"vs":[177,189],".":[178,190,295],"35%),":[179],"particularly":[180],"loop":[184,262,282],"(28%":[188],"9%)":[191],"more":[193,211],"common":[194],"African-Americans.":[199],"In":[200],"contrast,":[201],"polymorphic":[202],"codon":[205],"72":[206],"(Arginine":[207],"Proline)":[209],"frequent":[212],"African-Americans":[214],"(14%)":[215],"(4%).":[219],"had":[226],"mortality":[228],"those":[230],"wild":[232],"type":[233],"(5-year,":[235],"log-rank,":[236],"P=0.0377).":[237],"Conclusions:":[238],"These":[239,296],"findings":[240],"suggest":[241],"pattern":[245],"differs":[249],"patients;":[256],"specifically,":[257],"within":[259],"are":[268,298],"associated":[269],"poor":[271],"clinical":[272],"outcome":[273],"Thus,":[277],"may":[285],"be":[286],"indicators":[287],"aggressive":[289],"phenotypic":[290],"behavior":[291],"adenocarcinomas":[294],"studies":[297],"supported":[299],"NCI/NIH":[301],"grants":[302],"RO1-CA98932-01":[303],"RO3-CA097542-01.":[305]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}
