{"id":"https://openalex.org/W149068059","doi":null,"title":"\u00c9valuation des r\u00e9ponses cellulaires et tissulaires pr\u00e9coces induites par des implants sous-chondraux et pr\u00e9solidifi\u00e9s compos\u00e9s de chitosane/sang dans un mod\u00e8le ost\u00e9ochondral","display_name":"\u00c9valuation des r\u00e9ponses cellulaires et tissulaires pr\u00e9coces induites par des implants sous-chondraux et pr\u00e9solidifi\u00e9s compos\u00e9s de chitosane/sang dans un mod\u00e8le ost\u00e9ochondral","publication_year":2011,"publication_date":"2011-12-01","ids":{"openalex":"https://openalex.org/W149068059","mag":"149068059"},"language":"fr","primary_location":{"id":"pmh:oai:publications.polymtl.ca:735","doi":null,"is_oa":true,"landing_page_url":"https://publications.polymtl.ca/735/","pdf_url":"https://publications.polymtl.ca/735/1/2011_CharlesHubertLafantaisieFavreau.pdf","source":{"id":"https://openalex.org/S4306401013","display_name":"PolyPublie (\u00c9cole Polytechnique de Montr\u00e9al)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45683168","host_organization_name":"Polytechnique Montr\u00e9al","host_organization_lineage":["https://openalex.org/I45683168"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Lafantaisie-Favreau, C.-H. (2011). \u00c9valuation des r\u00e9ponses cellulaires et tissulaires pr\u00e9coces induites par des implants sous-chondraux et pr\u00e9solidifi\u00e9s compos\u00e9s de chitosane/sang dans un mod\u00e8le ost\u00e9ochondral [Master's thesis, \u00c9cole Polytechnique de Montr\u00e9al].","raw_type":"m\u00e9moire de ma\u00eetrise"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://publications.polymtl.ca/735/1/2011_CharlesHubertLafantaisieFavreau.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042072834","display_name":"Charles-Hubert Lafantaisie-Favreau","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Charles-Hubert Lafantaisie-Favreau","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5042072834"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9520999789237976,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9520999789237976,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.026900000870227814,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chitosan","display_name":"chitosan","score":0.640999972820282},{"id":"https://openalex.org/keywords/osteochondral-lesions","display_name":"osteochondral defects","score":0.6499999761581421},{"id":"https://openalex.org/keywords/cartilage-regeneration","display_name":"cartilage regeneration","score":0.847000002861023},{"id":"https://openalex.org/keywords/marrow-stimulation","display_name":"bone marrow stimulation","score":0.5849999785423279},{"id":"https://openalex.org/keywords/autologous-chondrocyte-implantation","display_name":"autologous chondrocyte implantation","score":0.7839999794960022},{"id":"https://openalex.org/keywords/fibrocartilage","display_name":"fibrocartilage","score":0.5429999828338623},{"id":"https://openalex.org/keywords/chondrogenic-differentiation","display_name":"chondrogenic differentiation","score":0.49000000953674316},{"id":"https://openalex.org/keywords/osteogenic-differentiation","display_name":"osteogenic differentiation","score":0.48399999737739563},{"id":"https://openalex.org/keywords/osteoarthritis-prevention","display_name":"osteoarthritis prevention","score":0.5260000228881836},{"id":"https://openalex.org/keywords/cartilage-defects","display_name":"cartilage defects","score":0.3199999928474426},{"id":"https://openalex.org/keywords/tissue-engineering","display_name":"tissue engineering","score":0.3790000081062317}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45085495710372925},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.383906751871109},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.37806436419487},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11764338612556458}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:publications.polymtl.ca:735","doi":null,"is_oa":true,"landing_page_url":"https://publications.polymtl.ca/735/","pdf_url":"https://publications.polymtl.ca/735/1/2011_CharlesHubertLafantaisieFavreau.pdf","source":{"id":"https://openalex.org/S4306401013","display_name":"PolyPublie (\u00c9cole Polytechnique de Montr\u00e9al)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45683168","host_organization_name":"Polytechnique Montr\u00e9al","host_organization_lineage":["https://openalex.org/I45683168"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Lafantaisie-Favreau, C.-H. (2011). \u00c9valuation des r\u00e9ponses cellulaires et tissulaires pr\u00e9coces induites par des implants sous-chondraux et pr\u00e9solidifi\u00e9s compos\u00e9s de chitosane/sang dans un mod\u00e8le ost\u00e9ochondral [Master's thesis, \u00c9cole Polytechnique de Montr\u00e9al].","raw_type":"m\u00e9moire de ma\u00eetrise"},{"id":"mag:149068059","doi":null,"is_oa":false,"landing_page_url":"https://publications.polymtl.ca/735/1/2011_CharlesHubertLafantaisieFavreau.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:publications.polymtl.ca:735","doi":null,"is_oa":true,"landing_page_url":"https://publications.polymtl.ca/735/","pdf_url":"https://publications.polymtl.ca/735/1/2011_CharlesHubertLafantaisieFavreau.pdf","source":{"id":"https://openalex.org/S4306401013","display_name":"PolyPublie (\u00c9cole Polytechnique de Montr\u00e9al)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45683168","host_organization_name":"Polytechnique Montr\u00e9al","host_organization_lineage":["https://openalex.org/I45683168"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Lafantaisie-Favreau, C.-H. (2011). \u00c9valuation des r\u00e9ponses cellulaires et tissulaires pr\u00e9coces induites par des implants sous-chondraux et pr\u00e9solidifi\u00e9s compos\u00e9s de chitosane/sang dans un mod\u00e8le ost\u00e9ochondral [Master's thesis, \u00c9cole Polytechnique de Montr\u00e9al].","raw_type":"m\u00e9moire de ma\u00eetrise"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4950347942","display_name":null,"funder_award_id":"185810-BME","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"},{"id":"https://openalex.org/G6127854273","display_name":null,"funder_award_id":"185810","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"}],"funders":[{"id":"https://openalex.org/F4320321747","display_name":"Fonds Qu\u00e9b\u00e9cois de la Recherche sur la Nature et les Technologies","ror":"https://ror.org/00b9f9778"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"},{"id":"https://openalex.org/F4320338092","display_name":"Canadian Arthritis Network","ror":"https://ror.org/00nd98w52"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W149068059.pdf","grobid_xml":"https://content.openalex.org/works/W149068059.grobid-xml"},"referenced_works_count":176,"referenced_works":["https://openalex.org/W17430403","https://openalex.org/W63434408","https://openalex.org/W75567358","https://openalex.org/W99630384","https://openalex.org/W139295034","https://openalex.org/W179053432","https://openalex.org/W192685294","https://openalex.org/W978382762","https://openalex.org/W1586069835","https://openalex.org/W1609024722","https://openalex.org/W1620233747","https://openalex.org/W1765719179","https://openalex.org/W1783345597","https://openalex.org/W1825470077","https://openalex.org/W1923917571","https://openalex.org/W1939015906","https://openalex.org/W1964189028","https://openalex.org/W1964905528","https://openalex.org/W1965552267","https://openalex.org/W1965595332","https://openalex.org/W1967980372","https://openalex.org/W1970144926","https://openalex.org/W1970839075","https://openalex.org/W1973411875","https://openalex.org/W1974897852","https://openalex.org/W1975775804","https://openalex.org/W1975953388","https://openalex.org/W1976947320","https://openalex.org/W1976971109","https://openalex.org/W1977588859","https://openalex.org/W1982167517","https://openalex.org/W1988592246","https://openalex.org/W1988667743","https://openalex.org/W1991392063","https://openalex.org/W1993818347","https://openalex.org/W1995063875","https://openalex.org/W1995523308","https://openalex.org/W1995659229","https://openalex.org/W1996090319","https://openalex.org/W1996161852","https://openalex.org/W1997276940","https://openalex.org/W1997353385","https://openalex.org/W1997568232","https://openalex.org/W1998837503","https://openalex.org/W1999014699","https://openalex.org/W1999868918","https://openalex.org/W2002315265","https://openalex.org/W2002554431","https://openalex.org/W2003026662","https://openalex.org/W2004395452","https://openalex.org/W2006665329","https://openalex.org/W2006708761","https://openalex.org/W2008708488","https://openalex.org/W2008776968","https://openalex.org/W2010575269","https://openalex.org/W2011931614","https://openalex.org/W2013024339","https://openalex.org/W2013309414","https://openalex.org/W2013462509","https://openalex.org/W2015224754","https://openalex.org/W2015423555","https://openalex.org/W2016363042","https://openalex.org/W2017621537","https://openalex.org/W2018777601","https://openalex.org/W2020103166","https://openalex.org/W2021115829","https://openalex.org/W2021781733","https://openalex.org/W2022804076","https://openalex.org/W2025501694","https://openalex.org/W2026458998","https://openalex.org/W2027245388","https://openalex.org/W2028470260","https://openalex.org/W2028506801","https://openalex.org/W2028615851","https://openalex.org/W2028980668","https://openalex.org/W2029437906","https://openalex.org/W2032536357","https://openalex.org/W2033535323","https://openalex.org/W2033559508","https://openalex.org/W2039451201","https://openalex.org/W2040299454","https://openalex.org/W2042058767","https://openalex.org/W2042511089","https://openalex.org/W2043584926","https://openalex.org/W2043614433","https://openalex.org/W2044137124","https://openalex.org/W2048299560","https://openalex.org/W2049278670","https://openalex.org/W2050567975","https://openalex.org/W2051255001","https://openalex.org/W2051292479","https://openalex.org/W2051398229","https://openalex.org/W2056449496","https://openalex.org/W2062620083","https://openalex.org/W2063141627","https://openalex.org/W2064184046","https://openalex.org/W2064216053","https://openalex.org/W2065722574","https://openalex.org/W2067587958","https://openalex.org/W2071906240","https://openalex.org/W2072366127","https://openalex.org/W2074331658","https://openalex.org/W2075079425","https://openalex.org/W2077778412","https://openalex.org/W2079634775","https://openalex.org/W2080953765","https://openalex.org/W2082516633","https://openalex.org/W2086382719","https://openalex.org/W2086514756","https://openalex.org/W2087692142","https://openalex.org/W2088699248","https://openalex.org/W2089042902","https://openalex.org/W2089739198","https://openalex.org/W2090080882","https://openalex.org/W2090248107","https://openalex.org/W2091921078","https://openalex.org/W2093252878","https://openalex.org/W2094124002","https://openalex.org/W2099166156","https://openalex.org/W2101795781","https://openalex.org/W2102308673","https://openalex.org/W2103066714","https://openalex.org/W2103420004","https://openalex.org/W2105855186","https://openalex.org/W2108740605","https://openalex.org/W2108927236","https://openalex.org/W2110213068","https://openalex.org/W2111250044","https://openalex.org/W2111519516","https://openalex.org/W2113457553","https://openalex.org/W2122542950","https://openalex.org/W2122720369","https://openalex.org/W2124755056","https://openalex.org/W2126461369","https://openalex.org/W2126472409","https://openalex.org/W2127324240","https://openalex.org/W2129083253","https://openalex.org/W2130976253","https://openalex.org/W2132551393","https://openalex.org/W2133014517","https://openalex.org/W2133529034","https://openalex.org/W2137215955","https://openalex.org/W2137902301","https://openalex.org/W2142027868","https://openalex.org/W2144997750","https://openalex.org/W2145932168","https://openalex.org/W2146567956","https://openalex.org/W2146992068","https://openalex.org/W2149171260","https://openalex.org/W2151799721","https://openalex.org/W2152805338","https://openalex.org/W2155322454","https://openalex.org/W2156334389","https://openalex.org/W2157332721","https://openalex.org/W2157884682","https://openalex.org/W2158143099","https://openalex.org/W2162682246","https://openalex.org/W2163000458","https://openalex.org/W2163660740","https://openalex.org/W2166028909","https://openalex.org/W2166174825","https://openalex.org/W2169758044","https://openalex.org/W2170089982","https://openalex.org/W2171859449","https://openalex.org/W2175540293","https://openalex.org/W2223297936","https://openalex.org/W2281112318","https://openalex.org/W2281256922","https://openalex.org/W2287548541","https://openalex.org/W2318151031","https://openalex.org/W2341978478","https://openalex.org/W2993782230","https://openalex.org/W3151290442","https://openalex.org/W4297755929","https://openalex.org/W4299574698","https://openalex.org/W7097432222"],"related_works":["https://openalex.org/W2118362648","https://openalex.org/W1173078052","https://openalex.org/W7032931332","https://openalex.org/W7008652715","https://openalex.org/W7018017689","https://openalex.org/W7112868885","https://openalex.org/W2114087193","https://openalex.org/W6981900657","https://openalex.org/W7066073220","https://openalex.org/W2537975985"],"abstract_inverted_index":{"RESUME\r\nLes":[0],"lesions":[1,24,160,188,401,556],"du":[2,25,35,105,154,179,190,367],"cartilage":[3,26,46,106,180,191,400,419,474,488,548,688,792],"articulaire":[4,27],"sont":[5,39,119,163,195,332],"tres":[6,64],"repandues":[7],"et":[8,71,82,148,266,347,353,396],"engendrent":[9],"des":[10,15,21,33,59,76,141,144,187,381],"douleurs":[11],"intenses":[12],"ainsi":[13,267,362],"que":[14,310,398],"pertes":[16,145],"de":[17,53,61,69,72,78,88,110,116,133,135,146,173,185,200,206,218,235,237,247,251,260,264,272,282,287,293,321,325,328,341,349,354,359,375],"fonction":[18],"au":[19,249,277],"niveau":[20],"articulations.":[22],"Les":[23,114],"s\u2019averent":[28],"en":[29,169,244],"plus":[30,41],"etre":[31],"une":[32,131,183,223],"pathologies":[34,426],"corps":[36],"humain":[37],"qui":[38,56,127,137,161,214,297,331],"les":[40,86,159,280,311,323],"difficiles":[42],"a":[43,93,140,143,150,203,306,318,336,478,509,552,573,581,586,592,683,699,704,762,779,795,802],"traiter.":[44],"Le":[45,171],"est":[47,181,289,361],"un":[48,204,211,216,291,338,343],"tissu":[49,286,292],"avasculaire":[50],"contenant":[51],"peu":[52],"cellules,":[54],"ce":[55,126,296],"lui":[57,74],"confere":[58,75],"proprietes":[60,77],"regenerescence":[62,178],"intrinseque":[63],"faibles.":[65],"Son":[66],"architecture":[67,449],"complexe":[68],"collagene":[70],"proteoglycanes":[73],"resistance":[79,460],"aux":[80,123,233,269,302],"compressions":[81],"d\u2019elasticite":[83],"avantageuses,":[84],"mais":[85,209],"tissus":[87,115,124],"reparation":[89,95,117,288,326],"typiquement":[90],"formes":[91],"suite":[92],"la":[94,102,151,177,238,245,252,273,365],"d\u2019une":[96],"lesion":[97,253,479,622],"ne":[98,162],"repliquent":[99],"souvent":[100,168,290],"pas":[101,164],"composition":[103,485],"exacte":[104],"articulaire,":[107,192],"ni":[108],"l\u2019organisation":[109],"sa":[111],"matrice":[112],"extracellulaire.":[113],"autologues":[118,202],"donc":[120,182],"mecaniquement":[121],"inferieurs":[122],"sains,":[125],"se":[128],"traduit":[129],"par":[130,231,364,385,388],"perte":[132],"stabilite":[134],"l\u2019articulation":[136,265],"peut":[138],"mener":[139],"douleurs,":[142],"mobilite":[147],"meme":[149],"degenerescence":[152],"chronique":[153],"joint":[155],"synovial.":[156],"En":[157],"effet,":[158],"traitees":[165],"adequatement":[166],"degenerent":[167],"arthrose.":[170],"developpement":[172],"nouvelles":[174],"therapies":[175,546],"pour":[176],"priorite.\r\nAfin":[184],"traiter":[186],"focales":[189],"plusieurs":[193],"traitements":[194,330],"disponibles.":[196],"Par":[197],"exemple,":[198],"l\u2019implantation":[199],"chondrocytes":[201,571],"taux":[205],"succes":[207],"eleve,":[208],"constitue":[210],"traitement":[212],"couteux":[213],"requiert":[215],"minimum":[217,587],"deux":[219],"chirurgies.":[220],"De":[221],"plus,":[222],"etude":[224],"clinique":[225,230],"n\u2019a":[226],"demontre":[227,309],"aucun":[228],"avantage":[229],"rapport":[232],"techniques":[234,242],"stimulation":[236,610],"moelle":[239,274],"osseuse.":[240],"Ces":[241],"consistent":[243],"perforation":[246],"trous":[248,382],"sein":[250],"prealablement":[254],"debridee":[255],"jusqu\u2019a":[256],"l\u2019os":[257],"sous-chondral":[258],"afin":[259],"causer":[261],"le":[262,285,298,377],"saignement":[263],"permettre":[268],"cellules":[270],"souches":[271],"osseuse":[275],"d\u2019acceder":[276],"cartilage.":[278,642],"Malgre":[279],"avantages":[281],"cette":[283],"technique,":[284,648],"type":[294],"fibrocartilagineux,":[295],"rend":[299],"moins":[300,316],"resistant":[301,661],"charges":[303],"mecaniques.":[304],"Il":[305],"aussi":[307],"ete":[308,394],"patients":[312,671,679],"\u00e2ges":[313],"repondaient":[314],"beaucoup":[315],"bien":[317],"ces":[319,329],"techniques.\r\nAfin":[320],"pallier":[322],"reponses":[324],"cartilagineuse":[327],"inadequates,":[333],"notre":[334],"laboratoire":[335],"developpe":[337],"implant":[339,373,701,722,732],"hybride":[340],"chitosane,":[342],"polymere":[344],"naturel":[345],"biodegradable":[346,709],"biocompatible,":[348,711],"glycerol":[350,712],"phosphate":[351,713],"(GP)":[352,714],"sang":[355,368],"autologue.":[356],"La":[357],"solidification":[358,719],"l\u2019implant":[360],"causee":[363],"coagulation":[366,727],"contenu":[369],"dans":[370],"l\u2019implant.":[371],"Cet":[372],"permet":[374],"stabiliser":[376],"caillot":[378],"sanguin":[379],"sur":[380],"chirurgicaux":[383],"perfores":[384],"microfracture":[386,741],"ou":[387],"percage.":[389],"Plusieurs":[390],"etudes":[391],"pre-cliniques":[392],"ont":[393],"faites":[395],"concluent":[397],"les----------ABSTRACT\r\nArticular":[399],"are":[402,420,470,499,534,563,794],"very":[403],"frequent":[404],"and":[405,410,453,463,489,524,628,710,715,751,769,800],"lead":[406,518,757],"to":[407,427,461,503,508,519,607,623,634,639,662,680,685,691,758,771],"intense":[408],"pain":[409],"loss":[411,510,521],"of":[412,416,423,451,459,477,486,492,511,513,522,528,544,557,569,576,580,588,646,655,702,720,728,736,761,798,805,809],"articular":[413,418,487,559],"function.":[414],"Lesions":[415,532],"the":[417,424,466,483,490,514,529,558,567,620,625,632,641,644,649,686,726,729,734,737,759,772,806],"also":[421,666],"one":[422],"hardest":[425],"treat":[428,554],"in":[429,442,456,540,615,619,631,778],"human.":[430],"Cartilage":[431],"is":[432,550,652,708,723,766],"an":[433],"avascular":[434],"tissue":[435,651,764,774],"that":[436,469,516,533,584,599,669,707,754,765],"contains":[437],"few":[438],"cells,":[439],"which":[440,506,657],"results":[441,455],"poor":[443],"intrinsic":[444],"regeneration":[445],"properties.":[446],"Its":[447],"complex":[448],"composed":[450],"collagen":[452],"proteoglycans":[454],"advantageous":[457],"properties":[458],"compression":[462],"elasticity,":[464],"but":[465,578],"repair":[467,475,497,549,650,689,763,793],"tissues":[468,498],"formed":[471],"following":[472],"typical":[473],"treatments":[476],"do":[480],"not":[481,535,673],"replicate":[482],"exact":[484],"organization":[491],"its":[493],"extracellular":[494],"matrix.":[495],"Autologous":[496],"thus":[500,551],"mechanically":[501],"inferior":[502],"healthy":[504],"tissues,":[505],"translates":[507],"stability":[512],"articulation":[515,633],"can":[517],"pain,":[520],"mobility":[523],"even":[525],"chronic":[526],"degeneration":[527],"synovial":[530],"joint.":[531],"properly":[536],"treated":[537],"often":[538,653],"degenerate":[539],"osteoarthritis.":[541],"The":[542,718,784],"development":[543],"new":[545],"for":[547],"priority.\r\nTo":[553],"focal":[555],"cartilage,":[560],"various":[561],"alternatives":[562],"available.":[564],"For":[565],"example,":[566],"implantation":[568],"autologous":[570,716],"has":[572,597,697],"high":[574],"rate":[575],"success,":[577],"consists":[579],"costly":[582],"treatment":[583,693],"requires":[585],"two":[589],"surgeries.":[590],"Additionally,":[591],"five":[593],"years":[594],"clinical":[595,604],"study":[596],"shown":[598,668],"it":[600,659],"had":[601,665],"no":[602],"apparent":[603],"benefit":[605],"compared":[606],"bone":[608,627],"marrow":[609],"techniques.":[611],"These":[612],"procedures":[613],"consist":[614],"creating":[616],"surgical":[617],"holes":[618],"debrided":[621],"perforate":[624],"subchondral":[626],"induce":[629],"bleeding":[630],"allow":[635],"marrow-derived":[636],"stem":[637],"cells":[638],"access":[640],"Despite":[643],"advantages":[645],"this":[647,721,790],"made":[654],"fibrocartilage,":[656],"makes":[658],"less":[660],"load-bearing.":[663],"It":[664],"been":[667,749],"aged":[670],"did":[672],"respond":[674],"as":[675,677],"well":[676],"young":[678],"these":[681],"techniques.\r\nAs":[682],"solution":[684],"inadequate":[687],"response":[690],"current":[692],"modalities,":[694],"our":[695],"laboratory":[696],"developed":[698],"hybrid":[700],"chitosan,":[703],"natural":[705],"polymer":[706],"blood.":[717,730],"caused":[724],"by":[725],"This":[731],"allows":[733],"stabilization":[735],"blood":[738],"clot":[739],"over":[740],"or":[742],"microdrilling":[743],"defects.":[744],"Many":[745],"preclinical":[746],"studies":[747],"have":[748,752],"performed":[750],"concluded":[753],"chitosan-GP/blood":[755],"implants":[756],"synthesis":[760,804],"more":[767],"hyaline":[768],"integrated":[770],"resident":[773],"after":[775],"8":[776],"weeks":[777],"skeletally":[780],"mature":[781],"rabbit":[782],"model.":[783],"short":[785],"term":[786],"events":[787],"associated":[788],"with":[789],"satisfying":[791],"strong":[796],"recruitment":[797],"neutrophils":[799],"osteoclasts,":[801],"delayed":[803],"principal":[807],"elements":[808]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}