{"id":"https://openalex.org/W1490846006","doi":null,"title":"Combining knowledge and data driven insights for identifying risk factors using electronic health records.","display_name":"Combining knowledge and data driven insights for identifying risk factors using electronic health records.","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W1490846006","mag":"1490846006","pmid":"https://pubmed.ncbi.nlm.nih.gov/23304365","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3540578"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3540578","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3540578","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AMIA Annu Symp Proc","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3540578","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084279065","display_name":"Jimeng Sun","orcid":"https://orcid.org/0000-0003-1512-6426","observed_orcids":["https://orcid.org/0000-0003-1512-6426"]},"institutions":[{"id":"https://openalex.org/I4210114115","display_name":"IBM Research - Thomas J. Watson Research Center","ror":"https://ror.org/0265w5591","country_code":"US","type":"facility","lineage":["https://openalex.org/I1341412227","https://openalex.org/I4210114115"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jimeng Sun","raw_affiliation_strings":["IBM T.J. Watson Research Center, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IBM T.J. Watson Research Center, NY, USA","institution_ids":["https://openalex.org/I4210114115"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040300380","display_name":"Jianying Hu","orcid":"https://orcid.org/0000-0001-7753-886X","observed_orcids":["https://orcid.org/0000-0001-7753-886X"]},"institutions":[{"id":"https://openalex.org/I1341412227","display_name":"IBM (United States)","ror":"https://ror.org/05hh8d621","country_code":"US","type":"company","lineage":["https://openalex.org/I1341412227"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianying Hu","raw_affiliation_strings":["IBM (United States), Armonk, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IBM (United States), Armonk, United States","institution_ids":["https://openalex.org/I1341412227"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101186016","display_name":"Dijun Luo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189196454","display_name":"The University of Texas at Arlington","ror":"https://ror.org/019kgqr73","country_code":"US","type":"education","lineage":["https://openalex.org/I189196454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dijun Luo","raw_affiliation_strings":["The University of Texas at Arlington, Arlington, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas at Arlington, Arlington, United States","institution_ids":["https://openalex.org/I189196454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009202015","display_name":"Marianthi Markatou","orcid":"https://orcid.org/0000-0002-1453-8229","observed_orcids":["https://orcid.org/0000-0002-1453-8229"]},"institutions":[{"id":"https://openalex.org/I1341412227","display_name":"IBM (United States)","ror":"https://ror.org/05hh8d621","country_code":"US","type":"company","lineage":["https://openalex.org/I1341412227"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marianthi Markatou","raw_affiliation_strings":["IBM (United States), Armonk, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IBM (United States), Armonk, United States","institution_ids":["https://openalex.org/I1341412227"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100455871","display_name":"Fei Wang","orcid":"https://orcid.org/0000-0002-7594-663X","observed_orcids":["https://orcid.org/0000-0002-7594-663X"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fei Wang","raw_affiliation_strings":["Yale University, New Haven, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University, New Haven, United States","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085298556","display_name":"Shahram Edabollahi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1341412227","display_name":"IBM (United States)","ror":"https://ror.org/05hh8d621","country_code":"US","type":"company","lineage":["https://openalex.org/I1341412227"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shahram Edabollahi","raw_affiliation_strings":["IBM (United States), Armonk, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IBM (United States), Armonk, United States","institution_ids":["https://openalex.org/I1341412227"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054364960","display_name":"Steven R. Steinhubl","orcid":"https://orcid.org/0000-0002-9256-7914","observed_orcids":["https://orcid.org/0000-0002-9256-7914"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steven E Steinhubl","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014160747","display_name":"Zahra S. Daar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1293487830","display_name":"Geisinger Medical Center","ror":"https://ror.org/03j9npf54","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1293487830","https://openalex.org/I54713919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zahra Daar","raw_affiliation_strings":["Geisinger Medical Center, Danville, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Geisinger Medical Center, Danville, United States","institution_ids":["https://openalex.org/I1293487830"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009524646","display_name":"Walter F. Stewart","orcid":"https://orcid.org/0000-0001-9297-7422","observed_orcids":["https://orcid.org/0000-0001-9297-7422"]},"institutions":[{"id":"https://openalex.org/I114073160","display_name":"Sutter Health","ror":"https://ror.org/0060avh92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I114073160"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Walter F Stewart","raw_affiliation_strings":["Sutter Health, Sacramento, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sutter Health, Sacramento, United States","institution_ids":["https://openalex.org/I114073160"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.3843,"has_fulltext":false,"cited_by_count":86,"citation_normalized_percentile":{"value":0.96715894,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"2012","issue":null,"first_page":"901","last_page":"10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13702","display_name":"Machine Learning in Healthcare","score":0.7973999977111816,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13702","display_name":"Machine Learning in Healthcare","score":0.7973999977111816,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11396","display_name":"Artificial Intelligence in Healthcare","score":0.1835000067949295,"subfield":{"id":"https://openalex.org/subfields/3605","display_name":"Health Information Management"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10350","display_name":"Electronic Health Records Systems","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/3605","display_name":"Health Information Management"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.8159999847412109},{"id":"https://openalex.org/keywords/risk-factor-identification","display_name":"risk factor identification","score":0.9829999804496765},{"id":"https://openalex.org/keywords/electronic-health-records","display_name":"electronic health records","score":0.9020000100135803},{"id":"https://openalex.org/keywords/sparse-regression","display_name":"sparse regression","score":0.8790000081062317},{"id":"https://openalex.org/keywords/regularization","display_name":"regularization","score":0.8769999742507935},{"id":"https://openalex.org/keywords/clinical-decision-support","display_name":"clinical decision support","score":0.43799999356269836}],"concepts":[{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.7192923426628113},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6450904607772827},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.5566712021827698},{"id":"https://openalex.org/C3019952477","wikidata":"https://www.wikidata.org/wiki/Q1324077","display_name":"Health records","level":3,"score":0.5538015365600586},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.5506817102432251},{"id":"https://openalex.org/C2779530757","wikidata":"https://www.wikidata.org/wiki/Q1207505","display_name":"Quality (philosophy)","level":2,"score":0.5193227529525757},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.4526002109050751},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.43802350759506226},{"id":"https://openalex.org/C32896092","wikidata":"https://www.wikidata.org/wiki/Q189447","display_name":"Risk management","level":2,"score":0.4286537766456604},{"id":"https://openalex.org/C120567893","wikidata":"https://www.wikidata.org/wiki/Q1582085","display_name":"Knowledge extraction","level":2,"score":0.41349148750305176},{"id":"https://openalex.org/C160735492","wikidata":"https://www.wikidata.org/wiki/Q31207","display_name":"Health care","level":2,"score":0.37330782413482666},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.3611180782318115},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19292095303535461},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.08926001191139221},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C50522688","wikidata":"https://www.wikidata.org/wiki/Q189833","display_name":"Economic growth","level":1,"score":0.0},{"id":"https://openalex.org/C10138342","wikidata":"https://www.wikidata.org/wiki/Q43015","display_name":"Finance","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015897","descriptor_name":"Comorbidity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057225","descriptor_name":"Data Mining","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057286","descriptor_name":"Electronic Health Records","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:3540578","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3540578","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AMIA Annu Symp Proc","raw_type":"Text"},{"id":"pmid:23304365","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23304365","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AMIA ... Annual Symposium proceedings. AMIA Symposium","raw_type":"Journal Article"},{"id":"mag:1490846006","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23304365","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3540578","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3540578","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AMIA Annu Symp Proc","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1608549042","https://openalex.org/W1986560547","https://openalex.org/W2012154384","https://openalex.org/W2012451988","https://openalex.org/W2017337590","https://openalex.org/W2042298135","https://openalex.org/W2063978378","https://openalex.org/W2117475302","https://openalex.org/W2135046866","https://openalex.org/W2144048294","https://openalex.org/W2145681479","https://openalex.org/W2154053567","https://openalex.org/W2154884142","https://openalex.org/W2159219753","https://openalex.org/W2159636537","https://openalex.org/W2160732687","https://openalex.org/W2404638125","https://openalex.org/W2547346359","https://openalex.org/W2615043561","https://openalex.org/W4211191293"],"related_works":["https://openalex.org/W4366687129","https://openalex.org/W3003385226","https://openalex.org/W1674043708","https://openalex.org/W2772738017","https://openalex.org/W2512244356","https://openalex.org/W2788242669","https://openalex.org/W4413360497","https://openalex.org/W2836893327","https://openalex.org/W2951969182","https://openalex.org/W2989764893"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,87,111,127,197],"ability":[2],"to":[3,9,54,73,102,218],"identify":[4,150,262],"the":[5,146,158,166,179,187,190,193,244,250],"risk":[6,31,64,77,82,108,152,176,199,208,214,239,266,274],"factors":[7,78,83,153,161,177,200,209,215,267],"related":[8],"an":[10],"adverse":[11],"condition,":[12],"e.g.,":[13],"heart":[14,121],"failures":[15],"(HF)":[16],"diagnosis,":[17,137],"is":[18,92,113],"very":[19],"important":[20],"for":[21,30,63,133,231,238],"improving":[22],"care":[23],"quality":[24],"and":[25,105,124,162,203,234,264],"reducing":[26],"cost.":[27],"Existing":[28],"approaches":[29],"factor":[32,65,240],"identification":[33],"are":[34,155,216],"either":[35],"knowledge":[36,58,104,202,233],"driven":[37,44,61,107,236],"(from":[38,45],"guidelines":[39],"or":[40,42],"literatures)":[41],"data":[43,60,106,204,235],"observational":[46],"data).":[47],"No":[48],"existing":[49,159],"method":[50,148],"provides":[51],"a":[52,70,93,116,223,228,269],"model":[53,96],"effectively":[55],"combine":[56],"expert":[57],"with":[59,79,97],"insight":[62],"identification.":[66,241],"METHODS:":[67],"We":[68,143,170,226,242],"present":[69,227],"systematic":[71,229],"approach":[72,91,112,259],"enhance":[74],"known":[75,160,272],"knowledge-based":[76,207],"additional":[80,213],"potential":[81],"derived":[84],"from":[85,141],"data.":[86],"core":[88],"of":[89,168,175,181,184,246,252,255,271],"our":[90,258],"sparse":[94],"regression":[95],"regularization":[98],"terms":[99],"that":[100,145,154],"correspond":[101],"both":[103],"factors.":[109,275],"RESULTS:":[110],"validated":[114],"using":[115,186],"large":[117],"dataset":[118],"containing":[119],"4,644":[120],"failure":[122],"cases":[123],"45,981":[125],"controls.":[126],"outpatient":[128],"electronic":[129],"health":[130],"records":[131],"(EHRs)":[132],"these":[134],"patients":[135],"include":[136],"medication,":[138],"lab":[139],"results":[140],"2003-2010.":[142],"demonstrate":[144,243],"proposed":[147],"can":[149,163,260],"complementary":[151],"not":[156],"in":[157,178,249],"better":[164],"predict":[165],"onset":[167,183,254],"HF.":[169],"quantitatively":[171],"compare":[172],"different":[173],"sets":[174],"context":[180,251],"predicting":[182,253],"HF":[185,273],"performance":[188],"metric,":[189],"Area":[191],"Under":[192],"ROC":[194],"Curve":[195],"(AUC).":[196],"combined":[198],"between":[201],"significantly":[205],"outperform":[206],"alone.":[210],"Furthermore,":[211],"those":[212],"confirmed":[217],"be":[219],"clinically":[220],"meaningful":[221],"by":[222],"cardiologist.":[224],"CONCLUSION:":[225],"framework":[230,248],"combining":[232],"insights":[237],"power":[245],"this":[247],"HF,":[256],"where":[257],"successfully":[261],"intuitive":[263],"predictive":[265],"beyond":[268],"set":[270]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}