{"id":"https://openalex.org/W1491095225","doi":"https://doi.org/10.1128/aem.65.4.1413-1419.1999","title":"Integrative Model for Binding of Bacillus thuringiensis Toxins in Susceptible and Resistant Larvae of the Diamondback Moth ( Plutella xylostella )","display_name":"Integrative Model for Binding of Bacillus thuringiensis Toxins in Susceptible and Resistant Larvae of the Diamondback Moth ( Plutella xylostella )","publication_year":1999,"publication_date":"1999-04-01","ids":{"openalex":"https://openalex.org/W1491095225","doi":"https://doi.org/10.1128/aem.65.4.1413-1419.1999","mag":"1491095225","pmid":"https://pubmed.ncbi.nlm.nih.gov/10103230","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/91200"},"language":"en","primary_location":{"id":"doi:10.1128/aem.65.4.1413-1419.1999","doi":"https://doi.org/10.1128/aem.65.4.1413-1419.1999","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aem.65.4.1413-1419.1999","pdf_url":null,"source":{"id":"https://openalex.org/S158228368","display_name":"Applied and Environmental Microbiology","issn_l":"0099-2240","issn":["0099-2240","1070-6291","1098-5336"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied and Environmental Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC91200","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113549486","display_name":"Victoria Ballester","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16097986","display_name":"Universitat de Val\u00e8ncia","ror":"https://ror.org/043nxc105","country_code":"ES","type":"education","lineage":["https://openalex.org/I16097986"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Victoria Ballester","raw_affiliation_strings":["<!--label omitted: 1-->Departament de Gene\u0300tica, Universitat de Vale\u0300ncia, 46100 Burjassot, Vale\u0300ncia, Spain1;","Departament de Gene\u0300tica, Universitat de Vale\u0300ncia, 46100 Burjassot, Vale\u0300ncia, Spain1;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Departament de Gene\u0300tica, Universitat de Vale\u0300ncia, 46100 Burjassot, Vale\u0300ncia, Spain1;","institution_ids":["https://openalex.org/I16097986"]},{"raw_affiliation_string":"Departament de Gene\u0300tica, Universitat de Vale\u0300ncia, 46100 Burjassot, Vale\u0300ncia, Spain1;","institution_ids":["https://openalex.org/I16097986"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022210747","display_name":"Francisco Granero","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16097986","display_name":"Universitat de Val\u00e8ncia","ror":"https://ror.org/043nxc105","country_code":"ES","type":"education","lineage":["https://openalex.org/I16097986"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Francisco Granero","raw_affiliation_strings":["<!--label omitted: 1-->Departament de Gene\u0300tica, Universitat de Vale\u0300ncia, 46100 Burjassot, Vale\u0300ncia, Spain1;","Departament de Gene\u0300tica, Universitat de Vale\u0300ncia, 46100 Burjassot, Vale\u0300ncia, Spain1;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Departament de Gene\u0300tica, Universitat de Vale\u0300ncia, 46100 Burjassot, Vale\u0300ncia, Spain1;","institution_ids":["https://openalex.org/I16097986"]},{"raw_affiliation_string":"Departament de Gene\u0300tica, Universitat de Vale\u0300ncia, 46100 Burjassot, Vale\u0300ncia, Spain1;","institution_ids":["https://openalex.org/I16097986"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021207885","display_name":"Bruce E. Tabashnik","orcid":"https://orcid.org/0000-0002-2430-2367","observed_orcids":["https://orcid.org/0000-0002-2430-2367"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bruce E. Tabashnik","raw_affiliation_strings":["<!--label omitted: 2-->Department of Entomology, University of Arizona, Tucson, Arizona 857212; and","Department of Entomology, University of Arizona, Tucson, Arizona 857212; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 2-->Department of Entomology, University of Arizona, Tucson, Arizona 857212; and","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"Department of Entomology, University of Arizona, Tucson, Arizona 857212; and","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068858828","display_name":"Thomas M. Malvar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1295346377","display_name":"Monsanto (United States)","ror":"https://ror.org/00j83wy46","country_code":"US","type":"company","lineage":["https://openalex.org/I1295346377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Malvar","raw_affiliation_strings":["<!--label omitted: 3-->Monsanto Co., St. Louis, Missouri 631983","Monsanto Co., St. Louis, Missouri 631983"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 3-->Monsanto Co., St. Louis, Missouri 631983","institution_ids":["https://openalex.org/I1295346377"]},{"raw_affiliation_string":"Monsanto Co., St. Louis, Missouri 631983","institution_ids":["https://openalex.org/I1295346377"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011707883","display_name":"Juan Ferr\u00e9","orcid":"https://orcid.org/0000-0001-5535-0612","observed_orcids":["https://orcid.org/0000-0001-5535-0612"]},"institutions":[{"id":"https://openalex.org/I16097986","display_name":"Universitat de Val\u00e8ncia","ror":"https://ror.org/043nxc105","country_code":"ES","type":"education","lineage":["https://openalex.org/I16097986"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Juan Ferre\u0301","raw_affiliation_strings":["<!--label omitted: 1-->Departament de Gene\u0300tica, Universitat de Vale\u0300ncia, 46100 Burjassot, Vale\u0300ncia, Spain1;","Departament de Gene\u0300tica, Universitat de Vale\u0300ncia, 46100 Burjassot, Vale\u0300ncia, Spain1;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Departament de Gene\u0300tica, Universitat de Vale\u0300ncia, 46100 Burjassot, Vale\u0300ncia, Spain1;","institution_ids":["https://openalex.org/I16097986"]},{"raw_affiliation_string":"Departament de Gene\u0300tica, Universitat de Vale\u0300ncia, 46100 Burjassot, Vale\u0300ncia, Spain1;","institution_ids":["https://openalex.org/I16097986"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.5857,"has_fulltext":false,"cited_by_count":105,"citation_normalized_percentile":{"value":0.89991747,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"65","issue":"4","first_page":"1413","last_page":"1419"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11075","display_name":"Insect Resistance and Genetics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11075","display_name":"Insect Resistance and Genetics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11065","display_name":"Insect Pest Control Strategies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11641","display_name":"Insect and Pesticide Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bacillus-thuringiensis-toxin","display_name":"Bacillus thuringiensis toxin","score":0.902999997138977},{"id":"https://openalex.org/keywords/plutella-xylostella","display_name":"Plutella xylostella","score":0.984000027179718},{"id":"https://openalex.org/keywords/insecticide-resistance","display_name":"insecticide resistance","score":0.7929999828338623},{"id":"https://openalex.org/keywords/toxin-binding-site","display_name":"toxin binding site","score":0.7200000286102295},{"id":"https://openalex.org/keywords/competitive-binding","display_name":"competitive binding","score":0.7120000123977661},{"id":"https://openalex.org/keywords/cry1aa","display_name":"Cry1Aa","score":0.9480000138282776},{"id":"https://openalex.org/keywords/cry1ab","display_name":"Cry1Ab","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cry1ac","display_name":"Cry1Ac","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cry1f","display_name":"Cry1F","score":1.0},{"id":"https://openalex.org/keywords/cross-resistance","display_name":"cross-resistance","score":0.8299999833106995},{"id":"https://openalex.org/keywords/resistance-mechanisms","display_name":"resistance mechanisms","score":0.421999990940094},{"id":"https://openalex.org/keywords/genetically-modified-crops","display_name":"genetically modified crops","score":0.6029999852180481}],"concepts":[{"id":"https://openalex.org/C2780942520","wikidata":"https://www.wikidata.org/wiki/Q1050343","display_name":"Diamondback moth","level":4,"score":0.9902799129486084},{"id":"https://openalex.org/C2779035793","wikidata":"https://www.wikidata.org/wiki/Q310467","display_name":"Bacillus thuringiensis","level":3,"score":0.9859558343887329},{"id":"https://openalex.org/C2777089804","wikidata":"https://www.wikidata.org/wiki/Q10350573","display_name":"Plutella","level":3,"score":0.9679349660873413},{"id":"https://openalex.org/C2781151318","wikidata":"https://www.wikidata.org/wiki/Q16953059","display_name":"Cry1Ac","level":5,"score":0.9255051612854004},{"id":"https://openalex.org/C2781326838","wikidata":"https://www.wikidata.org/wiki/Q787074","display_name":"Plutellidae","level":5,"score":0.8735016584396362},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6698992252349854},{"id":"https://openalex.org/C177756618","wikidata":"https://www.wikidata.org/wiki/Q6527674","display_name":"Lepidoptera genitalia","level":2,"score":0.48157644271850586},{"id":"https://openalex.org/C22508944","wikidata":"https://www.wikidata.org/wiki/Q568174","display_name":"PEST analysis","level":2,"score":0.4399257004261017},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3603329658508301},{"id":"https://openalex.org/C122172344","wikidata":"https://www.wikidata.org/wiki/Q1503477","display_name":"Genetically modified crops","level":4,"score":0.31781652569770813},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.2546595633029938},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17546340823173523},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.13403025269508362},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1300131380558014},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.12658950686454773}],"mesh":[{"descriptor_ui":"D000083722","descriptor_name":"Bacillus thuringiensis Toxins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001413","descriptor_name":"Bacillus thuringiensis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D001427","descriptor_name":"Bacterial Toxins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004731","descriptor_name":"Endotoxins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004731","descriptor_name":"Endotoxins","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D006460","descriptor_name":"Hemolysin Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007814","descriptor_name":"Larva","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009036","descriptor_name":"Moths","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D009036","descriptor_name":"Moths","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010572","descriptor_name":"Pest Control, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1128/aem.65.4.1413-1419.1999","doi":"https://doi.org/10.1128/aem.65.4.1413-1419.1999","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aem.65.4.1413-1419.1999","pdf_url":null,"source":{"id":"https://openalex.org/S158228368","display_name":"Applied and Environmental Microbiology","issn_l":"0099-2240","issn":["0099-2240","1070-6291","1098-5336"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied and Environmental Microbiology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:67445","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC91200","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:10103230","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10103230","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied and environmental microbiology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:91200","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC91200/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Appl Environ Microbiol","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.319.966","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.319.966","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://aem.asm.org/content/65/4/1413.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:67445","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC91200","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"score":0.6735000014305115,"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W327643136","https://openalex.org/W1482850564","https://openalex.org/W1506812395","https://openalex.org/W1507759842","https://openalex.org/W1508363397","https://openalex.org/W1573802423","https://openalex.org/W1593307737","https://openalex.org/W1752586708","https://openalex.org/W1966253950","https://openalex.org/W1974261846","https://openalex.org/W1978045508","https://openalex.org/W1978996079","https://openalex.org/W1987900456","https://openalex.org/W1992216718","https://openalex.org/W1992551265","https://openalex.org/W2003201696","https://openalex.org/W2006878347","https://openalex.org/W2008785815","https://openalex.org/W2011311364","https://openalex.org/W2016391189","https://openalex.org/W2020689211","https://openalex.org/W2024018480","https://openalex.org/W2026920317","https://openalex.org/W2027439474","https://openalex.org/W2028364985","https://openalex.org/W2031388815","https://openalex.org/W2036535446","https://openalex.org/W2043813981","https://openalex.org/W2055027777","https://openalex.org/W2062706925","https://openalex.org/W2065725349","https://openalex.org/W2068275575","https://openalex.org/W2078675196","https://openalex.org/W2081335753","https://openalex.org/W2085982657","https://openalex.org/W2089537592","https://openalex.org/W2094907186","https://openalex.org/W2099985023","https://openalex.org/W2103890327","https://openalex.org/W2107847732","https://openalex.org/W2111293707","https://openalex.org/W2119713789","https://openalex.org/W2128635872","https://openalex.org/W2151439893","https://openalex.org/W2156114416","https://openalex.org/W2166079561","https://openalex.org/W2168714455","https://openalex.org/W2330875727","https://openalex.org/W2782580918","https://openalex.org/W4248371845","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2138762452","https://openalex.org/W1482850564","https://openalex.org/W1978045508","https://openalex.org/W1992216718","https://openalex.org/W2076999228","https://openalex.org/W2109817794","https://openalex.org/W4239339102","https://openalex.org/W2088305100","https://openalex.org/W1507759842","https://openalex.org/W1992551265"],"abstract_inverted_index":{"Insecticidal":[0],"crystal":[1,124,182],"proteins":[2,125],"from":[3,94,105,165,188,291],"Bacillus":[4],"thuringiensis":[5,46,58,82,123],"in":[6,47,59,97,102,126,155,235,272],"sprays":[7],"and":[8,87,101,109,143,190,200,215,244,259,276,285],"transgenic":[9],"crops":[10],"are":[11],"extremely":[12],"useful":[13],"for":[14,119,133,249],"environmentally":[15],"sound":[16],"pest":[17],"management,":[18],"but":[19,174,279],"their":[20],"long-term":[21],"efficacy":[22],"is":[23,37,63,138,153,265],"threatened":[24],"by":[25,29],"evolution":[26],"of":[27,54,66,80,121,136,157,172,179,196,241,270,283,294,298],"resistance":[28,43,55,211,250,271,284],"target":[30],"pests.":[31],"The":[32,50,253],"diamondback":[33,61,274],"moth":[34,62,275],"(Plutella":[35],"xylostella)":[36],"the":[38,60,73,106,113,149,158,163,166,168,180,185,192,222,226,233,236,257,267,273,292],"first":[39],"insect":[40],"to":[41,44,56,68,89,212,218,251],"evolve":[42],"B.":[45,57,81,122],"open-field":[48],"populations.":[49],"only":[51,242,268],"known":[52],"mechanism":[53,269],"reduced":[64,170,263],"binding":[65,70,79,120,131,151,171,178,195,223,240,264,296],"toxin":[67],"midgut":[69],"sites.":[71],"In":[72,162,184],"present":[74],"work":[75],"we":[76,115],"analyzed":[77],"competitive":[78,295],"toxins":[83],"Cry1Aa,":[84,134,197],"Cry1Ab,":[85,141,198,213,243],"Cry1Ac,":[86,142,199,214],"Cry1F":[88,216],"brush":[90],"border":[91],"membrane":[92],"vesicles":[93],"larval":[95],"midguts":[96],"a":[98,117,206],"susceptible":[99,127,299],"strain":[100,164,238],"resistant":[103,160,186],"strains":[104,187],"Philippines,":[107,167],"Hawaii,":[108],"Pennsylvania.":[110],"Based":[111],"on":[112,221],"results,":[114],"propose":[116],"model":[118,258],"larvae":[128],"with":[129,140],"two":[130,228],"sites":[132],"one":[135,245],"which":[137],"shared":[139],"Cry1F.":[144,201],"Our":[145],"results":[146,293],"show":[147],"that":[148,205,262,277],"common":[150],"site":[152],"altered":[154],"each":[156],"three":[159],"strains.":[161,300],"alteration":[169,193],"Cry1Ab":[173],"did":[175],"not":[176,266,280],"affect":[177],"other":[181,229],"proteins.":[183],"Hawaii":[189],"Pennsylvania,":[191],"affected":[194,239],"Previously":[202],"reported":[203],"evidence":[204],"single":[207],"mutation":[208,234,246],"can":[209,287],"confer":[210],"corresponds":[217],"expectations":[219],"based":[220],"model.":[224],"However,":[225],"following":[227],"observations":[230,260],"do":[231],"not:":[232],"Philippines":[237],"was":[247],"sufficient":[248],"Cry1Aa.":[252],"imperfect":[254],"correspondence":[255],"between":[256],"suggests":[261],"some,":[278],"all,":[281],"patterns":[282],"cross-resistance":[286],"be":[288],"predicted":[289],"correctly":[290],"analyses":[297]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}