{"id":"https://openalex.org/W1491007308","doi":null,"title":"DHA does not protect ELOVL4 transgenic mice from retinal degeneration.","display_name":"DHA does not protect ELOVL4 transgenic mice from retinal degeneration.","publication_year":2009,"publication_date":"2009-06-13","ids":{"openalex":"https://openalex.org/W1491007308","mag":"1491007308","pmid":"https://pubmed.ncbi.nlm.nih.gov/19536303"},"language":"en","primary_location":{"id":"pmid:19536303","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19536303","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular vision","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2697457","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100448951","display_name":"Feng Li","orcid":"https://orcid.org/0000-0002-9680-4614","observed_orcids":["https://orcid.org/0000-0002-9680-4614"]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Feng Li","raw_affiliation_strings":["Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA","institution_ids":["https://openalex.org/I49332381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079660070","display_name":"Lea D. Marchette","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lea D Marchette","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059891728","display_name":"Richard S. Brush","orcid":"https://orcid.org/0000-0002-8527-5315","observed_orcids":["https://orcid.org/0000-0002-8527-5315"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard S Brush","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069505443","display_name":"Michael H. Elliott","orcid":"https://orcid.org/0000-0002-2289-8718","observed_orcids":["https://orcid.org/0000-0002-2289-8718"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael H Elliott","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113469985","display_name":"Yun-Zheng Le","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yun-Zheng Le","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054887671","display_name":"Kimberly Henry","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kimberly A Henry","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019302810","display_name":"Ashley G. Anderson","orcid":"https://orcid.org/0000-0002-3841-8344","observed_orcids":["https://orcid.org/0000-0002-3841-8344"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ashley G Anderson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037484052","display_name":"Chao Zhao","orcid":"https://orcid.org/0000-0003-1144-1621","observed_orcids":["https://orcid.org/0000-0003-1144-1621"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chao Zhao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058088302","display_name":"Xufang Sun","orcid":"https://orcid.org/0000-0001-7133-4508","observed_orcids":["https://orcid.org/0000-0001-7133-4508"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xufang Sun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100432232","display_name":"Kang Zhang","orcid":"https://orcid.org/0000-0002-4549-1697","observed_orcids":["https://orcid.org/0000-0002-4549-1697","https://orcid.org/0000-0002-5737-4084"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kang Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5004338167","display_name":"Robert E. Anderson","orcid":"https://orcid.org/0000-0001-5664-6968","observed_orcids":["https://orcid.org/0000-0001-5664-6968"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert E Anderson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.5594,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.80940472,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"15","issue":null,"first_page":"1185","last_page":"93"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/docosahexaenoic-acid","display_name":"docosahexaenoic acid","score":0.9440000057220459},{"id":"https://openalex.org/keywords/elovl4","display_name":"ELOVL4","score":0.9639999866485596},{"id":"https://openalex.org/keywords/retinal-degeneration","display_name":"retinal degeneration","score":0.8840000033378601},{"id":"https://openalex.org/keywords/photoreceptor-loss","display_name":"photoreceptor loss","score":0.753000020980835},{"id":"https://openalex.org/keywords/omega-3-fatty-acids","display_name":"omega-3 fatty acids","score":0.7480000257492065},{"id":"https://openalex.org/keywords/polyunsaturated-fatty-acids","display_name":"polyunsaturated fatty acids","score":0.7049999833106995},{"id":"https://openalex.org/keywords/rhodopsin","display_name":"rhodopsin","score":0.9390000104904175},{"id":"https://openalex.org/keywords/transgenic-mice","display_name":"transgenic mice","score":0.6579999923706055}],"concepts":[{"id":"https://openalex.org/C2777171753","wikidata":"https://www.wikidata.org/wiki/Q423345","display_name":"Docosahexaenoic acid","level":4,"score":0.7906135320663452},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7897748947143555},{"id":"https://openalex.org/C2781040256","wikidata":"https://www.wikidata.org/wiki/Q7316761","display_name":"Retinal degeneration","level":3,"score":0.7216918468475342},{"id":"https://openalex.org/C2778231335","wikidata":"https://www.wikidata.org/wiki/Q4113701","display_name":"Outer nuclear layer","level":3,"score":0.6477786302566528},{"id":"https://openalex.org/C19038510","wikidata":"https://www.wikidata.org/wiki/Q2005087","display_name":"Polyunsaturated fatty acid","level":3,"score":0.5990282297134399},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.5944585800170898},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.5629532933235168},{"id":"https://openalex.org/C2779113765","wikidata":"https://www.wikidata.org/wiki/Q681562","display_name":"Electroretinography","level":3,"score":0.5508775115013123},{"id":"https://openalex.org/C2777129432","wikidata":"https://www.wikidata.org/wiki/Q83133906","display_name":"Fatty acid desaturase","level":4,"score":0.45070454478263855},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4475569725036621},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.4466439187526703},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.44367411732673645},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.42810195684432983},{"id":"https://openalex.org/C30028475","wikidata":"https://www.wikidata.org/wiki/Q24785022","display_name":"Opsin","level":4,"score":0.42078787088394165},{"id":"https://openalex.org/C2781114197","wikidata":"https://www.wikidata.org/wiki/Q847057","display_name":"Retinitis pigmentosa","level":3,"score":0.4186444580554962},{"id":"https://openalex.org/C202033177","wikidata":"https://www.wikidata.org/wiki/Q423107","display_name":"Rhodopsin","level":3,"score":0.34767141938209534},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.24326270818710327},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004281","descriptor_name":"Docosahexaenoic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004281","descriptor_name":"Docosahexaenoic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004281","descriptor_name":"Docosahexaenoic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004596","descriptor_name":"Electroretinography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004596","descriptor_name":"Electroretinography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004596","descriptor_name":"Electroretinography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005136","descriptor_name":"Eye Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005136","descriptor_name":"Eye Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005136","descriptor_name":"Eye Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005136","descriptor_name":"Eye Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005136","descriptor_name":"Eye Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005136","descriptor_name":"Eye Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012162","descriptor_name":"Retinal Degeneration","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012162","descriptor_name":"Retinal Degeneration","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012162","descriptor_name":"Retinal Degeneration","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012162","descriptor_name":"Retinal Degeneration","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012162","descriptor_name":"Retinal Degeneration","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012162","descriptor_name":"Retinal Degeneration","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012162","descriptor_name":"Retinal Degeneration","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D012162","descriptor_name":"Retinal Degeneration","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D012162","descriptor_name":"Retinal Degeneration","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D012243","descriptor_name":"Rhodopsin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012243","descriptor_name":"Rhodopsin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012243","descriptor_name":"Rhodopsin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D029742","descriptor_name":"Caenorhabditis elegans Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029742","descriptor_name":"Caenorhabditis elegans Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029742","descriptor_name":"Caenorhabditis elegans Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029742","descriptor_name":"Caenorhabditis elegans Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029742","descriptor_name":"Caenorhabditis elegans Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029742","descriptor_name":"Caenorhabditis elegans Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044943","descriptor_name":"Fatty Acid Desaturases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044943","descriptor_name":"Fatty Acid Desaturases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044943","descriptor_name":"Fatty Acid Desaturases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044943","descriptor_name":"Fatty Acid Desaturases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044943","descriptor_name":"Fatty Acid Desaturases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044943","descriptor_name":"Fatty Acid Desaturases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:19536303","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19536303","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular vision","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2697457","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2697457","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Mol Vis","raw_type":"Text"},{"id":"mag:1491007308","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19536303","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2697457","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2697457","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Mol Vis","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1502379715","display_name":"GENETICS OF MACULAR DEGENERATION","funder_award_id":"7r01ey014448-06","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1854954188","display_name":"Core Grant for Vision Research","funder_award_id":"5p30ey012190-10","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2589857776","display_name":"Genetics and Functional Studies of Age-Related Macular Degeneration","funder_award_id":"R01EY018660","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G3948148410","display_name":"Mentoring Vision Research In Oklahoma","funder_award_id":"P20RR017703","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G457254518","display_name":"ELOVL4 and Retinal Disease","funder_award_id":"5r01ey014428-10","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5509712900","display_name":"Second Messengers in the Retina","funder_award_id":"5r01ey000871-45","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G781448320","display_name":"Lipid Metabolism in the Retina","funder_award_id":"5r01ey004149-36","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W35893819","https://openalex.org/W77565134","https://openalex.org/W127476475","https://openalex.org/W306715363","https://openalex.org/W1485407919","https://openalex.org/W1571668808","https://openalex.org/W1579290445","https://openalex.org/W1968877752","https://openalex.org/W1978126359","https://openalex.org/W1980056828","https://openalex.org/W1983354967","https://openalex.org/W1985707039","https://openalex.org/W1993085222","https://openalex.org/W1993813725","https://openalex.org/W1997118844","https://openalex.org/W1997160062","https://openalex.org/W1998732178","https://openalex.org/W1999919904","https://openalex.org/W2005390270","https://openalex.org/W2007633562","https://openalex.org/W2013238661","https://openalex.org/W2020169046","https://openalex.org/W2023215993","https://openalex.org/W2023707600","https://openalex.org/W2026478921","https://openalex.org/W2029479470","https://openalex.org/W2035659802","https://openalex.org/W2043251036","https://openalex.org/W2051565465","https://openalex.org/W2055020157","https://openalex.org/W2057976500","https://openalex.org/W2066066893","https://openalex.org/W2067472329","https://openalex.org/W2069722990","https://openalex.org/W2081839805","https://openalex.org/W2090912192","https://openalex.org/W2121883986","https://openalex.org/W2144137477","https://openalex.org/W2152311269","https://openalex.org/W2153396849","https://openalex.org/W2168526937","https://openalex.org/W2411099493","https://openalex.org/W2994487977"],"related_works":["https://openalex.org/W1485407919","https://openalex.org/W2035659802","https://openalex.org/W1567065116","https://openalex.org/W2154769471","https://openalex.org/W2153396849","https://openalex.org/W2148073546","https://openalex.org/W2076232924","https://openalex.org/W2043251036","https://openalex.org/W1990589151","https://openalex.org/W1608198396","https://openalex.org/W2137826993","https://openalex.org/W2134846445","https://openalex.org/W2055020157","https://openalex.org/W2013238661","https://openalex.org/W1579290445","https://openalex.org/W1539365968","https://openalex.org/W1501875486","https://openalex.org/W1984137433","https://openalex.org/W1983354967","https://openalex.org/W1941964179"],"abstract_inverted_index":{"PURPOSE:":[0],"Dominant":[1],"Stargardt":[2],"macular":[3,350],"dystrophy":[4],"(STGD3)":[5],"is":[6,334],"caused":[7],"by":[8,155,199,205],"several":[9,216],"different":[10],"mutations":[11,86],"in":[12,30,60,78,88,126,140,185,215,236,252,318,343],"a":[13,22,272],"gene":[14],"named":[15,158],"ELOVL4,":[16],"which":[17,106],"shares":[18],"sequence":[19],"homologies":[20],"with":[21,44],"family":[23],"of":[24,33,49,70,75,84,142,147,231,247,258,263,276,293,300,302,316,340,347],"genes":[25],"that":[26,42,81,131,137,177,313,332],"encode":[27],"proteins":[28],"involved":[29],"the":[31,54,68,73,85,103,148,168,224,267,298,305,338],"ELOngation":[32],"Very":[34],"Long":[35],"chain":[36],"fatty":[37,57,187,212,295],"acids.":[38,188],"Studies":[39],"have":[40,46],"suggested":[41],"patients":[43],"STGD3":[45,349],"aberrant":[47],"metabolism":[48],"docosahexaenoic":[50],"acid":[51,58,213],"(DHA,":[52],"22:6n3),":[53],"major":[55],"polyunsaturated":[56],"(PUFA)":[59],"retinal":[61,76,197,294,319,328,341],"rod":[62],"outer":[63,206],"segment":[64],"membranes.":[65],"We":[66,309,330],"tested":[67],"effect":[69,292],"DHA":[71,250,317,333],"on":[72,116,167,297],"progression":[74],"degeneration":[77,301,342],"transgenic":[79],"mice":[80,92,101,254,265],"express":[82],"one":[83],"identified":[87,154],"STGD3.":[89],"METHODS:":[90],"Transgenic":[91],"expressing":[93,102,180,223,266,304,324],"mutant":[94,268,325],"human":[95,348],"ELOVL4":[96,306,326],"(TG2)":[97],"were":[98,114,135,153,165,194,255],"bred":[99],"to":[100,110,173],"fat-1":[104,225,253],"protein,":[105],"can":[107],"convert":[108],"n6":[109,127],"n3":[111,143,186,232],"PUFA.":[112],"Mice":[113,222],"maintained":[115],"an":[117],"n3-deficient":[118],"diet":[119,170],"containing":[120],"10%":[121],"safflower":[122],"oil":[123],"(SFO,":[124],"enriched":[125],"PUFA;":[128],"n6/n3=273)":[129],"so":[130],"four":[132],"experimental":[133],"groups":[134,152],"produced":[136],"differed":[138],"only":[139],"levels":[141,230,251,285,315],"PUFA":[144],"and":[145,157,162,218,239,244,282],"expression":[146],"hELOVL4":[149,269],"transgene.":[150,307],"These":[151],"genotyping":[156],"Fat1+/TG2+,":[159],"Fat1(-)/TG2+,":[160],"Fat1+/TG2(-),":[161],"Fat1(-)/TG2(-).":[163],"All":[164],"continued":[166],"SFO":[169],"for":[171,196,337],"4":[172,243],"16":[174,245,261],"weeks":[175,246,262],"such":[176],"those":[178,257],"not":[179,335],"Fat1":[181],"would":[182],"be":[183],"deficient":[184],"At":[189],"both":[190],"time":[191],"points,":[192],"animals":[193],"analyzed":[195],"function":[198],"electroretinography":[200],"(ERG),":[201],"photoreceptor":[202,277,322],"cell":[203],"viability":[204],"nuclear":[207],"layer":[208],"(ONL)":[209],"thickness":[210],"measurements,":[211],"profiles":[214],"tissues,":[217],"rhodopsin":[219,284],"levels.":[220],"RESULTS:":[221],"transgene":[226,270],"had":[227,271],"significantly":[228,273],"higher":[229],"PUFA,":[233],"primarily":[234],"DHA,":[235],"retina,":[237],"liver,":[238],"plasma":[240],"lipids":[241],"at":[242],"age.":[248],"Retinal":[249],"twice":[256],"controls.":[259],"By":[260],"age,":[264],"greater":[274],"loss":[275],"cells,":[278],"reduced":[279],"ERG":[280],"amplitudes,":[281],"lower":[283],"than":[286],"control":[287],"mice.":[288],"There":[289],"was":[290],"no":[291,311],"acids":[296],"rate":[299],"retinas":[303],"CONCLUSIONS:":[308],"found":[310],"evidence":[312],"high":[314],"membranes":[320],"protected":[321],"cells":[323],"from":[327],"degeneration.":[329],"conclude":[331],"beneficial":[336],"treatment":[339],"this":[344],"animal":[345],"model":[346],"dystrophy.":[351]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}
