{"id":"https://openalex.org/W1490922209","doi":"https://doi.org/10.1111/hepr.12393","title":"Suppression of hepatocellular carcinoma development in hepatitis C patients given interferon\u2010based antiviral therapy","display_name":"Suppression of hepatocellular carcinoma development in hepatitis C patients given interferon\u2010based antiviral therapy","publication_year":2014,"publication_date":"2014-07-23","ids":{"openalex":"https://openalex.org/W1490922209","doi":"https://doi.org/10.1111/hepr.12393","mag":"1490922209","pmid":"https://pubmed.ncbi.nlm.nih.gov/25052449"},"language":"en","primary_location":{"id":"doi:10.1111/hepr.12393","doi":"https://doi.org/10.1111/hepr.12393","is_oa":false,"landing_page_url":"https://doi.org/10.1111/hepr.12393","pdf_url":null,"source":{"id":"https://openalex.org/S110399111","display_name":"Hepatology Research","issn_l":"1386-6346","issn":["1386-6346","1872-034X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023392452","display_name":"Naoki Hiramatsu","orcid":"https://orcid.org/0000-0002-8803-4488","observed_orcids":["https://orcid.org/0000-0002-8803-4488"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Naoki Hiramatsu","raw_affiliation_strings":["Department of Gastroenterology and Hepatology; Osaka University Graduate School of Medicine; Osaka Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology; Osaka University Graduate School of Medicine; Osaka Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043392003","display_name":"Tsugiko Oze","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tsugiko Oze","raw_affiliation_strings":["Department of Gastroenterology and Hepatology Osaka University Graduate School of Medicine  Osaka Japan","Osaka University Graduate School of Medicine Department of Gastroenterology and Hepatology Osaka Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology Osaka University Graduate School of Medicine  Osaka Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Osaka University Graduate School of Medicine Department of Gastroenterology and Hepatology Osaka Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040891927","display_name":"Tetsuo Takehara","orcid":"https://orcid.org/0000-0001-5036-3457","observed_orcids":["https://orcid.org/0000-0001-5036-3457"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tetsuo Takehara","raw_affiliation_strings":["Department of Gastroenterology and Hepatology Osaka University Graduate School of Medicine  Osaka Japan","Osaka University Graduate School of Medicine Department of Gastroenterology and Hepatology Osaka Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology Osaka University Graduate School of Medicine  Osaka Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Osaka University Graduate School of Medicine Department of Gastroenterology and Hepatology Osaka Japan","institution_ids":["https://openalex.org/I98285908"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5023392452"],"corresponding_institution_ids":["https://openalex.org/I98285908"],"apc_list":{"value":3400,"currency":"USD","value_usd":3400},"apc_paid":null,"fwci":3.6856,"has_fulltext":false,"cited_by_count":81,"citation_normalized_percentile":{"value":0.93884252,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"45","issue":"2","first_page":"152","last_page":"161"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9879999756813049},{"id":"https://openalex.org/keywords/chronic-hepatitis-c","display_name":"chronic hepatitis C","score":0.8799999952316284},{"id":"https://openalex.org/keywords/interferon-based-antiviral-therapy","display_name":"interferon-based antiviral therapy","score":0.984000027179718},{"id":"https://openalex.org/keywords/sustained-virologic-response","display_name":"sustained virological response","score":0.996999979019165},{"id":"https://openalex.org/keywords/hcc-risk-factors","display_name":"HCC risk factors","score":0.7979999780654907},{"id":"https://openalex.org/keywords/alpha-fetoprotein","display_name":"alpha-fetoprotein","score":0.9259999990463257},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.9509999752044678},{"id":"https://openalex.org/keywords/direct-acting-antivirals","display_name":"direct-acting antivirals","score":0.8820000290870667},{"id":"https://openalex.org/keywords/hepatitis-c-virus","display_name":"hepatitis C virus","score":0.5099999904632568},{"id":"https://openalex.org/keywords/hcc-incidence","display_name":"HCC incidence","score":0.6449999809265137}],"concepts":[{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.9109610319137573},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8239195346832275},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6310950517654419},{"id":"https://openalex.org/C2993512173","wikidata":"https://www.wikidata.org/wiki/Q846227","display_name":"Antiviral therapy","level":4,"score":0.6302413940429688},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.607585608959198},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.5964221358299255},{"id":"https://openalex.org/C2776455275","wikidata":"https://www.wikidata.org/wiki/Q154869","display_name":"Hepatitis C","level":2,"score":0.4736127555370331},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.46818673610687256},{"id":"https://openalex.org/C3020491458","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Chronic hepatitis","level":3,"score":0.4566144347190857},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4564097821712494},{"id":"https://openalex.org/C2776999253","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Combination therapy","level":2,"score":0.4454338848590851},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.39710041880607605},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.17633694410324097},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1111/hepr.12393","doi":"https://doi.org/10.1111/hepr.12393","is_oa":false,"landing_page_url":"https://doi.org/10.1111/hepr.12393","pdf_url":null,"source":{"id":"https://openalex.org/S110399111","display_name":"Hepatology Research","issn_l":"1386-6346","issn":["1386-6346","1872-034X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology Research","raw_type":"journal-article"},{"id":"pmid:25052449","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25052449","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology research : the official journal of the Japan Society of Hepatology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1760890369","https://openalex.org/W1966804887","https://openalex.org/W1980901087","https://openalex.org/W1983154697","https://openalex.org/W1987786149","https://openalex.org/W1998042657","https://openalex.org/W2000755883","https://openalex.org/W2011122771","https://openalex.org/W2011925705","https://openalex.org/W2012002512","https://openalex.org/W2012074642","https://openalex.org/W2012944241","https://openalex.org/W2022040029","https://openalex.org/W2022693941","https://openalex.org/W2026778931","https://openalex.org/W2034000389","https://openalex.org/W2041674075","https://openalex.org/W2043382282","https://openalex.org/W2046169642","https://openalex.org/W2046761147","https://openalex.org/W2048388753","https://openalex.org/W2058128629","https://openalex.org/W2068237814","https://openalex.org/W2072620637","https://openalex.org/W2080513440","https://openalex.org/W2084119969","https://openalex.org/W2091803730","https://openalex.org/W2100907005","https://openalex.org/W2102272818","https://openalex.org/W2104051780","https://openalex.org/W2107791782","https://openalex.org/W2111298327","https://openalex.org/W2117766751","https://openalex.org/W2122451741","https://openalex.org/W2126621933","https://openalex.org/W2132933944","https://openalex.org/W2143997139","https://openalex.org/W2157642105","https://openalex.org/W2162078710","https://openalex.org/W2168543151","https://openalex.org/W2169521738"],"related_works":["https://openalex.org/W2072620637","https://openalex.org/W2000755883","https://openalex.org/W2027795595","https://openalex.org/W2093640498","https://openalex.org/W2018086414","https://openalex.org/W2205287133","https://openalex.org/W2162078710","https://openalex.org/W7146011399","https://openalex.org/W2144792064","https://openalex.org/W2567234545"],"abstract_inverted_index":{"The":[0,59],"advance":[1],"of":[2,25,32,44,98,108,133,148,175],"antiviral":[3,69],"treatment":[4,100,168],"for":[5,38,78,139],"chronic":[6,50],"hepatitis":[7,51],"C":[8,52],"has":[9,62],"brought":[10],"a":[11,146],"high":[12],"sustained":[13],"virological":[14,109],"response":[15],"(SVR)":[16],"rate.":[17],"In":[18,111],"this":[19],"review":[20],"article,":[21],"the":[22,30,42,75,96,131,159,173],"suppressive":[23],"effect":[24],"interferon":[26],"(IFN)-based":[27],"therapy":[28,56,144],"on":[29],"development":[31,46],"hepatocellular":[33],"carcinoma":[34],"(HCC),":[35],"risk":[36,76,116],"factors":[37,77,117],"developing":[39,79],"HCC":[40,45,60,80,105,134,171],"and":[41,74,87,125],"characteristics":[43],"after":[47,95],"SVR":[48,141],"among":[49],"patients":[53,112],"given":[54],"IFN-based":[55,68,99,176],"were":[57,81,118],"studied.":[58],"incidence":[61,106,135],"been":[63],"revealed":[64],"to":[65,130,155,172,182],"decrease":[66],"with":[67,104,113,145],"therapy,":[70],"especially":[71],"in":[72,158],"SVR,":[73,114],"older":[82],"age,":[83],"advanced":[84],"liver":[85],"fibrosis":[86],"male":[88],"sex.":[89],"\u03b1-Fetoprotein":[90],"levels":[91],"at":[92],"24":[93],"weeks":[94],"end":[97],"was":[101],"associated":[102],"strongly":[103],"irrespective":[107],"response.":[110],"other":[115],"glucose":[119],"metabolism":[120,123],"disorders,":[121],"lipid":[122],"disorders":[124],"alcohol":[126],"intake.":[127],"Extra":[128],"attention":[129],"possibility":[132],"should":[136],"be":[137,156],"required":[138,181],"these":[140],"patients.":[142],"Antiviral":[143],"combination":[147],"HCV-specific":[149],"direct-acting":[150],"antivirals":[151],"(DAA)":[152],"is":[153,163,180],"expected":[154],"utilized":[157],"future.":[160],"However,":[161],"it":[162],"not":[164],"known":[165],"whether":[166],"DAA-based":[167],"can":[169],"suppress":[170],"level":[174],"treatment.":[177],"Further":[178],"research":[179],"clarify":[183],"this.":[184]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":14},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
