{"id":"https://openalex.org/W1490975110","doi":"https://doi.org/10.1158/1538-7445.am2014-3579","title":"Abstract 3579: Routinely applicable, highly multiplexed triple-negative breast cancer (TNBC) genotyping","display_name":"Abstract 3579: Routinely applicable, highly multiplexed triple-negative breast cancer (TNBC) genotyping","publication_year":2014,"publication_date":"2014-10-01","ids":{"openalex":"https://openalex.org/W1490975110","doi":"https://doi.org/10.1158/1538-7445.am2014-3579","mag":"1490975110"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2014-3579","doi":"https://doi.org/10.1158/1538-7445.am2014-3579","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2014-3579","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051365519","display_name":"Vassiliki Kotoula","orcid":"https://orcid.org/0000-0002-8657-9732","observed_orcids":["https://orcid.org/0000-0002-8657-9732"]},"institutions":[{"id":"https://openalex.org/I4210115932","display_name":"Hellenic Cooperative Oncology Group","ror":"https://ror.org/02bxsvn11","country_code":"GR","type":"company","lineage":["https://openalex.org/I4210115932"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Vassiliki Kotoula","raw_affiliation_strings":["Hellenic Cooperative Oncology Group (HeCOG), Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hellenic Cooperative Oncology Group (HeCOG), Athens, Greece","institution_ids":["https://openalex.org/I4210115932"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002833730","display_name":"Kyriaki Papadopoulou","orcid":"https://orcid.org/0000-0003-0389-4209","observed_orcids":["https://orcid.org/0000-0003-0389-4209"]},"institutions":[{"id":"https://openalex.org/I4210115932","display_name":"Hellenic Cooperative Oncology Group","ror":"https://ror.org/02bxsvn11","country_code":"GR","type":"company","lineage":["https://openalex.org/I4210115932"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Kyriaki Papadopoulou","raw_affiliation_strings":["Hellenic Cooperative Oncology Group (HeCOG), Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hellenic Cooperative Oncology Group (HeCOG), Athens, Greece","institution_ids":["https://openalex.org/I4210115932"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022230385","display_name":"Elpida Charalambous","orcid":"https://orcid.org/0009-0000-3462-2914","observed_orcids":["https://orcid.org/0009-0000-3462-2914"]},"institutions":[{"id":"https://openalex.org/I4210115932","display_name":"Hellenic Cooperative Oncology Group","ror":"https://ror.org/02bxsvn11","country_code":"GR","type":"company","lineage":["https://openalex.org/I4210115932"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Elpida Charalambous","raw_affiliation_strings":["Hellenic Cooperative Oncology Group (HeCOG), Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hellenic Cooperative Oncology Group (HeCOG), Athens, Greece","institution_ids":["https://openalex.org/I4210115932"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046758725","display_name":"Flora Zagouri","orcid":"https://orcid.org/0000-0001-7153-6556","observed_orcids":["https://orcid.org/0000-0001-7153-6556"]},"institutions":[{"id":"https://openalex.org/I4210115932","display_name":"Hellenic Cooperative Oncology Group","ror":"https://ror.org/02bxsvn11","country_code":"GR","type":"company","lineage":["https://openalex.org/I4210115932"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Flora Zagouri","raw_affiliation_strings":["Hellenic Cooperative Oncology Group (HeCOG), Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hellenic Cooperative Oncology Group (HeCOG), Athens, Greece","institution_ids":["https://openalex.org/I4210115932"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049206234","display_name":"Sotiris Lakis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115932","display_name":"Hellenic Cooperative Oncology Group","ror":"https://ror.org/02bxsvn11","country_code":"GR","type":"company","lineage":["https://openalex.org/I4210115932"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Sotiris Lakis","raw_affiliation_strings":["Hellenic Cooperative Oncology Group (HeCOG), Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hellenic Cooperative Oncology Group (HeCOG), Athens, Greece","institution_ids":["https://openalex.org/I4210115932"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061253769","display_name":"Angeliki Lymperopoulou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115932","display_name":"Hellenic Cooperative Oncology Group","ror":"https://ror.org/02bxsvn11","country_code":"GR","type":"company","lineage":["https://openalex.org/I4210115932"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Angeliki Lymperopoulou","raw_affiliation_strings":["Hellenic Cooperative Oncology Group (HeCOG), Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hellenic Cooperative Oncology Group (HeCOG), Athens, Greece","institution_ids":["https://openalex.org/I4210115932"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084537623","display_name":"Eleftheria Tsolaki","orcid":"https://orcid.org/0000-0003-1463-1754","observed_orcids":["https://orcid.org/0000-0003-1463-1754"]},"institutions":[{"id":"https://openalex.org/I4210115932","display_name":"Hellenic Cooperative Oncology Group","ror":"https://ror.org/02bxsvn11","country_code":"GR","type":"company","lineage":["https://openalex.org/I4210115932"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Eleftheria Tsolaki","raw_affiliation_strings":["Hellenic Cooperative Oncology Group (HeCOG), Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hellenic Cooperative Oncology Group (HeCOG), Athens, Greece","institution_ids":["https://openalex.org/I4210115932"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015437737","display_name":"George E. Pentheroudakis","orcid":"https://orcid.org/0000-0002-6632-2462","observed_orcids":["https://orcid.org/0000-0002-6632-2462"]},"institutions":[{"id":"https://openalex.org/I4210115932","display_name":"Hellenic Cooperative Oncology Group","ror":"https://ror.org/02bxsvn11","country_code":"GR","type":"company","lineage":["https://openalex.org/I4210115932"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"George Pentheroudakis","raw_affiliation_strings":["Hellenic Cooperative Oncology Group (HeCOG), Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hellenic Cooperative Oncology Group (HeCOG), Athens, Greece","institution_ids":["https://openalex.org/I4210115932"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084514906","display_name":"Kostas Lilakos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115932","display_name":"Hellenic Cooperative Oncology Group","ror":"https://ror.org/02bxsvn11","country_code":"GR","type":"company","lineage":["https://openalex.org/I4210115932"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Kostas Lilakos","raw_affiliation_strings":["Hellenic Cooperative Oncology Group (HeCOG), Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hellenic Cooperative Oncology Group (HeCOG), Athens, Greece","institution_ids":["https://openalex.org/I4210115932"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012112204","display_name":"Dimitrios G. Pectasides","orcid":"https://orcid.org/0000-0002-2102-2167","observed_orcids":["https://orcid.org/0000-0002-2102-2167"]},"institutions":[{"id":"https://openalex.org/I4210115932","display_name":"Hellenic Cooperative Oncology Group","ror":"https://ror.org/02bxsvn11","country_code":"GR","type":"company","lineage":["https://openalex.org/I4210115932"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Dimitrios Pectasides","raw_affiliation_strings":["Hellenic Cooperative Oncology Group (HeCOG), Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hellenic Cooperative Oncology Group (HeCOG), Athens, Greece","institution_ids":["https://openalex.org/I4210115932"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041575636","display_name":"George Fountzilas","orcid":"https://orcid.org/0000-0001-8045-2186","observed_orcids":["https://orcid.org/0000-0001-8045-2186"]},"institutions":[{"id":"https://openalex.org/I4210115932","display_name":"Hellenic Cooperative Oncology Group","ror":"https://ror.org/02bxsvn11","country_code":"GR","type":"company","lineage":["https://openalex.org/I4210115932"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"George Fountzilas","raw_affiliation_strings":["Hellenic Cooperative Oncology Group (HeCOG), Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hellenic Cooperative Oncology Group (HeCOG), Athens, Greece","institution_ids":["https://openalex.org/I4210115932"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210115932"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"74","issue":"19_Supplement","first_page":"3579","last_page":"3579"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.8008000254631042,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.8008000254631042,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.10939999669790268,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.07209999859333038,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/targeted-sequencing","display_name":"targeted sequencing","score":0.6710000038146973},{"id":"https://openalex.org/keywords/allelic-imbalance","display_name":"allelic imbalance","score":0.7929999828338623},{"id":"https://openalex.org/keywords/tp53-mutation","display_name":"TP53 mutation","score":0.8389999866485596},{"id":"https://openalex.org/keywords/pik3ca-mutation","display_name":"PIK3CA mutation","score":0.8629999756813049},{"id":"https://openalex.org/keywords/pik3r1-mutation","display_name":"PIK3R1 mutation","score":0.5730000138282776},{"id":"https://openalex.org/keywords/cdh1-mutation","display_name":"CDH1 mutation","score":0.5009999871253967},{"id":"https://openalex.org/keywords/pten-mutation","display_name":"PTEN mutation","score":0.9160000085830688},{"id":"https://openalex.org/keywords/notch1-mutation","display_name":"NOTCH1 mutation","score":0.8220000267028809},{"id":"https://openalex.org/keywords/tert-mutation","display_name":"TERT mutation","score":0.6790000200271606},{"id":"https://openalex.org/keywords/met-mutations","display_name":"MET mutations","score":0.7599999904632568},{"id":"https://openalex.org/keywords/brca1-mutation","display_name":"BRCA1 mutation","score":0.8330000042915344},{"id":"https://openalex.org/keywords/tumor-cellularity","display_name":"tumor cellularity","score":0.5559999942779541},{"id":"https://openalex.org/keywords/adjuvant-chemotherapy","display_name":"adjuvant chemotherapy","score":0.7609999775886536}],"concepts":[{"id":"https://openalex.org/C8185291","wikidata":"https://www.wikidata.org/wiki/Q2844457","display_name":"Amplicon","level":4,"score":0.8029303550720215},{"id":"https://openalex.org/C31467283","wikidata":"https://www.wikidata.org/wiki/Q912147","display_name":"Genotyping","level":4,"score":0.6424333453178406},{"id":"https://openalex.org/C192800701","wikidata":"https://www.wikidata.org/wiki/Q6784807","display_name":"Massive parallel sequencing","level":4,"score":0.6049273610115051},{"id":"https://openalex.org/C2780110267","wikidata":"https://www.wikidata.org/wiki/Q7843332","display_name":"Triple-negative breast cancer","level":4,"score":0.5963855981826782},{"id":"https://openalex.org/C164928082","wikidata":"https://www.wikidata.org/wiki/Q6063435","display_name":"Ion semiconductor sequencing","level":4,"score":0.5958568453788757},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5148469805717468},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.45314061641693115},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.43728065490722656},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.42839524149894714},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4153832793235779},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.4070914685726166},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.39364883303642273},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.38323143124580383},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.371738463640213},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.17335379123687744}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2014-3579","doi":"https://doi.org/10.1158/1538-7445.am2014-3579","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2014-3579","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W306640786","https://openalex.org/W2892127506","https://openalex.org/W1993837576","https://openalex.org/W2560871785","https://openalex.org/W2591104734","https://openalex.org/W2080960707","https://openalex.org/W2134133462","https://openalex.org/W4411452663","https://openalex.org/W562186340","https://openalex.org/W2074758840"],"abstract_inverted_index":{"Abstract":[0],"In":[1,193],"order":[2],"to":[3,151,310,335,397],"address":[4],"TNBC":[5,52,61,87,197,413],"diversity,":[6],"determining":[7],"the":[8,20,294,339,344,387,457,462],"individual":[9],"clonal":[10,407],"genotypes":[11],"of":[12,22,134,179,296,346,389,456,461],"each":[13],"tumor":[14,66,240,285],"is":[15,33,374],"urged":[16],"as":[17],"prerequisite.":[18],"However,":[19],"applicability":[21],"whole":[23],"genome":[24],"approaches":[25],"on":[26,103,109,168,353],"routinely":[27],"processed":[28,102],"paraffin":[29],"tissue":[30,382],"material":[31],"(FFPE)":[32],"still":[34],"limited.":[35],"Herein,":[36],"we":[37],"used":[38],"targeted":[39],"massive":[40],"parallel":[41],"sequencing":[42],"(MPS)":[43],"for":[44,65,72,90,142,163,207,303,338,378,411,465],"genotyping":[45],"FFPE":[46,60,98,148,381],"tumors":[47,205,249,264,320,402],"from":[48],"patients":[49,311,316],"with":[50,54,117,185,189,312,317,371,403],"operable":[51],"treated":[53],"adjuvant":[55],"chemotherapy.":[56],"Methods:":[57],"Centrally":[58],"assessed":[59,162],"(n=260)":[62],"were":[63,100,126,140,161,198,229,245,260,287],"evaluated":[64],"cell":[67],"content":[68],"(TCC)":[69],"and":[70,108,128,147,159,171,224,278,300,364,406,416],"submitted":[71,89],"DNA":[73,146],"extraction.":[74],"A":[75],"custom":[76,372],"panel":[77],"targeting":[78],"genomic":[79],"regions":[80],"in":[81,86,203,231,247,253,262,289,308,386],"43":[82],"genes":[83,233],"previously":[84],"implicated":[85],"was":[88,182,201,359],"primer":[91],"design":[92],"(286":[93],"amplicons":[94],"covering":[95],"21216bp).":[96],"Barcoded":[97],"libraries":[99],"massively":[101],"Ion":[104,110],"Proton\u2122":[105],"Sequencer":[106,112],"PI":[107],"PGM\u2122":[111],"318":[113],"chips":[114],"(30":[115],"samples":[116,181],"both":[118],"platforms,":[119],"at":[120,130],"least":[121],"2":[122],"runs":[123],"each).":[124],"Variants":[125],"called":[127],"annotated":[129],"higher-than-default-stringency":[131],"conditions":[132],"(63%":[133],"all":[135],"detected":[136],"variants":[137],"excluded).":[138],"Amplicons":[139],"checked":[141],"sequence":[143],"specificity,":[144],"blood":[145],"performance":[149],"prior":[150],"accepting":[152],"results":[153],"(informative:":[154],"280/286).":[155],"Annotated":[156],"SNVs":[157],"(coding":[158],"non-coding)":[160],"allelic":[164,169,404],"imbalance":[165],"(AI)":[166],"based":[167],"frequency":[170,282,366],"TCC":[172],"(AI:":[173],">0.3":[174],"unstable":[175,313,318],"SNVs/tumor).":[176],"The":[177,355],"rate":[178],"failed":[180],"significantly":[183,322],"higher":[184],"PGM":[186],"(29.5%)":[187],"than":[188],"Proton":[190],"(3%).":[191],"Results:":[192],"total,":[194],"238":[195],"informative":[196],"analyzed.":[199],"AI":[200,297,363],"noticed":[202],"169":[204],"(71%)":[206],"multiple":[208],"genes,":[209],"more":[210,251,266],"often":[211,252,267],"TP53":[212,268],"(124":[213],"tumors,":[214,256,270,315,342],"52.1%),":[215],"TERT":[216],"(39.9%),":[217],"MDM2":[218],"(35.7%),":[219],"MET":[220],"(24.4%),":[221],"BRCA1":[222],"(20.2%)":[223],"NOTCH1":[225],"(18.9%).":[226],"Coding":[227],"mutations":[228,244,259,283,301,347,408],"identified":[230],"40/43":[232],"but":[234],"their":[235],"number":[236],"varied":[237],"extensively":[238],"per":[239],"(0-87).":[241],"SNV":[242],"functional":[243],"observed":[246,261,337,360],"55":[248],"(23.1%),":[250],"PIK3CA":[254,279],"(12":[255],"5%).":[257],"Non-SNV":[258],"153":[263],"(64.2%),":[265],"(128":[269],"53.8%),":[271],"CDH1":[272],"(17.2%),":[273],"MAP3K1":[274],"(8%),":[275],"PTEN":[276],"(6.3%),":[277],"(4.6%).":[280],"High":[281],"(>50%":[284],"cells)":[286],"found":[288],"TP53,":[290],"PTEN,":[291],"PIK3CA.":[292],"Individually,":[293],"presence":[295,345],"(unstable":[298],"tumors)":[299],"predicted":[302],"worse":[304],"survival.":[305,354],"Importantly":[306],"though,":[307],"comparison":[309],"mutated":[314],"nonmutated":[319],"had":[321],"better":[323],"outcome":[324,415],"(DFS,":[325],"HR:0.41,":[326],"95%CI:0.20-0.84,":[327],"Wald":[328],"p=0.014;":[329],"OS,":[330],"HR:0.36,":[331],"95%CI:0.15-0.86,":[332],"p=0.021),":[333],"similar":[334],"that":[336],"favorable":[340],"stable":[341],"where":[343],"did":[348],"not":[349],"add":[350],"any":[351],"effect":[352],"same":[356],"survival":[357],"pattern":[358],"when":[361],"evaluating":[362],"high":[365],"mutations.":[367],"Conclusions:":[368],"Targeted":[369],"MPS":[370],"panels":[373],"an":[375],"attractive":[376],"option":[377],"highly":[379,446],"multiplexed":[380,447],"genotyping,":[383],"although":[384],"differences":[385],"efficiency":[388],"available":[390],"platforms":[391],"should":[392],"be":[393],"considered.":[394],"With":[395],"respect":[396],"potential":[398],"clinical":[399],"implications,":[400],"identifying":[401],"(in)stability":[405],"seems":[409],"important":[410],"assessing":[412],"patient":[414],"merits":[417],"further":[418],"validation.":[419],"Citation":[420],"Format:":[421],"Vassiliki":[422],"Kotoula,":[423],"Kyriaki":[424],"Papadopoulou,":[425],"Elpida":[426],"Charalambous,":[427],"Flora":[428],"Zagouri,":[429],"Sotiris":[430],"Lakis,":[431],"Angeliki":[432],"Lymperopoulou,":[433],"Eleftheria":[434],"Tsolaki,":[435],"George":[436,442],"Pentheroudakis,":[437],"Kostas":[438],"Lilakos,":[439],"Dimitrios":[440],"Pectasides,":[441],"Fountzilas.":[443],"Routinely":[444],"applicable,":[445],"triple-negative":[448],"breast":[449],"cancer":[450],"(TNBC)":[451],"genotyping.":[452],"[abstract].":[453],"In:":[454],"Proceedings":[455],"105th":[458],"Annual":[459],"Meeting":[460],"American":[463],"Association":[464],"Cancer":[466,477],"Research;":[467],"2014":[468],"Apr":[469],"5-9;":[470],"San":[471],"Diego,":[472],"CA.":[473],"Philadelphia":[474],"(PA):":[475],"AACR;":[476],"Res":[478],"2014;74(19":[479],"Suppl):Abstract":[480],"nr":[481],"3579.":[482],"doi:10.1158/1538-7445.AM2014-3579":[483]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}