{"id":"https://openalex.org/W1490765286","doi":null,"title":"MODULATION OF THE ADRENAL MEDULLARY RESPONSE TO STRESS BY ESTRADIOL IN THE FEMALE RAT","display_name":"MODULATION OF THE ADRENAL MEDULLARY RESPONSE TO STRESS BY ESTRADIOL IN THE FEMALE RAT","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W1490765286","mag":"1490765286"},"language":"en","primary_location":{"id":"pmh:oai:uknowledge.uky.edu:gradschool_diss-1422","doi":null,"is_oa":true,"landing_page_url":"https://uknowledge.uky.edu/gradschool_diss/419","pdf_url":"https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1422&context=gradschool_diss","source":{"id":"https://openalex.org/S4306402623","display_name":"UKnowledge (University of Kentucky)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143302722","host_organization_name":"University of Kentucky","host_organization_lineage":["https://openalex.org/I143302722"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"University of Kentucky Doctoral Dissertations","raw_type":"text"},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1422&context=gradschool_diss","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065774625","display_name":"Julye M Adams","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Julye M Adams","raw_affiliation_strings":["#N##TAB##TAB##TAB##TAB# Univ. of Kentucky#N##TAB##TAB##TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"#N##TAB##TAB##TAB##TAB# Univ. of Kentucky#N##TAB##TAB##TAB#","institution_ids":["https://openalex.org/I143302722"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5065774625"],"corresponding_institution_ids":["https://openalex.org/I143302722"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.079731,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.6636000275611877,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.6636000275611877,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.163100004196167,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.14110000431537628,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.9739999771118164},{"id":"https://openalex.org/keywords/adrenal-medulla","display_name":"adrenal medulla","score":0.8690000176429749},{"id":"https://openalex.org/keywords/epinephrine","display_name":"epinephrine","score":0.9369999766349792},{"id":"https://openalex.org/keywords/stress-response","display_name":"stress response","score":0.777999997138977},{"id":"https://openalex.org/keywords/insulin-induced-hypoglycemia","display_name":"insulin-induced hypoglycemia","score":0.9470000267028809},{"id":"https://openalex.org/keywords/ovariectomy","display_name":"ovariectomy","score":0.9279999732971191},{"id":"https://openalex.org/keywords/chromaffin-cells","display_name":"chromaffin cells","score":0.9390000104904175},{"id":"https://openalex.org/keywords/calcium-transients","display_name":"calcium transients","score":0.6449999809265137},{"id":"https://openalex.org/keywords/stimulus-secretion-coupling","display_name":"stimulus-secretion coupling","score":0.9580000042915344},{"id":"https://openalex.org/keywords/female-rats","display_name":"female rats","score":0.6970000267028809},{"id":"https://openalex.org/keywords/tyrosine-hydroxylase","display_name":"tyrosine hydroxylase","score":0.8700000047683716},{"id":"https://openalex.org/keywords/phenylethanolamine-n-methyltransferase","display_name":"phenylethanolamine N-methyltransferase","score":0.9940000176429749},{"id":"https://openalex.org/keywords/epinephrine-biosynthesis","display_name":"epinephrine biosynthesis","score":0.6200000047683716},{"id":"https://openalex.org/keywords/intracellular-calcium-signaling","display_name":"intracellular calcium signaling","score":0.5199999809265137},{"id":"https://openalex.org/keywords/hypothalamic-pituitary-adrenal-axis","display_name":"hypothalamic-pituitary-adrenal axis","score":0.7289999723434448}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6630792617797852},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6250443458557129},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.472443163394928},{"id":"https://openalex.org/C195121873","wikidata":"https://www.wikidata.org/wiki/Q1131385","display_name":"Medullary cavity","level":2,"score":0.47170376777648926},{"id":"https://openalex.org/C78604142","wikidata":"https://www.wikidata.org/wiki/Q1640582","display_name":"Fight-or-flight response","level":3,"score":0.4183264970779419},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.380293607711792},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35374122858047485},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:uknowledge.uky.edu:gradschool_diss-1422","doi":null,"is_oa":true,"landing_page_url":"https://uknowledge.uky.edu/gradschool_diss/419","pdf_url":"https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1422&context=gradschool_diss","source":{"id":"https://openalex.org/S4306402623","display_name":"UKnowledge (University of Kentucky)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143302722","host_organization_name":"University of Kentucky","host_organization_lineage":["https://openalex.org/I143302722"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"University of Kentucky Doctoral Dissertations","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.425.1285","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.425.1285","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://lib.uky.edu/ETD/ukyphyi2005d00312/etd.pdf","raw_type":"text"},{"id":"mag:1490765286","doi":null,"is_oa":false,"landing_page_url":"https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1422&context=gradschool_diss","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:uknowledge.uky.edu:gradschool_diss-1422","doi":null,"is_oa":true,"landing_page_url":"https://uknowledge.uky.edu/gradschool_diss/419","pdf_url":"https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1422&context=gradschool_diss","source":{"id":"https://openalex.org/S4306402623","display_name":"UKnowledge (University of Kentucky)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143302722","host_organization_name":"University of Kentucky","host_organization_lineage":["https://openalex.org/I143302722"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"University of Kentucky Doctoral Dissertations","raw_type":"text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1490765286.pdf","grobid_xml":"https://content.openalex.org/works/W1490765286.grobid-xml"},"referenced_works_count":143,"referenced_works":["https://openalex.org/W114466314","https://openalex.org/W276247196","https://openalex.org/W1512753125","https://openalex.org/W1579907219","https://openalex.org/W1586699954","https://openalex.org/W1772540613","https://openalex.org/W1806368578","https://openalex.org/W1821318981","https://openalex.org/W1964272344","https://openalex.org/W1964581337","https://openalex.org/W1965002718","https://openalex.org/W1967479464","https://openalex.org/W1969060000","https://openalex.org/W1970318500","https://openalex.org/W1973205654","https://openalex.org/W1973320610","https://openalex.org/W1975134558","https://openalex.org/W1976391449","https://openalex.org/W1977374270","https://openalex.org/W1977906709","https://openalex.org/W1977970397","https://openalex.org/W1978153033","https://openalex.org/W1978658082","https://openalex.org/W1980465374","https://openalex.org/W1980873267","https://openalex.org/W1981631038","https://openalex.org/W1981755144","https://openalex.org/W1982083136","https://openalex.org/W1982922725","https://openalex.org/W1983634929","https://openalex.org/W1984226490","https://openalex.org/W1984469178","https://openalex.org/W1984472719","https://openalex.org/W1988317556","https://openalex.org/W1991405020","https://openalex.org/W1993318146","https://openalex.org/W1994862684","https://openalex.org/W1994883195","https://openalex.org/W1997295279","https://openalex.org/W1998902468","https://openalex.org/W2000469015","https://openalex.org/W2000665527","https://openalex.org/W2003531665","https://openalex.org/W2003829388","https://openalex.org/W2006862162","https://openalex.org/W2007885045","https://openalex.org/W2008567394","https://openalex.org/W2010853752","https://openalex.org/W2012968728","https://openalex.org/W2014236193","https://openalex.org/W2015191970","https://openalex.org/W2017082833","https://openalex.org/W2017426495","https://openalex.org/W2017592125","https://openalex.org/W2017881894","https://openalex.org/W2018813284","https://openalex.org/W2019124565","https://openalex.org/W2022514816","https://openalex.org/W2026876021","https://openalex.org/W2030418316","https://openalex.org/W2031410442","https://openalex.org/W2032603793","https://openalex.org/W2033240973","https://openalex.org/W2035181778","https://openalex.org/W2035740858","https://openalex.org/W2036830265","https://openalex.org/W2039384624","https://openalex.org/W2041248871","https://openalex.org/W2041564029","https://openalex.org/W2043525975","https://openalex.org/W2046205991","https://openalex.org/W2047585722","https://openalex.org/W2047968184","https://openalex.org/W2048505082","https://openalex.org/W2048863570","https://openalex.org/W2048966788","https://openalex.org/W2049151105","https://openalex.org/W2050717023","https://openalex.org/W2051362544","https://openalex.org/W2051942816","https://openalex.org/W2052015917","https://openalex.org/W2054018085","https://openalex.org/W2055321662","https://openalex.org/W2055705342","https://openalex.org/W2057716139","https://openalex.org/W2059818560","https://openalex.org/W2066399601","https://openalex.org/W2067642579","https://openalex.org/W2070698172","https://openalex.org/W2072157130","https://openalex.org/W2073521953","https://openalex.org/W2073883348","https://openalex.org/W2074492718","https://openalex.org/W2075694093","https://openalex.org/W2075697446","https://openalex.org/W2076964246","https://openalex.org/W2078238765","https://openalex.org/W2083975235","https://openalex.org/W2086178662","https://openalex.org/W2089669887","https://openalex.org/W2091040275","https://openalex.org/W2092107317","https://openalex.org/W2092931393","https://openalex.org/W2093340936","https://openalex.org/W2093676604","https://openalex.org/W2101178259","https://openalex.org/W2101894693","https://openalex.org/W2103808181","https://openalex.org/W2104462420","https://openalex.org/W2105224505","https://openalex.org/W2113836226","https://openalex.org/W2113893197","https://openalex.org/W2120244650","https://openalex.org/W2121376289","https://openalex.org/W2131004274","https://openalex.org/W2132030042","https://openalex.org/W2136731377","https://openalex.org/W2136949300","https://openalex.org/W2137349578","https://openalex.org/W2141260882","https://openalex.org/W2141739145","https://openalex.org/W2146885602","https://openalex.org/W2162431031","https://openalex.org/W2168311566","https://openalex.org/W2175243815","https://openalex.org/W2183540982","https://openalex.org/W2185141716","https://openalex.org/W2185157995","https://openalex.org/W2188942155","https://openalex.org/W2198516513","https://openalex.org/W2209257886","https://openalex.org/W2262611348","https://openalex.org/W2278360218","https://openalex.org/W2278695688","https://openalex.org/W2395989130","https://openalex.org/W2401543985","https://openalex.org/W2404937090","https://openalex.org/W2406250196","https://openalex.org/W2414070262","https://openalex.org/W2418639171","https://openalex.org/W2472080748","https://openalex.org/W2569914917","https://openalex.org/W3021856666"],"related_works":["https://openalex.org/W2012968728","https://openalex.org/W3176654940","https://openalex.org/W2006062886","https://openalex.org/W1553971595","https://openalex.org/W2092931393","https://openalex.org/W2144272905","https://openalex.org/W2125838820","https://openalex.org/W2055067675","https://openalex.org/W7100511908","https://openalex.org/W2167660979"],"abstract_inverted_index":{"The":[0,100],"present":[1],"study":[2],"has":[3],"established":[4,113],"that":[5,88,135],"physiological":[6],"concentrations":[7],"of":[8,75,103,119],"estradiol":[9],"can":[10],"modulate":[11],"stress-induced":[12],"increases":[13,149],"in":[14,35,52,84,108,131,140,150,155],"plasma":[15,27,53],"epinephrine":[16],"(EPI).":[17],"In":[18,44],"anesthetized":[19],"female":[20],"rats,":[21,48,86,133],"insulininduced":[22],"hypoglycemia":[23],"(0.25":[24],"U/kg)":[25],"increased":[26,73],"EPI":[28,54,79,89,136],"concentration":[29,80],"to":[30,41,59,66],"a":[31],"significantly":[32,56,82],"greater":[33],"extent":[34],"14-day":[36],"ovariectomized":[37],"(OVEX)":[38],"rats":[39],"compared":[40,58],"sham-operated":[42],"controls.":[43],"17\u03b2estradiol":[45],"(E2)-replaced":[46],"OVEX":[47,60,143],"the":[49,92,116,120],"hypoglycemia-induced":[50],"rise":[51],"was":[55,64,81,95],"reduced":[57,83],"rats.":[61],"This":[62],"suppression":[63],"due":[65],"both":[67],"decreased":[68,96],"adrenal":[69,93,157],"medullary":[70],"output":[71],"and":[72,125,142,146],"clearance":[74],"EPI.":[76],"Adrenal":[77],"venous":[78],"OVEX+E2":[85,132],"suggesting":[87,134],"secretion":[90,109],"from":[91],"medulla":[94],"by":[97],"E2":[98],"replacement.":[99],"underlying":[101],"mechanism(s)":[102],"this":[104],"apparent":[105],"E2mediated":[106],"reduction":[107],"could":[110],"not":[111,129],"be":[112],"since":[114],"1)":[115],"expression":[117],"levels":[118],"biosynthetic":[121],"enzymes":[122],"tyrosine":[123],"hydroxylase":[124],"phenylethanolamine":[126],"N-methyltransferase":[127],"were":[128],"affected":[130],"biosynthesis":[137],"is":[138],"similar":[139],"these":[141],"2+":[144],"rats;":[145],"2)":[147],"agonist-induced":[148],"intracellular":[151],"CaP":[152],"Pwere":[153],"identical":[154],"isolated":[156]},"counts_by_year":[],"updated_date":"2026-08-31T07:19:18.363097","created_date":"2016-06-24T00:00:00"}